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International Journal of Chronic Obstructive Pulmonary Disease Volume 11, 2016 - Issue
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Original Research

Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD

Amir Soltani1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia
,
Eugene Haydn Walters1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia
,
David W Reid1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia;2 Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia
,
Shakti Dhar Shukla1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia
,
Kaosia Nowrin1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia
,
Chris Ward3 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK
,
H Konrad Muller1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia
&
Sukhwinder Singh Sohal1 NHMRC Center of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, TAS, Australia;4 School of Health Sciences, University of Tasmania, Launceston, TAS, AustraliaCorrespondence[email protected] [email protected]
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Pages 2359-2367 | Published online: 22 Sep 2016

Citations (30)

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Tegeleqi Bu, Li Fang Wang & Yi Qing Yin. (2020) How Do Innate Immune Cells Contribute to Airway Remodeling in COPD Progression?. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 107-116.
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Mathew Suji Eapen, Pawan Sharma, Archana Vijay Gaikwad, Wenying Lu, Stephen Myers, Philip M Hansbro & Sukhwinder Singh Sohal. (2019) Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1603-1610.
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Surajit Dey, Wenying Lu, Heinrich C. Weber, Sally Young, Josie Larby, Collin Chia, Greg Haug, Samuel James Brake, Stephen Myers, Archana Vijay Gaikwad, Prem Bhattarai, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen & Sukhwinder Singh Sohal. (2022) Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone. American Journal of Physiology-Lung Cellular and Molecular Physiology 323:4, pages L473-L483.
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Sukhwinder Singh Sohal. (2022) Therapeutic Modalities for Asthma, COPD, and Pathogenesis of COVID-19: Insights from the Special Issue. Journal of Clinical Medicine 11:15, pages 4525.
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Surajit Dey, Mathew Suji Eapen, Collin Chia, Archana Vijay Gaikwad, Peter A. B. Wark & Sukhwinder Singh Sohal. (2022) Pathogenesis, clinical features of asthma COPD overlap, and therapeutic modalities. American Journal of Physiology-Lung Cellular and Molecular Physiology 322:1, pages L64-L83.
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Malik Quasir Mahmood, Shakti D. Shukla, Chris Ward & Eugene Haydn Walters. (2021) The Underappreciated Role of Epithelial Mesenchymal Transition in Chronic Obstructive Pulmonary Disease and Its Strong Link to Lung Cancer. Biomolecules 11:9, pages 1394.
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Gang Liu, Ashleigh M. Philp, Tamera Corte, Mark A. Travis, Heidi Schilter, Nicole G. Hansbro, Chris J. Burns, Mathew S. Eapen, Sukhwinder S. Sohal, Janette K. Burgess & Philip M. Hansbro. (2021) Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacology & Therapeutics 225, pages 107839.
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E. Haydn Walters, Shakti D. Shukla, Malik Q. Mahmood & Chris Ward. (2021) Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision. European Respiratory Review 30:160, pages 200364.
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Qing Song, Ping Chen & Xiang-Ming Liu. (2021) The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD. Respiratory Research 22:1.
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Mathew Suji Eapen & Sukhwinder Singh Sohal. (2020) WNT/β-catenin pathway: A novel therapeutic target for attenuating airway remodelling and EMT in COPD. eBioMedicine 62, pages 103095.
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Li Lin, Gang Hou, Dan Han, Yan Yin, Jian Kang & Qiuyue Wang. (2019) Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats. BMC Pulmonary Medicine 19:1.
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Amir Soltani, Malik Q. Mahmood, David W. Reid & E. Haydn Walters. (2019) Cancer-protective effects of inhaled corticosteroids in COPD are likely related to modification of epithelial activation. European Respiratory Journal 54:3, pages 1901088.
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Brianna Atto, Mathew Suji Eapen, Pawan Sharma, Urs Frey, Alaina J. Ammit, James Markos, Collin Chia, Josie Larby, Greg Haug, Heinrich C. Weber, George Mabeza, Stephen Tristram, Stephen Myers, Dominic P. Geraghty, Katie L. Flanagan, Philip M. Hansbro & Sukhwinder Singh Sohal. (2019) New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways. Clinical Science 133:14, pages 1663-1703.
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Wenying Lu, Pawan Sharma, Mathew Suji Eapen & Sukhwinder Singh Sohal. (2019) Inhaled corticosteroids attenuate epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis. European Respiratory Journal 54:1, pages 1900778.
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Wei Hou, Siyi Hu, Chunyan Li, Hanbin Ma, Qi Wang, Guangping Meng, Tingting Guo & Jie Zhang. (2019) Cigarette Smoke Induced Lung Barrier Dysfunction, EMT, and Tissue Remodeling: A Possible Link between COPD and Lung Cancer. BioMed Research International 2019, pages 1-10.
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Li Lin, Gang Hou, Dan Han, Jian Kang & Qiuyue Wang. (2019) Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract. Frontiers in Pharmacology 10.
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Desiree M. Schumann, Diana Leeming, Eleni Papakonstantinou, Francesco Blasi, Konstantinos Kostikas, Wim Boersma, Renaud Louis, Branislava Milenkovic, Joachim Aerts, Jannie M.B. Sand, Emiel F.M. Wouters, Gernot Rohde, Christina Prat, Antoni Torres, Tobias Welte, Michael Tamm, Morten Karsdal & Daiana Stolz. (2018) Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease. Chest 154:4, pages 798-807.
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Anudeep Kota, Deepak A. Deshpande, Mehra Haghi, Brian Oliver & Pawan Sharma. (2018) Autophagy and airway fibrosis: Is there a link?. F1000Research 6, pages 409.
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