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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD

Henrik Watz1 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, GermanyCorrespondence[email protected]
,
Nitin Bagul2 DNA Medical Ltd, Langley, UK
,
Klaus F Rabe3 Department of Pulmonary Medicine, LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf;4 Department of Medicine, Christian Albrecht University Kiel, Kiel, Germany
,
Stephen Rennard5 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA;6 AstraZeneca, Cambridge, UK
,
Vijay KT Alagappan7 AstraZeneca, Gaithersburg, MD, USA
,
Jonas Román8 AstraZeneca R&D, Gothenburg, Sweden
,
Axel Facius9 thinkQ2 AG, Baar, Switzerland
&
Peter MA Calverley10 Department of Clinical Sciences, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
 show all
Pages 813-822 | Published online: 06 Mar 2018

Citations (16)

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Tai Sun Park, Jieun Kang, Jae Seung Lee, Yeon-Mok Oh, Sang-Do Lee & Sei Won Lee. (2019) Adherence to roflumilast under dose-escalation strategy in Korean patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 871-879.
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J. Alberto Neder, Alcides Rocha, Maria Clara N. Alencar, Flavio Arbex, Danilo C. Berton, Mayron F. Oliveira, Priscila A. Sperandio, Luiz E. Nery & Denis E. O’Donnell. (2018) Current challenges in managing comorbid heart failure and COPD. Expert Review of Cardiovascular Therapy 16:9, pages 653-673.
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Peter Kardos, Ingo Mokros, Rüdiger Sauer & Claus F Vogelmeier. (2018) Health status in patients with COPD treated with roflumilast: two large noninterventional real-life studies: DINO and DACOTA. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 1455-1468.
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Articles from other publishers (13)

Yazdan Hasani Nourian, Jafar Salimian, Ali Ahmadi, Zahra Salehi, Mehrdad Karimi, Alireza Emamvirdizadeh, Sadegh Azimzadeh Jamalkandi & Mostafa Ghanei. (2023) cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features. Biochemistry and Biophysics Reports 34, pages 101438.
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Dennis Williams. (2020) The Role of the Pharmacist in Optimizing Outcomes With Roflumilast, a PDE4 Inhibitor for the Treatment of COPD. Journal of Pharmacy Practice 35:3, pages 445-454.
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Sumbal Naseem, Muhammad Hassan, Shazia Nasim Akhtar, Fibhaa Syed, Naveed Ullah Khan & Muhammad Usman. (2022) Effectiveness of Roflumilast in Treating Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Cureus.
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Dave Singh. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 741 753 .
Dave Singh, Simon Lea & Alexander G. Mathioudakis. (2021) Inhaled Phosphodiesterase Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. Drugs 81:16, pages 1821-1830.
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Theerasuk Kawamatawong. (2021) Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases. Frontiers in Pharmacology 12.
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Dave Singh. (2021) Pharmacological treatment of stable chronic obstructive pulmonary disease. Respirology 26:7, pages 643-651.
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Dave Singh, Fernando J. Martinez, Henrik Watz, Thomas Bengtsson & Brian T. Maurer. (2020) A dose-ranging study of the inhaled dual phosphodiesterase 3 and 4 inhibitor ensifentrine in COPD. Respiratory Research 21:1.
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Imane Achir Alispahic, Rikke Sørensen, Josefin Eklöf, Pradeesh Sivapalan, Anders Løkke, Niels Seersholm, Jakob Hedemark Vestergaard & Jens-Ulrik Stæhr Jensen. (2020) Roflumilast in Severely Ill Patients with Chronic Obstructive Pulmonary Disease with Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations. Journal of Clinical Medicine 9:5, pages 1442.
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Sadia Janjua, Rebecca Fortescue & Phillippa Poole. (2020) Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2020:5.
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Chin Kook Rhee & Deog Kyeom Kim. (2020) Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease. The Korean Journal of Internal Medicine 35:2, pages 276-283.
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Dinesh Yogaratnam, Mary Bylo, Katherine M. Carey, Valerie Coppenrath, Aimee Dawson, Amy B.W. LaMothe, Ann M. Lynch & Nnamdi Okeke. 2019. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 171 182 .
Axel Facius, Eleonora Marostica, Philip Gardiner, Henrik Watz & Gezim Lahu. (2018) Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease. Clinical Pharmacokinetics 57:8, pages 1029-1038.
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