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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

Naimish R Patel1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden;2 Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Hospital, Boston, MA
,
Danen M Cunoosamy1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Malin Fagerås1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Ziad Taib1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Sara Asimus1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Tove Hegelund-Myrbäck1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Sofia Lundin1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Katerina Pardali1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Nisha Kurian1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Eva Ersdal1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Cecilia Kristensson1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Katarina Korsback1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Robert Palmér1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, Sweden
,
Mary N Brown3 Innovative Medicines and Early Development, AstraZeneca, Boston, MA, USA
,
Steven Greenaway4 Quintiles Drug Research Unit at Guy’s Hospital, London
,
Leonard Siew4 Quintiles Drug Research Unit at Guy’s Hospital, London
,
Graham W Clarke4 Quintiles Drug Research Unit at Guy’s Hospital, London;5 Department of Cardiothoracic Pharmacology, NHLI, Imperial College London, London, UK
,
Stephen I Rennard6 Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska, Omaha, NE, USA;7 Clinical Discovery Unit, Innovative Medicines and Early Development, AstraZeneca, Cambridge, UK
,
Barry J Make8 Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Health, University of Colorado, Denver, CO
,
Robert A Wise9 Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
&
Paul Jansson1 Innovative Medicines and Early Development, AstraZeneca, Gothenburg, SwedenCorrespondence[email protected]
 show all
Pages 1009-1019 | Published online: 27 Mar 2018

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Mario Cazzola, Nicola A Hanania, Clive P Page & Maria Gabriella Matera. (2023) Novel Anti-Inflammatory Approaches to COPD. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1333-1352.
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Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino & Girolamo Pelaia. (2021) Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies. Drug Design, Development and Therapy 15, pages 1275-1284.
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Jonathan R Baker & Louise E Donnelly. (2021) Leukocyte Function in COPD: Clinical Relevance and Potential for Drug Therapy. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2227-2242.
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Maria Gabriella Matera, Luigino Calzetta, Rosa Annibale, Francesco Russo & Mario Cazzola. (2021) Classes of drugs that target the cellular components of inflammation under clinical development for COPD. Expert Review of Clinical Pharmacology 14:8, pages 1015-1027.
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Corrado Pelaia, Alessandro Vatrella, Claudia Crimi, Luca Gallelli, Rosa Terracciano & Girolamo Pelaia. (2020) Clinical relevance of understanding mitogen-activated protein kinases involved in asthma. Expert Review of Respiratory Medicine 14:5, pages 501-510.
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Corrado Pelaia, Alessandro Vatrella, Angela Sciacqua, Rosa Terracciano & Girolamo Pelaia. (2020) Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives. Expert Review of Respiratory Medicine 14:5, pages 485-491.
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Nisha Kurian, Taylor S Cohen, Lisa Öberg, Erica De Zan, Gabriel Skogberg, Stefan Vollmer, Engin Baturcam, Petter Svanberg, Britta Bonn, Paul D Smith, Outi Vaarala & Danen M Cunoosamy. (2019) Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 2611-2624.
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Frauke Pedersen, Ulrich M Zissler, Henrik Watz, Klaus F Rabe, Jens M Hohlfeld & Olaf Holz. (2019) Rating sputum cell quality in clinical trials for asthma and COPD treatment. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 195-198.
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