Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Jing Wang1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Chunxia Qiao1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

He Xiao1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Zhou Lin1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Yan Li1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Jiyan Zhang1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Beifen Shen1 Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences

Tinghuan Fu2 First Affiliated Hospital of PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence[email protected] [email protected]

Jiannan Feng1 Department of Molecular Immunology, Beijing Institute of Basic Medical SciencesCorrespondence[email protected] [email protected]

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Harindu Rajapaksha, Bingun Tharusha Perera, Jeewani Meepage, Ruwan Tharanga Perera & Chithramala Dissanayake. (2020) Mitigate the cytokine storm due to the severe COVID-19: A computational investigation of possible allosteric inhibitory actions on IL-6R and IL-1R using selected phytochemicals. European Journal of Chemistry 11:4, pages 351-363.
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Jan Brábek, Milan Jakubek, Fréderic Vellieux, Jiří Novotný, Michal Kolář, Lukáš Lacina, Pavol Szabo, Karolína Strnadová, Daniel Rösel, Barbora Dvořánková & Karel SmetanaJr.Jr.. (2020) Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19. International Journal of Molecular Sciences 21:21, pages 7937.
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Deepyan Chatterjee, Gurkirat Kaur, Shilpa Muradia, Balvinder Singh & Javed N. Agrewala. (2019) ImmtorLig_DB: repertoire of virtually screened small molecules against immune receptors to bolster host immunity. Scientific Reports 9:1.
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Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

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Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

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