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Drug Design, Development and Therapy Volume 10, 2016 - Issue

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Original Research

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Chang Heng Hsieh1 Department of Life Science

Li-Ching Lee1 Department of Life Science

Wai-Yin Leong1 Department of Life Science

Tsai-Chen Yang1 Department of Life Science

Ching-Fa Yao2 Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan

Kang Fang1 Department of Life ScienceCorrespondence[email protected]

Pages 2947-2957 | Published online: 14 Sep 2016

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Huiling Hong, Alex Chun Koon, Zhefan Stephen Chen, Yuming Wei, Ying An, Wen Li, Matthew Ho Yan Lau, Kwok-Fai Lau, Jacky Chi Ki Ngo, Chun-Ho Wong, Ho Yu Au-Yeung, Steven C. Zimmerman & Ho Yin Edwin Chan. (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. Journal of Biological Chemistry 294:8, pages 2757-5526.
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