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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

Kai Wang1 School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China
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Jinqiu Rao1 School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China
,
Tingting Zhang1 School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China
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Qing Gao2 School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China
,
Jichao Zhang3 State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China
,
Chenxi Guang3 State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China
,
Liqin Ding3 State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China
&
Feng Qiu1 School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China;3 State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of ChinaCorrespondence[email protected]
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Pages 4423-4438 | Published online: 22 Oct 2020

Citations (6)

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Read on this site (1)

Caiqin Yan, Ting Peng, Tingting Zhang, Yuan Wang, Na Li, Kai Wang & Xijuan Jiang. (2023) Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus. Drug Metabolism Reviews 55:1-2, pages 75-93.
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Articles from other publishers (5)

Jinqiu Rao, Qing Gao, Na Li, Yuan Wang, Tianwang Wang, Kai Wang & Feng Qiu. (2024) Unraveling the enigma: Molecular mechanisms of berberrubine-induced nephrotoxicity reversed by its parent form berberine. Phytomedicine 129, pages 155648.
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Ze-Dong Xiang, Hui-Da Guan, Xiang Zhao, Qi Xie, Fu-Jie Cai, Zhe-Jun Xie, Rui Dang, Man-Lin Li & Chang-Hong Wang. (2024) Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity. Phytomedicine 126, pages 155444.
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Huiling Chen, Chenchen Liu, Meng Li, Yida Zhang, Zhendong Wang, Qiyao Jiang, Jianxin Wang, Qi Wang & Yue Zhuo. (2023) Ferulic acid prevents Diosbulbin B-induced liver injury by inhibiting covalent modifications on proteins. Drug Metabolism and Pharmacokinetics 50, pages 100507.
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Hui Sun, Meihua Chen, Xu He, Yue Sun, Jiaxin Feng, Xin Guo, Li Li, Junyi Zhu, Guangqing Xia & Hao Zang. (2023) Phytochemical analysis and in vitro and in vivo antioxidant properties of Plagiorhegma dubia Maxim as a medicinal crop for diabetes treatment. Arabian Journal of Chemistry 16:6, pages 104788.
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Na Zhang, Yi Yang, Wei Li, Shenzhi Zhou, Weiwei Li, Ying Peng & Jiang Zheng. (2022) Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo . Chemical Research in Toxicology 35:10, pages 1821-1830.
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