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Original Research

Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats

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Pages 901-908 | Published online: 20 Mar 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Engy F. El-Maraghi, Kamal I. Abdel-Fattah, Saeed M. Soliman & Wael M. El-Sayed. (2020) Taurine abates the liver damage induced by γ-irradiation in rats through anti-inflammatory and anti-apoptotic pathways. International Journal of Radiation Biology 96:12, pages 1550-1559.
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Alfredo G. Casanova, M. Teresa Hernández-Sánchez, Carlos Martínez-Salgado, Ana I. Morales, Laura Vicente-Vicente & Francisco J. López-Hernández. (2020) A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: implications for clinical application. Critical Reviews in Toxicology 50:9, pages 780-800.
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Wessam M Abdel-Wahab & Farouzia I Moussa. (2019) Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation. Drug Design, Development and Therapy 13, pages 1155-1162.
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Articles from other publishers (18)

Gamze ERKILINÇ, Mehmet BEDİR, Leyla Elif Özgü AYÖZGER, Hatice Kübra DOĞAN & Nasıf Fatih KARAKUYU. (2023) Nephroprotective effect of Astaxanthin against radiotherapy via TAS, TOS (biochemical), TNF-α, CASPASE-3 (immunohistochemical), SIRT-1, P53 (molecular) pathway in ratsAstaksantin'in sıçanlarda TAS, TOS (biyokimyasal), TNF-α, CASPASE-3 (immünohistokimyasal), SIRT-1-P53 (moleküler) yolu aracılığıyla radyoterapiye karşı nefroprotektif etkisi. Genel Tıp Dergisi.
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Ivan K. Domingo, Asna Latif & Amit P. Bhavsar. (2022) Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity. International Journal of Molecular Sciences 23:13, pages 7227.
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Zhen Liu, Ye Xu, Xinming Bai, Lvqian Guo, Xinran Li, Junling Gao, Yuou Teng & Peng Yu. (2022) Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation. Journal of Ethnopharmacology 292, pages 115241.
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Saber JedidiFoued AlouiSlimen SelmiHoucine SelmiHoucem SammariAla AyariChaabane AbbesHichem Sebai. (2022) Antioxidant Properties of Salvia officinalis Decoction Extract and Mechanism of Its Protective Effects on Ethanol-Induced Liver and Kidney Injuries . Journal of Medicinal Food 25:5, pages 546-556.
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Marie-Christin Barth, Stefanie Lange, Norman Häfner, Nico Ueberschaar, Helmar Görls, Ingo B. Runnebaum & Wolfgang Weigand. (2022) Synthesis and characterization of thiocarbonato-linked platinum( iv ) complexes . Dalton Transactions 51:14, pages 5567-5576.
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Peter F. Surai, Katie Earle-Payne & Michael T. Kidd. (2021) Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models. Antioxidants 10:12, pages 1876.
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Neveen Madbouly, Ayman Azmy, Abeer Salama & Azza El-Amir. (2021) The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation. The Journal of Antibiotics 74:9, pages 580-592.
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Alfredo G. Casanova, Mykola Harvat, Laura Vicente-Vicente, Óscar J. Pellicer-Valero, Ana I. Morales, Francisco J. López-Hernández & José D. Martín-Guerrero. (2021) Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity. Antioxidants 10:9, pages 1355.
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Asmaa Elsayed, Ashraf Elkomy, Reda Elkammar, Gehan Youssef, Ehab Yahya Abdelhiee, Walied Abdo, Sabreen Ezzat Fadl, Ahmed Soliman & Mohamed Aboubakr. (2021) Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats. Scientific Reports 11:1.
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Xiuli Li, Huiwu Zhang & Fuyun Sun. (2020) CdSe/ZnS quantum dots exhibited nephrotoxicity through mediating oxidative damage and inflammatory response. Aging 13:8, pages 12194-12206.
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Anongporn Kobroob, Wachirasek Peerapanyasut, Sirinart Kumfu, Nipon Chattipakorn & Orawan Wongmekiat. (2021) Effectiveness of N-Acetylcysteine in the Treatment of Renal Deterioration Caused by Long-Term Exposure to Bisphenol A. Biomolecules 11:5, pages 655.
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Fatima Alghamdi, Madeha N. Al-Seeni & Magdy A. Ghoneim. (2020) Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats. Clinical Nutrition Experimental 32, pages 29-37.
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Shirinsadat Badri, Rasool Soltani, Mina Sayadi, Farzin Khorvash, Mohsen Meidani & Shahram Taheri. (2020) Effect of N-acetylcysteine against Vancomycin-Induced Nephrotoxicity: A Randomized Controlled Clinical Trial. Archives of Iranian Medicine 23:6, pages 397-402.
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ZhiYu Duan, GuangYan Cai, JiJun Li & XiangMei Chen. (2020) Cisplatin-induced renal toxicity in elderly people. Therapeutic Advances in Medical Oncology 12, pages 175883592092343.
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Marina Delgobo, Jonathan Paulo Agnes, Rosângela Mayer Gonçalves, Vitória Wibbelt dos Santos, Eduardo Benedetti Parisotto, Ariane Zamoner & Alfeu Zanotto-Filho. (2019) N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. The Journal of Nutritional Biochemistry 67, pages 190-200.
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Marília B. Visacri, Júlia C. F. Quintanilha, Vanessa M. Sousa, Laís S. Amaral, Rosiane Ambrósio, Luciane Calonga, Silvia F. B. B. Curi, Mayra F. Leme, Carlos T. Chone, João M. C. Altemani, Priscila G. Mazzola, Carina Malaguti, Aníbal E. Vercesi, Carmen S. P. Lima & Patricia Moriel. (2019) Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer. Cancer Medicine 8:5, pages 2020-2030.
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Mohamed M. Abdel-Daim, Amina A. Dessouki, Haidy G. Abdel-Rahman, Rasha Eltaysh & Saad Alkahtani. (2019) Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats. Science of The Total Environment 650, pages 2063-2073.
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Muthuchamy Maruthupandy, Muruganantham Rethinasabapathy, Soyeon Jeon, Jiyoung Jeong, Eunsu Kim, Sinuk Lee, Songyeon Kim, Gyuri Kim, Yeonjeong Ha, Eunsol Bae, Yun Suk Huh & Wan-Seob Cho. (2022) Role of Reactive Oxygen Species in the Toxicity of Two-Dimensional Nanomaterials: A Study on Layered Ti3c2 Mxenes. SSRN Electronic Journal.
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