Drug Design, Development and Therapy, Volume 10, Issue (2016)

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Drug Design, Development and Therapy, Volume 10, Issue (2016)

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Original Research

Article
Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
Song Gao, Jianfeng Li, Chen Jiang, Bo Hong & Bing Hao
Pages: 1-11
Published online: 17 Dec 2015
AbstractforPlasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer | Full Text | References | PDF (6.2 MB)
  • 72 Views
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Open Access
Article
Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children
Ling Hou, Zhi-hang Chen, Dong Liu, Yuan-guo Cheng & Xiao-ping Luo
Pages: 13-21
Published online: 18 Dec 2015
AbstractforComparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children | Full Text | References | PDF (964.9 KB)
  • 207 Views
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Open Access

Review

Review Article
Modulation of neurotrophic signaling pathways by polyphenols
Fatemeh Moosavi, Razieh Hosseini, Luciano Saso & Omidreza Firuzi
Pages: 23-42
Published online: 21 Dec 2015
AbstractforModulation of neurotrophic signaling pathways by polyphenols | Full Text | References | PDF (2 MB)
  • 379 Views
  • 64 CrossRef citations
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Open Access
Review Article
MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy
Khiem A Tran, Michelle Y Cheng, Anupam Mitra, Hiromi Ogawa, Vivian Y Shi, Laura P Olney, April M Kloxin & Emanual Maverakis
Pages: 43-52
Published online: 21 Dec 2015
AbstractforMEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy | Full Text | References | PDF (587 KB)
  • 92 Views
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Open Access

Original Research

Article
Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials
Zhigang You, Lin Huang, Xiaoshu Cheng, Qinghua Wu, Xinghua Jiang & Yanqing Wu
Pages: 53-58
Published online: 24 Dec 2015
AbstractforEffect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials | Full Text | References | PDF (576 KB)
  • 67 Views
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Open Access
Article
BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo
Somayeh Kalanaky, Maryam Hafizi, Saideh Fakharzadeh, Mohammad Vasei, Ladan Langroudi, Ehsan Janzamin, Seyed Mahmoud Hashemi, Maryam Khayamzadeh, Masoud Soleimani, Mohammad Esmaeil Akbari & Mohammad Hassan Nazaran
Pages: 59-70
Published online: 30 Dec 2015
AbstractforBCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo | Full Text | References | PDF (3.4 MB)
  • 100 Views
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Open Access
Article
MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2
Xian Qin, Yajun Wan, Saiying Wang & Min Xue
Pages: 71-79
Published online: 24 Dec 2015
AbstractforMicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2 | Full Text | References | PDF (2.3 MB)
  • 74 Views
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Open Access
Article
Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells
Ramin Khanabdali, Anbarieh Saadat, Maizatul Fazilah, Khairul Fidaa’ Khairul Bazli, Rida-e-Maria Qazi, Ramla Sana Khalid, Durriyyah Sharifah Hasan Adli, Soheil Zorofchian Moghadamtousi, Nadia Naeem, Irfan Khan, Asmat Salim, ShamsulAzlin Ahmad Shamsuddin & Gokula Mohan
Pages: 81-91
Published online: 24 Dec 2015
AbstractforPromoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells | Full Text | References | PDF (4.1 MB)
  • 116 Views
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Open Access
Article
RETRACTED ARTICLE: The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats
Ibrahim Abdel Aziz Ibrahim, Mahmood Ameen Abdulla, Maryam Hajrezaie, Ammar Bader, Naiyer Shahzad, Saeed S Al-Ghamdi, Ahmad S Gushash & Mohadeseh Hasanpourghadi
Pages: 93-105
Published online: 30 Dec 2015
AbstractforRETRACTED ARTICLE: The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats | PDF (8 MB)
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Open Access
Article
Efficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review
Chun-Lei Li, He-Long Huang, Wan-Chun Wang & Hong Hua
Pages: 107-115
Published online: 31 Dec 2015
AbstractforEfficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review | Full Text | References | PDF (502.7 KB)
  • 331 Views
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Open Access
Article
Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol
Gehan F Balata, Ebtessam A Essa, Hanan A Shamardl, Samira H Zaidan & Mohammed AS Abourehab
Pages: 117-128
Published online: 05 Jan 2016
AbstractforSelf-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol | Full Text | References | PDF (1,020.3 KB)
  • 578 Views
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Open Access
Article
Design, synthesis, and antihypertensive activity of curcumin-inspired compounds via ACE inhibition and vasodilation, along with a bioavailability study for possible benefit in cardiovascular diseases
Xiao-dong Zhuang, Li-zhen Liao, Xiao-bian Dong, Xun Hu, Yue Guo, Zhi-min Du, Xin-xue Liao & Li-chun Wang
Pages: 129-139
Published online: 05 Jan 2016
AbstractforDesign, synthesis, and antihypertensive activity of curcumin-inspired compounds via ACE inhibition and vasodilation, along with a bioavailability study for possible benefit in cardiovascular diseases | Full Text | References | PDF (1.1 MB)
  • 133 Views
  • 1 CrossRef citations
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Open Access
Article
Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde
Daw-Shyong Perng, Yu-Hsin Tsai, Jonathan Cherng, Jeng-Shing Wang, Kuo-Shen Chou, Chia-Wen Shih & Jaw-Ming Cherng
Pages: 141-153
Published online: 05 Jan 2016
AbstractforDiscovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde | Full Text | References | PDF (2.7 MB)
  • 99 Views
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Open Access
Article
Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells
Huma Ali, Savita Dixit, Daoud Ali, Abdullah A Alkahtane, Saud Alarifi, Bahy A Ali & Saad Alkahtani
Pages: 155-162
Published online: 06 Jan 2016
AbstractforIsolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells | Full Text | References | PDF (2.2 MB)
  • 90 Views
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Open Access
Article
Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes
Debin Yu, Mingzhi Zhao, Liwei Dong, Lu Zhao, Mingwei Zou, Hetong Sun, Mengying Zhang, Hongyu Liu & Zhihua Zou
Pages: 163-182
Published online: 06 Jan 2016
AbstractforDesign and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes | Full Text | References | PDF (3.7 MB)
  • 79 Views
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Open Access
Article
Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways
Jing Luo, Jin-liang Kong, Bi-ying Dong, Hong Huang, Ke Wang, Li-hong Wu, Chang-chun Hou, Yue Liang, Bing Li & Yi-qiang Chen
Pages: 183-203
Published online: 07 Jan 2016
AbstractforBaicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways | Full Text | References | PDF (3.8 MB)
  • 259 Views
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Open Access
Article
Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil
Abdulrahman K Al Asmari, Zabih Ullah, Mohammad Tariq & Amal Fatani
Pages: 205-215
Published online: 12 Jan 2016
First Page PreviewforPreparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil | Full Text | References | PDF (4.1 MB)
  • 691 Views
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Open Access

Review

Review Article
Spotlight on ixazomib: potential in the treatment of multiple myeloma
Barbara Muz, Rachel Nicole Ghazarian, Monica Ou, Micah John Luderer, Hubert Daniel Kusdono & Abdel Kareem Azab
Pages: 217-226
Published online: 11 Jan 2016
AbstractforSpotlight on ixazomib: potential in the treatment of multiple myeloma | Full Text | References | PDF (827 KB)
  • 254 Views
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Open Access
Review Article
Pasireotide: a novel treatment for patients with acromegaly
Daniel Cuevas-Ramos & Maria Fleseriu
Pages: 227-239
Published online: 11 Jan 2016
AbstractforPasireotide: a novel treatment for patients with acromegaly | Full Text | References | PDF (1 MB)
  • 129 Views
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Open Access

Original Research

Article
A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy
Jing Qian, Yingying Qian, Jian Wang, Bing Gu, Dong Pei, Shaohua He, Fang Zhu, Oluf Dimitri Røe, Jin Xu, Lianke Liu, Yanhong Gu, Renhua Guo, Yongmei Yin, Yongqian Shu & Xiaofeng Chen
Pages: 241-258
Published online: 24 Feb 2016
AbstractforA clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy | Full Text | References | PDF (2.3 MB)
  • 62 Views
  • 3 CrossRef citations
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Open Access
Article
Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials
Narong Maneeton, Benchalak Maneeton, Pakapan Woottiluk, Surinporn Likhitsathian, Sirijit Suttajit, Vudhichai Boonyanaruthee & Manit Srisurapanont
Pages: 259-276
Published online: 12 Jan 2016
AbstractforQuetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (1.8 MB)
  • 462 Views
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Open Access
Article
Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery
Heba F Salem, Sayed M Ahmed & Mahmoud M Omar
Pages: 277-295
Published online: 13 Jan 2016
AbstractforLiposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery | Full Text | References | PDF (5.3 MB)
  • 191 Views
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Open Access
Article
Evidence of the gastroprotective and anti- Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume
Heyam Mohamed Ali Sidahmed, Najihah Mohd Hashim, Syam Mohan, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Firouzeh Dehghan, Maizatulakmal Yahayu, Gwendoline Cheng Lian Ee, Mun Fai Loke & Jamuna Vadivelu
Pages: 297-313
Published online: 13 Jan 2016
AbstractforEvidence of the gastroprotective and anti- Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume | Full Text | References | PDF (5.1 MB)
  • 89 Views
  • 17 CrossRef citations
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Open Access
Article
YiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice
Guosheng Cao, Xinyi Ye, Yingqiong Xu, Mingzhu Yin, Honglin Chen, Junping Kou & Boyang Yu
Pages: 315-325
Published online: 14 Jan 2016
AbstractforYiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice | Full Text | References | PDF (2.9 MB)
  • 62 Views
  • 7 CrossRef citations
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Open Access
Article
Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)
Tadakatsu Nakamura, Tomoko Kubota, Atsushi Iwakaji, Masayoshi Imada, Margit Kapás & Yasunori Morio
Pages: 327-338
Published online: 14 Jan 2016
AbstractforClinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment) | Full Text | References | PDF (684 KB)
  • 220 Views
  • 65 CrossRef citations
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Open Access
Article
Dose comparison of conivaptan (Vaprisol®) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics
Biff F Palmer, Amy D Rock & Emily J Woodward
Pages: 339-351
Published online: 18 Jan 2016
AbstractforDose comparison of conivaptan (Vaprisol®) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics | Full Text | References | PDF (939.9 KB)
  • 60 Views
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Open Access

Letter

Letter
Short-term maraviroc exposure, a clinical approach to decide on maraviroc prescription in HIV-1-infected treatment-naïve patients
Alejandro Gonzalez-Serna, Miguel Genebat, Ezequiel Ruiz-Mateos & Manuel Leal
Pages: 353-356
Published online: 18 Jan 2016
First Page PreviewforShort-term maraviroc exposure, a clinical approach to decide on maraviroc prescription in HIV-1-infected treatment-naïve patients | Full Text | References | PDF (184.2 KB)
  • 34 Views
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Open Access

Original Research

Article
Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
Yi-fan Zhang, Xiao-jian Dai, Yong Yang, Xiao-yan Chen, Ting Wang, Yun-biao Tang, Cheng-yuan Tsai, Li-wen Chang, Yu-ting Chang & Da-fang Zhong
Pages: 357-370
Published online: 20 Jan 2016
AbstractforEffects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers | Full Text | References | PDF (1.1 MB)
  • 62 Views
  • 3 CrossRef citations
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Open Access
Article
The improvement effects of edible bird’s nest on proliferation and activation of B lymphocyte and its antagonistic effects on immunosuppression induced by cyclophosphamide
Ran Zhao, Geng Li, Xiu-juan Kong, Xiu-yan Huang, Wei Li, Yao-ying Zeng & Xiao-ping Lai
Pages: 371-381
Published online: 21 Jan 2016
AbstractforThe improvement effects of edible bird’s nest on proliferation and activation of B lymphocyte and its antagonistic effects on immunosuppression induced by cyclophosphamide | Full Text | References | PDF (957.2 KB)
  • 180 Views
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Open Access

Case Report

Case Report
High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report
Tao Zhou, Xia Zhang, Yan Dong, Feifei Zhuang, Fengquan Jiang, Jinming Yu & Bin Zhang
Pages: 383-387
Published online: 19 Jan 2016
AbstractforHigh-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report | Full Text | References | PDF (228.1 KB)
  • 303 Views
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Open Access

Original Research

Article
Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism
Yan Guo, Juan Sun, Juan Ye, Wenyu Ma, Hualing Yan & Gang Wang
Pages: 389-403
Published online: 20 Jan 2016
AbstractforSaussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism | Full Text | References | PDF (3.9 MB)
  • 59 Views
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Open Access
Article
Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation
Tarek A Ahmed, Yasser A Alharby, Abdel-Rahim M El-Helw, Khaled M Hosny & Khalid M El-Say
Pages: 405-415
Published online: 20 Jan 2016
AbstractforDepot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation | Full Text | References | PDF (2.5 MB)
  • 215 Views
  • 4 CrossRef citations
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Open Access
Article
Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres
Lu Shan, En-Xue Tao, Qing-Hui Meng, Wen-Xia Hou, Kang Liu, Hong-Cai Shang, Jin-Bao Tang & Wei-Fen Zhang
Pages: 417-429
Published online: 25 Jan 2016
AbstractforFormulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres | Full Text | References | PDF (5.2 MB)
  • 91 Views
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Open Access
Article
In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere
Yan Xiong, Zeping Yu, Yun Lang, Juanyu Hu, Hong Li, Yonggang Yan, Chongqi Tu, Tianfu Yang, Yueming Song, Hong Duan & Fuxing Pei
Pages: 431-440
Published online: 25 Jan 2016
AbstractforIn vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere | Full Text | References | PDF (3.8 MB)
  • 68 Views
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Open Access

Corrigendum

Correction
Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]
Page: 441
Published online: 28 Jan 2016
CitationforEfficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum] | Full Text | PDF (101.6 KB)
  • 47 Views
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Open Access

Original Research

Article
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25−CD69+ subset proliferation
Qi Yang, Jianwei Wang, Ran Liu, Zhiqiang Wang, Yufeng Li, Yifan Zhang, Xiaohua Hao, Yubo Huang, Wen Xie & Hongshan Wei
Pages: 443-453
Published online: 25 Jan 2016
AbstractforAmelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25−CD69+ subset proliferation | Full Text | References | PDF (4.6 MB)
  • 59 Views
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Open Access
Article
Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2
Weitao Fu, Lingfeng Chen, Zhe Wang, Chengwei Zhao, Gaozhi Chen, Xing Liu, Yuanrong Dai, Yuepiao Cai, Chenglong Li, Jianmin Zhou & Guang Liang
Pages: 455-463
Published online: 27 Jan 2016
AbstractforDetermination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2 | Full Text | References | PDF (2.8 MB)
  • 82 Views
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Open Access

Review

Review Article
Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes
Christina N Kontoghiorghe & George J Kontoghiorghes
Pages: 465-481
Published online: 29 Jan 2016
AbstractforEfficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes | Full Text | References | PDF (740.6 KB)
  • 513 Views
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Open Access
Review Article
Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery
Tarek A Ahmed & Bader M Aljaeid
Pages: 483-507
Published online: 28 Jan 2016
AbstractforPreparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery | Full Text | References | PDF (1.8 MB)
  • 2543 Views
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Open Access
Review Article
Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials
Zhixing Xu, Changchun Fan, Xuechun Zhao & Hairong Tao
Pages: 509-517
Published online: 28 Jan 2016
AbstractforTreatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials | Full Text | References | PDF (606 KB)
  • 99 Views
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Open Access

Original Research

Article
Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets
Qi-ping Zeng, Zhi-hong Liu, Ai-wen Huang, Jing Zhang & Hong-tao Song
Pages: 519-531
Published online: 29 Jan 2016
AbstractforPreparation and characterization of silymarin synchronized-release microporous osmotic pump tablets | Full Text | References | PDF (1.6 MB)
  • 148 Views
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Open Access

Review

Review Article
Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis
V Di Lernia & F Bardazzi
Pages: 533-539
Published online: 29 Jan 2016
AbstractforProfile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis | Full Text | References | PDF (281.7 KB)
  • 151 Views
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Open Access

Hypothesis

Article
Antiviral therapy: a perspective
Amir Hashem Shahidi Bonjar
Pages: 541-546
Published online: 02 Feb 2016
AbstractforAntiviral therapy: a perspective | Full Text | References | PDF (424.5 KB)
  • 58 Views
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Open Access

Original Research

Article
Targeting the D1-N-methyl-d-aspartate receptor complex reduces l-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats
Lu Song, Zhanzhao Zhang, Rongguo Hu, Jie Cheng, Lin Li, Qinyi Fan, Na Wu, Jing Gan, Mingzhu Zhou & Zhenguo Liu
Pages: 547-555
Published online: 03 Feb 2016
AbstractforTargeting the D1-N-methyl-d-aspartate receptor complex reduces l-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats | Full Text | References | PDF (1.1 MB)
  • 58 Views
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Open Access
Article
Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species
Monika A Papież, Wirginia Krzyściak, Krzysztof Szade, Karolina Bukowska-Straková, Magdalena Kozakowska, Karolina Hajduk, Beata Bystrowska, Jozef Dulak & Alicja Jozkowicz
Pages: 557-570
Published online: 04 Feb 2016
AbstractforCurcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species | Full Text | References | PDF (1.4 MB)
  • 159 Views
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Open Access
Article
miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism
Xian-ye Tang, Wei Zheng, Min Ding, Kai-jin Guo, Feng Yuan, Hu Feng, Bin Deng, Wei Sun, Yang Hou & Lu Gao
Pages: 571-583
Published online: 24 Feb 2016
AbstractformiR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism | Full Text | References | PDF (2 MB)
  • 87 Views
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Open Access
Article
Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats
Kun Xu, Shi-Yin Pan, Jin-Xin Song, Xian-Ning Liu, Na An & Xuan Zheng
Pages: 585-592
Published online: 04 Feb 2016
AbstractforEstablishment of a novel therapeutic vector targeting the trigeminal ganglion in rats | Full Text | References | PDF (1.4 MB)
  • 64 Views
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Open Access
Article
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis
Carmen Cuffari, David Pierce, Bartosz Korczowski, Krzysztof Fyderek, Heather Van Heusen, Stuart Hossack, Hong Wan, Alena YZ Edwards & Patrick Martin
Pages: 593-607
Published online: 04 Feb 2016
AbstractforRandomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis | Full Text | References | PDF (862.3 KB)
  • 107 Views
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Open Access

Review

Review Article
Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide
Fabrizio Stocchi & Margherita Torti
Pages: 609-618
Published online: 05 Feb 2016
AbstractforAdjuvant therapies for Parkinson’s disease: critical evaluation of safinamide | Full Text | References | PDF (421.8 KB)
  • 91 Views
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Open Access

Original Research

Article
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
Jingjing Li, Kan Chen, Sainan Li, Jiao Feng, Tong Liu, Fan Wang, Rong Zhang, Shizan Xu, Yuqing Zhou, Shunfeng Zhou, Yujing Xia, Jie Lu, Yingqun Zhou & Chuanyong Guo
Pages: 619-630
Published online: 12 Feb 2016
AbstractforProtective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy | Full Text | References | PDF (7.2 MB)
  • 126 Views
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Open Access
Article
Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
Sainan Li, Yujing Xia, Kan Chen, Jingjing Li, Tong Liu, Fan Wang, Jie Lu, Yingqun Zhou & Chuanyong Guo
Pages: 631-647
Published online: 15 Feb 2016
AbstractforEpigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3 | Full Text | References | PDF (9.4 MB)
  • 71 Views
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Open Access
Article
Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction
Yu-ting Huang, Lan Zhao, Zheng Fu, Meng Zhao, Xiao-meng Song, Jing Jia, Song Wang, Jin-ping Li, Zhi-feng Zhu, Gang Lin, Rong Lu & Zhi Yao
Pages: 649-663
Published online: 03 Mar 2016
AbstractforTherapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction | Full Text | References | PDF (1.8 MB)
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Review

Review Article
Drug-loaded erythrocytes: on the road toward marketing approval
Vanessa Bourgeaux, José M Lanao, Bridget E Bax & Yann Godfrin
Pages: 665-676
Published online: 11 Feb 2016
AbstractforDrug-loaded erythrocytes: on the road toward marketing approval | Full Text | References | PDF (666.3 KB)
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Original Research

Article
Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Bastian Schmack, Christian Erbel, Christian A Gleissner, Mohammadreza Akhavanpoor, Lutz Frankenstein, Fabrice F Darche, Patrick A Schweizer, Dierk Thomas, Philipp Ehlermann, Tom Bruckner, Hugo A Katus & Andreas O Doesch
Pages: 677-686
Published online: 16 Feb 2016
AbstractforLong-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation | Full Text | References | PDF (531.3 KB)
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Article
Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine
Ren-ai Xu, Er-min Gu, Quan Zhou, Lingjing Yuan, Xiaoxia Hu, Jianping Cai & Guoxin Hu
Pages: 687-696
Published online: 15 Feb 2016
AbstractforEffects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine | Full Text | References | PDF (1.2 MB)
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Corrigendum

Correction
Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials [Corrigendum]
Page: 697
Published online: 16 Feb 2016
CitationforTreatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials [Corrigendum] | Full Text | PDF (92.7 KB)
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Original Research

Article
The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
Xiaoyu Wu, Guannan Wu, Xuequan Yao, Gang Hou & Feng Jiang
Pages: 699-709
Published online: 15 Feb 2016
AbstractforThe clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review | Full Text | References | PDF (1.5 MB)
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Article
5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors
Taiping Gan, Yuji Wang, Ming Zhao, Jianhui Wu, Jian Yang & Shiqi Peng
Pages: 711-721
Published online: 16 Feb 2016
Abstractfor5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors | Full Text | References | PDF (2.5 MB)
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Article
Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17
Ding-Siang Huang, Hsuan-Yuan Lin, Guey-Jen Lee-Chen, Hsiu-Mei Hsieh-Li, Chung-Hsin Wu & Jung-Yaw Lin
Pages: 723-731
Published online: 18 Feb 2016
AbstractforTreatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17 | Full Text | References | PDF (2.7 MB)
  • 87 Views
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Article
A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis
Shizhang Wei, Ming Niu, Jian Wang, Jiabo Wang, Haibin Su, Shengqiang Luo, Xiaomei Zhang, Yanlei Guo, Liping Liu, Fengqun Liu, Qingguo Zhao, Hongge Chen, Xiaohe Xiao, Pan Zhao & Yanling Zhao
Pages: 733-743
Published online: 19 Feb 2016
AbstractforA network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis | Full Text | References | PDF (4.3 MB)
  • 141 Views
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Article
Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways
Qing-jun Liu, Hong-liang Shen, Jun Lin, Xiu-hong Xu, Zheng-guo Ji, Xiao Han, Dong-hao Shang & Pei-qian Yang
Pages: 745-755
Published online: 18 Feb 2016
AbstractforSynergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways | Full Text | References | PDF (1,007.7 KB)
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Review

Review Article
Potential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia
Caroline Le Jeune & Xavier Thomas
Pages: 757-765
Published online: 18 Feb 2016
AbstractforPotential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia | Full Text | References | PDF (446.3 KB)
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Original Research

Article
Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
Xiao-hu Nie, Jia Ou-yang, Ying Xing, Dan-yan Li, Ru-en Liu & Ru-xiang Xu
Pages: 767-779
Published online: 22 Feb 2016
AbstractforCalycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells | Full Text | References | PDF (3.6 MB)
  • 69 Views
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Article
Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model
Chun-xiao Li, Hua-guo Li, Hui Zhang, Ru-hong Cheng, Ming Li, Jian-ying Liang, Yan Gu, Bo Ling, Zhi-rong Yao & Hong Yu
Pages: 781-791
Published online: 19 Feb 2016
AbstractforAndrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model | Full Text | References | PDF (3.3 MB)
  • 84 Views
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Article
Effects of Xuanbai Chengqi decoction on lung compliance for patients with exogenous pulmonary acute respiratory distress syndrome
Zhengrong Mao & Haifeng Wang
Pages: 793-798
Published online: 19 Feb 2016
AbstractforEffects of Xuanbai Chengqi decoction on lung compliance for patients with exogenous pulmonary acute respiratory distress syndrome | Full Text | References | PDF (204.2 KB)
  • 54 Views
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Article
Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy
Changrun Guo, Gang Ding, Wenzhe Huang, Zhenzhong Wang, Zhaoqing Meng & Wei Xiao
Pages: 799-810
Published online: 24 Feb 2016
AbstractforTotal saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy | Full Text | References | PDF (5 MB)
  • 74 Views
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Article
Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique
Charu Sharma, Nihar R Biswas, Shreesh Ojha & Thirumurthy Velpandian
Pages: 811-823
Published online: 22 Feb 2016
AbstractforComprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique | Full Text | References | PDF (2.1 MB)
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Article
Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper–Lin small composite design
Khalid Mohamed El-Say
Pages: 825-839
Published online: 24 Feb 2016
AbstractforMaximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper–Lin small composite design | Full Text | References | PDF (2.7 MB)
  • 169 Views
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Article
The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1
Xingsi Liang, Bin Zhang, Quan Chen, Jing Zhang, Biao Lei, Bo Li, Yangchao Wei, Run Zhai, Zhiqing Liang, Songqing He & Bo Tang
Pages: 841-850
Published online: 24 Feb 2016
AbstractforThe mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1 | Full Text | References | PDF (3.4 MB)
  • 57 Views
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Article
Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway
Yalong Dang, Yalin Mu, Kun Wang, Ke Xu, Jing Yang, Yu Zhu & Bin Luo
Pages: 851-859
Published online: 26 Feb 2016
AbstractforPapaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway | Full Text | References | PDF (2 MB)
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Review

Review Article
The interplay of post-translational modification and gene therapy
Victor Chukwudi Osamor, Shalom N Chinedu, Dominic E Azuh, Emeka Joshua Iweala & Olubanke Olujoke Ogunlana
Pages: 861-871
Published online: 29 Feb 2016
AbstractforThe interplay of post-translational modification and gene therapy | Full Text | References | PDF (521.9 KB)
  • 82 Views
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Review Article
Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives
Ricardo Costa, Benedito A Carneiro, Sunandana Chandra, Sachin G Pai, Young Kwang Chae, Jason B Kaplan, Hannah B Garrett, Mark Agulnik, Peter A Kopp & Francis J Giles
Pages: 873-884
Published online: 29 Feb 2016
AbstractforSpotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives | Full Text | References | PDF (391.5 KB)
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Original Research

Article
The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease
Kuo-Hsuan Chang, I-Cheng Chen, Hsuan-Yuan Lin, Hsuan-Chiang Chen, Chih-Hsin Lin, Te-Hsien Lin, Yu-Ting Weng, Chih-Ying Chao, Yih-Ru Wu, Jung-Yaw Lin, Guey-Jen Lee-Chen & Chiung-Mei Chen
Pages: 885-896
Published online: 29 Feb 2016
AbstractforThe aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease | Full Text | References | PDF (2.2 MB)
  • 111 Views
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Article
Cost-effectiveness comparison of lamivudine plus adefovir combination treatment and nucleos(t)ide analog monotherapies in Chinese chronic hepatitis B patients
Chi Zhang, Weixia Ke, Li Liu, Yanhui Gao, Zhenjiang Yao, Xiaohua Ye, Shudong Zhou & Yi Yang
Pages: 897-910
Published online: 01 Mar 2016
AbstractforCost-effectiveness comparison of lamivudine plus adefovir combination treatment and nucleos(t)ide analog monotherapies in Chinese chronic hepatitis B patients | Full Text | References | PDF (3 MB)
  • 53 Views
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Article
Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics
Peng Ji, Tong Yu, Ying Liu, Jie Jiang, Jie Xu, Ying Zhao, Yanna Hao, Yang Qiu, Wenming Zhao & Chao Wu
Pages: 911-925
Published online: 01 Mar 2016
AbstractforNaringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics | Full Text | References | PDF (2.2 MB)
  • 487 Views
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Article
Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury
Faruk Metin Çomu, Yiğit Kılıç, Abdullah Özer, Mehmet Kirişçi, Ali Doğan Dursun, Tolga Tatar, Mustafa Hakan Zor, Hakan Kartal, Ayşegül Küçük, Hakan Boyunağa & Mustafa Arslan
Pages: 927-931
Published online: 01 Mar 2016
AbstractforEffect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury | Full Text | References | PDF (428 KB)
  • 53 Views
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Article
Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro
Yu-Cong Zou, Xian-Wen Yang, Shi-Guo Yuan, Pei Zhang & Yi-Kai Li
Pages: 933-948
Published online: 07 Mar 2016
AbstractforCelastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro | Full Text | References | PDF (2.5 MB)
  • 68 Views
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Article
Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia
Guan-Cheng Huang, Shih-Yu Chen, Po-Wei Tsai, Jerome G Ganzon, Chia-Jung Lee, Her-Shyong Shiah & Ching-Chiung Wang
Pages: 949-957
Published online: 02 Mar 2016
AbstractforEffects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia | Full Text | References | PDF (648 KB)
  • 177 Views
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Article
Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis
MMR Meor Mohd Affandi, Minaketan Tripathy, Syed Adnan Ali Shah & ABA Majeed
Pages: 959-969
Published online: 02 Mar 2016
AbstractforSolubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis | Full Text | References | PDF (1.2 MB)
  • 123 Views
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Article
Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats
Ho-Shan Niu, I-Min Liu, Chiang-Shan Niu, Po-Ming Ku, Chao-Tien Hsu & Juei-Tang Cheng
Pages: 971-978
Published online: 02 Mar 2016
AbstractforEucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats | Full Text | References | PDF (1.2 MB)
  • 61 Views
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Article
Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells
Rong Jin, Yiqun Xia, Qiuxiang Chen, Wulan Li, Dahui Chen, Hui Ye, Chengguang Zhao, Xiaojing Du, Dengjian Shi, Jianzhang Wu & Guang Liang
Pages: 979-995
Published online: 02 Mar 2016
AbstractforDa0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells | Full Text | References | PDF (3.9 MB)
  • 76 Views
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Article
A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice
Yu Huang, Yumeng Wei, Hongru Yang, Chao Pi, Hao Liu, Yun Ye & Ling Zhao
Pages: 997-1008
Published online: 03 Mar 2016
AbstractforA 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice | Full Text | References | PDF (1.7 MB)
  • 101 Views
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Article
Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway
Mingli Liu, Carmen Dickinson-Copeland, Salifu Hassana & Jonathan K Stiles
Pages: 1009-1018
Published online: 03 Mar 2016
AbstractforPlasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway | Full Text | References | PDF (1.4 MB)
  • 69 Views
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Article
Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics
Yi-Ping Fang, Chih-Hung Chuang, Pao-Chu Wu, Yaw-Bin Huang, Cherng-Chyi Tzeng, Yeh-Long Chen, Ya-Ting Liu, Yi-Hung Tsai & Ming-Jun Tsai
Pages: 1019-1028
Published online: 04 Mar 2016
AbstractforAmsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics | Full Text | References | PDF (2.2 MB)
  • 71 Views
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Article
Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids
Petra Czarniak, Michael Boddy, Bruce Sunderland & Jeff D Hughes
Pages: 1029-1034
Published online: 07 Mar 2016
AbstractforStability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids | Full Text | References | PDF (370.4 KB)
  • 151 Views
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Article
Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment
Liang Qin, Tianyuan Xu, Leilei Xia, Xianjin Wang, Xiang Zhang, Xiaohua Zhang, Zhaowei Zhu, Shan Zhong, Chuandong Wang & Zhoujun Shen
Pages: 1035-1045
Published online: 07 Mar 2016
AbstractforChloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment | Full Text | References | PDF (3.2 MB)
  • 79 Views
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Review

Review Article
Efficacy and safety of modified-release prednisone in patients with rheumatoid arthritis
Marco Krasselt & Christoph Baerwald
Pages: 1047-1058
Published online: 08 Mar 2016
AbstractforEfficacy and safety of modified-release prednisone in patients with rheumatoid arthritis | Full Text | References | PDF (1.1 MB)
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Original Research

Article
RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids
Xueyun Jiang, Ming Zhao, Yuji Wang, Haimei Zhu, Shurui Zhao, Jianhui Wu, Yuanbo Song & Shiqi Peng
Pages: 1059-1076
Published online: 08 Mar 2016
AbstractforRGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids | Full Text | References | PDF (5.3 MB)
  • 68 Views
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Article
Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study
Senem Yaman Tunc, Elif Agacayak, Neval Yaman Goruk, Mehmet Sait Icen, Abdulkadir Turgut, Ulas Alabalik, Cihan Togrul, Cenap Ekinci, Aysun Ekinci & Talip Gul
Pages: 1077-1083
Published online: 08 Mar 2016
AbstractforProtective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study | Full Text | References | PDF (2.3 MB)
  • 72 Views
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Review

Review Article
Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity
Michelle Kaku & David M Simpson
Pages: 1085-1099
Published online: 08 Mar 2016
AbstractforSpotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity | Full Text | References | PDF (359.1 KB)
  • 111 Views
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Original Research

Article
Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis
Fatma M Mady, Hanaa Essa, Tarek El-Ammawi, Hamdy Abdelkader & Amal K Hussein
Pages: 1101-1110
Published online: 10 Mar 2016
AbstractforFormulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis | Full Text | References | PDF (2.2 MB)
  • 317 Views
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Review

Review Article
Laquinimod in the treatment of multiple sclerosis: a review of the data so far
Jan Thöne & Ralf A Linker
Pages: 1111-1118
Published online: 14 Mar 2016
AbstractforLaquinimod in the treatment of multiple sclerosis: a review of the data so far | Full Text | References | PDF (228.8 KB)
  • 121 Views
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Review Article
Selective use of sorafenib in the treatment of thyroid cancer
Fabián Pitoia & Fernando Jerkovich
Pages: 1119-1131
Published online: 11 Mar 2016
AbstractforSelective use of sorafenib in the treatment of thyroid cancer | Full Text | References | PDF (383.1 KB)
  • 111 Views
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Original Research

Article
Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines
Magdy M Youssef, Reem K Arafa & Mohamed A Ismail
Pages: 1133-1146
Published online: 11 Mar 2016
AbstractforSynthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines | Full Text | References | PDF (872.7 KB)
  • 80 Views
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Article
Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosisl,d-transpeptidase 2
Junie B Billones, Maria Constancia O Carrillo, Voltaire G Organo, Stephani Joy Y Macalino, Jamie Bernadette A Sy, Inno A Emnacen, Nina Abigail B Clavio & Gisela P Concepcion
Pages: 1147-1157
Published online: 11 Mar 2016
AbstractforToward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosisl,d-transpeptidase 2 | Full Text | References | PDF (2.9 MB)
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Letter

Letter
Comments on a meta-analysis and systematic review of the clinicopathological significance of CDH1 in gastric cancer
Chao Tu, Lianwen Yuan & Jianping Zhou
Pages: 1159-1160
Published online: 15 Mar 2016
CitationforComments on a meta-analysis and systematic review of the clinicopathological significance of CDH1 in gastric cancer | Full Text | References | PDF (170.8 KB)
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Original Research

Article
Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis
Xin Lyu, Chen Zhao, Zhi-min Yan & Hong Hua
Pages: 1161-1171
Published online: 16 Mar 2016
AbstractforEfficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis | Full Text | References | PDF (1 MB)
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Article
Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo
Cong Xue, Ying Tian, Jing Zhang, Yuanyuan Zhao, Jianhua Zhan, Wenfeng Fang & Li Zhang
Pages: 1173-1180
Published online: 15 Mar 2016
AbstractforEfficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo | Full Text | References | PDF (2.3 MB)
  • 52 Views
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Article
Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer
Bo-Yong Wang, Quan-Yan Liu, Jun Cao, Ji-Wei Chen & Zhi-Su Liu
Pages: 1181-1189
Published online: 16 Mar 2016
AbstractforSelective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer | Full Text | References | PDF (1.3 MB)
  • 107 Views
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Corrigendum

Correction
Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]
Page: 1191
Published online: 17 Mar 2016
CitationforSonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum] | Full Text | PDF (94.9 KB)
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Original Research

Article
Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins
Hadi Mirzaei, Bahram Kazemi, Mojgan Bandehpour, Alireza Shoari, Vahid Asgary, Mehdi Shafiee Ardestani, Armin Madadkar-Sobhani & Reza Ahangari Cohan
Pages: 1193-1200
Published online: 16 Mar 2016
AbstractforComputational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins | Full Text | References | PDF (1.8 MB)
  • 71 Views
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Article
Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice
Dubravka Svob Strac, Josipa Vlainic, Janko Samardzic, Julija Erhardt & Zeljka Krsnik
Pages: 1201-1215
Published online: 21 Mar 2016
AbstractforEffects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice | Full Text | References | PDF (942.6 KB)
  • 67 Views
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Article
Regional differences in hepatitis C treatment with peginterferon and ribavirin in Japan: a retrospective cohort study
Kazuki Ide, Yohei Kawasaki, Hiroshi Yamada & Naohiko Masaki
Pages: 1217-1223
Published online: 22 Mar 2016
AbstractforRegional differences in hepatitis C treatment with peginterferon and ribavirin in Japan: a retrospective cohort study | Full Text | References | PDF (1 MB)
  • 43 Views
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Article
Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
Shuo Chen, Kai-Xuan Sun, Miao-Xiao Feng, Xiu-Bo Sang, Bo-Liang Liu & Yang Zhao
Pages: 1225-1232
Published online: 18 Mar 2016
AbstractforRole of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer | Full Text | References | PDF (5.7 MB)
  • 78 Views
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Letter

Letter
The renoprotective effects of sulodexide
Rik HG Olde Engberink & Liffert Vogt
Pages: 1233-1234
Published online: 22 Mar 2016
CitationforThe renoprotective effects of sulodexide | Full Text | References | PDF (150.1 KB)
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Original Research

Article
Zolav®: a new antibiotic for the treatment of acne
Alexa Dinant & Ramiz A Boulos
Pages: 1235-1242
Published online: 22 Mar 2016
AbstractforZolav®: a new antibiotic for the treatment of acne | Full Text | References | PDF (842.1 KB)
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Article
A small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model of hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery
Yu Zou, Chuan-Gen Guo, Zheng-Gang Yang, Jun-Hui Sun, Min-Ming Zhang & Cai-Yun Fu
Pages: 1243-1255
Published online: 24 Mar 2016
AbstractforA small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model of hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery | Full Text | References | PDF (2.7 MB)
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Article
Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis
Hai Wang, Li Bo Man, Guang Lin Huang, Gui Zhong Li & Jian Wei Wang
Pages: 1257-1265
Published online: 29 Mar 2016
AbstractforComparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis | Full Text | References | PDF (1.2 MB)
  • 67 Views
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Article
Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro
Jie Xiao, Xi Sheng, Xinyu Zhang, Mengqi Guo & Xiaoping Ji
Pages: 1267-1277
Published online: 29 Mar 2016
AbstractforCurcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro | Full Text | References | PDF (3.5 MB)
  • 156 Views
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Article
Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa
Asman Manaf, Raymond R Tjandrawinata & Desi Malinda
Pages: 1279-1289
Published online: 29 Mar 2016
AbstractforInsulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa | Full Text | References | PDF (576.3 KB)
  • 154 Views
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Article
RETRACTED ARTICLE: A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation
Kefang Guo & Jing Cang
Pages: 1291-1298
Published online: 30 Mar 2016
AbstractforRETRACTED ARTICLE: A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation | PDF (2.4 MB)
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Article
In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma
Cong Xue, Ying Tian, Jing Zhang, Yuanyuan Zhao, Jianhua Zhan, Wenfeng Fang & Li Zhang
Pages: 1299-1306
Published online: 31 Mar 2016
AbstractforIn vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma | Full Text | References | PDF (924.2 KB)
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Article
Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening
Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, David Solow-Cordero, Kwang-Min Kim, Aneesh V Samineni, Mansi B Parekh, Lobat Tayebi & Jayakumar Rajadas
Pages: 1307-1322
Published online: 01 Apr 2016
AbstractforIdentification of new drug candidates against Borrelia burgdorferi using high-throughput screening | Full Text | References | PDF (1.6 MB)
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Article
Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation
Shaimaa M Badr-Eldin & Osamaa AA Ahmed
Pages: 1323-1333
Published online: 05 Apr 2016
AbstractforOptimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation | Full Text | References | PDF (2.1 MB)
  • 265 Views
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Article
Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models
Bei Zhang, Ying Wang, Hui Li, Ran Xiong, Zongbo Zhao, Xingkun Chu, Qiongqiong Li, Suya Sun & Shengdi Chen
Pages: 1335-1343
Published online: 06 Apr 2016
AbstractforNeuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models | Full Text | References | PDF (3.4 MB)
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Article
Clinicopathological significance and a potential drugtarget of RARβ in non-small-cell lung carcinoma: a meta-analysis and a systematic review
Xiaoyun Song, Kang Shi, Shi-Jie Zhou, Da-Ping Yu, Zhidong Liu & Yi Han
Pages: 1345-1354
Published online: 06 Apr 2016
AbstractforClinicopathological significance and a potential drugtarget of RARβ in non-small-cell lung carcinoma: a meta-analysis and a systematic review | Full Text | References | PDF (1.1 MB)
  • 42 Views
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Article
Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect
Hee Jun Park, Ga Hyeon Lee, Joonho Jun, Miwon Son & Myung Joo Kang
Pages: 1355-1364
Published online: 07 Apr 2016
AbstractforMultiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect | Full Text | References | PDF (1.1 MB)
  • 213 Views
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Article
Per-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents
Favourite N Cele, Muthusamy Ramesh & Mahmoud ES Soliman
Pages: 1365-1377
Published online: 11 Apr 2016
AbstractforPer-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents | Full Text | References | PDF (4 MB)
  • 98 Views
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Article
Functionalized d-form self-assembling peptide hydrogels for bone regeneration
Bin He, Yunsheng Ou, Ao Zhou, Shuo Chen, Weikang Zhao, Jinqiu Zhao, Hong Li, Yong Zhu, Zenghui Zhao & Dianming Jiang
Pages: 1379-1388
Published online: 11 Apr 2016
AbstractforFunctionalized d-form self-assembling peptide hydrogels for bone regeneration | Full Text | References | PDF (2.7 MB)
  • 102 Views
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Article
Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
Tingfang Yang, Shuluan Yao, Xianfeng Zhang & Yan Guo
Pages: 1389-1397
Published online: 11 Apr 2016
AbstractforAndrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways | Full Text | References | PDF (1.6 MB)
  • 114 Views
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Article
Acetogenins from Annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study
Priya Antony & Ranjit Vijayan
Pages: 1399-1410
Published online: 13 Apr 2016
AbstractforAcetogenins from Annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study | Full Text | References | PDF (1.8 MB)
  • 231 Views
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Article
Pharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects
Su-jin Rhee, SeungHwan Lee, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang & Kyung-Sang Yu
Pages: 1411-1418
Published online: 13 Apr 2016
AbstractforPharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects | Full Text | References | PDF (427.9 KB)
  • 130 Views
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Article
Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway
Xingcong Ma, Wanjun Yan, Zhijun Dai, Xiaoyan Gao, Yinan Ma, Quntao Xu, Jiantao Jiang & Shuqun Zhang
Pages: 1419-1441
Published online: 18 Apr 2016
AbstractforBaicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway | Full Text | References | PDF (11.2 MB)
  • 158 Views
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Article
Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease
Yixuan Zeng, Wenyuan Guo, Guangqing Xu, Qinmei Wang, Luyang Feng, Simei Long, Fengyin Liang, Yi Huang, Xilin Lu, Shichang Li, Jiebin Zhou, Jean-Marc Burgunder, Jiyan Pang & Zhong Pei
Pages: 1443-1451
Published online: 13 Apr 2016
AbstractforXyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease | Full Text | References | PDF (1.9 MB)
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Article
Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress
Mehmet Zuhuri Arun, Buket Reel, Graciela B Sala-Newby, Mark Bond, Aikaterini Tsaousi, Perry Maskell & Andrew C Newby
Pages: 1453-1460
Published online: 18 Apr 2016
AbstractforZoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress | Full Text | References | PDF (1 MB)
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Article
Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1
Si-jun Liu, Cong Yang, Yue Zhang, Ru-yu Su, Jun-li Chen, Meng-meng Jiao, Hui-fang Chen, Na Zheng, Si Luo, Yun-bo Chen, Shi-jian Quan & Qi Wang
Pages: 1461-1469
Published online: 15 Apr 2016
AbstractforNeuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1 | Full Text | References | PDF (1.3 MB)
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Case Report

Case Report
Possible association between acetazolamide administration during pregnancy and multiple congenital malformations
Afnan I Al-Saleem & Asma M Al-Jobair
Pages: 1471-1476
Published online: 15 Apr 2016
AbstractforPossible association between acetazolamide administration during pregnancy and multiple congenital malformations | Full Text | References | PDF (634.2 KB)
  • 132 Views
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Original Research

Article
Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation
Kyoung In Jung & Chan Kee Park
Pages: 1477-1488
Published online: 15 Apr 2016
AbstractforPirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation | Full Text | References | PDF (5.6 MB)
  • 83 Views
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Article
Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1
Zhiguo Liu, Shufang Yu, Di Chen, Guoliang Shen, Yu Wang, Leping Hou, Dan Lin, Jinsan Zhang & Faqing Ye
Pages: 1489-1500
Published online: 03 May 2016
AbstractforDesign, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1 | Full Text | References | PDF (1.1 MB)
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Article
Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells
Ji-Fan Lin, Yi-Chia Lin, Shan-Che Yang, Te-Fu Tsai, Hung-En Chen, Kuang-Yu Chou & Thomas I-Sheng Hwang
Pages: 1501-1513
Published online: 18 Apr 2016
AbstractforAutophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells | Full Text | References | PDF (1.6 MB)
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Article
Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study
Fabio Guerriero, Anna Roberto, Maria Teresa Greco, Carmelo Sgarlata, Marco Rollone & Oscar Corli
Pages: 1515-1523
Published online: 19 Apr 2016
AbstractforLong-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study | Full Text | References | PDF (687.7 KB)
  • 109 Views
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Article
The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan
Namyi Gu, Joo-Youn Cho, Kwang-Hee Shin, In-Jin Jang & Moo-Yong Rhee
Pages: 1525-1531
Published online: 19 Apr 2016
AbstractforThe influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan | Full Text | References | PDF (592.8 KB)
  • 63 Views
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Article
Effects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats
Mahesh Kumar Seth, M Ejaz Hussain, Santosh Pasha & Mohammad Fahim
Pages: 1533-1542
Published online: 20 Apr 2016
AbstractforEffects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats | Full Text | References | PDF (2.9 MB)
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Letter

Letter
Efficacy and safety of different doses of a slow release corticosteroid implant for macular edema
John Hall
Pages: 1543-1546
Published online: 20 Apr 2016
First Page PreviewforEfficacy and safety of different doses of a slow release corticosteroid implant for macular edema | Full Text | References | PDF (216.3 KB)
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Corrigendum

Correction
Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum]
Page: 1547
Published online: 27 Apr 2016
CitationforEfficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum] | Full Text | PDF (105.6 KB)
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Correction
Zolav®: a new antibiotic for the treatment of acne [Corrigendum]
Page: 1549
Published online: 29 Apr 2016
CitationforZolav®: a new antibiotic for the treatment of acne [Corrigendum] | Full Text | PDF (92.9 KB)
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Original Research

Article
Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans
Elena Campione, Roberta Gaziano, Daniele Marino & Augusto Orlandi
Pages: 1551-1555
Published online: 29 Apr 2016
AbstractforFungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans | Full Text | References | PDF (1.7 MB)
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Article
Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases
Saqib Uzma & Mirza S Baig
Pages: 1557-1572
Published online: 04 May 2016
AbstractforSimultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases | Full Text | References | PDF (2.7 MB)
  • 56 Views
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Article
Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension
Mi-Seung Shin, Dae Ryong Kang, Changsoo Kim, Eun Joo Cho, Ki-Chul Sung, Seok-Min Kang, Dong-Soo Kim, Seung Jae Joo, Seung Hwan Lee, Kyung-Kuk Hwang & Jeong Bae Park
Pages: 1573-1580
Published online: 05 May 2016
AbstractforFimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension | Full Text | References | PDF (442.2 KB)
  • 57 Views
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Article
Spirolactone provides protection from renal fibrosis by inhibiting the endothelial–mesenchymal transition in isoprenaline-induced heart failure in rats
Hao Zhou, Dan Xi, Jichen Liu, Jinjin Zhao, Si Chen & Zhigang Guo
Pages: 1581-1588
Published online: 05 May 2016
AbstractforSpirolactone provides protection from renal fibrosis by inhibiting the endothelial–mesenchymal transition in isoprenaline-induced heart failure in rats | Full Text | References | PDF (4.2 MB)
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Clinical Trial Report

Article
Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study
Andrea Antinori, Paola Meraviglia, Antonella d’Arminio Monforte, Antonella Castagna, Cristina Mussini, Teresa Bini, Nicola Gianotti, Stefano Rusconi, Elisa Colella, Giuseppe Airoldi, Daniela Mancusi & Roberta Termini
Pages: 1589-1603
Published online: 06 May 2016
AbstractforEffectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study | Full Text | References | PDF (674.6 KB)
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Original Research

Article
Pharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB8
Sheikh Arslan Sehgal, Shazia Mannan & Sannia Ali
Pages: 1605-1618
Published online: 06 May 2016
AbstractforPharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB8 | Full Text | References | PDF (2.3 MB)
  • 325 Views
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Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study
Hongrong Xu, Lei Sheng, Weili Chen, Fei Yuan, Mengjie Yang, Hui Li, Xuening Li, John Choi, Guiyu Zhao, Tianxin Hu, Yongguo Li, Yi Zhang & Li Chen
Pages: 1619-1626
Published online: 09 May 2016
AbstractforSafety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study | Full Text | References | PDF (931.8 KB)
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Review

Review Article
Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date
José Fernando Vilela-Martin
Pages: 1627-1639
Published online: 09 May 2016
AbstractforSpotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date | Full Text | References | PDF (572.6 KB)
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Review Article
Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression
Dawn Bruijnzeel & Rajiv Tandon
Pages: 1641-1647
Published online: 11 May 2016
AbstractforSpotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression | Full Text | References | PDF (304.7 KB)
  • 52 Views
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Original Research

Article
The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway
Juanjuan Zhu, Tingting Ren, Mingyu Zhou & Mingliang Cheng
Pages: 1649-1661
Published online: 12 May 2016
AbstractforThe combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway | Full Text | References | PDF (3.3 MB)
  • 113 Views
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Article
Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury
Yanzhe Wang, Zhiyi He & Shumin Deng
Pages: 1663-1674
Published online: 17 May 2016
AbstractforUrsolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury | Full Text | References | PDF (5.4 MB)
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Review

Review Article
Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension
Thomas J Monaco & Carlos D Davila
Pages: 1675-1682
Published online: 18 May 2016
AbstractforSafety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension | Full Text | References | PDF (288.1 KB)
  • 117 Views
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Review Article
Spotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran
Pierre Sié
Pages: 1683-1689
Published online: 18 May 2016
AbstractforSpotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran | Full Text | References | PDF (181.9 KB)
  • 54 Views
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Original Research

Article
Reducing the trigger dose of recombinant hCG in high-responder patients attending an assisted reproductive technology program: an observational study
Gian Mario Tiboni, Enrica Concetta Colangelo & Adalisa Ponzano
Pages: 1691-1694
Published online: 18 May 2016
AbstractforReducing the trigger dose of recombinant hCG in high-responder patients attending an assisted reproductive technology program: an observational study | Full Text | References | PDF (169.6 KB)
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Article
Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration
Szilvia Berkó, Kálmán F Szűcs, Boglárka Balázs, Erzsébet Csányi, Gábor Varju, Anita Sztojkov-Ivanov, Mária Budai-Szűcs, Judit Bóta & Róbert Gáspár
Pages: 1695-1701
Published online: 19 May 2016
AbstractforElectroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration | Full Text | References | PDF (976.1 KB)
  • 64 Views
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Article
Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares
Radha Mahendran, Suganya Jeyabaskar, Gayathri Sitharaman, Rajamani Dinakaran Michael & Agnal Vincent Paul
Pages: 1703-1714
Published online: 23 May 2016
AbstractforComputer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares | Full Text | References | PDF (1.7 MB)
  • 325 Views
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Article
Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model
Abubakar Amali Muhammad, Palanisamy Arulselvan, Pike See Cheah, Farida Abas & Sharida Fakurazi
Pages: 1715-1730
Published online: 24 May 2016
AbstractforEvaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model | Full Text | References | PDF (5.2 MB)
  • 811 Views
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Review

Review Article
Critical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia
Bernardo Carpiniello & Federica Pinna
Pages: 1731-1742
Published online: 24 May 2016
AbstractforCritical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia | Full Text | References | PDF (370.4 KB)
  • 100 Views
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Original Research

Article
RETRACTED ARTICLE: Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury
Ya-Ru Wang, Fei-Long Tian, Ming-Xian Yan, Jin-Hua Fan, Li-Yun Wang, Rong-Guang Kuang & Yan-Qing Li
Pages: 1743-1751
Published online: 24 May 2016
AbstractforRETRACTED ARTICLE: Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury | PDF (5.7 MB)
  • 17 Views
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Article
Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani
Manas R Dikhit, Bidyut Purkait, Ruby Singh, Bikash Ranjan Sahoo, Ashish Kumar, Rajiv K Kar, Md Yousuf Ansari, Savita Saini, Kumar Abhishek, Ganesh C Sahoo, Sushmita Das & Pradeep Das
Pages: 1753-1761
Published online: 26 May 2016
AbstractforActivity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani | Full Text | References | PDF (1.4 MB)
  • 75 Views
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Review

Review Article
Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis
Paolo Gisondi & Giampiero Girolomoni
Pages: 1763-1770
Published online: 25 May 2016
AbstractforApremilast in the therapy of moderate-to-severe chronic plaque psoriasis | Full Text | References | PDF (2.5 MB)
  • 94 Views
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Original Research

Article
An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy
Ozlem Goker-Alpan, Nicola Longo, Marie McDonald, Suma P Shankar, Raphael Schiffmann, Peter Chang, Yinghua Shen & Arian Pano
Pages: 1771-1781
Published online: 25 May 2016
AbstractforAn open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy | Full Text | References | PDF (860 KB)
  • 74 Views
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Article
Efficacy of α-blocker in improving ureteral stent-related symptoms: a meta-analysis of both direct and indirect comparison
Feng He, Li-bo Man, Gui-zhong Li & Ning Liu
Pages: 1783-1793
Published online: 26 May 2016
AbstractforEfficacy of α-blocker in improving ureteral stent-related symptoms: a meta-analysis of both direct and indirect comparison | Full Text | References | PDF (1,011.3 KB)
  • 66 Views
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Review

Review Article
The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
John R Brannon & Maria Hadjifrangiskou
Pages: 1795-1806
Published online: 27 May 2016
AbstractforThe arsenal of pathogens and antivirulence therapeutic strategies for disarming them | Full Text | References | PDF (319.7 KB)
  • 117 Views
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Original Research

Article
Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ
Liang Ma, Taijin Wang, Min Shi & Haoyu Ye
Pages: 1807-1815
Published online: 30 May 2016
AbstractforSynthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ | Full Text | References | PDF (3.8 MB)
  • 59 Views
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Article
Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity
Muhanna M Alshaibani, Juriyati Jalil, Nik M Sidik, Ruangelie Edrada-Ebel & Noraziah M Zin
Pages: 1817-1827
Published online: 31 May 2016
AbstractforIsolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity | Full Text | References | PDF (715.5 KB)
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Article
Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway
Jin-Hua Zhang, Zhao-Shui Shangguan, Chao Chen, Hui-Jie Zhang & Yi Lin
Pages: 1829-1835
Published online: 01 Jun 2016
AbstractforAnti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway | Full Text | References | PDF (577.4 KB)
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Article
Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings
Mitzie-Ann Davis, Joe R Delaney, Chandni B Patel, Ryan Storgard & Dwayne G Stupack
Pages: 1837-1846
Published online: 02 Jun 2016
AbstractforNelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings | Full Text | References | PDF (4.3 MB)
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Article
Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model
Mohamed A Dkhil, Mohamed S Al-Khalifa, Saleh Al-Quraishy, Rafat Zrieq & Ahmed Esmat Abdel Moneim
Pages: 1847-1856
Published online: 02 Jun 2016
AbstractforIndigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model | Full Text | References | PDF (2.4 MB)
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Review

Review Article
Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review
Shiqi Yang, Jingke Zhao & Xiaodong Sun
Pages: 1857-1867
Published online: 02 Jun 2016
AbstractforResistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review | Full Text | References | PDF (382 KB)
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Original Research

Article
Stability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems
Fu-chao Chen, Jun Zhu, Bin Li, Fang-jun Yuan & Lin-hai Wang
Pages: 1869-1875
Published online: 03 Jun 2016
AbstractforStability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems | Full Text | References | PDF (406.6 KB)
  • 83 Views
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Article
Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats
Ho-Shan Niu, Chin-Hong Chang, Chiang-Shan Niu, Juei-Tang Cheng & Kung-Shing Lee
Pages: 1877-1884
Published online: 03 Jun 2016
AbstractforErythropoietin ameliorates hyperglycemia in type 1-like diabetic rats | Full Text | References | PDF (736.7 KB)
  • 72 Views
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Review

Review Article
Molecular mechanisms of cisplatin resistance in cervical cancer
Haiyan Zhu, Hui Luo, Wenwen Zhang, Zhaojun Shen, Xiaoli Hu & Xueqiong Zhu
Pages: 1885-1895
Published online: 07 Jun 2016
AbstractforMolecular mechanisms of cisplatin resistance in cervical cancer | Full Text | References | PDF (1 MB)
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Original Research

Article
Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line
Norlaily Mohd Ali, M Nadeem Akhtar, Huynh Ky, Kian Lam Lim, Nadiah Abu, Seema Zareen, Wan Yong Ho, Han Kiat Alan-Ong, Sheau Wei Tan, Noorjahan Banu Alitheen, Jamil bin Ismail, Swee Keong Yeap & Tunku Kamarul
Pages: 1897-1907
Published online: 10 Jun 2016
AbstractforFlavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line | Full Text | References | PDF (2.5 MB)
  • 71 Views
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Article
Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro
Zhe Wang, Li Wang, Ren-ai Xu, Yun-yun Zhan, Cheng-ke Huang, Da-peng Dai, Jian-ping Cai & Guo-xin Hu
Pages: 1909-1916
Published online: 08 Jun 2016
AbstractforRole of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro | Full Text | References | PDF (795.9 KB)
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Article
In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs
Jeong Soo Kim, Kwang Ho Cha, Seung Yeob Kang, Donghan Won, Sun Woo Jang, Miwon Son, Moon Ho Son, Ho Jung Choi, Young Won Lee & Myung Joo Kang
Pages: 1917-1925
Published online: 09 Jun 2016
AbstractforIn vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs | Full Text | References | PDF (2.1 MB)
  • 124 Views
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Article
The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma
Hatem A Sarhan, Omar H EL-Garhy, Mohamed A Ali & Nouran A Youssef
Pages: 1927-1933
Published online: 09 Jun 2016
AbstractforThe efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma | Full Text | References | PDF (294.8 KB)
  • 235 Views
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Article
Inhibitory effects of compounds from Phyllanthus amarus on nitric oxide production, lymphocyte proliferation, and cytokine release from phagocytes
Yuandani, Ibrahim Jantan, Menaga Ilangkovan, Khairana Husain & Kok Meng Chan
Pages: 1935-1945
Published online: 09 Jun 2016
AbstractforInhibitory effects of compounds from Phyllanthus amarus on nitric oxide production, lymphocyte proliferation, and cytokine release from phagocytes | Full Text | References | PDF (1.3 MB)
  • 143 Views
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Article
A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo
Xiangting Ge, Zhiguo Feng, Tingting Xu, Beibei Wu, Hongjin Chen, Fengli Xu, Lili Fu, Xiaoou Shan, Yuanrong Dai, Yali Zhang & Guang Liang
Pages: 1947-1959
Published online: 24 Jun 2016
AbstractforA novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo | Full Text | References | PDF (2.4 MB)
  • 66 Views
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Article
Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis
Yuan Wang, Guo-fang Hu, Qian-qian Zhang, Ning Tang, Jun Guo, Li-yan Liu, Xiao Han, Xia Wang & Zhe-hai Wang
Pages: 1961-1972
Published online: 13 Jun 2016
AbstractforEfficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis | Full Text | References | PDF (943.1 KB)
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Article
Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers
Shaymaa Fadhel Abbas Albaayit, Yusuf Abba, Rasedee Abdullah & Noorlidah Abdullah
Pages: 1973-1986
Published online: 15 Jun 2016
AbstractforProphylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers | Full Text | References | PDF (6.7 MB)
  • 177 Views
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Article
Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain
Pérola Grinberg Plapler, Morton Aaron Scheinberg, Christina da Cunha Ecclissato, Monalisa Fernanda Bocchi de Oliveira & Roberto Bleuel Amazonas
Pages: 1987-1993
Published online: 17 Jun 2016
AbstractforDouble-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain | Full Text | References | PDF (475.8 KB)
  • 233 Views
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Article
MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells
Shih-Wei Yang, Chi-Ying Tsai, Yi-Chun Pan, Chun-Nan Yeh, Jong-Hwei S Pang, Masashi Takano, Atsushi Kittaka, Horng-Heng Juang, Tai C Chen & Kun-Chun Chiang
Pages: 1995-2002
Published online: 17 Jun 2016
AbstractforMART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells | Full Text | References | PDF (1.4 MB)
  • 56 Views
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Article
The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis
Jian-He Chen, Seung-Hun Kim, Po-Wei Fan, Chun-Yen Liu, Chang-Hung Hsieh & Kang Fang
Pages: 2003-2013
Published online: 17 Jun 2016
AbstractforThe aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis | Full Text | References | PDF (3.1 MB)
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Review

Review Article
Position and enforcement practice of the People’s Republic of China’s pharmaceutical data exclusivity protection
Na Li, Xiang Yu & Michael Pecht
Pages: 2015-2020
Published online: 22 Jun 2016
AbstractforPosition and enforcement practice of the People’s Republic of China’s pharmaceutical data exclusivity protection | Full Text | References | PDF (424.9 KB)
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Original Research

Article
A novel pH–enzyme-dependent mesalamine colon-specific delivery system
Lei Jin, Yi-cun Ding, Yu Zhang, Xiao-qing Xu & Qin Cao
Pages: 2021-2028
Published online: 20 Jun 2016
AbstractforA novel pH–enzyme-dependent mesalamine colon-specific delivery system | Full Text | References | PDF (1.8 MB)
  • 144 Views
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Article
Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology
Deqing Sun, Aiying Xue, Bin Zhang, Xia Xue, Jie Zhang & Wenjie Liu
Pages: 2029-2039
Published online: 21 Jun 2016
AbstractforEnhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology | Full Text | References | PDF (2.1 MB)
  • 77 Views
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Article
Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients
Bruno Amato, Rita Compagna, Aldo Rocca, Tommaso Bianco, Marco Milone, Luigi Sivero, Gabriele Vigliotti, Maurizio Amato, Michele Danzi, Giovanni Aprea, Luca Gallelli, Stefano de Franciscis & Raffaele Serra
Pages: 2041-2046
Published online: 23 Jun 2016
AbstractforFondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients | Full Text | References | PDF (246.8 KB)
  • 58 Views
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Letter

Letter
Anti-dengue drug: viral polyprotein, a potential target
Syed Uzair Mahmood, Maryam Mushtaq & Maryam Jamil Syed
Pages: 2047-2048
Published online: 24 Jun 2016
CitationforAnti-dengue drug: viral polyprotein, a potential target | Full Text | References | PDF (184.9 KB)
  • 52 Views
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Original Research

Article
Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D
Zhongcheng Ke, Xuefeng Hou & Xiao-bin Jia
Pages: 2049-2060
Published online: 28 Jun 2016
AbstractforDesign and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D | Full Text | References | PDF (1.1 MB)
  • 151 Views
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Article
The cytotoxicity study of praziquantel enantiomers
Qian Sun, Ruifeng Mao, Dongling Wang, Changyan Hu, Yang Zheng & Dequn Sun
Pages: 2061-2068
Published online: 24 Jun 2016
AbstractforThe cytotoxicity study of praziquantel enantiomers | Full Text | References | PDF (1.6 MB)
  • 97 Views
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Review

Review Article
Secukinumab for rheumatology: development and its potential place in therapy
Marije I Koenders & Wim B van den Berg
Pages: 2069-2080
Published online: 24 Jun 2016
AbstractforSecukinumab for rheumatology: development and its potential place in therapy | Full Text | References | PDF (747.6 KB)
  • 127 Views
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Original Research

Article
Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study
Ferhan Yaman, Izzet Acikan, Serkan Dundar, Sercan Simsek, Mehmet Gul, Ibrahim Hanifi Ozercan, James Komorowski & Kazim Sahin
Pages: 2081-2086
Published online: 27 Jun 2016
AbstractforDietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study | Full Text | References | PDF (2.1 MB)
  • 85 Views
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Review

Review Article
Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials
Eric Toussirot, Charline Vauchy, Delphine Binda & Fabrice Michel
Pages: 2087-2094
Published online: 01 Jul 2016
AbstractforGolimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials | Full Text | References | PDF (250.6 KB)
  • 62 Views
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Original Research

Article
Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
Nouf M Al-Rasheed, Nawal M Al-Rasheed, Iman H Hasan, Maha A Al-Amin, Hanaa N Al-Ajmi & Ayman M Mahmoud
Pages: 2095-2107
Published online: 28 Jun 2016
AbstractforSitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats | Full Text | References | PDF (4.3 MB)
  • 198 Views
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Review

Review Article
Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod
Jorge Correale, Erwin Chiquete, Alexey Boyko, Roy G Beran, Jorge Barahona Strauch, Snezana Milojevic & Nadina Frider
Pages: 2109-2117
Published online: 30 Jun 2016
AbstractforClinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod | Full Text | References | PDF (444 KB)
  • 73 Views
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Review Article
Spotlight on grazoprevir–elbasvir once-daily combination and its potential in the treatment of hepatitis C
Duminda Suraweera, Ashley N Weeratunga & Sammy Saab
Pages: 2119-2127
Published online: 29 Jun 2016
AbstractforSpotlight on grazoprevir–elbasvir once-daily combination and its potential in the treatment of hepatitis C | Full Text | References | PDF (226.9 KB)
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Original Research

Article
Comparison of cisplatinum/paclitaxel with cisplatinum/5-fluorouracil as first-line therapy for nonsurgical locally advanced esophageal squamous cell carcinoma patients
Guofang Hu, Zhehai Wang, Yuan Wang, Qingqing Zhang, Ning Tang, Jun Guo, Liyan Liu & Xiao Han
Pages: 2129-2136
Published online: 01 Jul 2016
AbstractforComparison of cisplatinum/paclitaxel with cisplatinum/5-fluorouracil as first-line therapy for nonsurgical locally advanced esophageal squamous cell carcinoma patients | Full Text | References | PDF (535.8 KB)
  • 64 Views
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Article
Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants
Fidele Ntie-Kang, Conrad Veranso Simoben, Berin Karaman, Valery Fuh Ngwa, Philip Neville Judson, Wolfgang Sippl & Luc Meva’a Mbaze
Pages: 2137-2154
Published online: 04 Jul 2016
AbstractforPharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants | Full Text | References | PDF (3.5 MB)
  • 266 Views
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Article
Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells
NamHuk Baek, Ok Won Seo, Jaehwa Lee, John Hulme & Seong Soo A An
Pages: 2155-2165
Published online: 04 Jul 2016
AbstractforReal-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells | Full Text | References | PDF (4.8 MB)
  • 354 Views
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Review

Review Article
Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy
Paolo Grassi, Elena Verzoni, Raffaele Ratta, Alessia Mennitto, Filippo de Braud & Giuseppe Procopio
Pages: 2167-2172
Published online: 05 Jul 2016
AbstractforCabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy | Full Text | References | PDF (219.1 KB)
  • 85 Views
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Original Research

Article
The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage
Haigang Li, Yang Wang, Rong Fan, Huiying Lv, Hua Sun, Haitang Xie, Tao Tang, Jiekun Luo & Zian Xia
Pages: 2173-2180
Published online: 06 Jul 2016
AbstractforThe effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage | Full Text | References | PDF (1.2 MB)
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Article
Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide
Jinfang Jiang, Xuehai Pang, Liang Li, Xiaojian Dai, Xingxing Diao, Xiaoyan Chen, Dafang Zhong, Yingwei Wang & Yuanwei Chen
Pages: 2181-2191
Published online: 07 Jul 2016
AbstractforEffect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide | Full Text | References | PDF (964 KB)
  • 165 Views
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Article
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4
Joshua Runtuwene, Kai-Chun Cheng, Akihiro Asakawa, Haruka Amitani, Marie Amitani, Akinori Morinaga, Yoshiyuki Takimoto, Bernabas Harold Ralph Kairupan & Akio Inui
Pages: 2193-2202
Published online: 07 Jul 2016
AbstractforRosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4 | Full Text | References | PDF (1,011.7 KB)
  • 257 Views
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Article
Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro
Daniel Rocco, James Ross, Paul E Murray & Rima Caccetta
Pages: 2203-2209
Published online: 08 Jul 2016
AbstractforAcyl lipidation of a peptide: effects on activity and epidermal permeability in vitro | Full Text | References | PDF (598.1 KB)
  • 60 Views
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Article
Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients
Sohyun Jeong, In-Wha Kim, Kook-Hwan Oh, Nayoung Han, Kwon Wook Joo, Hyo Jin Kim & Jung Mi Oh
Pages: 2211-2225
Published online: 08 Jul 2016
AbstractforPharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients | Full Text | References | PDF (726.3 KB)
  • 64 Views
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Article
Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol
Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Zhi-Hao Tian, Chang Yang, Hui-Chao Wu & Zhen Wang
Pages: 2227-2237
Published online: 08 Jul 2016
AbstractforPuerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol | Full Text | References | PDF (2.2 MB)
  • 88 Views
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Article
Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats
Osama Adnan Kensara, Adel Galal El-Shemi, Amr Mohamed Mohamed, Bassem Refaat, Shakir Idris & Jawwad Ahmad
Pages: 2239-2253
Published online: 11 Jul 2016
AbstractforThymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats | Full Text | References | PDF (8 MB)
  • 215 Views
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Review

Review Article
An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis
Julien Paccou & René-Marc Flipo
Pages: 2255-2262
Published online: 11 Jul 2016
AbstractforAn appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis | Full Text | References | PDF (386.6 KB)
  • 44 Views
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Review Article
Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy
Jennifer Hayes, Rosie Anderson & Jeffrey W Stephens
Pages: 2263-2270
Published online: 19 Jul 2016
AbstractforSitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy | Full Text | References | PDF (281.3 KB)
  • 273 Views
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Original Research

Article
Simvastatin attenuates radiation-induced salivary gland dysfunction in mice
Liping Xu, Xi Yang, Jiayan Chen, Xiaolin Ge, Qin Qin, Hongcheng Zhu, Chi Zhang & Xinchen Sun
Pages: 2271-2278
Published online: 13 Jul 2016
AbstractforSimvastatin attenuates radiation-induced salivary gland dysfunction in mice | Full Text | References | PDF (2.8 MB)
  • 62 Views
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Article
The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats
Joanna Kabat-Koperska, Agnieszka Kolasa-Wołosiuk, Bartosz Wojciuk, Iwona Wojciechowska-Koszko, Paulina Roszkowska, Barbara Krasnodębska-Szponder, Edyta Paczkowska, Krzysztof Safranow, Edyta Gołembiewska, Bogusław Machaliński & Kazimierz Ciechanowski
Pages: 2279-2288
Published online: 14 Jul 2016
AbstractforThe influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats | Full Text | References | PDF (298.7 KB)
  • 60 Views
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Review

Review Article
Galeterone for the treatment of advanced prostate cancer: the evidence to date
Diogo A Bastos & Emmanuel S Antonarakis
Pages: 2289-2297
Published online: 15 Jul 2016
AbstractforGaleterone for the treatment of advanced prostate cancer: the evidence to date | Full Text | References | PDF (601.3 KB)
  • 101 Views
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Original Research

Article
Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
Sidhartha S Kar, Varadaraj Bhat G, Praveen PN Rao, Vishnu P Shenoy, Indira Bairy & G Gautham Shenoy
Pages: 2299-2310
Published online: 18 Jul 2016
AbstractforRational design and synthesis of novel diphenyl ether derivatives as antitubercular agents | Full Text | References | PDF (725.7 KB)
  • 81 Views
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Article
SPOCK1 promotes tumor growth and metastasis in human prostate cancer
Qi Chen, Yuan-ting Yao, Huan Xu, Yan-bo Chen, Meng Gu, Zhi-kang Cai & Zhong Wang
Pages: 2311-2321
Published online: 18 Jul 2016
AbstractforSPOCK1 promotes tumor growth and metastasis in human prostate cancer | Full Text | References | PDF (2.7 MB)
  • 76 Views
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Article
Prediction of selective estrogen receptor beta agonist using open data and machine learning approach
Ai-qin Niu, Liang-jun Xie, Hui Wang, Bing Zhu & Sheng-qi Wang
Pages: 2323-2331
Published online: 18 Jul 2016
AbstractforPrediction of selective estrogen receptor beta agonist using open data and machine learning approach | Full Text | References | PDF (1.4 MB)
  • 117 Views
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Article
Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study
I-Hung Shao, Chia-Chen Wu, Hsiao-Jung Tseng, Ta-Jen Lee, Yu-Hsiang Lin & Yuan-Yun Tam
Pages: 2333-2339
Published online: 19 Jul 2016
AbstractforVoiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study | Full Text | References | PDF (730.9 KB)
  • 95 Views
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Article
Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model
Zhen-hua Zhou, Jing Peng, Zhao-you Meng, Lin Chen, Jia-Lu Huang, He-qing Huang, Li Li, Wen Zeng, Yong Wei, Chu-Hong Zhu & Kang-Ning Chen
Pages: 2341-2351
Published online: 08 Aug 2016
AbstractforNovel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model | Full Text | References | PDF (3.1 MB)
  • 56 Views
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Article
Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial
Sachio Fushida, Jun Kinoshita, Masahide Kaji, Katsunobu Oyama, Yasuo Hirono, Tomoya Tsukada, Takashi Fujimura, Tetsuo Ohta & On behalf of the Digestive Disease Support Organization Study Group
Pages: 2353-2358
Published online: 25 Jul 2016
AbstractforPaclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial | Full Text | References | PDF (466.5 KB)
  • 66 Views
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Article
Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese females
Meng Wang, Zheng Wang, Xi-Jing Wang, Tian-Bo Jin, Zhi-Ming Dai, Hua-Feng Kang, Hai-Tao Guan, Xiao-Bin Ma, Xing-Han Liu & Zhi-Jun Dai
Pages: 2359-2367
Published online: 25 Jul 2016
AbstractforDistinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese females | Full Text | References | PDF (374 KB)
  • 46 Views
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Review

Review Article
A review of omalizumab for the management of severe asthma
Ching-Hsiung Lin & Shih-Lung Cheng
Pages: 2369-2378
Published online: 26 Jul 2016
AbstractforA review of omalizumab for the management of severe asthma | Full Text | References | PDF (310.7 KB)
  • 109 Views
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Review Article
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections
Jose A Hidalgo, Celeste M Vinluan & Nishaal Antony
Pages: 2379-2386
Published online: 26 Jul 2016
AbstractforCeftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections | Full Text | References | PDF (311.9 KB)
  • 128 Views
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Review Article
Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date
Yehenew A Ebstie, Solomon M Abay, Wondmagegn T Tadesse & Dawit A Ejigu
Pages: 2387-2399
Published online: 26 Jul 2016
AbstractforTafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date | Full Text | References | PDF (1.2 MB)
  • 133 Views
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Original Research

Article
Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling
Zaman Ashraf, Alamgeer, Munazza Kanwal, Mubashir Hassan, Sahar Abdullah, Mamuna Waheed, Haseeb Ahsan & Song Ja Kim
Pages: 2401-2419
Published online: 27 Jul 2016
AbstractforFlurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling | Full Text | References | PDF (5.4 MB)
  • 212 Views
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Article
Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate
Ayat Allam & Gihan Fetih
Pages: 2421-2433
Published online: 02 Aug 2016
AbstractforSublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate | Full Text | References | PDF (2 MB)
  • 335 Views
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Article
The role of CD147 expression in prostate cancer: a systematic review and meta-analysis
Yun Ye, Su-Liang Li, Yao Wang, Yang Yao, Juan Wang, Yue-Yun Ma & Xiao-Ke Hao
Pages: 2435-2442
Published online: 01 Aug 2016
AbstractforThe role of CD147 expression in prostate cancer: a systematic review and meta-analysis | Full Text | References | PDF (1 MB)
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Review

Review Article
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
Maryam Abbaspour Babaei, Behnam Kamalidehghan, Mohammad Saleem, Hasniza Zaman Huri & Fatemeh Ahmadipour
Pages: 2443-2459
Published online: 01 Aug 2016
AbstractforReceptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells | Full Text | References | PDF (1.2 MB)
  • 414 Views
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Original Research

Article
Chinese herbal medicine, Jianpi Ligan decoction, improves prognosis of unresectable hepatocellular carcinoma after transarterial chemoembolization: a retrospective study
Cheng Wu Tang, Ming Zhu, Wen Ming Feng, Ying Bao & Yin Yuan Zheng
Pages: 2461-2466
Published online: 03 Aug 2016
AbstractforChinese herbal medicine, Jianpi Ligan decoction, improves prognosis of unresectable hepatocellular carcinoma after transarterial chemoembolization: a retrospective study | Full Text | References | PDF (606.5 KB)
  • 44 Views
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Article
Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis
Marina Pinheiro, Ricardo Ribeiro, Alexandre Vieira, Fernanda Andrade & Salette Reis
Pages: 2467-2475
Published online: 02 Aug 2016
AbstractforDesign of a nanostructured lipid carrier intended to improve the treatment of tuberculosis | Full Text | References | PDF (841.6 KB)
  • 220 Views
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Article
Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats
Hande Arpacı, Faruk Metin Çomu, Ayşegül Küçük, Bahadır Kösem, Seyfi Kartal, Volkan Şıvgın, Hüseyin Cihad Turgut, Muhammed Enes Aydın, Derya Sebile Koç & Mustafa Arslan
Pages: 2477-2481
Published online: 03 Aug 2016
AbstractforEffects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats | Full Text | References | PDF (466.3 KB)
  • 54 Views
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Article
Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome
Marta Kiałka, Tomasz Milewicz, Krystyna Sztefko, Iwona Rogatko & Renata Majewska
Pages: 2483-2490
Published online: 03 Aug 2016
AbstractforMetformin increases pressure pain threshold in lean women with polycystic ovary syndrome | Full Text | References | PDF (494.7 KB)
  • 122 Views
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Article
RETRACTED ARTICLE: Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib
Chao Ji, Ziping Zhang, Lihong Chen, Kunli Zhou, Dongjun Li, Ping Wang, Shuying Huang, Ting Gong & Bo Cheng
Pages: 2491-2498
Published online: 04 Aug 2016
AbstractforRETRACTED ARTICLE: Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib | PDF (1.8 MB)
  • 33 Views
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Article
Preparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice
Qiang Ni, Wurong Chen, Lei Tong, Jue Cao & Chao Ji
Pages: 2499-2506
Published online: 04 Aug 2016
AbstractforPreparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice | Full Text | References | PDF (806.7 KB)
  • 94 Views
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Article
Quantification of simvastatin in mice plasma by near-infrared and chemometric analysis of spectral data
Usama A Fahmy
Pages: 2507-2513
Published online: 05 Aug 2016
AbstractforQuantification of simvastatin in mice plasma by near-infrared and chemometric analysis of spectral data | Full Text | References | PDF (1.1 MB)
  • 59 Views
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Article
NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
Mostafa M Ghorab, Mansour S Alsaid, Maureen Higgins, Albena T Dinkova-Kostova, Abdelaaty A Shahat, Nehal H Elghazawy & Reem K Arafa
Pages: 2515-2524
Published online: 08 Aug 2016
AbstractforNAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives | Full Text | References | PDF (788.3 KB)
  • 44 Views
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Article
Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects
Su-jin Rhee, YoonJung Choi, SeungHwan Lee, Jaeseong Oh, Sung-Jin Kim, Seo Hyun Yoon, Joo-Youn Cho & Kyung-Sang Yu
Pages: 2525-2534
Published online: 10 Aug 2016
AbstractforPharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects | Full Text | References | PDF (774.5 KB)
  • 106 Views
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Article
Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice
Yanzhi Liu, Yang Cui, Xiao Zhang, Xiang Gao, Yanjie Su, Bilian Xu, Tie Wu, Wenshuang Chen & Liao Cui
Pages: 2535-2546
Published online: 09 Aug 2016
AbstractforEffects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice | Full Text | References | PDF (5.6 MB)
  • 65 Views
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Article
Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
Anna Szlachcic, Malgorzata Zakrzewska, Michal Lobocki, Piotr Jakimowicz & Jacek Otlewski
Pages: 2547-2560
Published online: 09 Aug 2016
AbstractforDesign and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy | Full Text | References | PDF (3.4 MB)
  • 84 Views
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Article
PIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome
John L Yovich, Birgit Alsbjerg, Jason L Conceicao, Peter M Hinchliffe & Kevin N Keane
Pages: 2561-2573
Published online: 10 Aug 2016
AbstractforPIVET rFSH dosing algorithms for individualized controlled ovarian stimulation enables optimized pregnancy productivity rates and avoidance of ovarian hyperstimulation syndrome | Full Text | References | PDF (3 MB)
  • 111 Views
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Article
Dexamethasone-(C21-phosphoramide)-[anti-EGFR]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency against pulmonary adenocarcinoma (A549)
Cody P Coyne & Lakshmi Narayanan
Pages: 2575-2597
Published online: 12 Aug 2016
AbstractforDexamethasone-(C21-phosphoramide)-[anti-EGFR]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency against pulmonary adenocarcinoma (A549) | Full Text | References | PDF (1 MB)
  • 88 Views
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Article
Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong)
Jin-Sun Park, Joon-Han Shin, Taek-Jong Hong, Hong-Seog Seo, Wan-Joo Shim, Sang-Hong Baek, Jin-Ok Jeong, Youngkeun Ahn, Woong-Chol Kang, Young-Hak Kim, Sang-Hyun Kim, Min-Su Hyon, Dong-Hoon Choi, Chang-Wook Nam, Tae-Ho Park, Sang-Chol Lee & Hyo-Soo Kim
Pages: 2599-2609
Published online: 16 Aug 2016
AbstractforEfficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong) | Full Text | References | PDF (514.2 KB)
  • 106 Views
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Article
Construction of p66Shc gene interfering lentivirus vectors and its effects on alveolar epithelial cells apoptosis induced by hyperoxia
Chan Zhang, Wen-Bin Dong, Shuai Zhao, Qing-Ping Li, Lan Kang, Xiao-Ping Lei, Lin Guo & Xue-Song Zhai
Pages: 2611-2622
Published online: 16 Aug 2016
AbstractforConstruction of p66Shc gene interfering lentivirus vectors and its effects on alveolar epithelial cells apoptosis induced by hyperoxia | Full Text | References | PDF (4.3 MB)
  • 53 Views
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Article
Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents
Qosay A Al-Balas, Mohammad A Hassan, Nizar A Al-Shar’i, Nizar M Mhaidat, Ammar M Almaaytah, Fatima M Al-Mahasneh & Israa H Isawi
Pages: 2623-2629
Published online: 17 Aug 2016
AbstractforNovel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents | Full Text | References | PDF (1.1 MB)
  • 110 Views
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Clinical Trial Report

Article
Pharmacokinetic profile of defibrotide in patients with renal impairment
Paola Tocchetti, Elena Tudone, Jean-Francois Marier, Thomas C Marbury, Katie Zomorodi & Mark Eller
Pages: 2631-2641
Published online: 16 Aug 2016
AbstractforPharmacokinetic profile of defibrotide in patients with renal impairment | Full Text | References | PDF (1 MB)
  • 123 Views
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Original Research

Article
Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation
Zhiwang Song, Yonglin Lu, Xia Zhang, Haiping Wang, Junyi Han & Chunyan Dong
Pages: 2643-2649
Published online: 17 Aug 2016
AbstractforNovel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation | Full Text | References | PDF (866.1 KB)
  • 116 Views
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Article
Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats
Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Mustafa Arslan & Ayşegül Küçük
Pages: 2651-2658
Published online: 19 Aug 2016
AbstractforEffects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats | Full Text | References | PDF (3 MB)
  • 106 Views
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Article
Very rapid virologic response and early HCV response kinetics, as quick measures to compare efficacy and guide a personalized response-guided therapy
Mostafa Yakoot, Alaa M Abdo, Ahmed Yousry & Sherine Helmy
Pages: 2659-2667
Published online: 25 Aug 2016
AbstractforVery rapid virologic response and early HCV response kinetics, as quick measures to compare efficacy and guide a personalized response-guided therapy | Full Text | References | PDF (752.2 KB)
  • 60 Views
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Article
Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay
Shih-Hsiang Lo, Kai-Chung Cheng, Ying-Xiao Li, Chin-Hong Chang, Juei-Tang Cheng & Kung-Shing Lee
Pages: 2669-2676
Published online: 22 Aug 2016
AbstractforDevelopment of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay | Full Text | References | PDF (1 MB)
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Letter

Letter
Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients
Hikmat Abdel-Razeq & Asem Mansour
Pages: 2677-2679
Published online: 24 Aug 2016
First Page PreviewforFondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients | Full Text | References | PDF (224.9 KB)
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Original Research

Article
Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis
Katharigatta N Venugopala, G B Dharma Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama Ibrahim Alwassil, Sree Harsha & Koleka Mlisana
Pages: 2681-2690
Published online: 25 Aug 2016
AbstractforDesign, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis | Full Text | References | PDF (1.2 MB)
  • 134 Views
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Article
Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis
Michael R Preusch, Jonas Rusnak, Kathrin Staudacher, Carolin Mogler, Lorenz Uhlmann, Philipp Sievers, Florian Bea, Hugo A Katus, Erwin Blessing & Ingo Staudacher
Pages: 2691-2699
Published online: 26 Aug 2016
AbstractforTicagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis | Full Text | References | PDF (1.7 MB)
  • 84 Views
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Article
Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT
Ning Song, Ming Zhao, Yuji Wang, Xi Hu, Jianhui Wu, Xueyun Jiang, Shan Li, Chunying Cui & Shiqi Peng
Pages: 2701-2711
Published online: 30 Aug 2016
AbstractforNanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT | Full Text | References | PDF (2.3 MB)
  • 180 Views
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Article
Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir
Hanan Polansky, Adrian Javaherian & Edan Itzkovitz
Pages: 2713-2722
Published online: 29 Aug 2016
AbstractforClinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir | Full Text | References | PDF (648.6 KB)
  • 25728 Views
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Review

Review Article
Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis
Lazaros I Sakkas
Pages: 2723-2728
Published online: 29 Aug 2016
AbstractforSpotlight on tocilizumab and its potential in the treatment of systemic sclerosis | Full Text | References | PDF (354.8 KB)
  • 236 Views
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Original Research

Article
Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice
Xun Yuan, Yi-Chuan Xiao, Gui-Ping Zhang, Ning Hou, Xiao-Qian Wu, Wen-Liang Chen, Jian-Dong Luo & Gen-Shui Zhang
Pages: 2729-2737
Published online: 30 Aug 2016
AbstractforChloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice | Full Text | References | PDF (2.5 MB)
  • 90 Views
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Article
The effects of the insulin resistance index on the virologic response to entecavir in patients with HBeAg-positive chronic hepatitis B and nonalcoholic fatty liver disease
Li-Yao Zhu, Yu-Gang Wang, Li-Qing Wei, Jian Zhou, Wei-Jie Dai & Xiao-Yu Zhang
Pages: 2739-2744
Published online: 30 Aug 2016
AbstractforThe effects of the insulin resistance index on the virologic response to entecavir in patients with HBeAg-positive chronic hepatitis B and nonalcoholic fatty liver disease | Full Text | References | PDF (269.6 KB)
  • 67 Views
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Review

Review Article
Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors
Shouta Miyatake, Yuko Shimizu-Motohashi, Shin’ichi Takeda & Yoshitsugu Aoki
Pages: 2745-2758
Published online: 30 Aug 2016
AbstractforAnti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors | Full Text | References | PDF (1.1 MB)
  • 186 Views
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Original Research

Article
Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma
Piotr Kuna, Leif Bjermer & Göran Tornling
Pages: 2759-2770
Published online: 31 Aug 2016
AbstractforTwo Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma | Full Text | References | PDF (1.2 MB)
  • 65 Views
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Article
Efficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials
Min Wei & Dongmei Duan
Pages: 2771-2777
Published online: 09 Sep 2016
AbstractforEfficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials | Full Text | References | PDF (613.8 KB)
  • 58 Views
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Article
Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
Pinki Rawat & Saurabh Manaswita Verma
Pages: 2779-2788
Published online: 02 Sep 2016
AbstractforDesign and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities | Full Text | References | PDF (480.6 KB)
  • 101 Views
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Article
The use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis
Ying Hua, Wenwen Zhang, Xiaoli Hu, Ansu Yang & Xueqiong Zhu
Pages: 2789-2801
Published online: 06 Sep 2016
AbstractforThe use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis | Full Text | References | PDF (1.1 MB)
  • 145 Views
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Article
Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system
Jeremy WD McGowan, Qingmei Shao, Parminder JS Vig & Gene L Bidwell III
Pages: 2803-2813
Published online: 06 Sep 2016
AbstractforIntranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system | Full Text | References | PDF (1.1 MB)
  • 86 Views
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Article
RETRACTED ARTICLE: Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study
Dianbo Li & Liping Gong
Pages: 2815-2821
Published online: 06 Sep 2016
AbstractforRETRACTED ARTICLE: Preparation of novel pirfenidone microspheres for lung-targeted delivery: in vitro and in vivo study | PDF (2.1 MB)
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Article
Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections
Jochen Reinbold, Teresa Hierlemann, Helena Hinkel, Ingrid Müller, Martin E Maier, Tobias Weindl, Christian Schlensak, Hans Peter Wendel & Stefanie Krajewski
Pages: 2823-2832
Published online: 07 Sep 2016
AbstractforDevelopment and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections | Full Text | References | PDF (2.5 MB)
  • 62 Views
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Review

Review Article
Eltrombopag for the treatment of aplastic anemia: current perspectives
Su Han Lum & John D Grainger
Pages: 2833-2843
Published online: 13 Sep 2016
AbstractforEltrombopag for the treatment of aplastic anemia: current perspectives | Full Text | References | PDF (673.4 KB)
  • 136 Views
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Original Research

Article
Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition
Da-jin Chen, Wei Chen, Hong Jiang, Hao Yang, Yu-cheng Wang & Jiang-hua Chen
Pages: 2845-2853
Published online: 08 Sep 2016
AbstractforDownregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition | Full Text | References | PDF (2.4 MB)
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Article
In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer
Lu-Lu Wang, Shuai Huang, Hui-Hui Guo, Yan-Xing Han, Wen-Sheng Zheng & Jian-Dong Jiang
Pages: 2855-2867
Published online: 08 Sep 2016
AbstractforIn situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer | Full Text | References | PDF (3.9 MB)
  • 127 Views
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Article
Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents
Gisele Zapata-Sudo, Isabelle Karine da Costa Nunes, Josenildo Segundo Chaves Araujo, Jaqueline Soares da Silva, Margarete Manhães Trachez, Tiago Fernandes da Silva, Filipe P da Costa, Roberto Takashi Sudo, Eliezer J Barreiro & Lídia Moreira Lima
Pages: 2869-2879
Published online: 09 Sep 2016
AbstractforSynthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents | Full Text | References | PDF (1.2 MB)
  • 68 Views
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Article
Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design
Samaneh Masoumi, Aditya Harisankar, Aileen Gracias, Fabian Bachinger, Temesgen Fufa, Gayathri Chandrasekar, Frank Gaunitz, Julian Walfridsson & Satish S Kitambi
Pages: 2881-2897
Published online: 12 Sep 2016
AbstractforUnderstanding cytoskeleton regulators in glioblastoma multiforme for therapy design | Full Text | References | PDF (3.8 MB)
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Article
Effects of an immunosuppressive treatment on the rat prostate
Marta Grabowska, Karolina Kędzierska, Katarzyna Michałek, Sylwia Słuczanowska-Głąbowska, Maciej Grabowski, Małgorzata Piasecka, Andrzej Kram, Iwona Rotter, Aleksandra Rył & Maria Laszczyńska
Pages: 2899-2915
Published online: 12 Sep 2016
AbstractforEffects of an immunosuppressive treatment on the rat prostate | Full Text | References | PDF (6.4 MB)
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Article
Gender differences in the adverse events’ profile registered in seven observational studies of a wide gender-medicine (MetaGeM) project: the MetaGeM safety analysis
Delia Colombo, Emanuela Zagni, Mihaela Nica, Sara Rizzoli, Alessandra Ori & Gilberto Bellia
Pages: 2917-2927
Published online: 13 Sep 2016
AbstractforGender differences in the adverse events’ profile registered in seven observational studies of a wide gender-medicine (MetaGeM) project: the MetaGeM safety analysis | Full Text | References | PDF (498.8 KB)
  • 69 Views
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Article
Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection
Abhinav Kanwal, Sujatha Kasetti, Uday Kumar Putcha, Shailendra Asthana & Sanjay K Banerjee
Pages: 2929-2938
Published online: 14 Sep 2016
AbstractforProtein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection | Full Text | References | PDF (2.5 MB)
  • 60 Views
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Article
Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP
Teresa Esposito, Jean Marc Lobaccaro, Maria Grazia Esposito, Vincenzo Monda, Antonietta Messina, Giuseppe Paolisso, Bruno Varriale, Marcellino Monda & Giovanni Messina
Pages: 2939-2946
Published online: 14 Sep 2016
AbstractforEffects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP | Full Text | References | PDF (594.9 KB)
  • 258 Views
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Article
A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
Chang Heng Hsieh, Li-Ching Lee, Wai-Yin Leong, Tsai-Chen Yang, Ching-Fa Yao & Kang Fang
Pages: 2947-2957
Published online: 14 Sep 2016
AbstractforA triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells | Full Text | References | PDF (3 MB)
  • 52 Views
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Article
Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans
Jee Sun Min, Doyun Kim, Jung Bae Park, Hyunjin Heo, Soo Hyeon Bae, Jae Hong Seo, Euichaul Oh & Soo Kyung Bae
Pages: 2959-2972
Published online: 14 Sep 2016
AbstractforApplication of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans | Full Text | References | PDF (1.3 MB)
  • 97 Views
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Article
Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles
Shao-Hui Lin, Wei Cui, Gui-Ling Wang, Shuai Meng, Ying-Chun Liu, Hong-Wei Jin, Liang-Ren Zhang & Ying Xie
Pages: 2973-2987
Published online: 15 Sep 2016
AbstractforCombined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles | Full Text | References | PDF (4.2 MB)
  • 150 Views
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Article
Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis
Marija Darkovska-Serafimovska, Emilija Janevik-Ivanovska, Icko Djorgoski, Zorica Arsova-Sarafinovska, Milka Zdravkovska, Trajan Balkanov & Nenad Ugresic
Pages: 2989-2996
Published online: 21 Sep 2016
AbstractforRadiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis | Full Text | References | PDF (1.1 MB)
  • 74 Views
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Review

Review Article
Profile of adalimumab and its potential in the treatment of uveitis
Stephen J Balevic & C Egla Rabinovich
Pages: 2997-3003
Published online: 19 Sep 2016
AbstractforProfile of adalimumab and its potential in the treatment of uveitis | Full Text | References | PDF (399.2 KB)
  • 121 Views
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Clinical Trial Report

Article
Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial
Shoaleh Shami, Karim Nasseri, Mousa Shirmohammadi, Farzad Sarshivi, Negin Ghadami, Ebrahim Ghaderi, Mokhtar Pouladi & Arvin Barzanji
Pages: 3005-3012
Published online: 20 Sep 2016
AbstractforEffect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial | Full Text | References | PDF (698.5 KB)
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Original Research

Article
Bulgecin A as a β-lactam enhancer for carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii clinical isolates containing various resistance mechanisms
Marion J Skalweit & Mei Li
Pages: 3013-3020
Published online: 20 Sep 2016
AbstractforBulgecin A as a β-lactam enhancer for carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii clinical isolates containing various resistance mechanisms | Full Text | References | PDF (651 KB)
  • 109 Views
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Article
Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study
YoonJung Choi, SeungHwan Lee, Sang-Min Cho, Won-Ho Kang, Kyu-Yeol Nam, In-Jin Jang & Kyung-Sang Yu
Pages: 3021-3028
Published online: 20 Sep 2016
AbstractforComparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study | Full Text | References | PDF (1 MB)
  • 161 Views
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Review

Review Article
The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis
Kok-Yong Chin
Pages: 3029-3042
Published online: 20 Sep 2016
AbstractforThe spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis | Full Text | References | PDF (491.7 KB)
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Original Research

Article
Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds
Ao Zhou, Shuo Chen, Bin He, Weikang Zhao, Xiaojun Chen & Dianming Jiang
Pages: 3043-3051
Published online: 22 Sep 2016
AbstractforControlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds | Full Text | References | PDF (2.9 MB)
  • 212 Views
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Article
TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53
Yinxiang Lv, Yanan Huo, Xican Yu, Rongrong Liu, Shufen Zhang, Xiaoxiao Zheng & Xianning Zhang
Pages: 3053-3064
Published online: 23 Sep 2016
AbstractforTopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53 | Full Text | References | PDF (5.3 MB)
  • 74 Views
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Article
Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation
Jamileh Moghimi, Ali Asghar Rezaei, Raheb Ghorbani, Mohammad Reza Razavi & Daryoush Pahlevan
Pages: 3065-3069
Published online: 23 Sep 2016
AbstractforEfficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation | Full Text | References | PDF (324.9 KB)
  • 53 Views
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Article
Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway
Jianming Wu, Xiao Ke, Na Ma, Wei Wang, Wei Fu, Hongcheng Zhang, Manxi Zhao, Xiaoping Gao, Xiaofeng Hao & Zhirong Zhang
Pages: 3071-3081
Published online: 23 Sep 2016
AbstractforFormononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway | Full Text | References | PDF (3.4 MB)
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Review

Review Article
Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date
Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Giacomo Maria Guidelli, Enrico Selvi, Maurizio Acampa & Franco Laghi-Pasini
Pages: 3083-3098
Published online: 26 Sep 2016
AbstractforSpotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date | Full Text | References | PDF (2.6 MB)
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Original Research

Article
Evaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells
Tomoki Tada, Kensaku Aki, Wataru Oboshi, Kazuyoshi Kawazoe, Toshiyuki Yasui & Eiji Hosoi
Pages: 3099-3107
Published online: 26 Sep 2016
AbstractforEvaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells | Full Text | References | PDF (1.4 MB)
  • 54 Views
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Article
Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases
Bincy Baby, Priya Antony, Walaa Al Halabi, Zahrah Al Homedi & Ranjit Vijayan
Pages: 3109-3123
Published online: 27 Sep 2016
AbstractforStructural insights into the polypharmacological activity of quercetin on serine/threonine kinases | Full Text | References | PDF (5 MB)
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Clinical Trial Report

Article
Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach
Stephen Flach, Marie Croft, Jie Ding, Ron Budhram, Todd Pankratz, Mike Pennick, Graeme Scarfe, Steven Troy & Jay Getsy
Pages: 3125-3132
Published online: 27 Sep 2016
AbstractforPharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach | Full Text | References | PDF (529.3 KB)
  • 76 Views
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Review

Review Article
Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?
Jan M Keppel Hesselink, Flavia Chiosi & Ciro Costagliola
Pages: 3133-3141
Published online: 27 Sep 2016
AbstractforResolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? | Full Text | References | PDF (370.2 KB)
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Original Research

Article
Andrographolide promotes vincristine-induced SK-NEP-1 tumor cell death via PI3K-AKT-p53 signaling pathway
Mingsheng Zhang, Enda Xue & Wei Shao
Pages: 3143-3152
Published online: 28 Sep 2016
AbstractforAndrographolide promotes vincristine-induced SK-NEP-1 tumor cell death via PI3K-AKT-p53 signaling pathway | Full Text | References | PDF (2 MB)
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Article
Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis
Xi Zhang, Yuge Ran, Kunjie Wang, Yuanxue Zhu & Jinghua Li
Pages: 3153-3161
Published online: 28 Sep 2016
AbstractforIncidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis | Full Text | References | PDF (939.8 KB)
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Article
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach
Vicente Galiano, Pablo Garcia-Valtanen, Vicente Micol & José Antonio Encinar
Pages: 3163-3181
Published online: 11 Oct 2016
AbstractforLooking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach | Full Text | References | PDF (5.1 MB)
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Article
Methyl salicylate 2-O-β-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction
Yang-Yang He, Yu Yan, Hui-Fang Zhang, Yi-Huang Lin, Yu-Cai Chen, Yi Yan, Ping Wu, Jian-Song Fang, Shu-Hui Yang & Guan-Hua Du
Pages: 3183-3196
Published online: 29 Sep 2016
AbstractforMethyl salicylate 2-O-β-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction | Full Text | References | PDF (5.2 MB)
  • 91 Views
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Article
Druggability analysis and classification of protein tyrosine phosphatase active sites
Mohammad A Ghattas, Noor Raslan, Asil Sadeq, Mohammad Al Sorkhy & Noor Atatreh
Pages: 3197-3209
Published online: 30 Sep 2016
AbstractforDruggability analysis and classification of protein tyrosine phosphatase active sites | Full Text | References | PDF (1.7 MB)
  • 122 Views
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Article
Rapid disintegrating tablets of simvastatin dispersions in polyoxyethylene–polypropylene block copolymer for maximized disintegration and dissolution
Gehan F Balata, Ahmad S Zidan, Mohamad AS Abourehab & Ebtessam A Essa
Pages: 3211-3223
Published online: 03 Oct 2016
AbstractforRapid disintegrating tablets of simvastatin dispersions in polyoxyethylene–polypropylene block copolymer for maximized disintegration and dissolution | Full Text | References | PDF (1.6 MB)
  • 108 Views
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Review

Review Article
Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine
Gianni Allais & Chiara Benedetto
Pages: 3225-3236
Published online: 03 Oct 2016
AbstractforSpotlight on frovatriptan: a review of its efficacy in the treatment of migraine | Full Text | References | PDF (1.1 MB)
  • 73 Views
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Original Research

Article
Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus
Baki Vijaya Bhaskar, Tirumalasetty Muni Chandra Babu, Netala Vasudeva Reddy & Wudayagiri Rajendra
Pages: 3237-3252
Published online: 03 Oct 2016
AbstractforHomology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus | Full Text | References | PDF (9 MB)
  • 250 Views
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Article
Stability of apomorphine in solutions containing selected antioxidant agents
Zen Yang Ang, Michael Boddy, Yandi Liu & Bruce Sunderland
Pages: 3253-3265
Published online: 03 Oct 2016
AbstractforStability of apomorphine in solutions containing selected antioxidant agents | Full Text | References | PDF (1 MB)
  • 132 Views
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Review

Review Article
A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease
William James Deardorff & George T Grossberg
Pages: 3267-3279
Published online: 03 Oct 2016
AbstractforA fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease | Full Text | References | PDF (413.5 KB)
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Original Research

Article
Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats
Chun Yeh, Ching-Heng Ting, Ming-Luen Doong, Chin-Wen Chi, Shou-Dong Lee & Chih-Yen Chen
Pages: 3281-3290
Published online: 03 Oct 2016
AbstractforIntracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats | Full Text | References | PDF (1.3 MB)
  • 44 Views
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Article
Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis
Sabrina Giacoppo, Thangavelu Soundara Rajan, Gina Rosalinda De Nicola, Renato Iori, Placido Bramanti & Emanuela Mazzon
Pages: 3291-3304
Published online: 04 Oct 2016
AbstractforMoringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis | Full Text | References | PDF (3.2 MB)
  • 111 Views
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Review

Review Article
Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer
Dmitriy Smolensky, Kusum Rathore & Maria Cekanova
Pages: 3305-3322
Published online: 05 Oct 2016
AbstractforMolecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer | Full Text | References | PDF (410.3 KB)
  • 135 Views
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Original Research

Article
The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
Razieh Taghizadeh, Zahra Taghipour, Akbar Karimi, Ali Shamsizadeh, Mohammad Mohsen Taghavi, Mahdi Shariati, Ahmad Shabanizadeh, Hamid Reza Jafari Naveh, Reza Bidaki & Fariba Aminzadeh
Pages: 3323-3329
Published online: 02 Nov 2016
AbstractforThe expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine | Full Text | References | PDF (2.1 MB)
  • 64 Views
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Article
Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach
Keyhaneh Karimi, Edina Pallagi, Piroska Szabó-Révész, Ildikó Csóka & Rita Ambrus
Pages: 3331-3343
Published online: 12 Oct 2016
AbstractforDevelopment of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach | Full Text | References | PDF (3.2 MB)
  • 204 Views
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Review

Review Article
Yellow fever vaccine-associated viscerotropic disease: current perspectives
Roger E Thomas
Pages: 3345-3353
Published online: 12 Oct 2016
AbstractforYellow fever vaccine-associated viscerotropic disease: current perspectives | Full Text | References | PDF (462.8 KB)
  • 145 Views
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Review Article
Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations
Dilek Keskin, Sevil Sadri & Ahmet Emre Eskazan
Pages: 3355-3361
Published online: 13 Oct 2016
AbstractforDasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations | Full Text | References | PDF (268.2 KB)
  • 105 Views
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Original Research

Article
Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7
Si-Ying Wu, Gil-Yong Park, So-Hee Kim, John Hulme & Seong Soo A An
Pages: 3363-3378
Published online: 14 Oct 2016
AbstractforDiminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7 | Full Text | References | PDF (2.2 MB)
  • 64 Views
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Review

Review Article
Alemtuzumab in the treatment of multiple sclerosis: patient selection and special considerations
Jan Dörr & Karl Baum
Pages: 3379-3386
Published online: 18 Oct 2016
AbstractforAlemtuzumab in the treatment of multiple sclerosis: patient selection and special considerations | Full Text | References | PDF (360.2 KB)
  • 76 Views
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Original Research

Article
Investigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development
Abdulrahman K Al Asmari & Abdul Quaiyoom Khan
Pages: 3387-3397
Published online: 18 Oct 2016
AbstractforInvestigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development | Full Text | References | PDF (5.9 MB)
  • 93 Views
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Article
Early intervention of long-acting nifedipine GITS reduces brachial–ankle pulse wave velocity and improves arterial stiffness in Chinese patients with mild hypertension: a 24-week, single-arm, open-label, prospective study
Jidong Zhang, Yan Wang, Haijuan Hu, Xiaohong Yang, Zejun Tian, Demin Liu, Guoqiang Gu, Hongmei Zheng, Ruiqin Xie & Wei Cui
Pages: 3399-3406
Published online: 18 Oct 2016
AbstractforEarly intervention of long-acting nifedipine GITS reduces brachial–ankle pulse wave velocity and improves arterial stiffness in Chinese patients with mild hypertension: a 24-week, single-arm, open-label, prospective study | Full Text | References | PDF (669.3 KB)
  • 45 Views
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Review

Review Article
Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction
Marilita M Moschos & Eirini Nitoda
Pages: 3407-3413
Published online: 19 Oct 2016
AbstractforPathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction | Full Text | References | PDF (266.2 KB)
  • 128 Views
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Original Research

Article
Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration
Wenbo Li, Lijie Dong, Minwang Ma, Bojie Hu, Zhenyu Lu, Xun Liu, Juping Liu & Xiaorong Li
Pages: 3415-3423
Published online: 19 Oct 2016
AbstractforPreliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration | Full Text | References | PDF (1.8 MB)
  • 58 Views
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Article
N-acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats
Ahmed M Abu El-Saad, Mohammed A Al-Kahtani & Ashraf M Abdel-Moneim
Pages: 3425-3434
Published online: 20 Oct 2016
AbstractforN-acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats | Full Text | References | PDF (1 MB)
  • 91 Views
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Article
The clinical outcomes of triple antiplatelet therapy versus dual antiplatelet therapy for high-risk patients after coronary stent implantation: a meta-analysis of 11 clinical trials and 9,553 patients
Zhong-Guo Fan, Guo-Bin Ding, Xiao-Bo Li, Xiao-Fei Gao, Ya-Li Gao & Nai-Liang Tian
Pages: 3435-3448
Published online: 20 Oct 2016
AbstractforThe clinical outcomes of triple antiplatelet therapy versus dual antiplatelet therapy for high-risk patients after coronary stent implantation: a meta-analysis of 11 clinical trials and 9,553 patients | Full Text | References | PDF (1.7 MB)
  • 61 Views
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Article
α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension
Xiaolei Wang, Jier Su, Jingwen Ding, Song Han, Wei Ma, Hong Luo, Guy Hughes, Zhaoyang Meng, Yi Yin, Yanling Wang & Junfa Li
Pages: 3449-3457
Published online: 20 Oct 2016
Abstractforα-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension | Full Text | References | PDF (2.5 MB)
  • 52 Views
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Review

Review Article
Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors
Rosa Maria Paragliola, Alessandro Prete, Giampaolo Papi, Francesco Torino, Andrea Corsello, Alfredo Pontecorvi & Salvatore Maria Corsello
Pages: 3459-3470
Published online: 25 Oct 2016
AbstractforClinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors | Full Text | References | PDF (556.2 KB)
  • 62 Views
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Original Research

Article
Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway
Shouhai Wu, Tianpeng Zhang & Jingsheng Du
Pages: 3471-3481
Published online: 25 Oct 2016
AbstractforUrsolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway | Full Text | References | PDF (3 MB)
  • 176 Views
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Article
Cardioprotective activity of placental growth factor combined with oral supplementation of l-arginine in a rat model of acute myocardial infarction
Liyun Luo, Bairong Chen, Yin Huang, Zibin Liang, Songbiao Li, Yuelan Yin, Jian Chen & Wei Wu
Pages: 3483-3492
Published online: 28 Oct 2016
AbstractforCardioprotective activity of placental growth factor combined with oral supplementation of l-arginine in a rat model of acute myocardial infarction | Full Text | References | PDF (4.2 MB)
  • 57 Views
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Article
Pharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men
Hyang-Ki Choi, Jong-Lyul Ghim, Jihong Shon, Young-Kyung Choi & Jin Ah Jung
Pages: 3493-3499
Published online: 25 Oct 2016
AbstractforPharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men | Full Text | References | PDF (514.9 KB)
  • 119 Views
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Article
Hyaluronic acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models
Yan Zhang, Qin Liu, Ning Yang & Xuegang Zhang
Pages: 3501-3507
Published online: 25 Oct 2016
AbstractforHyaluronic acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models | Full Text | References | PDF (2 MB)
  • 80 Views
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Article
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study
Zancong Shen, Michael Gillen, Kathy Tieu, Mai Nguyen, Erin Harmon, David M Wilson, Bradley Kerr & Caroline A Lee
Pages: 3509-3517
Published online: 27 Oct 2016
AbstractforSupratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study | Full Text | References | PDF (743 KB)
  • 58 Views
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Article
Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation
Iúri Frias, Ana Rute Neves, Marina Pinheiro & Salette Reis
Pages: 3519-3528
Published online: 31 Oct 2016
AbstractforDesign, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation | Full Text | References | PDF (1.4 MB)
  • 143 Views
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Article
Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues
Md Jahangir Alam, Ozair Alam, Suroor Ahmad Khan, Mohd Javed Naim, Mohammad Islamuddin & Girdhar Singh Deora
Pages: 3529-3543
Published online: 31 Oct 2016
AbstractforSynthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues | Full Text | References | PDF (3.1 MB)
  • 205 Views
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Article
Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats
Tatyana A Gudasheva, Polina Povarnina, Ilya O Logvinov, Tatyana A Antipova & Sergey B Seredenin
Pages: 3545-3553
Published online: 02 Nov 2016
AbstractforMimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats | Full Text | References | PDF (1.9 MB)
  • 71 Views
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Article
Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers
Michael Gillen, Shakti Valdez, Dongmei Zhou, Bradley Kerr, Caroline A Lee & Zancong Shen
Pages: 3555-3562
Published online: 01 Nov 2016
AbstractforEffects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers | Full Text | References | PDF (715.3 KB)
  • 77 Views
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Article
Evaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells
Binbing Ling, Deborah Michel, Meena Kishore Sakharkar & Jian Yang
Pages: 3563-3572
Published online: 01 Nov 2016
AbstractforEvaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells | Full Text | References | PDF (4.6 MB)
  • 137 Views
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Corrigendum

Correction
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]
Page: 3573
Published online: 01 Nov 2016
CitationforMechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum] | Full Text | PDF (296.6 KB)
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Review

Review Article
Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold
Mithun Rudrapal & Dipak Chetia
Pages: 3575-3590
Published online: 01 Nov 2016
AbstractforEndoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold | Full Text | References | PDF (1.3 MB)
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Original Research

Article
Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway
Ching-Han Lin, Shang-Yu Lee, Chun-Cheng Zhang, Ye-Fong Du, Hao-Chang Hung, Hung-Tsung Wu & Horng-Yih Ou
Pages: 3591-3597
Published online: 01 Nov 2016
AbstractforFenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway | Full Text | References | PDF (684.5 KB)
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Article
The aqueous extract of Brucea javanica suppresses cell growth and alleviates tumorigenesis of human lung cancer cells by targeting mutated epidermal growth factor receptor
Seung-Hun Kim, Chun-Yen Liu, Po-Wei Fan, Chang-Heng Hsieh, Hsuan-Yuan Lin, Ming-Chung Lee & Kang Fang
Pages: 3599-3609
Published online: 03 Nov 2016
AbstractforThe aqueous extract of Brucea javanica suppresses cell growth and alleviates tumorigenesis of human lung cancer cells by targeting mutated epidermal growth factor receptor | Full Text | References | PDF (4.5 MB)
  • 76 Views
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Article
Development of novel HER2 inhibitors against gastric cancer derived from flavonoid source of Syzygium alternifolium through molecular dynamics and pharmacophore-based screening
Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Vijaya Bhaskar Baki, Savita Devi, Duvvuru Gunasekar & Wudayagiri Rajendra
Pages: 3611-3632
Published online: 04 Nov 2016
AbstractforDevelopment of novel HER2 inhibitors against gastric cancer derived from flavonoid source of Syzygium alternifolium through molecular dynamics and pharmacophore-based screening | Full Text | References | PDF (5.4 MB)
  • 114 Views
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Article
Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists
Bassem Sadek, Ali Saad, Johannes Stephan Schwed, Lilia Weizel, Miriam Walter & Holger Stark
Pages: 3633-3651
Published online: 07 Nov 2016
AbstractforAnticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists | Full Text | References | PDF (1.8 MB)
  • 66 Views
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Article
Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives
Muhamad Ali K Shakhatreh, Mousa L Al-Smadi, Omar F Khabour, Fatima A Shuaibu, Emad I Hussein & Karem H Alzoubi
Pages: 3653-3660
Published online: 08 Nov 2016
AbstractforStudy of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives | Full Text | References | PDF (403.3 KB)
  • 377 Views
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Article
Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis
Mona Mohamed El-Naa, Mohamed Othman & Sheren Younes
Pages: 3661-3672
Published online: 16 Nov 2016
AbstractforSildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis | Full Text | References | PDF (5.2 MB)
  • 94 Views
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Article
More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
Jin Lu, Jing Lu, Wenming Chen, Jing Wang, Yuliang Huo, Jian Hou & Xiaojun Huang
Pages: 3673-3679
Published online: 08 Nov 2016
AbstractforMore frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis | Full Text | References | PDF (1 MB)
  • 62 Views
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Open Access

Letter

Letter
Comment on the case report “Possible association between acetazolamide administration during pregnancy and multiple congenital malformations”
Elif Keskin-Arslan & Yusuf Cem Kaplan
Pages: 3681-3683
Published online: 10 Nov 2016
First Page PreviewforComment on the case report “Possible association between acetazolamide administration during pregnancy and multiple congenital malformations” | Full Text | References | PDF (224.2 KB)
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Review

Review Article
Ustekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy
Parakkal Deepak & Edward V Loftus Jr
Pages: 3685-3698
Published online: 11 Nov 2016
AbstractforUstekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy | Full Text | References | PDF (791.1 KB)
  • 197 Views
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Original Research

Article
Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats
Jiapeng Li, Yang Liu, Jingru Zhang, Xiaotong Yu, Xiaoling Wang & Libo Zhao
Pages: 3699-3706
Published online: 15 Nov 2016
AbstractforEffects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats | Full Text | References | PDF (656.8 KB)
  • 83 Views
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Article
Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats
Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu & Yuqing Zhao
Pages: 3707-3716
Published online: 10 Nov 2016
AbstractforImproved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats | Full Text | References | PDF (2.6 MB)
  • 67 Views
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Article
Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability
Francesca Bandinelli, Francesco Scazzariello, Emanuela Pimenta da Fonseca, Mittermayer Barreto Santiago, Claudio Marcassa, Francesca Nacci & Marco Matucci Cerinic
Pages: 3717-3724
Published online: 14 Nov 2016
AbstractforLow-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability | Full Text | References | PDF (556.5 KB)
  • 90 Views
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Review

Review Article
Systematic review and meta-analysis of randomized controlled trials on Wenxin keli
Xiaoyi Wang, Ying Wang, Xiaoyuan Feng, Ying Lu, Yu Zhang, Wenwen Wang & Wentao Zhu
Pages: 3725-3736
Published online: 14 Nov 2016
AbstractforSystematic review and meta-analysis of randomized controlled trials on Wenxin keli | Full Text | References | PDF (1.4 MB)
  • 83 Views
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Original Research

Article
Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis
Mutian Lv, Yaming Li, Xin Tian, Shundong Dai, Jing Sun, Guojiang Jin & Shenyi Jiang
Pages: 3737-3746
Published online: 15 Nov 2016
AbstractforLentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis | Full Text | References | PDF (2.5 MB)
  • 64 Views
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Review

Review Article
Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy
Elizabeth Ashley Hardin & Kelly M Chin
Pages: 3747-3754
Published online: 15 Nov 2016
AbstractforSelexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy | Full Text | References | PDF (583.6 KB)
  • 92 Views
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Original Research

Article
Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
Chunhua Yang, Hang Cao, Ning Liu, Kai Xu, Meng Ding & Li-jun Mao
Pages: 3755-3761
Published online: 15 Nov 2016
AbstractforOncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma | Full Text | References | PDF (1.3 MB)
  • 74 Views
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Open Access
Article
Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects
Choon Ok Kim, Eun Sil Oh, Chungam Choi, Yeonjoo Kim, Sera Lee, Semi Kim & Min Soo Park
Pages: 3763-3770
Published online: 15 Nov 2016
AbstractforPharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects | Full Text | References | PDF (934.4 KB)
  • 49 Views
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Article
Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis
Serkan Dundar, Abubekir Eltas, Sema S Hakki, Sıddık Malkoc, M Ozay Uslu, Mehmet Tuzcu, James Komorowski, I Hanifi Ozercan, Fatih Akdemir & Kazim Sahin
Pages: 3771-3778
Published online: 15 Nov 2016
AbstractforDietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis | Full Text | References | PDF (1.3 MB)
  • 71 Views
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Article
Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection
Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi & Myung Joo Kang
Pages: 3779-3787
Published online: 16 Nov 2016
AbstractforIncreased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection | Full Text | References | PDF (1.7 MB)
  • 113 Views
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Article
Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability
Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin & Haiyan Hu
Pages: 3789-3798
Published online: 17 Nov 2016
AbstractforComparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability | Full Text | References | PDF (1.1 MB)
  • 87 Views
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Review

Review Article
CARD9 as a potential target in cardiovascular disease
Matthew R Peterson, Samantha E Haller, Jun Ren, Sreejayan Nair & Guanglong He
Pages: 3799-3804
Published online: 22 Nov 2016
AbstractforCARD9 as a potential target in cardiovascular disease | Full Text | References | PDF (223.7 KB)
  • 66 Views
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Original Research

Article
Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization
Irshad Hussain, Nisar Hussain, Abdul Manan, Abdur Rashid, Barkat Khan & Sattar Bakhsh
Pages: 3805-3816
Published online: 22 Nov 2016
AbstractforFabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization | Full Text | References | PDF (1.7 MB)
  • 413 Views
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Article
Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study
Sang-Hyun Ihm, Hui-Kyung Jeon, Tae-Joon Cha, Taek-Jong Hong, Sang-Hyun Kim, Nae-Hee Lee, Jung Han Yoon, Namsik Yoon, Kyung-Kuk Hwang, Sang-Ho Jo & Ho-Joong Youn
Pages: 3817-3826
Published online: 23 Nov 2016
AbstractforEfficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study | Full Text | References | PDF (574.4 KB)
  • 103 Views
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Article
Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study
Atsushi Tsuruta, Kazuki Yamashita, Hiroaki Tanioka, Akihito Tsuji, Michio Inukai, Toshiki Yamakawa, Tomoki Yamatsuji, Masanori Yoshimitsu, Kazuhiro Toyota, Taketoshi Yamano, Takeshi Nagasaka, Masazumi Okajima & On behalf of the Japan Southwest Oncology Group (JSWOG)
Pages: 3827-3835
Published online: 23 Nov 2016
AbstractforFeasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study | Full Text | References | PDF (982.1 KB)
  • 58 Views
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Article
Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation
Syed Muhammad Hassan Shah, Farhat Ullah, Shahzeb Khan, Syed Muhammad Mukarram Shah, Marcel de Matas, Zahid Hussain, Muhammad Usman Minhas, Naser M AbdEl-Salam, Khaled Hafez Assi & Mohammad Isreb
Pages: 3837-3850
Published online: 24 Nov 2016
AbstractforSmart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation | Full Text | References | PDF (1.8 MB)
  • 210 Views
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Article
Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery
Wen Zhao, Yifan Zhang, Xueyun Jiang & Chunying Cui
Pages: 3851-3865
Published online: 24 Nov 2016
AbstractforDesign, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery | Full Text | References | PDF (4.1 MB)
  • 50 Views
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Review

Review Article
Three generations of epidermal growth factor receptor tyrosine kinase inhibitors developed to revolutionize the therapy of lung cancer
Haijun Zhang
Pages: 3867-3872
Published online: 24 Nov 2016
AbstractforThree generations of epidermal growth factor receptor tyrosine kinase inhibitors developed to revolutionize the therapy of lung cancer | Full Text | References | PDF (586 KB)
  • 110 Views
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Original Research

Article
Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use
Baoxia Fang, Linhai Wang, Junfeng Gu, Fuchao Chen & Xiao-ya Shi
Pages: 3873-3878
Published online: 24 Nov 2016
AbstractforPhysicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use | Full Text | References | PDF (329.3 KB)
  • 102 Views
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Article
Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
Bassem Sadek, Ali Saad, Gniewomir Latacz, Kamil Kuder, Agnieszka Olejarz, Tadeusz Karcz, Holger Stark & Katarzyna Kieć-Kononowicz
Pages: 3879-3898
Published online: 25 Nov 2016
AbstractforNon-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats | Full Text | References | PDF (4.1 MB)
  • 86 Views
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Article
Efficacy and tolerability of vilazodone for major depressive disorder: evidence from phase III/IV randomized controlled trials
Ligen Shi, Jingyi Wang, Shenbin Xu & Yunrong Lu
Pages: 3899-3907
Published online: 25 Nov 2016
AbstractforEfficacy and tolerability of vilazodone for major depressive disorder: evidence from phase III/IV randomized controlled trials | Full Text | References | PDF (834.6 KB)
  • 77 Views
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Article
Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets
Fei Sun, Bing Xu, Yi Zhang, Shengyun Dai, Chan Yang, Xianglong Cui, Xinyuan Shi & Yanjiang Qiao
Pages: 3909-3924
Published online: 28 Nov 2016
AbstractforStatistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets | Full Text | References | PDF (2.7 MB)
  • 80 Views
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Article
Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells
Mario Bonomini, Sara Di Silvestre, Pamela Di Tomo, Natalia Di Pietro, Domitilla Mandatori, Lorenzo Di Liberato, Vittorio Sirolli, Francesco Chiarelli, Cesare Indiveri, Assunta Pandolfi & Arduino Arduini
Pages: 3925-3932
Published online: 28 Nov 2016
AbstractforEffect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells | Full Text | References | PDF (944.2 KB)
  • 61 Views
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Article
Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy
Xiaojie Lv, Ming Zhao, Yuiji Wang, Xi Hu, Jianhui Wu, Xueyun Jiang, Shan Li, Chunying Cui & Shiqi Peng
Pages: 3933-3946
Published online: 01 Dec 2016
AbstractforLoading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy | Full Text | References | PDF (3.5 MB)
  • 66 Views
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Article
Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation
Md Al-Amin, Jiafu Cao, Muhammad Naeem, Hasanul Banna, Min-Soo Kim, Yunjin Jung, Hae Young Chung, Hyung Ryong Moon & Jin-Wook Yoo
Pages: 3947-3957
Published online: 02 Dec 2016
AbstractforIncreased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation | Full Text | References | PDF (1.9 MB)
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Hypothesis

Article
Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress
Kiran Kumar Soni, Hye Kyung Kim, Bo Ram Choi, Keshab Kumar Karna, Jae Hyung You, Jai Seong Cha, Yu Seob Shin, Sung Won Lee, Chul Young Kim & Jong Kwan Park
Pages: 3959-3968
Published online: 12 Dec 2016
AbstractforDose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress | Full Text | References | PDF (8.8 MB)
  • 265 Views
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Original Research

Article
Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers
Gisèle Pickering, Nicolas Macian, Claude Dubray & Bruno Pereira
Pages: 3969-3976
Published online: 05 Dec 2016
AbstractforParacetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers | Full Text | References | PDF (494.6 KB)
  • 113 Views
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Article
Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study
Marilita M Moschos, Eirini Nitoda, Irini P Chatziralli, Georgios D Panos & Constantinos A Demopoulos
Pages: 3977-3981
Published online: 07 Dec 2016
AbstractforImpact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study | Full Text | References | PDF (205.8 KB)
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Review

Review Article
Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations
Minhui Hu, Chunlan Zheng & Feng Gao
Pages: 3983-3994
Published online: 07 Dec 2016
AbstractforUse of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations | Full Text | References | PDF (359.6 KB)
  • 135 Views
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Original Research

Article
Comparison of oral absorption models for pregabalin: usefulness of transit compartment model
Taegon Hong, Seunghoon Han, Jongtae Lee, Sangil Jeon & Dong-Seok Yim
Pages: 3995-4003
Published online: 07 Dec 2016
AbstractforComparison of oral absorption models for pregabalin: usefulness of transit compartment model | Full Text | References | PDF (1.4 MB)
  • 121 Views
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Article
Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013
Hoon Young Suh, Carl C Peck, Kyung-Sang Yu & Howard Lee
Pages: 4005-4016
Published online: 08 Dec 2016
AbstractforDetermination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013 | Full Text | References | PDF (1.1 MB)
  • 232 Views
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Article
Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols
Hyo-Jung Lee, Ji-Hyun Kang, Hong-Goo Lee, Dong-Wook Kim, Yun-Seok Rhee, Ju-Young Kim, Eun-Seok Park & Chun-Woong Park
Pages: 4017-4030
Published online: 13 Dec 2016
AbstractforPreparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols | Full Text | References | PDF (4.6 MB)
  • 208 Views
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Article
Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation
Mohamed A El-Nabarawi, Adel A Ali, Heba M Aboud, Amira H Hassan & Amany H Godah
Pages: 4031-4045
Published online: 14 Dec 2016
AbstractforTransbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation | Full Text | References | PDF (2 MB)
  • 195 Views
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Review

Review Article
Spotlight on fluticasone furoate/vilanterol trifenatate for the once-daily treatment of asthma: design, development and place in therapy
Timothy E Albertson, Samuel W Bullick, Michael Schivo & Mark E Sutter
Pages: 4047-4060
Published online: 14 Dec 2016
AbstractforSpotlight on fluticasone furoate/vilanterol trifenatate for the once-daily treatment of asthma: design, development and place in therapy | Full Text | References | PDF (416 KB)
  • 80 Views
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Original Research

Article
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride
Sayed M Ahmed, Adel Ahmed Ali, Ahmed MA Ali & Omiya A Hassan
Pages: 4061-4071
Published online: 14 Dec 2016
AbstractforDesign and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride | Full Text | References | PDF (2 MB)
  • 219 Views
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Letter

Letter
Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with nontransfusion-dependent thalassemia syndromes
Ali T Taher, John B Porter, Antonis Kattamis, Vip Viprakasit & M Domenica Cappellini
Pages: 4073-4078
Published online: 15 Dec 2016
First Page PreviewforEfficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with nontransfusion-dependent thalassemia syndromes | Full Text | References | PDF (272.6 KB)
  • 141 Views
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Original Research

Article
Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium
Şehmus Pala, Remzi Atilgan, Tuncay Kuloğlu, Murat Kara, Melike Başpinar, Behzat Can & Gökhan Artaş
Pages: 4079-4089
Published online: 15 Dec 2016
AbstractforProtective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium | Full Text | References | PDF (6 MB)
  • 75 Views
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Article
Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database
Jing Wang, Chunxia Qiao, He Xiao, Zhou Lin, Yan Li, Jiyan Zhang, Beifen Shen, Tinghuan Fu & Jiannan Feng
Pages: 4091-4100
Published online: 15 Dec 2016
AbstractforStructure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database | Full Text | References | PDF (1.4 MB)
  • 85 Views
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Article
Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform
Xia Li, Myron R Szewczuk & Cecile Malardier-Jugroot
Pages: 4101-4110
Published online: 15 Dec 2016
AbstractforFolic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform | Full Text | References | PDF (3.8 MB)
  • 135 Views
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