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Original Research

Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients: an interventional, randomized, double-blind clinical trial

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Pages 1917-1923 | Published online: 11 Sep 2015

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Fiammetta Danzo, Dejan Radovanovic, Marina Gatti, Marina Saad, Luca Perotto, Elisa Franceschi & Pierachille Santus. (2022) A reappraisal of inspiratory capacity in chronic obstructive pulmonary disease: clinical correlates and role of long-acting muscarinic antagonists and long-acting β2 agonists. Expert Review of Respiratory Medicine 16:6, pages 623-635.
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Jia-Jie Wang. (2021) Risk of Coronary Heart Disease in People with Chronic Obstructive Pulmonary Disease: A Meta-Analysis. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2939-2944.
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Nirupama Putcha, Ayca Ozol-Godfrey, Shahin Sanjar & Sanjay Sharma. (2021) Impact of Comorbidity Prevalence and Cardiovascular Disease Status on the Efficacy and Safety of Nebulized Glycopyrrolate in Patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 1061-1073.
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Alberto Braghiroli, Fulvio Braido, Alessio Piraino, Paola Rogliani, Pierachille Santus & Nicola Scichilone. (2020) Day and Night Control of COPD and Role of Pharmacotherapy: A Review. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 1269-1285.
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Jose Luis Lopez-Campos & Stefano Centanni. (2018) Current Approaches for Phenotyping as a Target for Precision Medicine in COPD Management. COPD: Journal of Chronic Obstructive Pulmonary Disease 15:2, pages 108-117.
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Marco Mantero, Dejan Radovanovic, Pierachille Santus & Francesco Blasi. (2018) Management of severe COPD exacerbations: focus on beclomethasone dipropionate/formoterol/glycopyrronium bromide. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 2319-2333.
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Amnon Ariel, Alan Altraja, Andrey Belevskiy, Piotr W Boros, Edvardas Danila, Matjaz Fležar, Vladimir Koblizek, Zvi G Fridlender, Kosta Kostov, Alvils Krams, Branislava Milenkovic, Attila Somfay, Ruzena Tkacova, Neven Tudoric, Ruxandra Ulmeanu & Arschang Valipour. (2018) Inhaled therapies in patients with moderate COPD in clinical practice: current thinking. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 45-56.
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Fernando Sergio Leitao Filho, Nawaf M. Alotaibi, Kei Yamasaki, David A. Ngan & Don D. Sin. (2018) The role of beta-blockers in the management of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 12:2, pages 125-135.
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Pierachille Santus, Dejan Radovanovic, Andrea Cristiano, Vincenzo Valenti & Maurizio Rizzi. (2017) Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease. Drug Design, Development and Therapy 11, pages 3257-3271.
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Konstantinos Kostikas & Nikolaos M. Siafakas. (2016) Does the Term “Deflators” Reflect More Accurately the Beneficial Effects of Long-acting Bronchodilators in COPD?. COPD: Journal of Chronic Obstructive Pulmonary Disease 13:5, pages 537-539.
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Gary T Ferguson, Jill P Karpel, Emmanuelle Clerisme-Beaty, Lars Grönke, Florian Voß & Roland Buhl. (2016) Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO® and OTEMTO® studies: a subgroup analysis by age. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 2701-2710.
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A. Calderón Montero. (2023) El eje cardiopulmonar y la mortalidad cardiovascular en el paciente EPOC. Medicina de Familia. SEMERGEN 49:4, pages 101928.
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N. Siafakas & A. Trachalaki. (2023) By deflating the lungs pulmonologists help the cardiologists. A literature review. Pulmonology.
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Yanan Cui, Zijie Zhan, Yiming Ma, Ke Huang, Chen Liang, Xihua Mao, Yaowen Zhang, Xiaoxia Ren, Jieping Lei, Yan Chen, Ting Yang & Chen Wang. (2022) Clinical and economic burden of comorbid coronary artery disease in patients with acute exacerbation of chronic obstructive pulmonary disease: sex differences in a nationwide cohort study. Respiratory Research 23:1.
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Paolo Solidoro, Carlo Albera, Fulvia Ribolla, Michela Bellocchia, Luisa Brussino & Filippo Patrucco. (2022) Triple Therapy in COPD: Can We Welcome the Reduction in Cardiovascular Risk and Mortality?. Frontiers in Medicine 9.
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Thomas M. Siler, Claire Hohenwarter, Kuangnan Xiong, Kenneth Sciarappa, Shahin Sanjar & Sanjay Sharma. (2021) Efficacy of Nebulized Glycopyrrolate on Lung Hyperinflation in Patients with COPD. Pulmonary Therapy 7:2, pages 503-516.
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Pierachille Santus, Elisa Franceschi, Stefano Pini, Francesca Frassanito, Francesco Amati, Fiammetta Danzo, Marina Gatti & Dejan Radovanovic. (2021) Switching to nebulised short acting bronchodilators does not increase the risk of arrhythmia in patients hospitalized with a COPD exacerbation. Pharmacological Research 173, pages 105915.
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Peter Alter, Jan Orszag, Christina Kellerer, Kathrin Kahnert, Tim Speicher, Henrik Watz, Robert Bals, Tobias Welte, Claus F. Vogelmeier & Rudolf A. Jörres. (2020) Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET. ERJ Open Research 6:3, pages 00092-2020.
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Vicente Benavides-Cordoba, Sebastian Aviles, Camila Ascuntar, Lina Orozco, Ricardo Mosquera & Julian Rivera. (2020) Dual use of bronchodilators versus monotherapy, and its impact on pulmonary rehabilitation in COPD patients. Pulmonary Pharmacology & Therapeutics 61, pages 101898.
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Roy Pleasants. 2020. Cardiac Considerations in Chronic Lung Disease. Cardiac Considerations in Chronic Lung Disease 161 212 .
N. Struß, J. Bauersachs, T. Welte & J. M. Hohlfeld. (2019) Left heart function in COPDLinksherzfunktion bei COPD. Herz 44:6, pages 477-482.
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José Luis López-Campos, Laura Carrasco Hernández & Esther Quintana Gallego. (2019) El dilema entre el pulmón y el corazón en EPOC: historia de dos ciudades. Archivos de Bronconeumología 55:4, pages 185-186.
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José Luis López-Campos, Laura Carrasco Hernández & Esther Quintana Gallego. (2019) The Heart–Lung Dilemma in COPD: A Tale of Two Cities. Archivos de Bronconeumología (English Edition) 55:4, pages 185-186.
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Klaus F. Rabe, John R. Hurst & Samy Suissa. (2018) Cardiovascular disease and COPD: dangerous liaisons?. European Respiratory Review 27:149, pages 180057.
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Jens M Hohlfeld, Jens Vogel-Claussen, Heike Biller, Dominik Berliner, Korbinian Berschneider, Hanns-Christian Tillmann, Simone Hiltl, Johann Bauersachs & Tobias Welte. (2018) Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. The Lancet Respiratory Medicine 6:5, pages 368-378.
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Paulo de Tarso Müller, Gustavo Christofoletti, Rodrigo Koch, João Henrique Zardetti Nogueira, Luiz Armando Pereira Patusco & Gaspar Rogério Chiappa. (2017) CPAP and EPAP elicit similar lung deflation in a non‐equivalent mode in GOLD 3‐4 COPD patients. The Clinical Respiratory Journal 12:4, pages 1598-1606.
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Marco Contoli, Gianluca Campo, Rita Pavasini, Irene Marchi, Alessia Pauletti, Cristina Balla, Antonio Spanevello, Roberto Ferrari & Alberto Papi. (2018) Inhaled corticosteroid/long-acting bronchodilator treatment mitigates STEMI clinical presentation in COPD patients. European Journal of Internal Medicine 47, pages 82-86.
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David M. Halpin, Alan G. Kaplan & Richard K. Russell. (2017) Why choose tiotropium for my patient? A comprehensive review of actions and outcomes versus other bronchodilators. Respiratory Medicine 128, pages 28-41.
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Dave Singh, Giorgia Ciurlia, Annalisa Piccinno, Annamaria Muraro, Maria Bocchi & Mario Scuri. (2017) Acute cardiovascular safety of two formulations of beclometasone dipropionate/formoterol fumarate in COPD patients: A single-dose, randomised, placebo-controlled crossover study. Pulmonary Pharmacology & Therapeutics 42, pages 43-51.
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Giovanni Sotgiu, Dejan Radovanovic & Pierachille Santus. (2016) State of the Heart in Chronic Obstructive Pulmonary Disease: The Best Is Yet to Come. American Journal of Respiratory and Critical Care Medicine 194:11, pages 1433-1434.
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Henrik Watz. (2016) Chronic Obstructive Pulmonary Disease: When Pulmonologists Do Something Good for the Heart. American Journal of Respiratory and Critical Care Medicine 193:7, pages 703-704.
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Pierachille Santus, Dejan Radovanovic, Giovanni Balzano, Matteo Pecchiari, Rita Raccanelli, Nicola Sarno, Fabiano Di Marco, Paul W. Jones & Mauro Carone. (2016) Improvements in Lung Diffusion Capacity following Pulmonary Rehabilitation in COPD with and without Ventilation Inhomogeneity. Respiration 92:5, pages 295-307.
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Bruno-Pierre Dubé, Antoine Guerder, Capucine Morelot-Panzini & Pierantonio Laveneziana. (2016) The clinical relevance of the emphysema-hyperinflated phenotype in COPD. COPD Research and Practice 2:1.
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