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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Bassem Sadek1 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesCorrespondence[email protected]
,
Ali Saad1 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
,
Johannes Stephan Schwed2 Biocenter, Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany;3 Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Düsseldorf, Germany
,
Lilia Weizel2 Biocenter, Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany
,
Miriam Walter2 Biocenter, Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany
&
Holger Stark2 Biocenter, Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany;3 Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Düsseldorf, GermanyCorrespondence[email protected]
Pages 3633-3651 | Published online: 07 Nov 2016

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Mingxia Song, Rui Yan, Yanhui Zhang, Dongfu Guo, Naiming Zhou & XianQing Deng. (2020) Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1310-1321.
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Salim M Bastaki, Yousef M Abdulrazzaq, Mohamed Shafiullah, Małgorzata Więcek, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2018) Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice. Drug Design, Development and Therapy 12, pages 179-194.
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Articles from other publishers (18)

Yi Hua, Mingxia Song, Qiaoyue Guo, Yiqin Luo, Xianqing Deng & Yushan Huang. (2023) Antiseizure Properties of Histamine H3 Receptor Antagonists Belonging 3,4-Dihydroquinolin-2(1H)-Ones. Molecules 28:8, pages 3408.
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Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou & Chiara Villa. (2022) Psychosis in Parkinson’s Disease: A Lesson from Genetics. Genes 13:6, pages 1099.
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Chung-Min Tsai, Shwu-Fen Chang & Hsi Chang. (2022) Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats. BMC Complementary Medicine and Therapies 22:1.
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Lin Yang, Yi Wang & Zhong Chen. (2021) Central histaminergic signalling, neural excitability and epilepsy. British Journal of Pharmacology 179:1, pages 3-22.
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Palanisamy Sivanandy, Tan Choo Leey, Tan Chi Xiang, Tan Chi Ling, Sean Ang Wey Han, Samantha Lia Anak Semilan & Phoon Kok Hong. (2021) Systematic Review on Parkinson’s Disease Medications, Emphasizing on Three Recently Approved Drugs to Control Parkinson’s Symptoms. International Journal of Environmental Research and Public Health 19:1, pages 364.
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Alaa Alachkar, Mohamed Lotfy, Ernest Adeghate, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2021) Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats. Behavioural Brain Research 405, pages 113193.
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Feng Xiao, Rui Yan, Yanhui Zhang, Shiben Wang, Shilong Chen, Naiming Zhou & Xianqing Deng. (2020) Synthesis and antiseizure effect evaluation of nonimidazole histamine H 3 receptor antagonists containing the oxazole moiety . Archiv der Pharmazie 354:4.
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Mahin Khatami. (2020) Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis. Clinical and Translational Medicine 10:8.
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Alaa Alachkar, Shreesh K. Ojha, Adel Sadeq, Abdu Adem, Annika Frank, Holger Stark & Bassem Sadek. (2020) Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. Current Pharmaceutical Design 26:15, pages 1693-1711.
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Alaa Alachkar, Sheikh Azimullah, Mohamed Lotfy, Ernest Adeghate, Shreesh K. Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2020) Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats. Molecules 25:7, pages 1575.
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Alaa Alachkar, Sheikh Azimullah, Shreesh K. Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2019) The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats. Molecules 24:22, pages 4106.
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Salim M. A. Bastaki, Naheed Amir, Małgorzata Więcek, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2019) Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice. Frontiers in Pharmacology 10.
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Alaa Alachkar, Dorota Łażewska, Gniewomir Latacz, Annika Frank, Agata Siwek, Annamaria Lubelska, Ewelina Honkisz-Orzechowska, Jadwiga Handzlik, Holger Stark, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2018) Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats. International Journal of Molecular Sciences 19:11, pages 3386.
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Alaa Alachkar, Gniewomir Latacz, Agata Siwek, Annamaria Lubelska, Ewelina Honkisz, Anna Gryboś, Dorota Łażewska, Jadwiga Handzlik, Holger Stark, Katarzyna Kiec-Kononowicz & Bassem Sadek. (2018) Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats. Pharmacology Biochemistry and Behavior 170, pages 14-24.
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Katarzyna Szczepańska, Tadeusz Karcz, Szczepan Mogilski, Agata Siwek, Kamil J. Kuder, Gniewomir Latacz, Monika Kubacka, Stefanie Hagenow, Annamaria Lubelska, Agnieszka Olejarz, Magdalena Kotańska, Bassem Sadek, Holger Stark & Katarzyna Kieć-Kononowicz. (2018) Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands. European Journal of Medicinal Chemistry 152, pages 223-234.
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Dorota Łażewska, Maria Kaleta, Stefanie Hagenow, Szczepan Mogilski, Gniewomir Latacz, Tadeusz Karcz, Annamaria Lubelska, Ewelina Honkisz, Jadwiga Handzlik, David Reiner, Grzegorz Satała, Barbara Filipek, Holger Stark & Katarzyna Kieć-Kononowicz. (2018) Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation. Bioorganic & Medicinal Chemistry 26:9, pages 2573-2585.
Crossref
Bassem Sadek, Murat Oz, Syed M. Nurulain, Petrilla Jayaprakash, Gniewomir Latacz, Katarzyna Kieć-Kononowicz & Ewa Szymańska. (2017) Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats. Epilepsy Research 138, pages 124-131.
Crossref
Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2017) The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats. Frontiers in Pharmacology 8.
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