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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway

Ching-Han Lin1 Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan
,
Shang-Yu Lee2 Department of Internal Medicine, Division of Endocrinology and Metabolism, Chi-Mei Medical Center
,
Chun-Cheng Zhang3 Department of Internal Medicine, Division of Holistic Care, Chi-Mei Medical Center
,
Ye-Fong Du1 Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan
,
Hao-Chang Hung1 Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan
,
Hung-Tsung Wu4 Research Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, TaiwanCorrespondence[email protected]
&
Horng-Yih Ou1 Department of Internal Medicine, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, TainanCorrespondence[email protected]
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Pages 3591-3597 | Published online: 01 Nov 2016

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Yong Cao, Yan Lin, Yan Sun, Weiyu Liu, Yichuan Shao & Changqing Zheng. (2021) Fenretinide regulates macrophage polarization to protect against experimental colitis induced by dextran sulfate sodium. Bioengineered 12:1, pages 151-161.
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Articles from other publishers (21)

Sapir Ya'ar Bar, Noam Pintel, Hesen Abd Alghne, Hamdan Khattib & Dorit Avni. (2023) The therapeutic potential of sphingolipids for cardiovascular diseases. Frontiers in Cardiovascular Medicine 10.
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Azuah L. GonzalezMatthew M. DunganC. Duncan SmartMeena S. MadhurAmanda C. Doran. (2023) Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease. Antioxidants & Redox Signaling.
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Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay & Sib Sankar Roy. (2023) Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells. Biochemistry and Cell Biology 101:3, pages 220-234.
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Rodrigo Meade, Yang Chao, Nikolai Harroun, Chenglong Li, Shahab Hafezi, Fong-Fu Hsu, Clay F. Semenkovich & Mohamed A. Zayed. (2023) Ceramides in peripheral arterial plaque lead to endothelial cell dysfunction. JVS-Vascular Science 4, pages 100181.
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Samuel William, Todd Duncan & T. Michael Redmond. (2022) Pretreatment of human retinal pigment epithelial cells with sterculic acid forestalls fenretinide-induced apoptosis. Scientific Reports 12:1.
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Rosa Luisa Potenza, Pietro Lodeserto & Isabella Orienti. (2022) Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule. International Journal of Molecular Sciences 23:13, pages 7426.
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Ran Hee Choi, Sean M. Tatum, J. David Symons, Scott A. Summers & William L. Holland. (2021) Ceramides and other sphingolipids as drivers of cardiovascular disease. Nature Reviews Cardiology 18:10, pages 701-711.
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Xiao-Han Tang, Marta Melis, Karen Mai, Lorraine J. Gudas & Steven E. Trasino. (2021) Fenretinide Improves Intestinal Barrier Function and Mitigates Alcohol Liver Disease. Frontiers in Pharmacology 12.
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Myeongjoo Son, Seyeon Oh, Hye Sun Lee, Junwon Choi, Bae-Jin Lee, Joung-Hyun Park, Chul Hyun Park, Kuk Hui Son & Kyunghee Byun. (2021) Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice. The Korean Journal of Physiology & Pharmacology 25:1, pages 27-38.
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Dušan Garić, Daciana Catalina Dumut, Juhi Shah, Juan Bautista De Sanctis & Danuta Radzioch. (2020) The role of essential fatty acids in cystic fibrosis and normalizing effect of fenretinide. Cellular and Molecular Life Sciences 77:21, pages 4255-4267.
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Bo Wang, Maren Kasper, Björn Laffer, Gerd Meyer zu Hörste, Susanne Wasmuth, Martin Busch, Tida Viola Jalilvand, Solon Thanos, Arnd Heiligenhaus, Dirk Bauer & Carsten Heinz. (2020) Increased Hydrostatic Pressure Promotes Primary M1 Reaction and Secondary M2 Polarization in Macrophages. Frontiers in Immunology 11.
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Ting Li, Li-Na Zheng & Xiu-Hua Han. (2020) Fenretinide attenuates lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) and depressive-like behavior in mice by targeting Nrf-2 signaling. Biomedicine & Pharmacotherapy 125, pages 109680.
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Amit Kumar Srivastav, Sanjeev K. Gupta & Umesh Kumar. (2020) A molecular simulation approach towards the development of universal nanocarriers by studying the pH- and electrostatic-driven changes in the dynamic structure of albumin. RSC Advances 10:23, pages 13451-13459.
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Dušan Garić, Juan B. De Sanctis, Daciana Catalina Dumut, Juhi Shah, Maria Johanna Peña, Mina Youssef, Basil J. Petrof, Francisek Kopriva, John W. Hanrahan, Marian Hajduch & Danuta Radzioch. (2020) Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865:2, pages 158538.
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Sophie N. Saxton, Ben J. Clark, Sarah B. Withers, Etto C. Eringa & Anthony M. Heagerty. (2019) Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue. Physiological Reviews 99:4, pages 1701-1763.
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Alessandro Greco, Jon Sanchez Valle, Vera Pancaldi, Anaïs Baudot, Emmanuel Barillot, Michele Caselle, Alfonso Valencia, Andrei Zinovyev & Laura Cantini. (2019) Molecular Inverse Comorbidity between Alzheimer’s Disease and Lung Cancer: New Insights from Matrix Factorization. International Journal of Molecular Sciences 20:13, pages 3114.
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Heewon Song, Joonwoo Park, KeunOh Choi, Jeonggeun Lee, Jie Chen, Hyun-Ju Park, Byeung-Il Yu, Mitsuru Iida, Mee-Ra Rhyu & YoungJoo Lee. (2019) Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator–activated receptor gamma in A549 cells. Journal of Ginseng Research 43:2, pages 319-325.
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Wenyi Zhao, Chengye Che, Kuixiang LiuJie Zhang, Nan Jiang, Kelan Yuan & Guiqiu Zhao. (2018) Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis. Cornea 37:12, pages 1579-1585.
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Maneka Hoonjan, Geetanjali Sachdeva, Sudeshna Chandra, Prashant S. Kharkar, Niteshkumar Sahu & Purvi Bhatt. (2018) Investigation of HSA as a biocompatible coating material for arsenic trioxide nanoparticles. Nanoscale 10:17, pages 8031-8041.
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Sailesh C. Harwani. (2018) Macrophages under pressure: the role of macrophage polarization in hypertension. Translational Research 191, pages 45-63.
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Dušan Garić, Juan B. De Sanctis, Gabriella Wojewodka, Daniel Houle, Shanon Cupri, Asmahan Abu-Arish, John W. Hanrahan, Marian Hajduch, Elias Matouk & Danuta Radzioch. (2017) Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside. Journal of Molecular Medicine 95:10, pages 1053-1064.
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