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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD

Wilfried De Backer1 Department of Respiratory Medicine, University of Antwerp, Antwerp, Belgium, [email protected]Correspondence[email protected]
,
Jan De Backer2 FLUIDDA, Los Angeles, CA, USA
,
Wim Vos3 FLUIDDA, Kontich, Belgium
,
Ilse Verlinden3 FLUIDDA, Kontich, Belgium
,
Cedric Van Holsbeke3 FLUIDDA, Kontich, Belgium
,
Johan Clukers1 Department of Respiratory Medicine, University of Antwerp, Antwerp, Belgium, [email protected]
,
Bita Hajian1 Department of Respiratory Medicine, University of Antwerp, Antwerp, Belgium, [email protected]
,
Shahid Siddiqui4 AstraZeneca, Gaithersburg, MD, USA
,
Martin Jenkins5 AstraZeneca, Cambridge, UK
,
Colin Reisner4 AstraZeneca, Gaithersburg, MD, USA;6 Pearl – A member of the AstraZeneca Group, Morristown, NJ, USA
&
Ubaldo J Martin4 AstraZeneca, Gaithersburg, MD, USA
 show all
Pages 2673-2684 | Published online: 30 Aug 2018

Citations (21)

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Jennifer M Wang, Sundaresh Ram, Wassim W Labaki, MeiLan K Han & Craig J Galbán. (2022) CT-Based Commercial Software Applications: Improving Patient Care Through Accurate COPD Subtyping. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 919-930.
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Fiammetta Danzo, Dejan Radovanovic, Marina Gatti, Marina Saad, Luca Perotto, Elisa Franceschi & Pierachille Santus. (2022) A reappraisal of inspiratory capacity in chronic obstructive pulmonary disease: clinical correlates and role of long-acting muscarinic antagonists and long-acting β2 agonists. Expert Review of Respiratory Medicine 16:6, pages 623-635.
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Omar S Usmani, Nicolas Roche, Martin Jenkins, Neda Stjepanovic, Peter Mack & Wilfried De Backer. (2021) Consistent Pulmonary Drug Delivery with Whole Lung Deposition Using the Aerosphere Inhaler: A Review of the Evidence. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 113-124.
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Pierre-Edouard Grillet, Cosette Le Souder, Juliette Rohou, Olivier Cazorla, Jérémy Charriot & Arnaud Bourdin. (2021) Glycopyrrolate and formoterol fumarate for the treatment of COPD. Expert Review of Respiratory Medicine 15:1, pages 13-25.
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Articles from other publishers (17)

Eduardo Genofre, Donna Carstens, Wilfried DeBacker, Patrick Muchmore, Reynold A. PanettieriJrJr, Kirsty Rhodes, Vivian H. Shih & Frank Trudo. (2023) The effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach. Respiratory Research 24:1.
Crossref
Miranda Kirby & Benjamin M. Smith. (2023) Quantitative CT Scan Imaging of the Airways for Diagnosis and Management of Lung Disease. Chest.
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Maarten van den Berge, Jan De Backer, Cedric Van Holsbeke, Wilfried De Backer, Roopa Trivedi, Martin Jenkins, Paul Dorinsky & Magnus Aurivillius. (2021) Functional respiratory imaging assessment of budesonide/glycopyrrolate/formoterol fumarate and glycopyrrolate/formoterol fumarate metered dose inhalers in patients with COPD: the value of inhaled corticosteroids. Respiratory Research 22:1.
Crossref
Eline Lauwers, Annemiek Snoeckx, Kris Ides, Kim Van Hoorenbeeck, Maarten Lanclus, Wilfried De Backer, Jan De Backer & Stijn Verhulst. (2021) Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study. BMC Pulmonary Medicine 21:1.
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Jonattan Gallegos-Catalán, Zachary Warnken, Tania F. Bahamondez-Canas & Daniel Moraga-Espinoza. (2021) Innovating on Inhaled Bioequivalence: A Critical Analysis of the Current Limitations, Potential Solutions and Stakeholders of the Process. Pharmaceutics 13:7, pages 1051.
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Omar S. Usmani, MeiLan K. Han, David A. Kaminsky, James Hogg, Josephine Hjoberg, Naimish Patel, Megan Hardin, Christina Keen, Stephen Rennard, François-Xavier Blé & Mary N. Brown. (2021) Seven Pillars of Small Airways Disease in Asthma and COPD. Chest 160:1, pages 114-134.
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Omar S. UsmaniBenjamin MignotIrvin KendallRoberta De MariaDaniela CocconiGeorge GeorgesNicola Scichilone. (2021) Predicting Lung Deposition of Extrafine Inhaled Corticosteroid-Containing Fixed Combinations in Patients with Chronic Obstructive Pulmonary Disease Using Functional Respiratory Imaging: An In Silico Study . Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:3, pages 204-211.
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Sandeep Bodduluri, Abhilash Kizhakke Puliyakote, Arie Nakhmani, Jean-Paul Charbonnier, Joseph M. Reinhardt & Surya P. Bhatt. (2021) Computed Tomography–based Airway Surface Area–to-Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 203:2, pages 185-191.
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Gen Tamura, Jang-Woon Choi, Shinichiro Takeda, Naoya Nishina & Ai Hayashi. (2021) Aerosol velocity of two pressurized metered-dose inhalers using AEROSPHERE® Delivery Technology. Respiratory Investigation 59:1, pages 153-154.
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Yasuhiro Gon, Koichi Nishi, Kazuhiro Sato, Andrea Maes, Shahid Siddiqui, Nobuya Hayashi, Hajime Hirata, Ubaldo J. Martin & Colin Reisner. (2021) Efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler delivered using co-suspension delivery technology in Japanese patients with moderate-to-very severe chronic obstructive pulmonary disease. Respiratory Investigation 59:1, pages 135-144.
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David Langton, Kim Bennetts, Peter Noble, Virginia Plummer & Francis Thien. (2020) Bronchial thermoplasty reduces airway resistance. Respiratory Research 21:1.
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Justin L. Garner & Pallav L. Shah. (2020) Challenges of evaluating lung function as part of cancer care during the COVID-19 pandemic. European Respiratory Journal 56:2, pages 2001621.
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Leonard J. Dunn, Edward M. Kerwin, Kiernan DeAngelis, Patrick Darken, Michael Gillen & Paul Dorinsky. (2020) Pharmacokinetics of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler formulated using co-suspension delivery technology after single and chronic dosing in patients with COPD. Pulmonary Pharmacology & Therapeutics 60, pages 101873.
Crossref
Wilfried De Backer, Jan De Backer, Ilse Verlinden, Glenn Leemans, Cedric Van Holsbeke, Benjamin Mignot, Martin Jenkins, Dianne Griffis, Stefan Ivanov, Jane Fitzpatrick, Earl St Rose, Ubaldo J. Martin & Colin Reisner. (2020) Functional respiratory imaging assessment of glycopyrrolate and formoterol fumarate metered dose inhalers formulated using co-suspension delivery technology in patients with COPD. Therapeutic Advances in Respiratory Disease 14, pages 175346662091699.
Crossref
Zaina T. Al-Salama & James E. Frampton. (2019) Glycopyrronium/Formoterol: A Review in COPD. Drugs 79:13, pages 1455-1466.
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François Maltais, Gary T. Ferguson, Gregory J. Feldman, Gaëtan Deslee, Arnaud Bourdin, Harald Fjällbrant, Agnieszka Siwek-Posłuszna, Martin A. Jenkins & Ubaldo J. Martin. (2019) A Randomized, Double-Blind, Double-Dummy Study of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Relative to Umeclidinium/Vilanterol Dry Powder Inhaler in COPD. Advances in Therapy 36:9, pages 2434-2449.
Crossref
Denis Menshykau & Simon Tanaka. 2019. Concepts and Principles of Pharmacology. Concepts and Principles of Pharmacology 231 261 .

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