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Drug Design, Development and Therapy Volume 7, 2013 - Issue
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Original Research

Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells

Zhi-Jun Dai1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of ChinaCorrespondence[email protected] [email protected]
,
Jie Gao2 Department of Nephrology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’s Republic of China
,
Hua-Feng Kang1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Yu-Guang Ma1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Xiao-Bin Ma1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Wang-Feng Lu1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Shuai Lin1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Hong-Bing Ma1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of China
,
Xi-Jing Wang1 Department of Oncology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’sRepublic of ChinaCorrespondence[email protected] [email protected]
&
Wen-Ying Wu3 Department of Pharmacology, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, People’s Republic of China
 show all
Pages 149-159 | Published online: 19 Mar 2013

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Jingbo Li, Xin Chen, Rui Kang, Herbert Zeh, Daniel J. Klionsky & Daolin Tang. (2021) Regulation and function of autophagy in pancreatic cancer. Autophagy 17:11, pages 3275-3296.
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Articles from other publishers (18)

David Andi Wijaya, Melva Louisa, Heri Wibowo, Aslim Taslim, Tiara Bunga Mayang Permata, Handoko Handoko, Endang Nuryadi, Henry Kodrat & Soehartati Argadikoesoema Gondhowiardjo. (2021) The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review . Journal of Herbmed Pharmacology 10:2, pages 166-178.
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Xiaoping Zhang & Maoquan Li. 2021. Integrative Pancreatic Intervention Therapy. Integrative Pancreatic Intervention Therapy 487 503 .
Elena Vila-Navarro, Elena Fernandez-Castañer, Maria Rovira-Rigau, Giulia Raimondi, Maria Vila-Casadesus, Juan Jose Lozano, Philippe Soubeyran, Juan Iovanna, Antoni Castells, Cristina Fillat & Meritxell Gironella. (2020) MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamics. Oncogenesis 9:5.
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Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr & Kirsten Lauber. (2019) Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches. Radiation Oncology 14:1.
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Elke Decrock, Delphine Hoorelbeke, Raghda Ramadan, Tinneke Delvaeye, Marijke De Bock, Nan Wang, Dmitri V Krysko, Sarah Baatout, Geert Bultynck, An Aerts, Mathieu Vinken & Luc Leybaert. (2017) Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:6, pages 1099-1120.
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Zhibing Wu, Saisai Jing, Yanhong Li, Yabo Gao, Shuhuan Yu, Zhitian Li, Yanyan Zhao, Jigang Piao, Shenglin Ma & Xufeng Chen. (2017) The effects of SAHA on radiosensitivity in pancreatic cancer cells by inducing apoptosis and targeting RAD51. Biomedicine & Pharmacotherapy 89, pages 705-710.
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Lelin Hu, Hao Wang, Li Huang, Yong Zhao & Junjie Wang. (2016) Crosstalk between autophagy and intracellular radiation response (Review). International Journal of Oncology 49:6, pages 2217-2226.
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Eun Joo Chung, Anastasia Sowers, Angela Thetford, Grace McKay-Corkum, Su I. Chung, James B. Mitchell & Deborah E. Citrin. (2016) Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model. International Journal of Radiation Oncology*Biology*Physics 96:4, pages 857-866.
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Yong Li, Fen Liu, Yong Wang, Donghai Li, Fei Guo, Liyao Xu, Zhengguo Zeng, Xiaojun Zhong & Kejian Qian. (2016) Rapamycin‐induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition . Thoracic Cancer 7:4, pages 379-386.
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Hang ZhengMiao WangJing WuZhi-Ming WangHai-Jun NanHe Sun. (2016) Inhibition of mTOR enhances radiosensitivity of lung cancer cells and protects normal lung cells against radiation. Biochemistry and Cell Biology 94:3, pages 213-220.
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Sentia Iriana, Shahzad Ahmed, Jun Gong, Alagappan Anand Annamalai, Richard Tuli & Andrew Eugene Hendifar. (2016) Targeting mTOR in Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 6.
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RAMADEVI SUBRAMANI, LAXMAN GANGWANI, SUSHMITA BOSE NANDY, ARUNKUMAR ARUMUGAM, MUNMUN CHATTOPADHYAY & RAJKUMAR LAKSHMANASWAMY. (2015) Emerging roles of microRNAs in pancreatic cancer diagnosis, therapy and prognosis (Review). International Journal of Oncology 47:4, pages 1203-1210.
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GUANGYU ZHANG, ZHENRAN WANG, FENG QIAN, CHEN ZHAO & CHAOWEN SUN. (2015) Silencing of the ABCC4 gene by RNA interference reverses multidrug resistance in human gastric cancer. Oncology Reports 33:3, pages 1147-1154.
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Fang Tian, Lijie Dong, Yu Zhou, Yan Shao, Wenbo Li, Hong Zhang & Fei Wang. (2014) Rapamycin-Induced Apoptosis in HGF-Stimulated Lens Epithelial Cells by AKT/mTOR, ERK and JAK2/STAT3 Pathways. International Journal of Molecular Sciences 15:8, pages 13833-13848.
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Qiang Xie, Yangliang Zhou, Guoqiang Lan, Liye Yang, Wenjie Zheng, Yuanwei Liang & Tianfeng Chen. (2014) Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways. Biochemical and Biophysical Research Communications 449:1, pages 88-93.
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Dan Li, Xiaohan Li, Wei Cao, Yafei Qi & Xianghong Yang. (2014) Antagonism of microRNA-99a promotes cell invasion and down-regulates E-cadherin expression in pancreatic cancer cells by regulating mammalian target of rapamycin. Acta Histochemica 116:5, pages 723-729.
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Cristina E. Gallegos, Severino Michelin, Sofía Baffa Trasci, Elizabeth Aballay Lobos, Diana Dubner & Edgardo D. Carosella. (2014) HLA-G1 increases the radiosensitivity of human tumoral cells. Cellular Immunology 287:2, pages 106-111.
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