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Original Research

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

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Pages 1011-1026 | Published online: 29 Mar 2017

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Arakkaveettil Kabeer Farha, Ren-You Gan, Hua-Bin Li, Ding-Tao Wu, Atanas G. Atanasov, Khalid Gul, Jia-Rong Zhang, Qiong-Qiong Yang & Harold Corke. (2022) The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives. Critical Reviews in Food Science and Nutrition 62:3, pages 832-859.
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Parisa Hasanein, Abbasali Emamjomeh, Nasibeh Chenarani & Mussa Bohlooli. (2020) Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats. Nutritional Neuroscience 23:7, pages 563-574.
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Aliyu Muhammad, David Ebuka Arthur, Sanusi Babangida, Ochuko L. Erukainure, Ibrahim Malami, Hadiza Sani, Aliyu Waziri Abdulhamid, Idayat Omoyemi Ajiboye, Ahmed Ariyo Saka, Nafisa Muhammed Hamza, Suleiman Asema, Zaharaddeen Muhammad Ado & Taibat Ishaq Musa. (2020) Modulatory role of rutin on 2,5-hexanedione-induced chromosomal and DNA damage in rats: validation of computational predictions. Drug and Chemical Toxicology 43:2, pages 113-126.
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Shirin Asgharian, Mohammad Reza Hojjati, Mohsen Ahrari, Elham Bijad, Fatemeh Deris & Zahra Lorigooini. (2020) Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats. Pharmaceutical Biology 58:1, pages 447-453.
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Vijayapandi Pandy, Srinivasa Reddy Bonam, Anji Reddy Raya & Rama Rao Nadendla. 2020. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. Oxidative Stress and Dietary Antioxidants in Neurological Diseases 291 307 .
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Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Ahmed Esmat & Samar S. Azab. (2019) Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. Cancer Chemotherapy and Pharmacology 84:1, pages 1-14.
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Hong LiuLili ZhongYuwei ZhangXuewei LiuJi Li. (2018) Rutin attenuates cerebral ischemia–reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF–TrkB and NGF–TrkA signaling. Biochemistry and Cell Biology 96:5, pages 672-681.
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Jessica C. Santos & Leah M. Pyter. (2018) Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments. Frontiers in Immunology 9.
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Mashal M. Almutairi, Wael A. Alanazi, Musaad A. Alshammari, Moureq Rashed Alotaibi, Ali R. Alhoshani, Salim Salah Al-Rejaie, Mohamed M. Hafez & Othman A. Al-Shabanah. (2017) Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model. BMC Complementary and Alternative Medicine 17:1.
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Taiwo Olayemi Elufioye, Tomayo Ireti Berida & Solomon Habtemariam. (2017) Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-27.
Crossref
Alessandra Suuberg. (2018) Mechanisms and Treatment of Chemotherapy-Induced Cognitive Impairment ('Chemobrain'). SSRN Electronic Journal.
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