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Original Research

Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study

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Pages 159-167 | Published online: 27 Mar 2013

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Ingrid Fricke-Galindo & Ramcés Falfán-Valencia. (2022) Current pharmacogenomic recommendations in chronic respiratory diseases: Is there a biomarker ready for clinical implementation?. Expert Review of Respiratory Medicine 16:11-12, pages 1145-1152.
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Timothy E Albertson, Willis S Bowman, Richart W Harper, Regina M Godbout & Susan Murin. (2019) Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1251-1265.
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Gaetano Caramori, Paolo Ruggeri, Paolo Casolari, Kian Fan Chung, Giuseppe Girbino & Ian M. Adcock. (2017) Fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 11:12, pages 955-967.
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Mario Malerba, Alessandro Radaeli, Paolo Montuschi & Jaymin B. Morjaria. (2016) Vilanterol trifenatate for the treatment of COPD. Expert Review of Respiratory Medicine 10:7, pages 719-731.
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Sabrina Nickel, Caoimhe G. Clerkin, Mohammed Ali Selo & Carsten Ehrhardt. (2016) Transport mechanisms at the pulmonary mucosa: implications for drug delivery. Expert Opinion on Drug Delivery 13:5, pages 667-690.
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Rashmi Mehta, Kelly Hardes, Noushin Brealey, Lee Tombs, Andrew Preece & Dennis Kelleher. (2015) Effect of severe renal impairment on umeclidinium and umeclidinium/vilanterol pharmacokinetics and safety: a single-blind, nonrandomized study. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 15-23.
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Maria Gabriella Matera, Paola Rogliani, Barbara Rinaldi & Mario Cazzola. (2015) Umeclidinium bromide + vilanterol for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology 8:1, pages 35-41.
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Mario Malerba, Jaymin Bhagwanji Morjaria & Alessandro Radaeli. (2014) Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD – role of umeclidinium/vilanterol. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 687-695.
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Andrea Segreti, Luigino Calzetta, Paola Rogliani & Mario Cazzola. (2014) Umeclidinium for the treatment of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 8:6, pages 665-671.
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Articles from other publishers (19)

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Yan Li, Huafang Li, Yucheng Sheng, Xin Du, Yuhui Yao, Xian Luo & Peiming Ma. (2019) Pharmacokinetics of Single and Repeat Doses of Fluticasone Furoate/Umeclidinium/Vilanterol in Healthy Chinese Adults. Clinical Pharmacology in Drug Development 8:6, pages 721-733.
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Carsten Ehrhardt, Per Bäckman, William Couet, Chris Edwards, Ben Forbes, Markus Fridén, Mark Gumbleton, Ken-Ichi Hosoya, Yukio Kato, Takeo Nakanishi, Mikihisa Takano, Tetsuya Terasaki & Ryoko Yumoto. (2017) Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs. Journal of Pharmaceutical Sciences 106:9, pages 2234-2244.
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Han Ni, Aung Htet & Soe Moe. (2017) Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD). Cochrane Database of Systematic Reviews 2017:6.
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Kesavan Suresh Babu & Jaymin Bhagwanji Morjaria. (2017) Umeclidinium in chronic obstructive pulmonary disease: latest evidence and place in therapy. Therapeutic Advances in Chronic Disease 8:4-5, pages 81-91.
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Editorial Article. (2016) Therapeutic strategy to prevent acute exacerbations of chronic obstructive pulmonary disease: clinical guidelines of American College of Chest Physicians and Canadian Thoracic Society Guideline (Part 2). PULMONOLOGIYA 26:3, pages 267-291.
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Roy A. Pleasants, Tiansheng Wang, Jinming Gao, Huilin Tang & James F. Donohue. (2016) Inhaled Umeclidinium in COPD Patients: A Review and Meta-Analysis. Drugs 76:3, pages 343-361.
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Johanna J. Salomon, Yohannes Hagos, Sören Petzke, Annett Kühne, Julia C. Gausterer, Ken-ichi Hosoya & Carsten Ehrhardt. (2015) Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1. Molecular Pharmaceutics 12:8, pages 2633-2641.
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Gerard J. Criner, Jean Bourbeau, Rebecca L. Diekemper, Daniel R. Ouellette, Donna Goodridge, Paul Hernandez, Kristen Curren, Meyer S. Balter, Mohit Bhutani, Pat G. Camp, Bartolome R. Celli, Gail Dechman, Mark T. Dransfield, Stanley B. Fiel, Marilyn G. Foreman, Nicola A. Hanania, Belinda K. Ireland, Nathaniel Marchetti, Darcy D. Marciniuk, Richard A. Mularski, Joseph Ornelas, Jeremy D. Road & Michael K. Stickland. (2015) Prevention of Acute Exacerbations of COPD. Chest 147:4, pages 894-942.
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Chaoying Hu, Jingying Jia, Kelly Dong, Linda Luo, Kai Wu, Rashmi Mehta, Jack Peng, Yan Ren, Annette Gross & Hui Yu. (2015) Pharmacokinetics and Tolerability of Inhaled Umeclidinium and Vilanterol Alone and in Combination in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Trial. PLOS ONE 10:3, pages e0121264.
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Hannah A. Blair & Emma D. Deeks. (2014) Umeclidinium/Vilanterol: A Review of Its Use as Maintenance Therapy in Adults with Chronic Obstructive Pulmonary Disease. Drugs 75:1, pages 61-74.
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Rashmi Mehta, Kelly Hardes, Dennis Kelleher, Andrew Preece, Lee Tombs & Noushin Brealey. (2014) Effects of Moderate Hepatic Impairment on the Pharmacokinetic Properties and Tolerability of Umeclidinium and Vilanterol in Inhalational Umeclidinium Monotherapy and Umeclidinium/Vilanterol Combination Therapy: An Open-Label, Nonrandomized Study. Clinical Therapeutics 36:7, pages 1016-1027.e2.
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Lesley J. Scott & Philip Hair. (2014) Umeclidinium/Vilanterol: First Global Approval. Drugs 74:3, pages 389-395.
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Johanna J. Salomon, Carsten Ehrhardt & Ken-ichi Hosoya. (2014) The Verapamil Transporter Expressed in Human Alveolar Epithelial Cells (A549) Does Not Interact with β2-Receptor Agonists. Drug Metabolism and Pharmacokinetics 29:1, pages 101-104.
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A. Prakash, K.S. Babu & J.B. Morjaria. (2013) Novel anti-cholinergics in COPD. Drug Discovery Today 18:21-22, pages 1117-1126.
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Ghaith Al-Jayyoussi, Daniel F. Price, Danielle Francombe, Glyn Taylor, Mathew W. Smith, Chris Morris, Chris D. Edwards, Peter Eddershaw & Mark Gumbleton. (2013) Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout. Journal of Pharmaceutical Sciences 102:9, pages 3382-3394.
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