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Original Research

UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma

Li-Li Liu1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Ji-Min Zhu1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2150-473X
ORCID Icon,
Xiang-Nan Yu1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Hai-Rong Zhu1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Xuan Shi1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Enkhnaran Bilegsaikhan1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Hong-Ying Guo1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China
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Jian Wu1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China;3 Department of Medical Microbiology and Parasitology, Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of ChinaCorrespondence[email protected]
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Xi-Zhong Shen1 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai200032, People’s Republic of China;2 Shanghai Institute of Liver Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of China;3 Department of Medical Microbiology and Parasitology, Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai200032, People’s Republic of ChinaCorrespondence[email protected]
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Pages 8359-8370 | Published online: 13 Sep 2019

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Jia-Xi Mao, Yuan-Yu Zhao, Jia-Yong Dong, Cong Liu, Qiang Xue, Guo-Shan Ding, Fei Teng & Wen-Yuan Guo. (2021) UBE2T And CYP3A4: hub genes regulating the transformation of cirrhosis into hepatocellular carcinoma. All Life 14:1, pages 509-521.
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Articles from other publishers (24)

Ming Zhang, Tingju Wei & Danfeng Guo. (2024) The role of abnormal ubiquitination in hepatocellular carcinoma pathology. Cellular Signalling 114, pages 110994.
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Yunshu Zhu, Leilei Liang, Yuxi Zhao, Jian Li, Jia Zeng, Yihang Yuan, Ning Li & Lingying Wu. (2024) CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination. Journal of Nanobiotechnology 22:1.
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Xiaoyu Zou, Hong Yu & Qi Li. (2023) Genome-wide identification and transcriptome-based expression profiling of E2 gene family: Implication for potential roles in gonad development of Crassostrea gigas. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 47, pages 101108.
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Nengqian Ma, Zhangzhan Li, Jingting Yan, Xianrong Liu, Liyan He, Ruijie Xie & Xianzhou Lu. (2023) Diverse roles of UBE2T in cancer (Review). Oncology Reports 49:4.
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Xiangxiang Lei, Xiaoge Hu, Qiliang Lu, Wen Fu, Wen Sun, Qiancheng Ma, Dongsheng Huang & Qiuran Xu. (2023) Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review). Oncology Reports 49:3.
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Xiaoyun Bin, Zongjiang Luo, Jianchu Wang & Sufang Zhou. (2023) Identification of a Five Immune Term Signature for Prognosis and Therapy Options (Immunotherapy versus Targeted Therapy) for Patients with Hepatocellular Carcinoma. Computational and Mathematical Methods in Medicine 2023, pages 1-17.
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Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu & Wencui Li. (2022) ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis. Cancer Cell International 22:1.
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Feng Xu, Na Xiong, Yuhong Yuan & Jun Liu. (2022) Prognostic Value of UBE2T and Its Correlation with Immune Infiltrates in Lung Adenocarcinoma. Journal of Oncology 2022, pages 1-9.
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Ping Cui, Hao Li, Can Wang, Yuan Liu, Mengjun Zhang, Yue Yin, Zhenxing Sun, Yiru Wang & Xiuwei Chen. (2022) UBE2T regulates epithelial–mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer. Journal of Ovarian Research 15:1.
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Fang Wang, Shanshan Zhong, Chunjie Mao, Jingbo Jin & Haifeng Wang. (2022) Circ_0000291 contributes to hepatocellular carcinoma tumorigenesis by binding to miR-1322 to up-regulate UBE2T. Annals of Hepatology 27:5, pages 100722.
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Chun-Ye Zhang & Ming Yang. (2022) Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. World Journal of Hepatology 14:5, pages 957-972.
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Chun-Ye Zhang & Ming Yang. (2022) Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. World Journal of Hepatology 14:5, pages 956-971.
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Yucai Wu, Cuijian Zhang, Ding Peng, Shiming He, Cong Huang, Jinqin Qian, Weijie Zhu, Ninghan Feng, Yanqing Gong, Xuesong Li & Liqun Zhou. (2022) MiR-182-5p inhibits the tumorigenesis of clear cell renal cell carcinoma by repressing UBE2T. Human Cell 35:2, pages 542-556.
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Zhenru Zhu, Chuanhui Cao, Dongyan Zhang, Zhihong Zhang, Li Liu, Dehua Wu & Jingyuan Sun. (2022) UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism. Cell Death & Disease 13:2.
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Min Luo & Yuqian Zhou. (2021) Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation. Oncology Letters 22:4.
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Gaoda Ju, Tianhao Zhou, Rui Zhang, Xiaozao Pan, Bing Xue & Sen Miao. (2021) DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PeerJ 9, pages e11929.
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Xiaomei Li, Jiahui Yuan, Conghua Song, Yongbin Lei, Jiajia Xu, Gongye Zhang, Weiwei Wang & Gang Song. (2021) Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma. Cell Death & Differentiation 28:8, pages 2315-2332.
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Xiaodi Du, Hongyu Song, Nengxing Shen, Ruiqi Hua & Guangyou Yang. (2021) The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy. International Journal of Molecular Sciences 22:7, pages 3440.
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Zeyuan Yu, Xiangyan Jiang, Long Qin, Haixiao Deng, Jianli Wang, Wen Ren, Hongbin Li, Lei Zhao, Huanxiang Liu, Hong Yan, Wengui Shi, Qi Wang, Changjiang Luo, Bo Long, Huinian Zhou, Hui Sun & Zuoyi Jiao. (2020) A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene 40:5, pages 1027-1042.
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Nicole Pui Yu Ho, Carmen Oi Ning Leung, Tin Lok Wong, Eunice Yuen Ting Lau, Martina Mang Leng Lei, Etienne Ho Kit Mok, Hoi Wing Leung, Man Tong, Irene Oi Lin Ng, Jing Ping Yun, Stephanie Ma & Terence Kin Wah Lee. (2021) The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression. Cell Death & Disease 12:2.
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Ruoyao ZouHaoya XuFeifei LiShengke WangLiancheng Zhu. (2021) Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s , Clinical Samples, and the GEO Database . DNA and Cell Biology 40:1, pages 36-60.
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Fangfeng Liu, Chengfang Zhu, Pengfei Gao, Shunzhen Zheng & Chunyou Li. (2020) Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma. Anti-Cancer Drugs 31:8, pages 836-846.
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Peng Huang, Yuduo Guo, Zitong Zhao, Weihai Ning, Haoran Wang, Chunyu Gu, Mingshan Zhang, Yanming Qu, Hongwei Zhang & Yongmei Song. (2020) UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT. Aging 12:11, pages 10275-10289.
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Chunnan Li, Meng Lan, Jingwei Lv, Ye Zhang, Xiaochen Gao, Xu Gao, Lihua Dong, Guangming Luo, Hui Zhang & Jiaming Sun. (2019) Screening of the Hepatotoxic Components in Fructus Gardeniae and Their Effects on Rat Liver BRL-3A Cells. Molecules 24:21, pages 3920.
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