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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Zhe Wang1 Department of Pharmacy, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Li Wang2 Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Department of Pharmacy, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
,
Ren-ai Xu4 Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Yun-yun Zhan2 Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Cheng-ke Huang1 Department of Pharmacy, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Da-peng Dai5 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, People’s Republic of China
,
Jian-ping Cai5 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, People’s Republic of ChinaCorrespondence[email protected]
&
Guo-xin Hu2 Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1909-1916 | Published online: 08 Jun 2016

Citations (9)

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Jian-Chang Qian, Jian-Ping Cai & Guo-Xin Hu. (2021) Han Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties. Expert Opinion on Drug Metabolism & Toxicology 17:6, pages 707-716.
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Articles from other publishers (8)

Mehmet Uluturk, Atakan Yilmaz, Murat Seyit, Mert Ozen, Alten Oskay, Aykut Kemanci, Medine Unal, Hande Senol, Aylin Koseler & Ibrahim Turkcuer. (2023) Diltiazem efficacy and CYP2D6 gene polymorphism in patients with atrial fibrillation with rapid ventricular response. The Egyptian Heart Journal 75:1.
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Zhe Wang, Qing-qing Li, Cheng-ke Huang, Yan-yan Dong, Li-ping Lang, Wei Sun, Jian-chang Qian & Xiao-dan Zhang. (2023) Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis 224, pages 115191.
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A.V. Kuzikov, R.A. Masamrekh, T.A. Filippova & V.V. Shumyantseva. (2022) Electrochemical Analysis of Metabolites as a Method for Cytochromes P450 Activity Determination. Biomedical Chemistry: Research and Methods 5:4, pages e00176.
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Siquan Xu, Xinyi Xing, Yongyi Liu & Hui Gao. (2022) A hemicyanine-based fluorescence probe for selective detection of CYP2D6 in living cells and tumor-bearing mice. Dyes and Pigments 198, pages 109959.
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Ferbian Milas Siswanto, Ami Oguro, Saki Arase & Susumu Imaoka. (2020) WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes. Drug Metabolism and Pharmacokinetics 35:5, pages 441-455.
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Xiang-yu Li, Xiao-xia Hu, Fang Yang, Ling-jing Yuan, Jian-ping Cai & Guo-xin Hu. (2019) Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro. Chemico-Biological Interactions 313, pages 108840.
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José Roberto Macías-Pérez, Bruno Jesús Vázquez-López, Martin Humberto Muñoz-Ortega, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Esperanza Sánchez-Alemán & Javier Ventura-Juárez. (2019) Curcumin and α / β -Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF- κ B . Journal of Immunology Research 2019, pages 1-12.
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Katarzyna Zawadzka, Aleksandra Felczak, Janusz Szemraj & Katarzyna Lisowska. (2018) Novel metabolites from Cunninghamella elegans as a microbial model of the β-blocker carvedilol biotransformation in the environment. International Biodeterioration & Biodegradation 127, pages 227-235.
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