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Original Research

Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients

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Pages 1027-1033 | Published online: 30 Mar 2017

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Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Mohammad Hassan Javanbakht & Abbas Mirshafiey. (2019) Anti-diabetic effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on insulin production, blood glucose, and inflammatory markers in the experimental diabetes model. Archives of Physiology and Biochemistry 125:5, pages 435-440.
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Articles from other publishers (20)

V. Janakiraman, M. Sudhan, Shankargouda Patil, Khalid J. Alzahrani, Fuad M. Alzahrani, Ibrahim F. Halawani & Shiek S.S.J. Ahmed. (2023) Rheumatoid arthritis treatment with zoledronic acid, a potential inhibitor of GWAS-derived pharmacogenetics STAT3 and IL2 targets. Gene 866, pages 147338.
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Eduardo Delabio Auer, Denisson de Carvalho Santos, Ismael Júnior Valério de Lima & Angelica Beate Winter Boldt. (2022) Non-coding RNA network associated with obesity and rheumatoid arthritis. Immunobiology 227:6, pages 152281.
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Spandana Rajendra Kopalli, Venkata Prakash Annamneedi & Sushruta Koppula. (2022) Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis. Molecules 27:14, pages 4660.
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Reda Ben Mrid, Najat Bouchmaa, Hassan Ainani, Rachid El Fatimy, Gabriel Malka & Loubna Mazini. (2022) Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis. Biomedicine & Pharmacotherapy 151, pages 113126.
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Anis Barati, Raheleh Masoudi, Reza Yousefi, Malihezaman Monsefi & Abbas Mirshafiey. (2022) Tau and amyloid beta differentially affect the innate immune genes expression in Drosophila models of Alzheimer’s disease and β- D Mannuronic acid (M2000) modulates the dysregulation. Gene 808, pages 145972.
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Eunji Ha, So-Young Bang, Jiwoo Lim, Jun Ho Yun, Jeong-Min Kim, Jae-Bum Bae, Hye-Soon Lee, Bong-Jo Kim, Kwangwoo Kim & Sang-Cheol Bae. (2021) Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4 + T cells through differential DNA methylation, explaining a substantial proportion of heritability . Annals of the Rheumatic Diseases 80:7, pages 876-883.
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Nada A.G. Gaafar, Alireza Razavi & Abbas Mirshafiey. (2021) β-D-Mannuronic Acid (M2000) as a Landmark in Pharmacology. Current Drug Discovery Technologies 18:1, pages 47-57.
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Mona Aslani, Arman Ahmadzadeh, Zahra Aghazadeh, Majid Zaki-Dizaji, Laleh Sharifi, Mostafa Hosseini & Abbas Mirshafiey. (2021) Influence of β-D-mannuronic Acid, as a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis. Current Drug Discovery Technologies 18:1, pages 65-74.
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Afshin Ghaderi, Sayyed Reza Safaee Nodehi, Tahereh Bakhtiari, Mona Aslani, Zahra Aghazadeh, Hidenori Matsuo, Bernd H. A. Rehm, Salvatore Cuzzocrea & Abbas Mirshafiey. (2020) Mannuronic Acid in Low‐Risk and Intermediate‐1‐Risk Myelodysplastic Syndromes. The Journal of Clinical Pharmacology 60:7, pages 879-888.
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Atousa Khalatbari, Mehdi Mahdavi, Fahimeh Jafarnezhad, Sanaz Afraei, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Afshin Ghaderi & Abbas Mirshafiey. (2020) Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC. Current Drug Discovery Technologies 17:2, pages 225-232.
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Seyed Shahabeddin Mortazavi‐Jahromi, Mona Aslani, Saiedeh Omidian, Arman Ahmadzadeh, Zahra Rezaieyazdi & Abbas Mirshafiey. (2019) Immunopharmacological effect of β‐ d ‐mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR‐155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients . Drug Development Research 81:3, pages 295-304.
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Ali N. Kamali, Haleh Hamedifar, Nima Sepehri, Saeed Tahmasebi, Hosein Miladi, Shakiba Moniri, Mahdi Goudarzvand, Gholamreza Azizi & Abbas Mirshafiey. (2020) The Effect of β- d -Mannuronic Acid in Animal Model of Epilepsy . Natural Product Communications 15:4, pages 1934578X2092003.
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Xiaojun Dong, Yuan Gan, Lina Ding, Fujia Zeng & Dou Ding. (2019) Effect of Jiawei Fengshining on Synovial Cell Apoptosis and TGF- β 1/Smad Signaling Pathway in Rats with Rheumatoid Arthritis . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-12.
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Mahsa Taeb, Abdollah Jafarzadeh, Seyed Shahabeddin Mortazavi-Jahromi, Nahid Zainodini, Mohammad Reza Mirzaei, Fahimeh Jafarnezhad-Ansariha, Zahra Aghazadeh & Abbas Mirshafiey. (2019) Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes’ Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. Current Drug Discovery Technologies 16:3, pages 265-271.
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Zahra Rezaieyazdi, Abid Farooqi, Hossein Soleymani-Salehabadi, Arman Ahmadzadeh, Mona Aslani, Saiedeh Omidian, Arezoo Sadoughi, Zohreh Vahidi, Mandana Khodashahi, Shazia Zamurrad, Seyed Shahabeddin Mortazavi-Jahromi, Hossein Fallahzadeh, Mostafa Hosseini, Zahra Aghazadeh, Parvin Ekhtiari, Hidenori Matsuo, Bernd H. A. Rehm, Salvatore Cuzzocrea, Antimo D’Aniello & Abbas Mirshafiey. (2019) International multicenter randomized, placebo-controlled phase III clinical trial of β-d-mannuronic acid in rheumatoid arthritis patients. Inflammopharmacology 27:5, pages 911-921.
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Laleh Sharifi, Asghar Aghamohammadi, Somaye Aletaha, Razieh Bigdeli, Vahid Asgary, Saied Bokaie, Mohammad Hossein Asgardoon, Gholamreza Azizi & Abbas Mirshafiey. (2019) Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:2, pages 144-149.
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Yaochao Zheng, Yang Sun, Yanling Yang, Subo Zhang, Ting Xu, Wenjun Xin, Shaoling Wu & Xiangzhong Zhang. (2019) GATA3-dependent epigenetic upregulation of CCL21 is involved in the development of neuropathic pain induced by bortezomib. Molecular Pain 15, pages 174480691986329.
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Mohammad Javad Fattahi, Hossein Ahmadi, Fahimeh Jafarnezhad-Ansariha, Seyed Shahabeddin Mortazavi-Jahromi, Bernd H.A. Rehm, Salvatore Cuzzocrea, Hidenori Matsuo & Abbas Mirshafiey. (2018) Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis. Biomedicine & Pharmacotherapy 100, pages 495-500.
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Hossein Ahmadi, Mahdi Mahmoudi, Farhad Gharibdoost, Mahdi Vojdanian, Ahmad reza Jamshidi, Mohammad javad Fattahi, Zahra Aghazadeh, Anis Barati & Abbas Mirshafiey. (2017) Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis. Inflammopharmacology 26:1, pages 57-65.
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Rosalia Crupi & Salvatore Cuzzocrea. 2018. Alginates and Their Biomedical Applications. Alginates and Their Biomedical Applications 257 268 .