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Original Research

Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients

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Pages 569-579 | Published online: 22 Nov 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2018) Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 12:8, pages 693-708.
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Wilfried De Backer, Jan De Backer, Wim Vos, Ilse Verlinden, Cedric Van Holsbeke, Johan Clukers, Bita Hajian, Shahid Siddiqui, Martin Jenkins, Colin Reisner & Ubaldo J Martin. (2018) A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 2673-2684.
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Bita Hajian, Jan De Backer, Wim Vos, Wouter H van Geffen, Paul De Winter, Omar Usmani, Tony Cahn, Huib AM Kerstjens, Massimo Pistolesi & Wilfried De Backer. (2018) Changes in ventilation–perfusion during and after an COPD exacerbation: an assessment using fluid dynamic modeling. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 833-842.
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Bita Hajian, Jan De Backer, Wim Vos, Jelle Aerts, Johan Cluckers & Wilfried De Backer. (2016) Efficacy of inhaled medications in asthma and COPD related to disease severity. Expert Opinion on Drug Delivery 13:12, pages 1719-1727.
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Mario Cazzola, Paola Rogliani, Josuel Ora & Maria Gabriella Matera. (2016) Treatment options for moderate-to-very severe chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 17:7, pages 977-988.
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Wim Vos, Bita Hajian, Jan De Backer, Cedric Van Holsbeke, Samir Vinchurkar, Rita Claes, Annemie Hufkens, Paul M Parizel, Lieven Bedert & Wilfried De Backer. (2016) Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 263-271.
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Bita Hajian, Jan De Backer, Wim Vos, Cedric Van Holsbeke, Johan Clukers & Wilfried De Backer. (2016) Functional respiratory imaging (FRI) for optimizing therapy development and patient care. Expert Review of Respiratory Medicine 10:2, pages 193-206.
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Maria Gabriella Matera, Luigino Calzetta & Mario Cazzola. (2016) Oxidation pathway and exacerbations in COPD: the role of NAC. Expert Review of Respiratory Medicine 10:1, pages 89-97.
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Jia-Qiang Zhang, Jian-Qing Zhang, Li-Zhou Fang, Ling Liu, Wei-Ping Fu & Lu-Ming Dai. (2015) Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter. Drug Design, Development and Therapy 9, pages 6379-6387.
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Jian-Qing Zhang, Jia-Qiang Zhang, Hua Liu, Zhi-Huan Zhao, Li-Zhou Fang, Ling Liu, Wei-Ping Fu, Jing-Kui Shu, Jia-Gang Feng & Lu-Ming Dai. (2015) Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 917-923.
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Articles from other publishers (18)

Guangbin ChenHongzhou Lu. (2022) Oral high-dose acetylcysteine: Effective against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)?. Drug Discoveries & Therapeutics 16:3, pages 139-141.
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Ruth M. Saunders, Michael Biddle, Yassine Amrani & Christopher E. Brightling. (2022) Stressed out - The role of oxidative stress in airway smooth muscle dysfunction in asthma and COPD. Free Radical Biology and Medicine 185, pages 97-119.
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Glenn D. Crater, Karmon Johnson, Jonathan Ward & Jan De Backer. (2022) Lung deposition of inhaled once-daily long-acting muscarinic antagonists via standard jet nebulizer or dry powder inhaler, measured using functional respiratory imaging, in patients with chronic obstructive pulmonary disease . Therapeutic Advances in Respiratory Disease 16, pages 175346662210775.
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Xuequn Guo, Hongsheng Lin, Donghao Guo & Qiu Luo. (2022) Azithromycin use prior to ICU admission is associated with a lower short-term mortality for critically ill acute exacerbations of chronic obstructive pulmonary disease patients: A retrospective cohort study. Chronic Respiratory Disease 19, pages 147997312211407.
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Brandon W. Lewis, Maria L. Ford, Lynette K. Rogers & Rodney D. BrittJr.Jr.. (2021) Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants 10:9, pages 1335.
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Jia Liu, Jie Liu & Yong Zou. (2019) Relationship between neutrophil–lymphocyte ratio and short-term prognosis in the chronic obstructive pulmonary patients with acute exacerbation. Bioscience Reports 39:5.
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Phillippa Poole, Kavin Sathananthan & Rebecca Fortescue. (2019) Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2020:3.
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Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 331 348 .
Chenghao Yang, Fokko J. Bosker, Jie Li & Robert A. Schoevers. (2018) N-acetylcysteine as add-on to antidepressant medication in therapy refractory major depressive disorder patients with increased inflammatory activity: study protocol of a double-blind randomized placebo-controlled trial. BMC Psychiatry 18:1.
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Qianwen Zhang, Yuanrong Ju, Yan Ma & Tao Wang. (2018) N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia. Medicine 97:45, pages e13087.
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Yuliya A. Petrovskaya, Ludmila M. Ogorodova & Fedor I. Petrovskiy. (2018) Principles of Decision Making on the Prescription of Medicines. What else Do You Need to Know when Interpreting the Results of Clinical Trials?. Pediatric pharmacology 15:4, pages 343-348.
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Cedric Van Holsbeke, Jan De Backer, Wim Vos & Jonathan Marshall. (2018) Use of functional respiratory imaging to characterize the effect of inhalation profile and particle size on lung deposition of inhaled corticosteroid/long-acting β2-agonists delivered via a pressurized metered-dose inhaler . Therapeutic Advances in Respiratory Disease 12, pages 175346661876094.
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Rebecca A. Fanning, Deirdre P. Campion, Maeve O’Shea, Michael F. Carey & John J. O’Connor. (2017) A comparison of the effects of lindane and FeCl 3 /ADP on spontaneous contractions in isolated rat or human term myometrium. Reproductive Toxicology 74, pages 164-173.
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Kaushal Fowdar, Huan Chen, Zhiyi He, Jiujin Zhang, Xiaoning Zhong, Jianquan Zhang, Meihua Li & Jing Bai. (2017) The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review. Heart & Lung 46:2, pages 120-128.
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Carla Nunes, Natércia Teixeira, Diana Serra, Víctor Freitas, Leonor Almeida & João Laranjinha. (2016) Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways. Toxicology Research 5:1, pages 53-65.
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Claudio M. Sanguinetti. (2016) N-acetylcysteine in COPD: why, how, and when?. Multidisciplinary Respiratory Medicine 11:1.
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Phillippa Poole, Jimmy Chong & Christopher J Cates. (2015) Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews.
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Mario Cazzola & Maria Gabriella Matera. (2014) N-acetylcysteine in COPD may be beneficial, but for whom?. The Lancet Respiratory Medicine 2:3, pages 166-167.
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