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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

Blood eosinophils: a biomarker of COPD exacerbation reduction with inhaled corticosteroids

Salman H Siddiqui1 University of Leicester, Leicester, UK, [email protected];2 National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK, [email protected]Correspondence[email protected]
,
Ian D Pavord3 Respiratory Theme, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK;4 Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
,
Neil C Barnes5 Glaxo Smith Kline, Brentford, London, UK;6 Barts and The London School of Medicine and Dentistry, London, UK
,
Alessandro Guasconi7 Chiesi Farmaceutici SpA, Parma, Italy
,
Sally Lettis8 GSK, Uxbridge, London, UK
,
Steven Pascoe9 GSK, King of Prussia, PA, USA
&
Stefano Petruzzelli7 Chiesi Farmaceutici SpA, Parma, Italy
 show all
Pages 3669-3676 | Published online: 06 Nov 2018

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Calvin You Jia Chen, Min Sen Yew, John Arputhan Abisheganaden & Huiying Xu. (2022) Predictors of Influenza PCR Positivity in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 25-32.
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Jaco Voorham, Simonetta Baldi, Luigi Santoro, Marjan Kerkhof, Marco Contoli, Leonardo M Fabbri, Huib A M Kerstjens, Jose Luis López-Campos, Nicolas Roche, Dave Singh, Claus F Vogelmeier & David B Price. (2020) Extrafine Beclometasone Dipropionate/Formoterol Fumarate vs Double Bronchodilation Therapy in Patients with COPD: A Historical Real-World Non-Inferiority Study. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2739-2750.
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Hiroaki Kume, Ryuki Yamada & Yuki Sato. 2023. A Compendium of Chronic Obstructive Pulmonary Disease. A Compendium of Chronic Obstructive Pulmonary Disease.
Smit Patel, Scott Dickinson, Kevin Morris, Helen F. Ashdown & James D. Chalmers. (2022) A descriptive cohort study of withdrawal from inhaled corticosteroids in COPD patients. npj Primary Care Respiratory Medicine 32:1.
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Vasilis Nikolaou, Sebastiano Massaro, Masoud Fakhimi & Wolfgang Garn. (2022) Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response. Life 12:6, pages 775.
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Thais Beauperthuy, Amina Bekki & Miguel Ángel Martínez-García. (2022) Chronic bronchial infection in stable COPD: An under-recognized situation that needs attention. Respiratory Medicine and Research 81, pages 100894.
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Fabrizio Facchinetti, Maurizio Civelli, Dave Singh, Alberto Papi, Aida Emirova & Mirco Govoni. (2021) Tanimilast, A Novel Inhaled Pde4 Inhibitor for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease. Frontiers in Pharmacology 12.
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Howraman Meteran, Pradeesh Sivapalan & Jens-Ulrik Stæhr Jensen. (2021) Treatment Response Biomarkers in Asthma and COPD. Diagnostics 11:9, pages 1668.
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Sumitra Shantakumar, Yu-Fan Ho, Janine Beale & Barry Gribben. (2021) Burden of illness in blood eosinophilic phenotype COPD patients in New Zealand. Respiratory Investigation 59:4, pages 487-497.
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Songsong Yu, Jie Zhang, Qiuhong Fang & Zhaohui Tong. (2021) Blood Eosinophil Levels and Prognosis of Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The American Journal of the Medical Sciences 362:1, pages 56-62.
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Mario Cazzola, Maria Gabriella Matera & Paola Rogliani. (2021) Blood Eosinophils in Chronic Obstructive Pulmonary Disease: Is There Enough Evidence?. US Respiratory & Pulmonary Diseases 6:1, pages 31.
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Dave Singh, Michele Bassi, Deborah Balzano, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Gera Jellema, Ebenezer K. Afolabi, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz & Mirco Govoni. (2020) COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum. Journal of Cellular and Molecular Medicine 25:2, pages 905-918.
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Alvar Agustí, Claus Vogelmeier & Rosa Faner. (2020) COPD 2020: changes and challenges. American Journal of Physiology-Lung Cellular and Molecular Physiology 319:5, pages L879-L883.
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Marjan Kerkhof, Jaco Voorham, Paul Dorinsky, Claudia Cabrera, Patrick Darken, Janwillem WH Kocks, Mohsen Sadatsafavi, Don D Sin, Victoria Carter & David B Price. (2020) Association between COPD exacerbations and lung function decline during maintenance therapy. Thorax 75:9, pages 744-753.
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Katarzyna Mycroft, Rafal Krenke & Katarzyna Górska. (2020) Eosinophils in COPD—Current Concepts and Clinical Implications. The Journal of Allergy and Clinical Immunology: In Practice 8:8, pages 2565-2574.
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Dave Singh, Henrik Watz, Kai Michael Beeh, Oliver Kornmann, Brian Leaker, Brendan Colgan, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Debora Santoro, Deborah Balzano & Mirco Govoni. (2020) COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition. European Respiratory Journal 56:2, pages 2000237.
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Barbara Putman, Lies Lahousse, Ankura Singh, Rachel Zeig-Owens, Charles B. Hall, Melissa J. Fazzari, Theresa Schwartz, Mayris P. Webber, Hillel W. Cohen, David J. Prezant & Michael D. Weiden. (2020) Dyspnea and Inhaled Corticosteroid and Long-acting β-Agonist Therapy in an Occupational Cohort: A Longitudinal Study. Annals of the American Thoracic Society 17:6, pages 770-773.
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James D. Chalmers, Irena F. Laska, Frits M.E. Franssen, Wim Janssens, Ian Pavord, David Rigau, Melissa J. McDonnell, Nicolas Roche, Don D. Sin, Daiana Stolz, Samy Suissa, Jadwiga Wedzicha & Marc Miravitlles. (2020) Withdrawal of inhaled corticosteroids in COPD: a European Respiratory Society guideline. European Respiratory Journal 55:6, pages 2000351.
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David M.G. Halpin, Mark T. Dransfield, MeiLan K. Han, C. Elaine Jones, Sally Kilbride, Peter Lange, David A. Lipson, David A. Lomas, Fernando J. Martinez, Steve Pascoe, Dave Singh, Robert Wise & Gerard J. Criner. (2020) The effect of exacerbation history on outcomes in the IMPACT trial. European Respiratory Journal 55:5, pages 1901921.
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Tinè, Biondini, Semenzato, Bazzan, Cosio, Saetta & Turato. (2019) Reassessing the Role of Eosinophils as a Biomarker in Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine 8:7, pages 962.
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Jaco Voorham, Massimo Corradi, Alberto Papi, Claus F. Vogelmeier, Dave Singh, Leonardo M. Fabbri, Marjan Kerkhof, Janwillem H. Kocks, Victoria Carter & David Price. (2019) Comparative effectiveness of triple therapy versus dual bronchodilation in COPD . ERJ Open Research 5:3, pages 00106-2019.
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Frederico Leon Arrabal Fernandes & Suzana Erico Tanni. (2019) The future is now. Jornal Brasileiro de Pneumologia 45:6.
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Sarah H. Landis, Jeanne M. Pimenta, Shibing Yang, Chris Compton, Neil Barnes & Guy Brusselle. (2019) Association between blood eosinophils and acute exacerbation of COPD risk in patients with COPD in primary care. Respiratory Medicine: X 1, pages 100011.
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