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Review

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

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Pages 19-34 | Published online: 03 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Gurjasmine Kaur, Aman Sharma & Archana Bhatnagar. (2021) Role of oxidative stress in pathophysiology of rheumatoid arthritis: insights into NRF2-KEAP1 signalling. Autoimmunity 54:7, pages 385-397.
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Haishan Zhou, Yan Wang, Qidong You & Zhengyu Jiang. (2020) Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present). Expert Opinion on Therapeutic Patents 30:3, pages 209-225.
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Matej Sova & Luciano Saso. (2018) Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review. Drug Design, Development and Therapy 12, pages 3181-3197.
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Aaron J. Done, Michael J. Newell & Tinna Traustadóttir. (2017) Effect of exercise intensity on Nrf2 signalling in young men. Free Radical Research 51:6, pages 646-655.
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Giovanni Monastra, Sara De Grazia, Serap Cilaker Micili, Asli Goker & Vittorio Unfer. (2016) Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage. Expert Opinion on Drug Delivery 13:12, pages 1695-1708.
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Anna Maria Fratta Pasini, Marcello Ferrari, Chiara Stranieri, Paola Vallerio, Chiara Mozzini, Ulisse Garbin, Giorgia Zambon & Luciano Cominacini. (2016) Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild–moderate ex-smoker COPD patients with persistent oxidative stress. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 1733-1743.
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. (2016) ALSUntangled No. 31: Protandim. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 17:1-2, pages 154-156.
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Articles from other publishers (20)

Lauren Elizabeth Millichap, Elisabetta Damiani, Luca Tiano & Iain P. Hargreaves. (2021) Targetable Pathways for Alleviating Mitochondrial Dysfunction in Neurodegeneration of Metabolic and Non-Metabolic Diseases. International Journal of Molecular Sciences 22:21, pages 11444.
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Li-Fei Luo, Peng Guan, Lu-Yun Qin, Jian-Xin Wang, Na Wang & En-Sheng Ji. (2021) Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. Molecular and Cellular Biochemistry 476:7, pages 2603-2611.
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Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauß, Subhashini Bolisetty, Fred Lühder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen & Ari Waisman. (2020) Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier. Acta Neuropathologica 140:4, pages 549-567.
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Bryan J. Mathis & Taixing Cui. 2020. Nrf2 and its Modulation in Inflammation. Nrf2 and its Modulation in Inflammation 97 127 .
Hyttinen, Kannan, Felszeghy, Niittykoski, Salminen & Kaarniranta. (2019) The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology. International Journal of Molecular Sciences 20:22, pages 5800.
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Wooseong Kim, Soojin Kim, Sanghyun Ju, Hanju Lee, Seongkeun Jeong, Jin-Wook Yoo, In-Soo Yoon & Yunjin Jung. (2019) Colon-Targeted Delivery Facilitates the Therapeutic Switching of Sofalcone, a Gastroprotective Agent, to an Anticolitic Drug via Nrf2 Activation. Molecular Pharmaceutics 16:9, pages 4007-4016.
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Musthafa Mohamed Essa, Marzieh Moghadas, Taher Ba-Omar, M. Walid Qoronfleh, Gilles J. Guillemin, Thamilarasan Manivasagam, Arokiasamy Justin-Thenmozhi, Bipul Ray, Abid Bhat, Saravana Babu Chidambaram, Amanda J Fernandes, Byoung-Joon Song & Mohammed Akbar. (2019) Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review. Neurotoxicity Research 35:3, pages 739-774.
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Raul Carpi-Santos & Karin C. Calaza. (2018) Alterations in System xc− Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2. Molecular Neurobiology 55:10, pages 7941-7948.
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Mikko Karttunen, Wing-Yiu Choy & Elio A. Cino. (2018) Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High-Affinity Peptides. The Journal of Physical Chemistry B 122:22, pages 5851-5859.
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Hianara A. Bustamante, Alexis E. González, Cristobal Cerda-Troncoso, Ronan Shaughnessy, Carola Otth, Andrea Soza & Patricia V. Burgos. (2018) Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease. Frontiers in Cellular Neuroscience 12.
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Hongming Lv, Qingfei Xiao, Junfeng Zhou, Haihua Feng, Guowen Liu & Xinxin Ci. (2018) Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity. Frontiers in Pharmacology 9.
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Qin M. Chen & Anthony J. Maltagliati. (2018) Nrf2 at the heart of oxidative stress and cardiac protection. Physiological Genomics 50:2, pages 77-97.
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Yu-Ju Lin, I-Chun Lin, Hong-Ren Yu, Jiunn-Ming Sheen, Li-Tung Huang & You-Lin Tain. (2018) Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring. Oxidative Medicine and Cellular Longevity 2018, pages 1-8.
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Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis & Matthew G Vander Heiden. (2017) Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. eLife 6.
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Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge & Braulio Jiménez-Vélez. (2017) Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM 2.5 , Budesonide, and Cotreated Exposures . Mediators of Inflammation 2017, pages 1-12.
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Zheng-Yu Jiang, Meng-Chen Lu & Qi-Dong You. (2016) Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions. Journal of Medicinal Chemistry 59:24, pages 10837-10858.
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Zhe Qu, Valeri V. Mossine, Jiankun Cui, Grace Y. Sun & Zezong Gu. (2016) Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. NeuroMolecular Medicine 18:3, pages 474-482.
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Zhi-Zhong Xie, Yang Liu & Jin-Song Bian. (2016) Hydrogen Sulfide and Cellular Redox Homeostasis. Oxidative Medicine and Cellular Longevity 2016, pages 1-12.
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Kun-Ping Wang, Chao Zhang, Shou-Guo Zhang, En-Dong Liu, Lan Dong, Xiang-Zhen Kong, Peng Cao, Chun-Ping Hu, Ke Zhao, Yi-Qun Zhan, Xiao-Ming Dong, Chang-Hui Ge, Miao Yu, Hui Chen, Lin Wang, Xiao-Ming Yang & Chang-Yan Li. (2015) 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity 2015, pages 1-11.
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Danielle R. Bruns, Joshua C. Drake, Laurie M. Biela, Frederick F. Peelor, Benjamin F. Miller & Karyn L. Hamilton. (2015) Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models. Oxidative Medicine and Cellular Longevity 2015, pages 1-15.
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