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Drug Design, Development and Therapy Volume 6, 2012 - Issue
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Review

Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors

Hong-Tao Xiao1 Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaCorrespondence[email protected]
,
Zhi Liao2 Department of Gynecology and Obstetrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China
&
Rong-Sheng Tong1 Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China
Pages 317-322 | Published online: 01 Nov 2012

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Zhaohui Liu, Yanli Meng, Qianjie Wei, Yu Miao, Lili Yu, Yuqing Li & Bing Zhang. (2022) The Protective Activity of Penehyclidine Hydrochloride against Renal Ischemia/Reperfusion-Mediated NLRP3 Inflammasome Activation is Induced by SIRT1. Journal of Investigative Surgery 35:5, pages 1050-1061.
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Yaguang Wang, Yafen Gao & Jun Ma. (2018) Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride. Drug Design, Development and Therapy 12, pages 3289-3299.
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Articles from other publishers (20)

Ting Yan, Xin-Quan Liang, Guo-Jun Wang, Tong Wang, Wei-Ou Li, Yang Liu, Liang-Yu Wu, Kun-Yao Yu, Sai-Nan Zhu, Dong-Xin Wang & Daniel I. Sessler. (2022) Prophylactic Penehyclidine Inhalation for Prevention of Postoperative Pulmonary Complications in High-risk Patients: A Double-blind Randomized Trial. Anesthesiology 136:4, pages 551-566.
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Jiacheng Sun, Xiaofei Cao, Ting Lu, Nan Li, Xinxu Min & Zhengnian Ding. (2021) Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison. BMC Anesthesiology 21:1.
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Min Yuan, Guoqing Jing, Qian Kong, Tingqian Ming, Xuemin Song & Xiaojing Wu. (2021) Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model. Molecular Medicine Reports 24:5.
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Shi-yuan Yu, Yan-xia Gao, Joseph Walline, Xin Lu, Li-na Zhao, Yuan-xu Huang, Jiang Tao, An-yong Yu, Na Ta, Ren-ju Xiao & Yi Li. (2020) Role of penehyclidine in acute organophosphorus pesticide poisoning. World Journal of Emergency Medicine 11:1, pages 37.
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Yao Yuntai, Ying Hua, Fang Nengxin, Zhang Yongbao & Yuan Xin. (2020) Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis. Chinese Medical Sciences Journal 35:2, pages 121.
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Shaobing Ye, Xue Yang, Qiansong Wang, Qiang Chen & Yongda Ma. (2020) Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress. Journal of Surgical Research 245, pages 344-353.
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Junting Weng, Min Chen, Qunying Lin, Jianfei Chen, ShanZuan Wang & Dexiang Fang. (2019) Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway. Gene 721, pages 144095.
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Hongtao Xiao, Tingting Shi, Lizhu Han, Rongsheng Tong & Zhi Liao. (2019) Mechanism of penehyclidine hydrochloride on a dysmenorrhea rat model. Drug Development Research 80:3, pages 325-332.
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Yaguang Wang, Duomao Lin, Hongbao Tan, Yafen Gao & Jun Ma. (2018) Penehyclidine hydrochloride preconditioning provides pulmonary and systemic protection in a rat model of lung ischaemia reperfusion injury. European Journal of Pharmacology 839, pages 1-11.
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Min Feng, Lirui Wang, Siyuan Chang & Pu Yuan. (2018) Penehyclidine hydrochloride regulates mitochondrial dynamics and apoptosis through p38MAPK and JNK signal pathways and provides cardioprotection in rats with myocardial ischemia–reperfusion injury. European Journal of Pharmaceutical Sciences 121, pages 243-250.
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Rongtao Zhu, Yipu Zhao, Xiaobo Li, Tao Bai, Shuai Wang, Weijie Wang & Yuling Sun. (2018) Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats. Biomedicine & Pharmacotherapy 97, pages 1689-1693.
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Ting Yan, Xin-Quan Liang, Tong Wang, Wei-Ou Li, Hui-Juan Li, Sai-Nan Zhu & Dong-Xin Wang. (2017) Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial. Trials 18:1.
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Hongbao Tan, Duomao Lin, Zhaoqi Wang, Yanli Yang & Jun Ma. (2017) Cardioprotective time-window of Penehyclidine hydrochloride postconditioning: A rat study. European Journal of Pharmacology 812, pages 48-56.
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Duomao Lin, Jun Ma, Yanyan Xue & Zhaoqi Wang. (2015) Penehyclidine Hydrochloride Preconditioning Provides Cardioprotection in a Rat Model of Myocardial Ischemia/Reperfusion Injury. PLOS ONE 10:12, pages e0138051.
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Libo Zhao, Yannan Zang, Yuwen Sun, Zhongna Wei, Shan Jing, Qian Wang, Youzhong An, Yi Fang & Wanyu Feng. (2015) Development and validation of an improved HPLC-MS/MS method for comparative pharmacokinetics of penehyclidine hydrochloride following a single intravenous or intramuscular injection. Journal of Chromatography B 1004, pages 37-45.
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XIAO-BO LIU, SHU PAN, XI-GE YANG, ZHI-WEN LI, QING-SHAN SUN, ZHUANG ZHAO, HAI-CHUN MA & CHENG-RI CUI. (2015) Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Experimental and Therapeutic Medicine 10:1, pages 181-186.
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Gang-Ming Wu, Min Mou, Li-Qun Mo, Li Liu, Chang-He Ren, Ye Chen & Jun Zhou. (2015) Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model. Journal of Surgical Research 195:1, pages 219-227.
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Changshun Huang, Jianguo He, Yijun Chen, Yiwei Zhang & Chunru Chen. (2014) Penehyclidine hydrochloride inhibits the LPS-induced inflammatory response in microglia. Journal of Surgical Research 188:1, pages 260-267.
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Yun-peng Wang, Gang Li, Lu-lin Ma, Yi Zheng, Shu-dong Zhang, Hong-xian Zhang, Min Qiu & Xin Ma. (2014) Penehyclidine hydrochloride ameliorates renal ischemia–reperfusion injury in rats. Journal of Surgical Research 186:1, pages 390-397.
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Teng-Fei Ma, Li Zhou, Yun Wang, Shou-Jun Qin, Yuan Zhang, Bin Hu, Jing-Zhi Yan, Xing Ma, Cheng-Hua Zhou & Shu-Ling Gu. (2013) A selective M 1 and M 3 receptor antagonist, penehyclidine hydrochloride, prevents postischemic LTP: Involvement of NMDA receptors . Synapse 67:12, pages 865-874.
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