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Original Research

The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review

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Pages 409-418 | Published online: 30 Jan 2018

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Read on this site (7)

Yi-Ding Chen, Ci-You Huang, Zhuo-Ping Wang & Wen Wang. (2023) Increased YKL-40 levels are linked with disease severity of initially diagnosed Graves’ disease. Libyan Journal of Medicine 18:1.
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Tzu-Tao Chen, Kang-Yun Lee, Jer-Hwa Chang, Chi-Li Chung, Huan Minh Tran, Amja Manullang, Shu-Chuan Ho, Kuan-Yuan Chen, Chien-Hua Tseng, Sheng-Ming Wu & Hsiao-Chi Chuang. (2023) Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation. Annals of Medicine 55:2.
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Junnan Peng, Qian Yu, Shulei Fan, Xingru Chen, Rui Tang, Daoxin Wang & Di Qi. (2021) High Blood Eosinophil and YKL-40 Levels, as Well as Low CXCL9 Levels, are Associated with Increased Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 795-806.
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Mario F. Perez, Nkiruka C. Atuegwu, Eric M. Mortensen & Cheryl Oncken. (2021) The inflammatory biomarker YKL-40 is elevated in the serum, but not the sputum, of E-cigarette users. Experimental Lung Research 47:2, pages 55-66.
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Yi Kong, Suhan Zhang, Xin Su, Daoquan Peng & Yuwen Su. (2019) Serum levels of YKL-40 are increased in patients with psoriasis: a meta-analysis. Postgraduate Medicine 131:6, pages 405-412.
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Sebastian Majewski, Damian Tworek, Karolina Szewczyk, Justyna Kiszałkiewicz, Zofia Kurmanowska, Ewa Brzeziańska-Lasota, Hanna Jerczyńska, Adam Antczak, Wojciech Jerzy Piotrowski & Paweł Górski. (2019) Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1611-1631.
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Eda Celikbas, Deborah Penque & Jerome Zoidakis. (2019) Systematic review on recent potential biomarkers of chronic obstructive pulmonary disease. Expert Review of Molecular Diagnostics 19:1, pages 37-45.
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Articles from other publishers (31)

Romana Olivia Popețiu, Imola Donath-Miklos, Simona Maria Borta, Silviu Daniel Moldovan, Luminița Pilat, Dragoș Vasile Nica & Maria Pușchiță. (2023) Serum YKL-40 Levels in Patients with Asthma or COPD: A Pilot Study. Medicina 59:2, pages 383.
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Krzysztof Specjalski, Jan Romantowski & Marek Niedoszytko. (2023) YKL-40 as a possible marker of neutrophilic asthma. Frontiers in Medicine 10.
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Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner & Michael T. Heneka. (2023) Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study. Alzheimer's Research & Therapy 15:1.
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Rahim Kocabas. (2023) Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model. Korean Circulation Journal 53:2, pages 92.
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Ming Yang, Shilu Luo, Jinfei Yang, Wei Chen, Liyu He, Di Liu, Li Zhao & Xi Wang. (2022) Myokines: Novel therapeutic targets for diabetic nephropathy. Frontiers in Endocrinology 13.
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Barbara Dymek, Piotr Sklepkiewicz, Michal Mlacki, Nazan Cemre Güner, Patrycja Nejman-Gryz, Katarzyna Drzewicka, Natalia Przysucha, Aleksandra Rymaszewska, Magdalena Paplinska-Goryca, Agnieszka Zagozdzon, Małgorzata Proboszcz, Łukasz Krzemiński, Jan H von der Thüsen, Katarzyna Górska, Karolina Dzwonek, Zbigniew Zasłona, Pawel Dobrzanski & Rafał Krenke. (2022) Pharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis. Journal of Inflammation Research Volume 15, pages 5621-5634.
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Caoyang Fang, Zhenfei Chen, Jing Zhang, Jianyuan Pan, Xiaoqin Jin, Mengsi Yang & Luyao Huang. (2022) The Value of Serum YKL-40 and TNF-α in the Diagnosis of Acute ST-Segment Elevation Myocardial Infarction. Cardiology Research and Practice 2022, pages 1-7.
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Ummugulsum Can. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 767 785 .
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Hey Sung Baek, Ha Young Won, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Mi‐Ae Kim & Man Yong Han. (2021) Association of phthalate exposure and airway dysfunction with mediation by serum periostin. Pediatric Allergy and Immunology 32:8, pages 1681-1690.
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Fei Wang, Wenxuan Li, Zhen Liu, Ronghua Yu & Dalian Wang. (2021) LPS‑induced inflammatory response and apoptosis are mediated by Fra‑1 upregulation and binding to YKL‑40 in A549 cells. Experimental and Therapeutic Medicine 22:6.
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Xiaojing Liu, Bo Cui, Qian Wang, Yuan Ma, Li Li & Zhihong Chen. (2021) Biomarkers for respiratory diseases: Present applications and future discoveries. Clinical and Translational Discovery 1:1.
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James E Parkinson, Stella Pearson, Dominik Rückerl, Judith E Allen & Tara E Sutherland. (2021) The magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB/c versus C57BL/6 mice but matrix composition differs . Immunology & Cell Biology 99:6, pages 640-655.
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Qing Gan, Donge Tang, Qiang Yan, Jiejing Chen, Yong Xu, Wen Xue, Lu Xiao, Fengping Zheng, Huixuan Xu, Yingyun Fu & Yong Dai. (2021) Differential Expression Study of Lysine Crotonylation and Proteome for Chronic Obstructive Pulmonary Disease Combined with Type II Respiratory Failure. Canadian Respiratory Journal 2021, pages 1-12.
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P. Jacquerie, M. Henket, B. André, C. Moermans, D. de Seny, F. Gester, R. Louis, M. Malaise & J. Guiot. (2021) Inflammatory profile of induced sputum composition in systemic sclerosis and comparison with healthy volunteers. Scientific Reports 11:1.
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Keita Hirai, Toshihiro Shirai, Takayuki Shimoshikiryo, Megumi Ueda, Yasuhiro Gon, Shuichiro Maruoka & Kunihiko Itoh. (2020) Circulating microRNA‐15b‐5p as a biomarker for asthma‐COPD overlap. Allergy 76:3, pages 766-774.
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Xiang Tong, Yao Ma, Tao Liu, Zhenzhen Li, Sitong Liu, Guihui Wu & Hong Fan. (2021) Can YKL-40 be used as a biomarker for interstitial lung disease?. Medicine 100:17, pages e25631.
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Eric A. Hoste, Suvi T. Vaara, Jorien De Loor, Mikko Haapio, Lieve Nuytinck, Kristel Demeyere, Ville Pettilä & Evelyne Meyer. (2020) Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort. Critical Care 24:1.
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Jörn Steinke, Stefanie Samietz, Nele Friedrich, Stefan Weiss, Stephan Michalik, Reiner Biffar, Matthias Nauck, Uwe Völker, Henri Wallaschofski, Maik Pietzner & Anke Hannemann. (2020) Associations of plasma YKL-40 concentrations with heel ultrasound parameters and bone turnover markers in the general adult population. Bone 141, pages 115675.
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Caiqun Chen, Yan Liang, Zhiyu Zhang, Zhencheng Zhang & Zaixing Yang. (2020) Relationships between increased circulating YKL-40, IL-6 and TNF-α levels and phenotypes and disease activity of primary Sjögren's syndrome. International Immunopharmacology 88, pages 106878.
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Tao Yu, Wenquan Niu, Hongtao Niu, Ruirui Duan, Fen Dong & Ting Yang. (2020) Chitinase 3‐like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population. The Journal of Gene Medicine 22:9.
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Keiji Oishi, Kazuto Matsunaga, Toshihiro Shirai, Keita Hirai & Yasuhiro Gon. (2020) Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine 9:8, pages 2670.
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Hong Tan, Hua Yao, Zhenbang Lie, Guo Chen, Shuguang Lin & Ying Zhang. (2019) MicroRNA‑30a‑5p promotes proliferation and inhibits apoptosis of human pulmonary artery endothelial cells under hypoxia by targeting YKL‑40. Molecular Medicine Reports.
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