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Drug Design, Development and Therapy Volume 10, 2016 - Issue

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Clinical Trial Report

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach

Stephen Flach1 Covance Laboratories Inc., Madison, WI, USACorrespondence[email protected]

Marie Croft2 Xceleron Inc., Germantown, MD, USA

Jie Ding1 Covance Laboratories Inc., Madison, WI, USA

Ron Budhram3 Shire, Basingstoke, UK

Todd Pankratz2 Xceleron Inc., Germantown, MD, USA

Mike Pennick3 Shire, Basingstoke, UK

Graeme Scarfe3 Shire, Basingstoke, UK

Steven Troy4 Shire, Lexington, MA, USA

Jay Getsy4 Shire, Lexington, MA, USA

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Pages 3125-3132 | Published online: 27 Sep 2016

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Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf & V. Sashi Gopaul. (2023) Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans. Drug Metabolism and Disposition 51:4, pages 451-463.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .

Dipali Sonawane, Anuradha Reddy, Tarang Jadav, Amit K Sahu, Rakesh K Tekade & Pinaki Sengupta. (2021) Advancements in practical and scientific bioanalytical approaches to metabolism studies in drug development. Bioanalysis 13:11, pages 913-930.
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Clemens Muehlan, Hartmut Fischer, Dieter Zimmer, Hamed Aissaoui, Julien Grimont, Christoph Boss, Marie Croft, Joop van Gerven, Stephan Krähenbühl & Jasper Dingemanse. (2019) Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry. Current Drug Metabolism 20:4, pages 254-265.
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Daisuke Miyatake, Naoyuki Nakada, Akitsugu Takada, Kota Kato, Yuta Taniuchi, Masataka Katashima & Taiji Sawamoto. (2018) A phase I, open-label, single-dose micro tracer mass balance study of 14 C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry. Drug Metabolism and Pharmacokinetics 33:2, pages 118-124.
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