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Drug Design, Development and Therapy Volume 10, 2016 - Issue

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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

Xiangrong Zhang1 Department of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education;2 Department of Pharmaceutics, School of Pharmacy

Yi Zhang1 Department of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education

Shuang Guo3 Department of Biomedical Science, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China

Feifei Bai1 Department of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education

Tong Wu1 Department of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education

Yuqing Zhao1 Department of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of EducationCorrespondence[email protected]

Pages 3707-3716 | Published online: 10 Nov 2016

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Chang-Can SHI, Kun-Ming QIN, Ke XU, An CHEN, Ting CAI & Bao-Chang CAI. (2020) Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability. Chinese Journal of Natural Medicines 18:12, pages 916-921.
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Dohyun Kim, Minwoo Park, Iqra Haleem, Younghong Lee, Jain Koo, Young Chae Na, Gidong Song & Jaehwi Lee. (2020) Natural Product Ginsenoside 20(S)-25-Methoxyl-Dammarane-3β, 12β, 20-Triol in Cancer Treatment: A Review of the Pharmacological Mechanisms and Pharmacokinetics. Frontiers in Pharmacology 11.
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Meng Ding, Yumeng Zhang, Xude Wang & Yuqing Zhao. (2018) Gender-related differences in pharmacokinetics, tissue distribution, and excretion of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol and its metabolite in rats and anti-ovarian cancer evaluation. Journal of Pharmaceutical and Biomedical Analysis 158, pages 327-338.
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Liang Ge, Xinyi He, Yajie Zhang, Yuan Zhang, Fujuan Chai, Liqun Jiang, Thomas J. Webster & Chunli Zheng. (2018) A dabigatran etexilate phospholipid complex nanoemulsion system for further oral bioavailability by reducing drug-leakage in the gastrointestinal tract. Nanomedicine: Nanotechnology, Biology and Medicine 14:4, pages 1455-1464.
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Meng Ding, Lei Xu, Yumeng Zhang & Yuqing Zhao. (2017) Polymorphic characterization and bioavailability of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol, a novel dammarane triterpenoid saponin, as anticancer agents. Journal of Pharmaceutical and Biomedical Analysis 145, pages 773-782.
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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

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