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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

Pharmacokinetics of glycopyrronium/formoterol fumarate dihydrate delivered via metered dose inhaler using co-suspension delivery technology in patients with moderate-to-very severe COPD

Gary T Ferguson1 Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USACorrespondence[email protected]
,
Roberto Rodriguez-Roisin2 Universitat de Barcelona, Hospital Clínic-The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
,
Colin Reisner3 Pearl – A member of the AstraZeneca Group, Morristown, NJ, USA;4 AstraZeneca, Gaithersburg, MD, USA
,
Andrea Maes3 Pearl – A member of the AstraZeneca Group, Morristown, NJ, USA
,
Shahid Siddiqui4 AstraZeneca, Gaithersburg, MD, USA
&
Ubaldo J Martin4 AstraZeneca, Gaithersburg, MD, USA
Pages 945-953 | Published online: 21 Mar 2018

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Weimin Li, Sami Z Daoud, Roopa Trivedi, Pradeep B Lukka, Eulalia Jimenez, Eduard Molins, Catherine Stewart, Pranob Bharali & Esther Garcia-Gil. (2023) The Pharmacokinetics, Safety and Tolerability of Aclidinium Bromide 400 μg Administered by Inhalation as Single and Multiple (Twice Daily) Doses in Healthy Chinese Participants. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 2725-2735.
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Pierre-Edouard Grillet, Cosette Le Souder, Juliette Rohou, Olivier Cazorla, Jérémy Charriot & Arnaud Bourdin. (2021) Glycopyrrolate and formoterol fumarate for the treatment of COPD. Expert Review of Respiratory Medicine 15:1, pages 13-25.
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Donald P Tashkin. (2020) Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3105-3122.
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Maria Gabriella Matera, Barbara Rinaldi, Clive Page, Paola Rogliani & Mario Cazzola. (2018) Pharmacokinetic considerations concerning the use of bronchodilators in the treatment of chronic obstructive pulmonary disease. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1101-1111.
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Articles from other publishers (10)

Mario Cazzola, Clive Page, Paola Rogliani, Luigino Calzetta & Maria Gabriella Matera. (2022) Dual bronchodilation for the treatment of COPD: From bench to bedside. British Journal of Clinical Pharmacology 88:8, pages 3657-3673.
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Hong Zhang, Sami Z. Daoud, Michael S. Gillen, Natalia Calderon, Maria Heijer, Eduard Molins, Esther Garcia-Gil, Hong Chen, Qianqian Li, Chengjiao Liu & Yanhua Ding. (2022) An Evaluation of the Pharmacokinetics, Safety, and Tolerability of Aclidinium/Formoterol Fixed-Dose Combination Administered in Chinese Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease. Drugs in R&D 22:1, pages 35-42.
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Omar S. Usmani, Rajiv Dhand, Federico Lavorini & David Price. (2021) Why We Should Target Small Airways Disease in Our Management of Chronic Obstructive Pulmonary Disease. Mayo Clinic Proceedings 96:9, pages 2448-2463.
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Mitsuo Higashimori, Kensuke Ishikawa, Michael Gillen & Diansong Zhou. (2021) Physiologically Based Pharmacokinetic Modelling of Glycopyrronium in Patients With Renal Impairment. Journal of Pharmaceutical Sciences 110:1, pages 438-445.
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Leonard J. Dunn, Edward M. Kerwin, Kiernan DeAngelis, Patrick Darken, Michael Gillen & Paul Dorinsky. (2020) Pharmacokinetics of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler formulated using co-suspension delivery technology after single and chronic dosing in patients with COPD. Pulmonary Pharmacology & Therapeutics 60, pages 101873.
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Zaina T. Al-Salama & James E. Frampton. (2019) Glycopyrronium/Formoterol: A Review in COPD. Drugs 79:13, pages 1455-1466.
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Maryam Khoubnasabjafari, Elaheh Rahimpour, Morteza Samini, Vahid Jouyban-Gharamaleki, Lan Chen, Donghao Chen, Hak-Kim Chan & Abolghasem Jouyban. (2019) A new hypothesis to investigate bioequivalence of pharmaceutical inhalation products. DARU Journal of Pharmaceutical Sciences 27:1, pages 517-524.
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Qian Chen, Chaoying Hu, Hui Yu, Kai Shen, Pryseley Nkouibert Assam, Michael Gillen, Yun Liu & Paul Dorinsky. (2019) Pharmacokinetics and Tolerability of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate and Glycopyrronium/Formoterol Fumarate Dihydrate Metered Dose Inhalers in Healthy Chinese Adults: A Randomized, Double-blind, Parallel-group Study. Clinical Therapeutics 41:5, pages 897-909.e1.
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Toshio Nakaki. 2019. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 151 161 .
Colin Reisner, Joel Miller, Paolo DePetrillo, Andrea Maes, Shahid Siddiqui & Ubaldo J. Martin. (2018) Pharmacokinetics and safety of a single dose of the novel LAMA/LABA fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler, formulated using co-suspension delivery technology, in Japanese healthy subjects. Pulmonary Pharmacology & Therapeutics 53, pages 33-38.
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