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Drug Design, Development and Therapy Volume 10, 2016 - Issue

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Original Research

Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway

Jin-Hua Zhang1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China;2 Department of Pharmacy, Xiamen Medical College, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

Zhao-Shui Shangguan3 Central Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

Chao Chen4 Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

Hui-Jie Zhang4 Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

Yi Lin1 College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of ChinaCorrespondence[email protected]

Pages 1829-1835 | Published online: 01 Jun 2016

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Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae & Sung-Joo Park. (2023) Guggulsterone protects against lipopolysaccharide-induced inflammation and lethal endotoxemia via heme oxygenase-1. International Immunopharmacology 124, pages 111073.
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Bui T. Tung, Tran V. Linh, Trinh P. Thao & Nguyen D. Thuan. 2023. Phytochemical Drug Discovery for Central Nervous System Disorders. Phytochemical Drug Discovery for Central Nervous System Disorders 219 250 .

Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed & Young Sup Lee. (2022) Role of Nrf2, STAT3, and Src as Molecular Targets for Cancer Chemoprevention. Pharmaceutics 14:9, pages 1775.
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Jing Liu, Ye Lin, Yang Yang, Yane Guo, Yanchang Shang, Bo Zhou, Tianlong Liu, Jiao Fan & Chao Wei. (2022) Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway. Biochemical Pharmacology 202, pages 115149.
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SK Sujitha Priya, Ankita Jha, Rajappan Chandra Satish Kumar & Sarvesh Sabarathinam. (2022) The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence. Future Science OA 8:6.
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Acharya Balkrishna, Sandeep Sinha, Shadrak Karumuri, Jyotish Srivastava, Swati Haldar & Anurag Varshney. (2022) Peedanil Gold, Herbo-Mineral Formulation, Moderates Cytokine Levels and Attenuates Pathophysiology in Monosodium Iodoacetate Induced Osteoarthritis in SD Rat Model. Frontiers in Pharmacology 13.
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Rishabh Khera, Sidharth Mehan, Sonalika Bhalla, Sumit Kumar, Abdulrahman Alshammari, Metab Alharbi & Satya Sai Sadhu. (2022) Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism. Molecules 27:3, pages 889.
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L. Preethi, Nila Ganamurali, Dhivya Dhanasekaran & Sarvesh Sabarathinam. (2021) Therapeutic use of Guggulsterone in COVID-19 induced obesity (COVIBESITY) and significant role in immunomodulatory effect. Obesity Medicine 24, pages 100346.
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Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen & Gui-Yuan Lv. (2021) Luteolin ameliorates lipopolysaccharide-induced microcirculatory disturbance through inhibiting leukocyte adhesion in rat mesenteric venules. BMC Complementary Medicine and Therapies 21:1.
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Colette Miller, Janaiya Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy & Srujana Rayalam. (2019) Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264.7 Macrophages. Medicines 6:1, pages 22.
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Tianlong Liu, Minna Liu, Tiejun Zhang, Wenxing Liu, Hang Xu, Fei Mu, Danjun Ren, Na Jia, Zhengjun Li, Yi Ding, Aidong Wen & Yuwen Li. (2018) Z‐Guggulsterone attenuates astrocytes‐mediated neuroinflammation after ischemia by inhibiting toll‐like receptor 4 pathway. Journal of Neurochemistry 147:6, pages 803-815.
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Solee Jin & Mi-Young Lee. (2018) Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity. International Journal of Molecular Sciences 19:11, pages 3457.
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Weiwei Liu, Yajie Zhang, Weina Zhu, Chunhua Ma, Jie Ruan, Hongyan Long & Yue Wang. (2018) Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets. Frontiers in Immunology 9.
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Solee Jin & Mi-Young Lee. (2018) The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes. PLOS ONE 13:8, pages e0202933.
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Ajaikumar B. Kunnumakkara, Kishore Banik, Devivasha Bordoloi, Choudhary Harsha, Bethsebie L. Sailo, Ganesan Padmavathi, Nand K. Roy, Subash C. Gupta & Bharat B. Aggarwal. (2018) Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Frontiers in Pharmacology 9.
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Gorla V. Reddy, Nagendra S. Yarla, Shobha Ediga, Dinesh K. Tiwari, Naresh Kumar, Sandhya Singh, Vasundhra Bhandari, Priyanka Voori Giri, Anupam Bishayee, Chintalapally V. Rao & Pallu Reddanna. 2017. Natural Products Targeting Clinically Relevant Enzymes. Natural Products Targeting Clinically Relevant Enzymes 163 208 .

Muna S. Elburki, Carlos RossaJrJr, Morgana R. Guimarães-Stabili, Hsi-Ming Lee, Fabiana A. Curylofo-Zotti, Francis Johnson & Lorne M. Golub. (2017) A Chemically Modified Curcumin (CMC 2.24) Inhibits Nuclear Factor κB Activation and Inflammatory Bone Loss in Murine Models of LPS-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis. Inflammation 40:4, pages 1436-1449.
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Solee Jin, A-Reum Ryu, Chung-Sub Han & Mi-Young Lee. (2016) A comparison of the anti-bacterial and anti-inflammatory effect between two forms of chlorins. Toxicology and Environmental Health Sciences 8:3, pages 271-276.
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Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway

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Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway

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