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Original Research

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

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Pages 2239-2253 | Published online: 11 Jul 2016

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Sahar E. M. El-Deek, Sary K. H. Abd-Elghaffar, Randa S. Hna, Heba G. Mohamed & Heba E. M. El-Deek. (2022) Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway. Nutrition and Cancer 74:2, pages 697-714.
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Articles from other publishers (46)

Natalia Kurowska, Marcel Madej & Barbara Strzalka-Mrozik. (2023) Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer. Current Issues in Molecular Biology 46:1, pages 121-139.
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Farhad Sheikhnia, Vahid Rashidi, Hossein Maghsoudi & Maryam Majidinia. (2023) Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer. Cancer Cell International 23:1.
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Fatemeh Madani, Sohrab Kazemi, Fatemeh Shirafkan, Mandana Lotfi, Seyed M. Hosseini & Ali A. Moghadamnia. (2023) Thymoquinone protects against 5‐Fluorouracil‐induced mucositis by NF‐κβ and HIF‐1 mechanisms in mice. Journal of Biochemical and Molecular Toxicology 37:9.
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Magdalena Grazul, Paweł Kwiatkowski, Kacper Hartman, Anna Kilanowicz & Monika Sienkiewicz. (2023) How to Naturally Support the Immune System in Inflammation—Essential Oils as Immune Boosters. Biomedicines 11:9, pages 2381.
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Kera Kwan, Albert Y. Han, Laith Mukdad, Frida Barragan, Omar Selim, Yazeed Alhiyari & Maie St. John. (2023) Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review. Laryngoscope Investigative Otolaryngology 8:4, pages 876-885.
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Wesam F. Farrash, Akhmed Aslam, Riyad Almaimani, Faisal Minshawi, Hussain Almasmoum, Aiman Alsaegh, Mohammad S. Iqbal, Aisha Tabassum, Mohamed E. Elzubier, Mahmoud Z. El‐Readi, Amani A. Mahbub, Shakir Idris & Bassem Refaat. (2023) Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K / mTOR / HIF1α pathway and increasing oxidative stress in colon cancer cells . BioFactors 49:4, pages 831-848.
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Eltayeb E. M. Eid, Amer A. Almaiman, Salah Abdalrazak Alshehade, Wardah Alsalemi, Sareh Kamran, FakhrEldin O. Suliman & Mohammed Abdullah Alshawsh. (2023) Characterization of Thymoquinone-Sulfobutylether-β-Cyclodextrin Inclusion Complex for Anticancer Applications. Molecules 28:10, pages 4096.
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Íris Neto, João Rocha, Maria Manuela Gaspar & Catarina P. Reis. (2023) Experimental Murine Models for Colorectal Cancer Research. Cancers 15:9, pages 2570.
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Yin-Xiao Du, Abdullah Al Mamun, Ai-Ping Lyu & Hong-Jie Zhang. (2023) Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer. International Journal of Molecular Sciences 24:8, pages 7310.
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Gajendran Nithya, Rajasekaran Santhanasabapathy, Manickam Kalappan Vanitha, Pandi Anandakumar & Dhanapalan Sakthisekaran. (2022) Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo( a )pyrene‐induced experimental lung cancer . Journal of Biochemical and Molecular Toxicology 37:1.
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Prince Ahad Mir, Roohi Mohi-ud-din, Nazia Banday, Mudasir Maqbool, Syed Naeim Raza, Saeema Farooq, Suhaib Afzal & Reyaz Hassan Mir. (2022) Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from Nigella sativa L. . Anti-Cancer Agents in Medicinal Chemistry 22:20, pages 3401-3415.
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Payam Ali khyavi, Amir Valizadeh, Dariush Shanehbandi, Bahman Yousefi & Jafar Soleimanpour. (2022) Thymoquinone Potentiates Methotrexate Mediated-Apoptosis in Saos-2 Osteosarcoma Cell Line. Drug Research 72:07, pages 390-395.
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Ammad Ahmad Farooqi, Rukset Attar & Baojun Xu. (2022) Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone. International Journal of Molecular Sciences 23:11, pages 6311.
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Shakir Idris, Bassem Refaat, Riyad A. Almaimani, Hussain G. Ahmed, Jawwad Ahmad, Mai Alhadrami, Mahmoud Zaki El-Readi, Mohamed E. Elzubier, Haneen A.A. Alaufi, Badriah Al-Amin, Ahmad A. Alghamdi, Fayez Bahwerth, Faisal Minshawi, Saeed M. Kabrah & Akhmed Aslam. (2022) Enhanced in vitro tumoricidal effects of 5-Fluorouracil, thymoquinone, and active vitamin D3 triple therapy against colon cancer cells by attenuating the PI3K/AKT/mTOR pathway. Life Sciences 296, pages 120442.
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Meiling Zheng, Zhiqiang Mei, Md. Junaid, Mousumi Tania, Junjiang Fu, Han-Chun Chen & Md. Asaduzzaman Khan. (2022) Synergistic Role of Thymoquinone on Anticancer Activity of 5-Fluorouracil in Triple Negative Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry 22:6, pages 1111-1118.
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Shah Jehan, Jiaxin Huang, Umar Farooq, Irum Basheer & Wenhu Zhou. (2022) Combinatorial effect of thymoquinone with chemo agents for tumor therapy. Phytomedicine 98, pages 153936.
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Seyed Parsa Eftekhar, Sohrab Kazemi & Ali Akbar Moghadamnia. (2022) Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell line in vitro . Human & Experimental Toxicology 41, pages 096032712211454.
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Tabish Mehraj, Rasha Mahmoud Elkanayati, Iqra Farooq & Tahir Maqbool Mir. 2022. Black Seeds (Nigella Sativa). Black Seeds (Nigella Sativa) 91 118 .
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Attabak Toofani milani, Mahshid Mohammadian & Roghayeh Paribananaem. (2021) Evaluation the Anti-proliferative Effect of NVP-AUY922 in Combination with Thymoquinone in Colorectal Cancer Cell Lines. Journal of Research in Applied and Basic Medical Sciences 7:3, pages 122-127.
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Caroline Yuin Hueii Phua, Zhi Ling Teoh, Bey-Hing Goh, Wei Hsum Yap & Yin-Quan Tang. (2021) Triangulating the pharmacological properties of thymoquinone in regulating reactive oxygen species, inflammation, and cancer: Therapeutic applications and mechanistic pathways. Life Sciences 287, pages 120120.
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Xiaoqun Lv & Guoxiong Xu. (2021) Regulatory role of the transforming growth factor-β signaling pathway in the drug resistance of gastrointestinal cancers. World Journal of Gastrointestinal Oncology 13:11, pages 1648-1667.
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Zaynab Fatfat, Maamoun Fatfat & Hala Gali-Muhtasib. (2021) Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells. World Journal of Clinical Oncology 12:7, pages 522-543.
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Nadia A. Thabet, Dalia El‐Khouly, Mohamed M. Sayed‐Ahmed & Mervat M. Omran. (2021) Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation. Clinical and Experimental Pharmacology and Physiology 48:6, pages 911-920.
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