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Review

State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments

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Pages 2151-2161 | Published online: 15 Mar 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Ali Al-Kaabi, Rachel S. van der Post, Leonie R. van der Werf, Bas P. L. Wijnhoven, Camiel Rosman, Maarten C. C. M. Hulshof, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven & Peter D. Siersema. (2021) Impact of pathological tumor response after CROSS neoadjuvant chemoradiotherapy followed by surgery on long-term outcome of esophageal cancer: a population-based study. Acta Oncologica 60:4, pages 497-504.
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Bochao Zhao, Wu Lv, Jingting Zhang, Jiale Zhang, Baojun Huang & Jie Lin. (2020) Different prognostic significance of signet ring cell histology for early and advanced gastric cancer patients: a systematic review and meta-analysis. Expert Review of Gastroenterology & Hepatology 14:6, pages 499-509.
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Articles from other publishers (39)

Jiali Ji, Xunlei Zhang, Shushu Yuan, Hong Liu & Lei Yang. (2024) Survival impact of gastrectomy and chemotherapy on gastric signet ring-cell carcinoma with different metastatic lesions: A population-based study. Asian Journal of Surgery 47:4, pages 1769-1775.
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Ronald Mauricio Blanco Montecino, Mikhail Sukhorosl, Mayi Ann Francis, Neeraj Kancherla, Ogbonnaya Akuma, Nkiruka Lauretta Nwangene, Shreyas Nandyal, Rohan Raj, Chinaza Mercy Akuma, Tamer Zahdeh, Sharanya Kaushik & Adil M. Khan. (2023) A Rare Case of Primary Gastric Signet Ring Cell Carcinoma: a Review of Guidelines for the Management of Gastric Cancer. Indian Journal of Surgical Oncology 15:1, pages 153-159.
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Ji Hyun Park, Jae Il Shin & Beom Jin Lim. (2024) Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta‐analysis. Histopathology.
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Jin Ho Baek, Byung Woog Kang, Hyojeung Kang, Miyeon Cho, Oh Kyoung Kwon, Ji Yeon Park, Ki Bum Park, An Na Seo & Jong Gwang Kim. (2023) Clinical implications and chemo-sensitivity of adjuvant chemotherapy in patients with poorly cohesive cells-gastric cancer. Cancer Chemotherapy and Pharmacology.
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Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng, Yihang Pan, Zhe-Sheng Chen & Yulong He. (2022) Signaling pathways and therapeutic interventions in gastric cancer. Signal Transduction and Targeted Therapy 7:1.
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João Barbosa-Martins, Salomé Marques, Olinda Miranda, Bárbara Lima & Jorge Cotter. (2022) Gastric Cancer With Multiple Bone Metastases: An Uncommon Primary Presentation. Cureus.
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Chaoran Yu, Zhiyuan Zhou, Bin Liu, Danhua Yao, Yuhua Huang, Pengfei Wang & Yousheng Li. (2022) Pathological Nodal Staging Score for Gastric Signet Ring Cell Carcinoma: A Clinical Tool of Adequate Nodal Staging. Diagnostics 12:10, pages 2289.
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Robert Lam, Nicholas Tarangelo, Rong Wang, Masayasu Horibe, Alyssa A Grimshaw, Dhanpat Jain, Samir Haffar, Fateh Bazerbachi, Pamela L Kunz & Darrick K Li. (2022) Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 27:9, pages 751-759.
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Eugen Ursu. (2022) Gastric Signet Ring Cell Carcinoma: An Overview. Journal of Medical and Radiation Oncology 2:1, pages 8-16.
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Jeronimo P. A. Da Silva, Mário R. Martins, Rogerio L. dos Santos, Luciana M. da Silva, Cecilia A. C. Lima, Leuridan C. Torres & Nora M. Forones. (2022) Evaluation of platelet activation marker expression and its correlation with tumorigenesis and tumor progression in patients with gastric cancer. Journal of Surgical Oncology 126:1, pages 125-131.
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Heisuke Iijima, Hiroaki Murata, Shinnosuke Oishi, Yusuke Kubota, Akihiko Sakamoto, Kuniaki Tanabe, Kazutaka Sugiyama, Akihiko Matsumoto, Ken Kuriki & Haruki Kume. (2022) Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case. IJU Case Reports 5:4, pages 300-303.
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Chengcheng Tong, Wei Wang, Yang Xia & Chiyi He. (2022) A potential novel biomarker in predicting lymph node metastasis of gastric signet ring cell carcinoma: A derived monocyte to lymphocyte ratio. The American Journal of Surgery 223:6, pages 1144-1150.
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Evangelia Pliakou, Dimitra Lampropoulou, Despoina Nasi & Gerasimos Aravantinos. (2022) Skin metastases from gastric cancer, a rare entity masquerading as erysipelas: A case report. Molecular and Clinical Oncology 16:6.
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Chunmei Zhang, Ruiyi Tang, Hanlong Zhu, Xianxiu Ge, Yue Wang, Xue Wang & Lin Miao. (2022) Comparison of treatment strategies and survival of early-onset gastric cancer: a population-based study. Scientific Reports 12:1.
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Rui Wang, Xiaowei Wu, Yan Song, Rui Lin, Zhongqing Zheng, Kui Jiang & Wentian Liu. (2022) 20-Year Trends in Detection Rates of Cardia Cancer via Endoscopic Surveillance in Tianjin, China: A Hospital-Based Study. Computational and Mathematical Methods in Medicine 2022, pages 1-9.
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Anum Aqsa, Sami Droubi, Hassan Al-Moussawi, Gloria Lan & Sherif Andrawes. (2022) Gastric Signet Ring Cell Adenocarcinoma Presenting as Intermittent Volvulus of Small Bowel: A Case Presentation and Review of the Literature. Cureus.
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Cong Li, Yun Qin, Wei‐Han Zhang, Hanyu Jiang, Bin Song, Mustafa R. Bashir, Heng Xu, Ting Duan, Mengjie Fang, Lianzhen Zhong, Lingwei Meng, Di Dong, Zhenhua Hu, Jie Tian & Jian‐Kun Hu. (2022) Deep learning‐based AI model for signet‐ring cell carcinoma diagnosis and chemotherapy response prediction in gastric cancer. Medical Physics 49:3, pages 1535-1546.
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Naveena A. N. Kumar, Anmi Jose, Nawaz Usman, Keshava Rajan, Murali Munisamy, Preethi S. Shetty & Mahadev Rao. (2021) Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges. Langenbeck's Archives of Surgery 407:1, pages 87-98.
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Marie FelleP. Flores & AngelitoD L. Magno. (2022) When the metastatic tumor presents as a primary tumor: Gastric signet-ring cell carcinoma presenting as advanced cervical cancer with ovarian metastasis. Philippine Journal of Obstetrics and Gynecology 46:1, pages 50.
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昕翌 刘. (2022) Establishment of Reference Interval for the Serum Tumour Marker CA72-4 Measured by the Microarray Chemiluminescence Immunoassay System. Advances in Clinical Medicine 12:04, pages 3278-3285.
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Marcin Nizioł, Justyna Zińczuk, Konrad Zaręba, Katarzyna Guzińska-Ustymowicz & Anna Pryczynicz. (2021) Increased tensin 4 expression is related to the histological type of gastric cancer. World Journal of Clinical Oncology 12:12, pages 1202-1214.
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Hiroaki Tanaka, Mami Yoshii, Takumi Imai, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Kosei Hirakawa & Masaichi Ohira. (2021) Clinical significance of coexisting histological diffuse type in stage II/III gastric cancer. Molecular and Clinical Oncology 15:5.
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Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu & Jieer Ying. (2021) Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study. Frontiers in Oncology 11.
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Cem Horozoglu, Dilara Sonmez, Ozlem Kucukhuseyin, Seyda Demirkol, Mehmet Tolgahan Hakan, Soykan Arikan & İlhan Yaylim. (2021) The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Turkish Journal of Biochemistry 46:3, pages 273-279.
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Kwangil Yim, Won Mo Jang & Sung Hak Lee. (2021) Modified Tumor Budding as a Better Predictor of Lymph Node Metastasis in Early Gastric Cancer: Possible Real-World Applications. Cancers 13:14, pages 3405.
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Ataollah Rajabnejad, Florin Vaida, Mark Valasek, Saqib Razzaque, Paul Fanta, Santiago Horgan, Michael Bouvet, Andrew M. Lowy & Kaitlyn J. Kelly. (2021) Predictors and significance of histologic response to neoadjuvant therapy for gastric cancer. Journal of Surgical Oncology 123:8, pages 1716-1723.
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Rawabi Khalid Algaw, Abrar Hassan Alnujaidi, ‏Alhanoof Abdulhakeem Hazazi, Maram Fahad Alsuwaidan, ‏Ibrahim Abdullah Homadi, Osama Murayah Alqahtani, ‏Sulaiman Turki Alanazi, Sultan Nawi Alanazi, Saleh Jadid Alanazl, ‏Abdullah Mohammed Alzahrani, Turki Mohammed Yahya Albarakati & Mohammed Nahar Alshammari. (2021) An Overview on Gastric Cancer Surgical Management Approach. International Journal Of Pharmaceutical Research And Allied Sciences 10:4, pages 105-109.
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Fahdi Kanavati, Shin Ichihara, Michael Rambeau, Osamu Iizuka, Koji Arihiro & Masayuki Tsuneki. (2021) Deep Learning Models for Gastric Signet Ring Cell Carcinoma Classification in Whole Slide Images. Technology in Cancer Research & Treatment 20, pages 153303382110279.
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Daniel J. CampbellEmily L. IschGeoffrey M. KozakCharles J. Yeo. (2021) Primary Pancreatic Signet Ring Cell Carcinoma: A Case Report and Review of the Literature. Journal of Pancreatic Cancer 7:1, pages 1-7.
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Gloria Ravegnini, Bruno Fosso, Viola Di Saverio, Giulia Sammarini, Federica Zanotti, Giulio Rossi, Monica Ricci, Federica D’Amico, Giorgia Valori, Antonella Ioli, Silvia Turroni, Patrizia Brigidi, Patrizia Hrelia & Sabrina Angelini. (2020) Gastric Adenocarcinomas and Signet-Ring Cell Carcinoma: Unraveling Gastric Cancer Complexity through Microbiome Analysis—Deepening Heterogeneity for a Personalized Therapy. International Journal of Molecular Sciences 21:24, pages 9735.
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Michael K. Rooney, Wajeeha Rasool, Zain Rahman, Kaitlin W. Qualls, Alisha Sharma, Randa Sharag Eldin, Nur Nabil, Solab Chitrakar & Dorota Filipiuk. (2020) Metastatic lobular carcinoma with signet-ring cells mimicking primary gastric signet-ring cell carcinoma. Current Problems in Cancer: Case Reports 1, pages 100006.
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Chao-Tao Tang, Youxiang Chen & Chunyan Zeng. (2020) Prognostic analysis of gastric signet ring cell carcinoma and mucinous carcinoma: a propensity score-matched study and competing risk analysis. Aging 12:21, pages 22059-22077.
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Natalia Rakislova, Miriam Cuatrecasas, Angel Molina, Maite Rodrigo, Leticia Moreira, Javier Laguna, María Rodríguez, Francisco M Pérez, Juan Carlos Laguna & Anna Merino. (2020) Signet ring cell carcinocythaemia in an advanced gastric carcinoma. International Journal of Laboratory Hematology 42:5.
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Raquel Machado-Neves, João Vale, Catarina Eloy & António Polónia. (2020) HER2 genomic heterogeneity is a frequent event in gastroesophageal adenocarcinoma and correlates with tumor morphology. Pathology - Research and Practice 216:9, pages 153090.
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Matthew G.K. Benesch & Alexander Mathieson. (2020) Epidemiology of Signet Ring Cell Adenocarcinomas. Cancers 12:6, pages 1544.
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Tong Wang, Beibei Shen, Liang Wang & Fangfang Liu. (2020) Primary signet ring cell carcinoma of the breast: A rare entity with unique biological behavior—A clinical study based on pure signet ring cell carcinoma cohort. Pathology - Research and Practice 216:6, pages 152948.
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Lili Wang, Yongzhi Miao, Tianwen Chen, Dengzhong Sun, Sitang Ge, Lugen Zuo & Mulin Liu. (2020) Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy. Molecular and Clinical Oncology.
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Hongyun Gong, Yuxin Chu, Qinyong Hu & Qibin Song. (2020) Preoperative Radiotherapy Is Associated With Significant Survival Benefits for Patients With Gastric Signet Ring Cell Carcinoma: A SEER-Based Approach. Technology in Cancer Research & Treatment 19, pages 153303382096074.
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Boubacar Efared, Mohamed Kadi, Laila Tahiri, Nada Lahmidani, Karim Ibn Majdoub Hassani, Hicham El Bouhaddouti, Zineb Benbrahim, Ibrahimi Sidi Adil & Laila Chbani. (2020) Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features. Cancer Control 27:1, pages 107327482097659.
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