Drug Design, Development and Therapy, Volume 6, Issue (2012)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Drug Design, Development and Therapy, Volume 6, Issue (2012)

See all volumes and issues
Vol 18, 2024 Vol 17, 2023 Vol 16, 2022 Vol 15, 2021 Vol 14, 2020 Vol 13, 2019 Vol 12, 2018 Vol 11, 2017 Vol 10, 2016 Vol 9, 2015 Vol 8, 2014 Vol 7, 2013 Volume 6, 2012 Vol 5, 2011 Vol 4, 2010 Vol 3, 2009 Vol 2, 2008 Vol 1, 2007
Download citations Download PDFs

Review

Review Article
Treatment for primary hypothyroidism: current approaches and future possibilities
Ali J Chakera, Simon HS Pearce & Bijay Vaidya
Pages: 1-11
Published online: 22 Dec 2011
AbstractforTreatment for primary hypothyroidism: current approaches and future possibilities | Full Text | References | PDF (198 KB)
  • 0 Views
  • 25 CrossRef citations
  • 0Altmetric
Review Article
Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer
Yasser Rehman & Jonathan E Rosenberg
Pages: 13-18
Published online: 16 Jan 2012
AbstractforAbiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer | Full Text | References | PDF (164.4 KB)
  • 0 Views
  • 72 CrossRef citations
  • 0Altmetric
Review Article
Inhaled treprostinil: a therapeutic review
Richard N Channick, Robert Voswinckel & Lewis J Rubin
Pages: 19-28
Published online: 24 Jan 2012
AbstractforInhaled treprostinil: a therapeutic review | Full Text | References | PDF (678.6 KB)
  • 0 Views
  • 33 CrossRef citations
  • 0Altmetric

Original Research

Article
Solubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations
Mohanad Naji Sahib, Shaymaa Abdalwahed Abdulameer, Yusrida Darwis, Kok Khiang Peh & Yvonne Tze Fung Tan
Pages: 29-42
Published online: 17 Feb 2012
AbstractforSolubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations | Full Text | References | PDF (3.1 MB)
  • 0 Views
  • 20 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetics of iron isomaltoside 1000 in patients with inflammatory bowel disease
Kim Nordfjeld, Hans Andreasen & Lars L Thomsen
Pages: 43-51
Published online: 05 Mar 2012
AbstractforPharmacokinetics of iron isomaltoside 1000 in patients with inflammatory bowel disease | Full Text | References | PDF (302.6 KB)
  • 0 Views
  • 5 CrossRef citations
  • 0Altmetric

Methodology

Article
Why (not) go east? Comparison of findings from FDA Investigational New Drug study site inspections performed in Central and Eastern Europe with results from the USA, Western Europe, and other parts of the world
Paul H Caldron, Svetlana I Gavrilova & Siegfried Kropf
Pages: 53-60
Published online: 29 Sep 2022
AbstractforWhy (not) go east? Comparison of findings from FDA Investigational New Drug study site inspections performed in Central and Eastern Europe with results from the USA, Western Europe, and other parts of the world | Full Text | References | PDF (186.7 KB)
  • 0 Views
  • 6 CrossRef citations
  • 0Altmetric

Original Research

Article
Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted
Olivier Lambert, Dirk Bandilla, Rupa Iyer, Leonore Witchey-Lakshmanan & Nagesh Palepu
Pages: 61-70
Published online: 28 Mar 2012
AbstractforStability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted | Full Text | References | PDF (175.6 KB)
  • 0 Views
  • 17 CrossRef citations
  • 0Altmetric
Article
A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers
Georg Golor, Ke Hu, Matthieu Ruffin, Alexandra Buchelt, Emmanuel Bouillaud, Yanfeng Wang & Mario Maldonado
Pages: 71-79
Published online: 19 Apr 2012
AbstractforA first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers | Full Text | References | PDF (403.7 KB)
  • 0 Views
  • 34 CrossRef citations
  • 0Altmetric

Review

Review Article
Imiglucerase in the treatment of Gaucher disease: a history and perspective
Patrick B Deegan & Timothy M Cox
Pages: 81-106
Published online: 18 Apr 2012
AbstractforImiglucerase in the treatment of Gaucher disease: a history and perspective | Full Text | References | PDF (311 KB)
  • 0 Views
  • 12 CrossRef citations
  • 0Altmetric
Review Article
Update on the development of lurasidone as a treatment for patients with acute schizophrenia
Norio Yasui-Furukori
Pages: 107-115
Published online: 08 May 2012
AbstractforUpdate on the development of lurasidone as a treatment for patients with acute schizophrenia | Full Text | References | PDF (245.7 KB)
  • 0 Views
  • 11 CrossRef citations
  • 0Altmetric
Review Article
Requirements for acquiring a high-quality house dust mite extract for allergen immunotherapy
Franco Frati, Cristoforo Incorvaia, Marie David, Silvia Scurati, Simona Seta, Guglielmo Padua, Eleonora Cattaneo, Carlo Cavaliere, Alessia Di Rienzo, Ilaria Dell’Albani & Paola Puccinelli
Pages: 117-123
Published online: 18 May 2012
AbstractforRequirements for acquiring a high-quality house dust mite extract for allergen immunotherapy | Full Text | References | PDF (219.6 KB)
  • 0 Views
  • 1 CrossRef citations
  • 0Altmetric
Review Article
Novel drug-delivery systems for patients with chronic rhinosinusitis
Silviu Albu
Pages: 125-132
Published online: 31 May 2012
AbstractforNovel drug-delivery systems for patients with chronic rhinosinusitis | Full Text | References | PDF (158.2 KB)
  • 0 Views
  • 27 CrossRef citations
  • 0Altmetric

Case Series

Case Report
Treating refractory dermatomyositis or polymyositis with adrenocorticotropic hormone gel: a retrospective case series
Todd Levine
Pages: 133-139
Published online: 11 Jun 2012
AbstractforTreating refractory dermatomyositis or polymyositis with adrenocorticotropic hormone gel: a retrospective case series | Full Text | References | PDF (150.9 KB)
  • 0 Views
  • 43 CrossRef citations
  • 0Altmetric

Review

Review Article
Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl
Peter A McCullough & Sajid Ali
Pages: 141-149
Published online: 14 Jun 2012
AbstractforCardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl | Full Text | References | PDF (836.1 KB)
  • 0 Views
  • 7 CrossRef citations
  • 0Altmetric
Review Article
Maintenance of nutritional status in patients with cystic fibrosis: new and emerging therapies
Daina Kalnins & Michael Wilschanski
Pages: 151-161
Published online: 20 Jun 2012
AbstractforMaintenance of nutritional status in patients with cystic fibrosis: new and emerging therapies | Full Text | References | PDF (278.7 KB)
  • 0 Views
  • 4 CrossRef citations
  • 0Altmetric

Correction

Correction
Erratum
Page: 163
Published online: 21 Jun 2012
CitationforErratum | Full Text | PDF (63.7 KB)
  • 67 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Emerging options for the management of scorpion stings
Jean-Philippe Chippaux
Pages: 165-173
Published online: 05 Jul 2012
AbstractforEmerging options for the management of scorpion stings | Full Text | References | PDF (977.2 KB)
  • 0 Views
  • 106 CrossRef citations
  • 0Altmetric
Review Article
Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach
Claudio Gasperini & Serena Ruggieri
Pages: 175-186
Published online: 19 Jul 2012
AbstractforDevelopment of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach | Full Text | References | PDF (254.7 KB)
  • 0 Views
  • 34 CrossRef citations
  • 0Altmetric

Original Research

Article
The preventive role of transurethral antibiotic delivery in a rat model
Hakki U Ozok, Okan Ekim, Hakan Saltas, Ata T Arikok, Orkun Babacan, Levent Sagnak, Hikmet Topaloglu & Hamit Ersoy
Pages: 187-194
Published online: 17 Jul 2012
AbstractforThe preventive role of transurethral antibiotic delivery in a rat model | Full Text | References | PDF (1.2 MB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric

Review

Review Article
Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies
Lindsay S Keir, Stephen D Marks & Jon Jin Kim
Pages: 195-208
Published online: 19 Jul 2012
AbstractforShigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies | Full Text | References | PDF (1.4 MB)
  • 0 Views
  • 9 CrossRef citations
  • 0Altmetric

Original Research

Article
Natural material adsorbed onto a polymer to enhance immune function
Ana Paula Barcelos Reinaque, Eduardo Luzía França, Edson Fredulin Scherer, Mayra Aparecida Côrtes, Francisco José Dutra Souto & Adenilda Cristina Honorio-França
Pages: 209-216
Published online: 27 Aug 2012
AbstractforNatural material adsorbed onto a polymer to enhance immune function | Full Text | References | PDF (560.2 KB)
  • 0 Views
  • 5 CrossRef citations
  • 0Altmetric

Review

Review Article
Exploring prospects of novel drugs for tuberculosis
Saskia Janssen, Rajesh Jayachandran, Lulama Khathi, Jakob Zinsstag, Martin P Grobusch & Jean Pieters
Pages: 217-224
Published online: 07 Sep 2012
AbstractforExploring prospects of novel drugs for tuberculosis | Full Text | References | PDF (980.5 KB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric

Original Research

Article
Adding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension
Takeshi Takami, Hiroshi Ito, Katsuhisa Ishii, Kenei Shimada, Katsuomi Iwakura, Hiroyuki Watanabe, Shota Fukuda & Junichi Yoshikawa
Pages: 225-233
Published online: 12 Sep 2012
AbstractforAdding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension | Full Text | References | PDF (268.7 KB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Stability and preservation of a new formulation of epoprostenol sodium for treatment of pulmonary arterial hypertension
Olivier Lambert & Dirk Bandilla
Pages: 235-244
Published online: 17 Sep 2012
AbstractforStability and preservation of a new formulation of epoprostenol sodium for treatment of pulmonary arterial hypertension | Full Text | References | PDF (316.1 KB)
  • 0 Views
  • 11 CrossRef citations
  • 0Altmetric

Review

Review Article
Kinase inhibitors: a new class of antirheumatic drugs
Vasileios C Kyttaris
Pages: 245-250
Published online: 21 Sep 2012
AbstractforKinase inhibitors: a new class of antirheumatic drugs | Full Text | References | PDF (160.7 KB)
  • 0 Views
  • 53 CrossRef citations
  • 0Altmetric
Review Article
Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib
Alyse S Goldberg & Robert A Hegele
Pages: 251-259
Published online: 24 Sep 2012
AbstractforCholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib | Full Text | References | PDF (381.1 KB)
  • 0 Views
  • 1 CrossRef citations
  • 0Altmetric
Review Article
Current and novel drug therapies for idiopathic pulmonary fibrosis
Huzaifa I Adamali & Toby M Maher
Pages: 261-272
Published online: 26 Sep 2012
AbstractforCurrent and novel drug therapies for idiopathic pulmonary fibrosis | Full Text | References | PDF (388.3 KB)
  • 0 Views
  • 17 CrossRef citations
  • 0Altmetric

Original Research

Article
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis
Yoshiaki Tsuboko, Shinhiro Takeda, Seiji Mii, Keiko Nakazato, Keiji Tanaka, Eiji Uchida & Atsuhiro Sakamoto
Pages: 273-278
Published online: 10 Oct 2012
AbstractforClinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis | Full Text | References | PDF (201.4 KB)
  • 0 Views
  • 13 CrossRef citations
  • 0Altmetric
Article
Efficacy of two novel 2,2′-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin
Wael M El-Sayed, Warda A Hussin & Mohamed A Ismail
Pages: 279-287
Published online: 12 Oct 2012
AbstractforEfficacy of two novel 2,2′-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin | Full Text | References | PDF (326.5 KB)
  • 0 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients
Andreas O Doesch, Janika Repp, Nina Hofmann, Christian Erbel, Lutz Frankenstein, Christian A Gleissner, Constanze Schmidt, Arjang Ruhparwar, Christian Zugck, Paul Schnitzler, Philipp Ehlermann, Thomas J Dengler & Hugo A Katus
Pages: 289-295
Published online: 12 Oct 2012
AbstractforEffects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients | Full Text | References | PDF (253.9 KB)
  • 0 Views
  • 14 CrossRef citations
  • 0Altmetric
Article
Therapy effects of gold nanorods on the CNE-1 nasopharyngeal carcinoma cell line
Jinyan Shao, Jianguo Tang, Jian Ji & Wenbo Zhou
Pages: 297-301
Published online: 25 Oct 2012
AbstractforTherapy effects of gold nanorods on the CNE-1 nasopharyngeal carcinoma cell line | Full Text | References | PDF (1.6 MB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy
Aritz Pérez Ruiz de Garibay, Diego Delgado, Ana del Pozo-Rodríguez, María Ángeles Solinís & Alicia Rodríguez Gascón
Pages: 303-310
Published online: 26 Oct 2012
AbstractforMulticomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy | Full Text | References | PDF (1.1 MB)
  • 0 Views
  • 23 CrossRef citations
  • 0Altmetric
Article
Bioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects
Raymond R Tjandrawinata, Effi Setiawati, Danang Agung Yunaidi, Iwan Dwi Santoso, Arini Setiawati & Liana W Susanto
Pages: 311-316
Published online: 30 Oct 2012
AbstractforBioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects | Full Text | References | PDF (426.8 KB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric

Review

Review Article
Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors
Hong-Tao Xiao, Zhi Liao & Rong-Sheng Tong
Pages: 317-322
Published online: 01 Nov 2012
AbstractforPenehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors | Full Text | References | PDF (595.2 KB)
  • 0 Views
  • 22 CrossRef citations
  • 0Altmetric

Original Research

Article
Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies
Michael F Wempe, Janet W Lightner, Bettina Miller, Timothy J Iwen, Peter J Rice, Shin Wakui, Naohiko Anzai, Promsuk Jutabha & Hitoshi Endou
Pages: 323-339
Published online: 08 Nov 2012
AbstractforPotent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies | Full Text | References | PDF (537.4 KB)
  • 0 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats
Xinxin Yang, Yinghui Chen, Xiaoyun Hong, Na Wu, Lu Song, Weien Yuan & Zhenguo Liu
Pages: 341-347
Published online: 20 Nov 2012
AbstractforLevodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats | Full Text | References | PDF (334.6 KB)
  • 0 Views
  • 9 CrossRef citations
  • 0Altmetric

Review

Review Article
Potential role of rivaroxaban in patients with acute coronary syndrome
David H Fitchett
Pages: 349-357
Published online: 22 Nov 2012
AbstractforPotential role of rivaroxaban in patients with acute coronary syndrome | Full Text | References | PDF (394.1 KB)
  • 0 Views
  • 3 CrossRef citations
  • 0Altmetric

Original Research

Article
Pretreatment data is highly predictive of liver chemistry signals in clinical trials
Zhaohui Cai, Anders Bresell, Mark H Steinberg, Debra G Silberg & Stephen T Furlong
Pages: 359-369
Published online: 27 Nov 2012
AbstractforPretreatment data is highly predictive of liver chemistry signals in clinical trials | Full Text | References | PDF (1.8 MB)
  • 0 Views
  • 2 CrossRef citations
  • 0Altmetric

Review

Review Article
Update on taxane development: new analogs and new formulations
Jean A Yared & Katherine HR Tkaczuk
Pages: 371-384
Published online: 11 Dec 2012
AbstractforUpdate on taxane development: new analogs and new formulations | Full Text | References | PDF (2 MB)
  • 0 Views
  • 53 CrossRef citations
  • 0Altmetric

Case Report

Case Report
Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease?
Wolfgang Hohenforst-Schmidt, Andreas Riedel, Paul Zarogoulidis, Christian Franke, Andreas Gschwendtner, Haidong Huang, Nikolaos Machairiotis, Vasiliki Dramba, Konstantinos Zarogoulidis & Johnannes Brachmann
Pages: 385-389
Published online: 10 Dec 2012
AbstractforChronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease? | Full Text | References | PDF (2.2 MB)
  • 0 Views
  • 0 CrossRef citations
  • 0Altmetric

Review

Review Article
Dabrafenib and its potential for the treatment of metastatic melanoma
Alexander M Menzies, Georgina V Long & Rajmohan Murali
Pages: 391-405
Published online: 11 Dec 2012
AbstractforDabrafenib and its potential for the treatment of metastatic melanoma | Full Text | References | PDF (917.6 KB)
  • 0 Views
  • 31 CrossRef citations
  • 0Altmetric

Original Research

Article
Effect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study
William B Smith, Erik Mannaert, Tom Verhaeghe, René Kerstens, Lieve Vandeplassche & Vera Van de Velde
Pages: 407-415
Published online: 18 Dec 2012
AbstractforEffect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study | Full Text | References | PDF (383.4 KB)
  • 0 Views
  • 5 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment
Jian Gao et al.
Review | Published online: 15 Jul 2024
Open Access
Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice
Cuiting Wang et al.
Article | Published online: 15 Jul 2024
Open Access
Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses
Fengfeng Li et al.
Article | Published online: 14 Jul 2024
Open Access
Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats
Teetat Kongratanapasert et al.
Article | Published online: 11 Jul 2024
Open Access