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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

Shih-Hsiang Lo1 Division of Cardiology, Department of Internal Medicine, Zhongxing Branch of Taipei City Hospital;2 Department of History and Geography, University of Taipei, Taipei, Taiwan
,
Kai-Chung Cheng3 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
,
Ying-Xiao Li3 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan;4 Department of Medical Research
,
Chin-Hong Chang4 Department of Medical Research;5 Department of Neurosurgery, Chi-Mei Medical Center, Yong Kang
,
Juei-Tang Cheng4 Department of Medical Research;6 Institute of Medical Science, College of Health Science, Chang Jung Christian University, TainanCorrespondence[email protected]
&
Kung-Shing Lee7 Department of Surgery, Pingtung Hospital;8 Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanCorrespondence[email protected]
Pages 2669-2676 | Published online: 22 Aug 2016

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Yingxiao Li, Kai Chun Cheng, Chiang-Shan Niu, Shih-Hsiang Lo, Juei-Tang Cheng & Ho-Shan Niu. (2017) Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals. Drug Design, Development and Therapy 11, pages 1127-1134.
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Articles from other publishers (21)

Weijun Lun, Qihao Yan, Xinghua Guo, Minchuan Zhou, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo & Zhengquan Su. (2023) Mechanism of action of the bile acid receptor TGR5 in obesity. Acta Pharmaceutica Sinica B.
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Yingxiao Li, Kai-Chun Cheng, I-Min Liu & Juei-Tang Cheng. (2023) Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats. Pharmaceuticals 16:10, pages 1417.
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Huanqing Zhu, Kaixi Wang, Shuna Chen, Jiaxin Kang, Na Guo, Hongbo Chen, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu & Bo Li. (2022) Saponins from Camellia sinensis Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5. Nutrients 14:16, pages 3413.
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Pedro Martín-Acosta, Qianli Meng, John Klimek, Ashok P. Reddy, Larry David, Stefanie Kaech Petrie, Bingbing X. Li & Xiangshu Xiao. (2022) A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target. Acta Pharmaceutica Sinica B 12:5, pages 2406-2416.
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Fangling Zhang, Xiaolin Xiao, Yong Li, Hefei Wu, Xinyu Deng, Yinxiao Jiang, Wenwen Zhang, Jian Wang, Xiao Ma & Yanling Zhao. (2022) Therapeutic Opportunities of GPBAR1 in Cholestatic Diseases. Frontiers in Pharmacology 12.
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Biswanath Dinda & Manikarna Dinda. 2022. Natural Products in Obesity and Diabetes. Natural Products in Obesity and Diabetes 101 275 .
Chia-Chen Hsu, Kai-Chun Cheng, Yingxiao Li, Ping-Hao Hsu, Juei-Tang Cheng & Ho-Shan Niu. (2021) TGR5 Expression Is Associated with Changes in the Heart and Urinary Bladder of Rats with Metabolic Syndrome. Life 11:7, pages 695.
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Lin-shan Jiang, Wei Li, Tong-xi Zhuang, Jie-jing Yu, Shuai Sun, Zheng-cai Ju, Zheng-tao Wang, Li-li Ding & Li Yang. (2021) Ginsenoside Ro Ameliorates High-Fat Diet–Induced Obesity and Insulin Resistance in Mice via Activation of the G Protein–Coupled Bile Acid Receptor 5 Pathway. Journal of Pharmacology and Experimental Therapeutics 377:3, pages 441-451.
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Adriana Carino, Federica Moraca, Bianca Fiorillo, Silvia Marchianò, Valentina Sepe, Michele Biagioli, Claudia Finamore, Silvia Bozza, Daniela Francisci, Eleonora Distrutti, Bruno Catalanotti, Angela Zampella & Stefano Fiorucci. (2020) Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain. Frontiers in Chemistry 8.
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Fatema Tuz Zohra, Yuri Tominaga, Yomi Matsumoto, Naoko Taguchi, Ai Okubo, Susumu Mitsutake & Nobuhiro Kotoda. (2020) Relationship Between the Limonoid Content in Different Parts of the Sour Orange (<i>Citrus aurantium</i> L.) and the Ligand Activity of a Bile Acid Receptor, TGR5. The Horticulture Journal 89:4, pages 384-393.
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Omotuyi I. Olaposi, Nash Oyekanmi, Metibemu D. Samuel, Ojochenemi A. Enejoh, Ukwenya O. Victor & Adelakun Niyi. (2019) Takeda G-protein Receptor (TGR)-5 Evolves Classical Activestate Conformational Signatures in Complex with Chromolaena Odorata-derived Flavonoid-5,7-dihydroxy-6-4-dimethoxyflavanone. Current Chemical Biology 13:3, pages 212-222.
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Zhenxi Li, Jinping Huang, Fanhua Wang, Wenjun Li, Xian Wu, Chenglong Zhao, Jian Zhao, Haifeng Wei, Zhipeng Wu, Ming Qian, Peng Sun, Liang He, Yunyun Jin, Jie Tang, Wenwei Qiu, Stefan Siwko, Mingyao Liu, Jian Luo & Jianru Xiao. (2019) Dual Targeting of Bile Acid Receptor‐1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen‐Dependent Bone Loss in Mice. Journal of Bone and Mineral Research 34:4, pages 765-776.
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Kai-Chun Cheng, Wei-Ting Chang, Feng Yu Kuo, Zhih-Cherng Chen, Yingxiao Li & Juei-Tang Cheng. (2019) TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells. Scientific Reports 9:1.
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Simona De Marino, Carmen Festa, Valentina Sepe & Angela Zampella. 2019. Bile Acids and Their Receptors. Bile Acids and Their Receptors 137 165 .
Yu-Jui Yvonne Wan & Lili Sheng. (2018) Regulation of bile acid receptor activity. Liver Research 2:4, pages 180-185.
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Shu‑Chun KuoYingxiao LiYung‑Ze ChengWei‑Jing LeeJuei‑Tang ChengKai‑Chun Cheng. (2018) Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells. Molecular Medicine Reports.
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Wen Pan, Yanan Zhang, Chun Zeng, Fen Xu, Jinhua Yan & Jianping Weng. (2018) miR‑192 is upregulated in T1DM, regulates pancreatic β‑cell development and inhibits insulin secretion through suppressing GLP‑1 expression. Experimental and Therapeutic Medicine.
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Lin-Yu Wang, Kai Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng & Ho-Shan Niu. (2017) Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomedicine & Pharmacotherapy 95, pages 599-604.
Crossref
Shih-Hsiang Lo, Yingxiao Li, Kai Chun Cheng, Chiang-Shan Niu, Juei-Tang Cheng & Ho-Shan Niu. (2017) Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats. Naunyn-Schmiedeberg's Archives of Pharmacology 390:11, pages 1097-1104.
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Lin-Yu Wang, Kai-Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng & Ho-Shan Niu. (2017) The Dietary Furocoumarin Imperatorin Increases Plasma GLP-1 Levels in Type 1-Like Diabetic Rats. Nutrients 9:11, pages 1192.
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Mang Hung Lin, Chia-Chen Hsu, Jenshinn Lin, Juei-Tang Cheng & Ming Chang Wu. (2017) Identification of morin as an agonist of imidazoline I-3 receptor for insulin secretion in diabetic rats. Naunyn-Schmiedeberg's Archives of Pharmacology 390:10, pages 997-1003.
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