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Original Research

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

Naglaa El-Nabarawi1 Faculty of Medicine, National Egyptian Center of Environmental and Toxicological ResearchCorrespondence[email protected]

Mohamed El-Wakd2 Rheumatology and Rehabilitation Department

Mostafa Salem3 Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Pages 1383-1391 | Published online: 02 May 2017

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Ambika Choudhary, Ujjawal Rawat, Piyush Kumar & Piyush Mittal. (2023) Pleotropic effects of statins: the dilemma of wider utilization of statin. The Egyptian Heart Journal 75:1.
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Sami Ali & Rana Makhous. (2022) Evaluation of the effect of Simvastatin Therapy on Bone remodeling in Rats. Research Journal of Pharmacy and Technology, pages 525-528.
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Tao Sun, Hai-Lin Xing, Zhen-Zhong Chen, Zhou-Shan Tao & Jian Li. (2021) Simvastatin reverses the harmful effects of high fat diet on titanium rod osseointegration in ovariectomized rats. Journal of Bone and Mineral Metabolism 39:6, pages 944-951.
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G. M. Hamed, N. A. Nassef, R. S. A. E. Mansour, M. K. E. Shawky, A. A. Abo Zeid & A. A. Hassan. (2021) The Effect of Early Application of a Combined Therapy of Bone Marrow Mesenchymal Stem Cells and Platelet-Rich Plasma on Blood and Bone Parameters in Ovariectomized Rats. Journal of Evolutionary Biochemistry and Physiology 57:4, pages 972-990.
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Sanghee Lee, Gwang Ju Jang, Miyoung Yoo, Haeng Jeon Hur & Mi Jeong Sung. (2021) Saururus chinensis Prevents Estrogen Deficiency-Induced Osteoporosis in Rats: A Metabolomic Study Using UPLC/Q-TOF MS. Applied Sciences 11:4, pages 1392.
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Maria V. Deligiorgi, Mihalis I. Panayiotidis, Gerasimos Siasos & Dimitrios T. Trafalis. (2021) Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and the Example of Statins. Current Medicinal Chemistry 28:7, pages 1443-1467.
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Zübeyir Huyut, Nuri Bakan & Serkan Yıldırım. (2021) Do avanafil and zaprinast exert positive effects on bone tissue via the nitric oxide/cyclic guanosine monophosphate/protein kinase-G signaling pathway in rats with ovariectomy-induced osteoporosis?. Brazilian Journal of Pharmaceutical Sciences 57.
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Wei Hong, Zhanying Wei, Zhaohui Qiu, Zheng Li, Chensheng Fu, Zhibin Ye & Xiaoya Xu. (2020) Atorvastatin promotes bone formation in aged apoE–/– mice through the Sirt1–Runx2 axis. Journal of Orthopaedic Surgery and Research 15:1.
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Jianmei Tian, Yongjie Tai, Mengrao Shi, Chunxiu Zhao, Wenwen Xu, Xuhua Ge & Guoji Zhu. (2019) Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus. Cellular and Molecular Neurobiology 40:4, pages 521-530.
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Xin Li, Yu-Mei Xue, Hui-Ming Guo, Chun-Yu Deng, De-Wei Peng, Hui Yang, Wei Wei, Yang Liu, Fang-Zhou Liu, Zhao-Yu Wang, Meng-Zhen Zhang, Fang Rao & Shu-Lin Wu. (2020) High hydrostatic pressure induces atrial electrical remodeling through upregulation of inflammatory cytokines. Life Sciences 242, pages 117209.
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Yu‐ning Chen, Peng Wei & Jian Yu, BS. (2019) Higher concentration of serum C‐terminal cross‐linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H‐type hypertension and osteoporosis. Orthopaedic Surgery 11:6, pages 1135-1141.
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Niloufar Mohammadkhani, Sedigheh Gharbi, Huda Fatima Rajani, Avishan Farzaneh, Golnoosh Mahjoob, Afsaneh Hoseinsalari & Eberhard Korsching. (2019) Statins: Complex outcomes but increasingly helpful treatment options for patients. European Journal of Pharmacology 863, pages 172704.
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W.-J. Hong, W. Chen, K.-J. Yeo, P.-H. Huang, D.-Y. Chen & J.-L. Lan. (2019) Increased risk of osteoporotic vertebral fracture in rheumatoid arthritis patients with new-onset cardiovascular diseases: a retrospective nationwide cohort study in Taiwan. Osteoporosis International 30:8, pages 1617-1625.
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Mostafa Shahrezaee, Ahmad Oryan, Farshid Bastami, Sepanta Hosseinpour, Mohammad Hossein Shahrezaee & Amir Kamali. (2018) Comparative impact of systemic delivery of atorvastatin, simvastatin, and lovastatin on bone mineral density of the ovariectomized rats. Endocrine 60:1, pages 138-150.
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Sisi He & Erik R. Nelson. (2017) 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. Maturitas 104, pages 29-35.
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Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

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Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

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