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Original Research

PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome

John L Yovich1 PIVET Medical Centre, Perth;2 School of Biomedical Science, Curtin Health Innovation Research Institute Bioscience, Curtin University, Perth, WA, AustraliaCorrespondence[email protected]

Birgit Alsbjerg3 The Fertility Clinic, Skive Regional Hospital, Skive;4 Faculty of Health, Aarhus University, Aarhus, Denmark

Jason L Conceicao1 PIVET Medical Centre, Perth

Peter M Hinchliffe1 PIVET Medical Centre, Perth

Kevin N Keane1 PIVET Medical Centre, Perth;2 School of Biomedical Science, Curtin Health Innovation Research Institute Bioscience, Curtin University, Perth, WA, Australia

Pages 2561-2573 | Published online: 10 Aug 2016

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Jean-Claude Emperaire & J. Charles Eldridge. 2023. IVF Technologies and Infertility - Current Practices and New Perspectives. IVF Technologies and Infertility - Current Practices and New Perspectives.

Kadrina Abdul Latif Abdullah, Tomiris Atazhanova, Alejandro Chavez-Badiola & Sourima Biswas Shivhare. (2022) Automation in ART: Paving the Way for the Future of Infertility Treatment. Reproductive Sciences 30:4, pages 1006-1016.
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Panagiotis Drakopoulos, Yakoub Khalaf, Sandro C. Esteves, Nikolaos P. Polyzos, Sesh K. Sunkara, Daniel Shapiro, Botros Rizk, Hong Ye, Michael Costello, Yulia Koloda, Bruno Salle, Monica Lispi, Thomas D'Hooghe & Antonio La Marca. (2023) Treatment algorithms for high responders: What we can learn from randomized controlled trials, real-world data and models. Best Practice & Research Clinical Obstetrics & Gynaecology 86, pages 102301.
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Bum Chae Choi, Canquan Zhou, Hong Ye, Yun Sun, Ying Zhong, Fei Gong, Ivan Sini, Nadezda Abramova, Salvatore Longobardi, Miranda Hickey & Thomas D’Hooghe. (2022) A comparative, observational study evaluating dosing characteristics and ovarian response using the recombinant human follicle-stimulating hormone pen injector with small-dose dial in assisted reproductive technologies treatment in Asia: IMPROVE study. Reproductive Biology and Endocrinology 20:1.
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Michael Fanton, Veronica Nutting, Arielle Rothman, Paxton Maeder-York, Eduardo Hariton, Oleksii Barash, Louis Weckstein, Denny Sakkas, Alan B. Copperman & Kevin Loewke. (2022) An interpretable machine learning model for individualized gonadotrophin starting dose selection during ovarian stimulation. Reproductive BioMedicine Online 45:6, pages 1152-1159.
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Ines de Santiago & Lukasz Polanski. (2022) Data-Driven Medicine in the Diagnosis and Treatment of Infertility. Journal of Clinical Medicine 11:21, pages 6426.
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Susana Montenegro Gouveia, Monica Lispi & Thomas Mary D'Hooghe. (2022) Comparison between follitropin-delta and follitropin-alfa for ovarian stimulation in context of ART is only scientifically sound and clinically relevant if individualization of starting dose is allowed in both arms!. Reproductive BioMedicine Online 45:3, pages 623-624.
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Rujun Zeng, Hanxiao Chen, Xun Zeng & Lang Qin. (2022) The Essential Role of Body Weight in Adjusting Gn Dosage to Prevent High Ovarian Response for Women With PCOS During IVF: A Retrospective Study. Frontiers in Endocrinology 13.
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Apoorva Nisal, Urmila Diwekar & Elie Hobeika. (2022) Personalized medicine for GnRH antagonist protocol in in vitro fertilization procedure using modeling and optimal control. Computers & Chemical Engineering 156, pages 107554.
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Human Fatemi, Wilma Bilger, Deborah Denis, Georg Griesinger, Antonio La Marca, Salvatore Longobardi, Mary Mahony, Xiaoyan Yin & Thomas D’Hooghe. (2021) Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017). Reproductive Biology and Endocrinology 19:1.
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John L. Yovich & Peter M. Hinchliffe. (2021) A 10-Year Perspective on the Utility of Three Adjuvants Often Used in IVF: Growth Hormone, Melatonin and DHEA. Reproductive Medicine 2:4, pages 155-162.
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John L. Yovich, Syeda Zaidi, Minh D. K. Nguyen & Peter M. Hinchliffe. (2020) Measuring IGF-1 and IGFBP-3 Profiles in Women Seeking Assisted Reproduction; Relationship to Clinical Parameters (Study 1). Journal of Personalized Medicine 10:3, pages 122.
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Ana Raquel Neves, Christophe Blockeel, Georg Griesinger, Juan Antonio Garcia-Velasco, Antonio La Marca, Ignacio Rodriguez, Panagiotis Drakopoulos, Manuel Alvarez, Herman Tournaye & Nikolaus P Polyzos. (2020) The performance of the Elecsys® anti-Müllerian hormone assay in predicting extremes of ovarian response to corifollitropin alfa. Reproductive BioMedicine Online 41:1, pages 29-36.
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Apoorva Nisal, Urmila Diwekar & Vibha Bhalerao. (2020) Personalized medicine for in vitro fertilization procedure using modeling and optimal control. Journal of Theoretical Biology 487, pages 110105.
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Urmila Diwekar, Apoorva Nisal, Kirti Yenkie & Vibha Bhalerao. 2020. Control Applications for Biomedical Engineering Systems. Control Applications for Biomedical Engineering Systems 383 403 .

Kevin N Keane, Yun Ye, Peter M Hinchliffe, Sheena LP Regan, Satvinder S Dhaliwal & John L Yovich. (2019) Live birth outcomes of vitrified embryos generated under growth hormone stimulation are improved for women categorized as poor-prognosis. Clinical and Experimental Reproductive Medicine 46:4, pages 178-188.
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John L. Yovich, Yun Ye, Sheena L. P. Regan & Kevin Noel Keane. (2019) The Evolving Concept of Poor-Prognosis for Women Undertaking IVF and the Notion of Growth Hormone as an Adjuvant; A Single-Center Viewpoint. Frontiers in Endocrinology 10.
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Ali Abbara, Aaran Patel, Tia Hunjan, Sophie A. Clarke, Germaine Chia, Pei Chia Eng, Maria Phylactou, Alexander N. Comninos, Stuart Lavery, Geoffrey H. Trew, Rehan Salim, Raj S. Rai, Tom W. Kelsey & Waljit S. Dhillo. (2019) FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation. Frontiers in Endocrinology 10.
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Carlos Dosouto, Joaquim Calaf, Ana Polo, Thor Haahr & Peter Humaidan. (2019) Growth Hormone and Reproduction: Lessons Learned From Animal Models and Clinical Trials. Frontiers in Endocrinology 10.
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Negjyp Sopa, Elisabeth Clare Larsen, Helene Westring Hvidman & Anders Nyboe Andersen. (2019) An AMH-based FSH dosing algorithm for OHSS risk reduction in first cycle antagonist protocol for IVF/ICSI. European Journal of Obstetrics & Gynecology and Reproductive Biology 237, pages 42-47.
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John Lui Yovich, Yun Ye & Kevin N. Keane. (2019) Growth Hormone Adjuvant trial for poor responders undergoing IVF. European Journal of Obstetrics & Gynecology and Reproductive Biology 236, pages 249.
Crossref

John L. Yovich. 2019. How to Prepare the Egg and Embryo to Maximize IVF Success. How to Prepare the Egg and Embryo to Maximize IVF Success 94 120 .

John Lui Yovich & Ian Logan Craft. (2018) Founding Pioneers of IVF: Independent innovative researchers generating livebirths within 4 years of the first birth. Reproductive Biology 18:4, pages 317-323.
Crossref

Sheena L.P. Regan, Phil G. Knight, John L. Yovich, Frank Arfuso & Arun Dharmarajan. (2018) Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. Fertility and Sterility 110:7, pages 1298-1310.
Crossref

John L. Yovich, Jason L. Conceicao, Nicole Marjanovich, Yun Ye, Peter M. Hinchliffe, Satvinder S. Dhaliwal & Kevin N. Keane. (2018) An ICSI rate of 90% minimizes complete failed fertilization and provides satisfactory implantation rates without elevating fetal abnormalities. Reproductive Biology 18:3, pages 301-311.
Crossref

Sandro C. Esteves, Matheus Roque, Giuliano M. Bedoschi, Alessandro Conforti, Peter Humaidan & Carlo Alviggi. (2018) Defining Low Prognosis Patients Undergoing Assisted Reproductive Technology: POSEIDON Criteria—The Why. Frontiers in Endocrinology 9.
Crossref

Kevin N. Keane, Peter M. Hinchliffe, Philip K. Rowlands, Gayatri Borude, Shanti Srinivasan, Satvinder S. Dhaliwal & John L. Yovich. (2018) DHEA Supplementation Confers No Additional Benefit to that of Growth Hormone on Pregnancy and Live Birth Rates in IVF Patients Categorized as Poor Prognosis. Frontiers in Endocrinology 9.
Crossref

John L. Yovich, Kevin N. Keane, Gayatri Borude, Satvinder S. Dhaliwal & Peter M. Hinchliffe. (2018) Finding a place for corifollitropin within the PIVET FSH dosing algorithms. Reproductive BioMedicine Online 36:1, pages 47-58.
Crossref

Kevin Keane, Vincius Fernandes Cruzat, Susbin Wagle, Nitin Chaudhary, Philip Newsholme & John Yovich. (2017) Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome. Reproductive Biology 17:1, pages 51-59.
Crossref

Kamarul B. Mustafa, Kevin N. Keane, Nikita L. Walz, Katarina I. Mitrovic, Peter M. Hinchliffe & John L. Yovich. (2017) Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients. Reproductive Biology 17:1, pages 34-41.
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PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome

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PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome

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