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Review

Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review

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Pages 3651-3662 | Published online: 05 Nov 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Xiaoyi Feng, Huaye Xiao, Yishan Duan, Qinxue Li & Xuemei Ou. (2023) Prognostic Value of Neutrophil to Lymphocyte Ratio for Predicting 90-Day Poor Outcomes in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1219-1230.
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Eiko Suzuki, Naoko Kawata, Ayako Shimada, Hirotaka Sato, Rie Anazawa, Masaki Suzuki, Yuki Shiko, Mayumi Yamamoto, Jun Ikari, Koichiro Tatsumi & Takuji Suzuki. (2023) Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1077-1090.
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Zhixiang Chen, Lei Zha, Guohong Feng, Qian An, Fei Shi, Jingjing Xu, Qiancheng Xu, Huimin Xia, Milan Zhang & Lu Li. (2023) Prognostic Value of Serum Cholinesterase Levels for In-Hospital Mortality among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 20:1, pages 178-185.
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Natalia Troianova, Barbara Mariotti, Valentina Micheletti, Federica Calzetti, Marta Donini, Gianluca Salvagno, Marcello Ferrari, Ernesto Crisafulli & Flavia Bazzoni. (2021) Impact of Sex on Circulating Leukocytes Composition in COPD Patients. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 3539-3550.
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Yiben Huang, Bingqian Jiang, Xiaqi Miao, Jiedong Ma, Jianing Wang, Keke Ding, Xianjing Chen, Qiaoming Hu, Fangyi Fu, Tian Zeng, Jingyu Hu, Binbin Hu, Dehao Yang & Xiaodiao Zhang. (2020) The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3159-3169.
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Alexa Nuñez, Viviana Marras, Matevz Harlander, Evgeni Mekov, Cristina Esquinas, Matjaz Turel, David Lestan, Rosen Petkov, Nikolay Yanev, Pietro Pirina, Silvia Negri, Marc Miravitlles & Miriam Barrecheguren. (2020) Association Between Routine Blood Biomarkers and Clinical Phenotypes and Exacerbations in Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 681-690.
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Articles from other publishers (21)

Ching-Hsiung Lin, Yi-Rong Li, Pei Ru Lin, Bing-Yen Wang, Sheng-Hao Lin, Kuo-Yang Huang & Chew-Teng Kor. (2022) Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study. Scientific Reports 12:1.
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Zhi-yuan Chen, Yu-mei Lin, Jian-hua Wu, Xiao-qi Zhang, Yi Zhang, Wen-xi Xie, Shu-qiang Chu & Yan Li. (2022) Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD. BMC Pulmonary Medicine 22:1.
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Miguel Ángel Martinez-García, Casilda Olveira, Rosa Girón, Marta García-Clemente, Luis Máiz-Carro, Oriol Sibila, Rafael Golpe, Raúl Méndez, Juan Luis Rodríguez Hermosa, Esther Barreiro, Concepción Prados, Juan Rodríguez López & David de la Rosa. (2022) Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity. Biomolecules 12:10, pages 1399.
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ShiYu Zhou, Lili Tao, Zheng Zhang, Zhenhui Zhang & Shengli An. (2022) Mediators of neutrophil–lymphocyte ratio in the relationship between ondansetron pre‐treatment and the mortality of ICU patients on mechanical ventilation: Causal mediation analysis from the MIMIC‐IV database. British Journal of Clinical Pharmacology 88:6, pages 2747-2756.
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M. R. Sarkarova & M. V. Maevskaya. (2022) Prognostic and diagnostic value of the ratio of neutrophils to lymphocytes of patients with diseases of the gastrointestinal tract and liver. Meditsinskiy sovet = Medical Council:7, pages 60-68.
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Ramazan Baldemir, Ayperi Öztürk, Guler Eraslan Doganay, Mustafa Ozgur Cirik & Ali Alagoz. (2022) Evaluation of Nutritional Status in Hospitalized Chronic Obstructive Pulmonary Disease Patients and Can C-reactive Protein-to-Albumin Ratio Be Used in the Nutritional Risk Assessment in These Patients. Cureus.
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Monalisa Biswas, Renuka Suvarna, Vimal Krishnan S, Tom Devasia, Vijetha Shenoy Belle & Krishnananda Prabhu. (2022) The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases. F1000Research 11, pages 960.
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Ramazan Baldemir & Mustafa Özgür Cirik. (2022) Practical parameters that can be used for nutritional assessment in patients hospitalized in the intensive care unit with the diagnosis of chronic obstructive pulmonary disease. Medicine 101:24, pages e29433.
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Milena-Adina Man, Lavinia Davidescu, Nicoleta-Stefania Motoc, Ruxandra-Mioara Rajnoveanu, Cosmina-Ioana Bondor, Carmen-Monica Pop & Claudia Toma. (2021) Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis. Diagnostics 12:1, pages 81.
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Ramazan Baldemir & Ali Alagoz. (2021) The Relationship Between Mortality, Nutritional Status, and Laboratory Parameters in Geriatric Chronic Obstructive Pulmonary Disease Patients. Cureus.
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Jens Ellingsen, Christer Janson, Kristina Bröms, Karin Lisspers, Björn Ställberg, Marieann Högman & Andrei Malinovschi. (2021) Neutrophil-to-lymphocyte ratio, blood eosinophils and COPD exacerbations: a cohort study. ERJ Open Research 7:4, pages 00471-2021.
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Aaron J. Heffernan & Kerina J. Denny. (2021) Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?. Current Infectious Disease Reports 23:4.
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Aseih Hatefi Olaee, Fariba Rezaeetalab & Nasim Lotfinejad. (2020) Comparison of diagnostic values of haematological and inflammatory parameters in predicting COPD exacerbation. Pneumologia 69:4, pages 227-233.
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Kamila Bołtuć, Arkadiusz Bociek, Robert Dziugieł, Martyna Bociek, Tomasz Zapolski, Wojciech Dąbrowski & Andrzej Jaroszyński. (2020) Neutrophil-Lymphocyte Ratio (NLR) Reflects Myocardial Inhomogeneities in Hemodialyzed Patients. Mediators of Inflammation 2020, pages 1-6.
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Yuya Kaino, Fumiaki Kitazawa, Yuki Maeno, Takahiro Oi, Reiko Banno, Ichiro Nakakura, Takahito Nakamura & Masahiko Tsujikawa. (2020) Influence of Antibiotics on the Antitumor Effect of Immune Checkpoint Inhibitors in Japanese Patients with Non-small-cell Lung Cancer非小細胞肺がん日本人患者における免疫チェックポイント阻害薬の抗腫瘍効果に及ぼす抗菌薬の影響. Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 46:8, pages 436-446.
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Sung Woo Moon, Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Yeon-Mok Oh, Hyejung Shin, Joon Chang & Ji Ye Jung. (2020) Low serum lymphocyte level is associated with poor exercise capacity and quality of life in chronic obstructive pulmonary disease. Scientific Reports 10:1.
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Xu Gao, Brent Coull, Xihong Lin, Pantel Vokonas, David Sparrow, Lifang Hou, Dawn L. DeMeo, Augusto A. Litonjua, Joel Schwartz & Andrea A. Baccarelli. (2020) Association of Neutrophil to Lymphocyte Ratio With Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open 3:7, pages e2010350.
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Pinar Altiaylik Ozer & Nalan Ogan. (2020) Correlatıon of neutrophyle/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease. The Clinical Respiratory Journal 14:4, pages 353-363.
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S. Özbir, R. B. Değirmentepe, H. A. Atalay, İ. Alkan, S. S. Çakır, A. Ötünçtemur & H. L. Canat. (2019) The role of inflammatory parameters (neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and monocyte‐to‐eosinophil ratio) in patients with Peyronie's disease. Andrology 8:2, pages 348-352.
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Rebekah C Merriman, Oshani Dissanayake, Sara Alnjar, Fiona Burns & Robert F Miller. (2019) Incidence and significance of elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios among hospitalised HIV-positive adult patients. International Journal of STD & AIDS 30:13, pages 1329-1332.
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Mario Cazzola, Ermanno Puxeddu, Josuel Ora & Paola Rogliani. (2019) Evolving Concepts in Chronic Obstructive Pulmonary Disease Blood-Based Biomarkers. Molecular Diagnosis & Therapy 23:5, pages 603-614.
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