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Cancer Management and Research Volume 3, 2011 - Issue
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Original Research

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Volker Wacheck1 Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
,
Michael Lahn2 Early Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN, USA;
,
Gemma Dickinson3 Department of Pharmacokinetics, Eli Lilly and Company, Erl Wood Research Centre, Windlesham, Surrey, UK;
,
Wolfgang Füreder4 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
,
Renata Meyer4 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
,
Susanne Herndlhofer4 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
,
Thorsten Füreder1 Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
,
Georg Dorfner5 Eli Lilly GesmbH, Medical Department, Vienna, Austria;
,
Sada Pillay2 Early Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN, USA;
,
Valérie André6 Department of Statistics, Eli Lilly and Company, Erl Wood Research Centre, Surrey, UK;
,
Timothy P Burkholder7 Discovery Chemistry Research and Technology, Eli Lilly and Company, Indianapolis, IN, USA;
,
Jacqueline K Akunda8 Nonclinical Toxicology, Eli Lilly and Company, Indianapolis, IN, USA;
,
Leann Flye-Blakemore9 Flow Cytometry and Cell Analysis, Esoterix Clinical Trials Services, Mechelen, Belgium;
,
Dirk Van Bockstaele9 Flow Cytometry and Cell Analysis, Esoterix Clinical Trials Services, Mechelen, Belgium;
,
Richard F Schlenk10 Universitätsklinikum Ulm, Klinik für Innere Medizin III, Ulm, Germany;
,
Wolfgang R Sperr4 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;
&
Peter Valent4 Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria;;11 Ludwig Boltzmann Cluster Oncology, Vienna, AustriaCorrespondence[email protected]
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Pages 157-175 | Published online: 30 Sep 2022

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Omar S. Aljitawi, Dandan Li, Yinghua Xiao, Da Zhang, Karthik Ramachandran, Lisa Stehno-Bittel, Peter Van Veldhuizen, Tara L. Lin, Suman Kambhampati & Rama Garimella. (2014) A novel three-dimensional stromal-based model for in vitro chemotherapy sensitivity testing of leukemia cells. Leukemia & Lymphoma 55:2, pages 378-391.
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Articles from other publishers (4)

Michael A. Cannarile, Bruno Gomes, Marta Canamero, Bernhard Reis, Allyson Byrd, Jehad Charo, Mahesh Yadav & Vaios Karanikas. (2021) Biomarker Technologies to Support Early Clinical Immuno-oncology Development: Advances and Interpretation. Clinical Cancer Research 27:15, pages 4147-4159.
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Michael Lahn. 2020. Phase I Oncology Drug Development. Phase I Oncology Drug Development 1 15 .
Alan Chramiec & Gordana Vunjak-Novakovic. (2019) Tissue engineered models of healthy and malignant human bone marrow. Advanced Drug Delivery Reviews 140, pages 78-92.
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Harry P. Erba, Hamid Sayar, Mark Juckett, Michael Lahn, Valerie Andre, Sophie Callies, Shelly Schmidt, Sunil Kadam, John T. Brandt, Dirk Van Bockstaele & Michael Andreeff. (2013) Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML). Investigational New Drugs 31:4, pages 1023-1034.
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