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Review

Potential treatment benefits and safety of roflumilast in COPD: a systematic review and meta-analysis

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Pages 1477-1483 | Published online: 30 Jun 2016

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Xiaoxue Zhu, Min Wu, Hong Wang, Haijun Li, Junjie Lin, Yun Peng, Yue Hu, Cuiyun Li & Yanhua Ding. (2021) Safety, tolerability, and pharmacokinetics of the novel pan-phosphodiesterase inhibitor ZSP1601 in healthy subjects: a double-blinded, placebo-controlled first-in-human single-dose and multiple-dose escalation and food effect study. Expert Opinion on Investigational Drugs 30:5, pages 579-589.
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Mahmoud A. Desouky, Mina Y. George, Haidy E. Michel & Doaa A. Elsherbiny. (2023) Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress. Chemico-Biological Interactions 379, pages 110491.
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Yuanzi Xu. (2022) The Analysis of Tiotropium bromide and Roflumilast: Two Potent Medications for Chronic Obstructive Pulmonary Disease. The Analysis of Tiotropium bromide and Roflumilast: Two Potent Medications for Chronic Obstructive Pulmonary Disease.
Hidehisa Saeki, Tomomi Imamura, Daisuke Yokota & Hidetsugu Tsubouchi. (2022) Difamilast Ointment in Japanese Adult and Pediatric Patients with Atopic Dermatitis: A Phase III, Long-Term, Open-Label Study. Dermatology and Therapy 12:7, pages 1589-1601.
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Vítor S. Fernandes, María Elvira López-Oliva, María Pilar Martínez, Ángel Agis-Torres, Paz Recio, Jorge Navarro-Dorado, María Victoria Barahona, Sara Benedito, Dolores Prieto, Belén Climent & Medardo Hernández. (2022) In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters. Life Sciences 296, pages 120432.
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Mitsugi Ookawara & Yasunori Nio. (2022) Phosphodiesterase 4 inhibitors in diabetic nephropathy. Cellular Signalling 90, pages 110185.
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Hang-yu Chen, Xiao-xiao Li, Chao Li, Hai-chuan Zhu, Hong-yan Hou, Bo Zhang, Li-ming Cheng, Hui Hu, Zhong-xin Lu, Jia-xing Liu, Ze-ruo Yang, Lei Zhang, Nuo Xu, Long Chen, Chuan He, Chao-ran Dong, Qing-gang Ge & Jian Lin. (2022) 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Early Warning Biomarkers for COVID-19 Progression and Myocardial Injury. Frontiers in Cell and Developmental Biology 9.
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Mohammad A. M. Momin, Bishal Raj Adhikari, Shubhra Sinha, Ian Larson & Shyamal C. Das. (2021) Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization. Pharmaceutics 13:8, pages 1254.
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O. V. Zhukova & A. L. Khokhlov. (2020) Analysis of the long-term effectiveness of a drug in the treatment of a chronic disease is the basis of rational pharmacotherapy (on the example of the use of roflumilast in the treatment of chronic obstructive pulmonary disease). Kachestvennaya klinicheskaya praktika:3, pages 35-39.
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Imane Achir Alispahic, Rikke Sørensen, Josefin Eklöf, Pradeesh Sivapalan, Anders Løkke, Niels Seersholm, Jakob Hedemark Vestergaard & Jens-Ulrik Stæhr Jensen. (2020) Roflumilast in Severely Ill Patients with Chronic Obstructive Pulmonary Disease with Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations. Journal of Clinical Medicine 9:5, pages 1442.
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Sadia Janjua, Rebecca Fortescue & Phillippa Poole. (2020) Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2020:5.
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Miriam Barrecheguren & Marc Miravitlles. (2019) Treatment with inhaled α1-antitrypsin: a square peg in a round hole?. European Respiratory Journal 54:5, pages 1901894.
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Amy E. Dunne, Theerasuk Kawamatawong, Peter S. Fenwick, Ceri M. Davies, Hannah Tullett, Peter J. Barnes & Louise E. Donnelly. (2019) Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology 60:4, pages 445-453.
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Thomas Southworth, Manminder Kaur, Lynsey Hodgson, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli & Dave Singh. (2019) Anti-inflammatory effects of the phosphodiesterase type 4 inhibitor CHF6001 on bronchoalveolar lavage lymphocytes from asthma patients. Cytokine 113, pages 68-73.
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Jose Luis Lopez-Campos, Laura Carrasco Hernández, Xavier Muñoz, Víctor Bustamante & Esther Barreiro. (2018) Current controversies in the stepping up and stepping down of inhaled therapies for COPD at the patient level. Respirology 23:9, pages 818-827.
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Øyvind Nicolay Ulland Salvesen, Jesper Rømhild Davidsen, Anton Pottegård & Daniel Pilsgaard Henriksen. (2018) Roflumilast Usage from 2010 to 2016: A Danish Nationwide Drug Utilization Study. Basic & Clinical Pharmacology & Toxicology 123:3, pages 314-319.
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Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Chen, Jinfeng Xie, Zhongzhen Zhou, Jiangping Xu & Haitao Wang. (2018) Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress. Redox Biology 16, pages 47-58.
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Ángel Agis-Torres, Paz Recio, María Elvira López-Oliva, María Pilar Martínez, María Victoria Barahona, Sara Benedito, Salvador Bustamante, Miguel Ángel Jiménez-Cidre, Albino García-Sacristán, Dolores Prieto, Vítor S. Fernandes & Medardo Hernández. (2018) Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission. Scientific Reports 8:1.
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V. Pauwelyn, W. Ceelen & R. A. Lefebvre. (2018) Synergy between 5-HT 4 receptor stimulation and phosphodiesterase 4 inhibition in facilitating acetylcholine release in human large intestinal circular muscle . Neurogastroenterology & Motility 30:2, pages e13162.
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Joy Creaser-Thomas, Vignesh Rajasundaram & Gwyneth A Davies. 2017. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 161 171 .