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Original Research

Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio

Pages 1273-1285 | Published online: 24 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Peipei Xu, Ruju Wang, Xiaohui Wang & Jian Ouyang. (2016) Recent advancements in erythrocytes, platelets, and albumin as delivery systems. OncoTargets and Therapy 9, pages 2873-2884.
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Jui-Yang Lai, Pei-Ran Wang, Li-Jyuan Luo & Si-Tan Chen. (2014) Stabilization of collagen nanofibers with l-lysine improves the ability of carbodiimide cross-linked amniotic membranes to preserve limbal epithelial progenitor cells. International Journal of Nanomedicine 9, pages 5117-5130.
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Antonio Maria Fea, Cristina Novarese, Paolo Caselgrandi & Giacomo Boscia. (2022) Glaucoma Treatment and Hydrogel: Current Insights and State of the Art. Gels 8:8, pages 510.
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Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Carla M. Caramella & Franca Ferrari. (2020) Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes. Pharmaceutics 12:9, pages 859.
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Beauty Das, Dipankar Chattopadhyay & Dipak Rana. (2020) The gamut of perspectives, challenges, and recent trends for in situ hydrogels: a smart ophthalmic drug delivery vehicle . Biomaterials Science 8:17, pages 4665-4691.
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Li-Jyuan Luo & Jui-Yang Lai. (2019) Amination degree of gelatin is critical for establishing structure-property-function relationships of biodegradable thermogels as intracameral drug delivery systems. Materials Science and Engineering: C 98, pages 897-909.
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Li-Jyuan Luo & Jui-Yang Lai. (2017) Epigallocatechin Gallate-Loaded Gelatin-g-Poly(N-Isopropylacrylamide) as a New Ophthalmic Pharmaceutical Formulation for Topical Use in the Treatment of Dry Eye Syndrome. Scientific Reports 7:1.
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Jui-Yang Lai & Li-Jyuan Luo. (2017) Chitosan- g -poly( N -isopropylacrylamide) copolymers as delivery carriers for intracameral pilocarpine administration. European Journal of Pharmaceutics and Biopharmaceutics 113, pages 140-148.
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Pierre-Louis Destruel, Ni Zeng, Marc Maury, Nathalie Mignet & Vincent Boudy. (2017) In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond. Drug Discovery Today 22:4, pages 638-651.
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Shih-Feng Chou, Li-Jyuan Luo & Jui-Yang Lai. (2017) In vivo Pharmacological Evaluations of Pilocarpine-Loaded Antioxidant-Functionalized Biodegradable Thermogels in Glaucomatous Rabbits. Scientific Reports 7:1.
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Li-Jyuan Luo & Jui-Yang Lai. (2017) The role of alkyl chain length of monothiol-terminated alkyl carboxylic acid in the synthesis, characterization, and application of gelatin-g-poly(N-isopropylacrylamide) carriers for antiglaucoma drug delivery. Acta Biomaterialia 49, pages 344-357.
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Yu-Te Liao, Chih-Hung Lee, Si-Tan Chen, Jui-Yang Lai & Kevin C.-W. Wu. (2017) Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma. Journal of Materials Chemistry B 5:34, pages 7008-7013.
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A. Samanta, K. Merrett, M. Gerasimov & M. Griffith. 2017. Bioresorbable Polymers for Biomedical Applications. Bioresorbable Polymers for Biomedical Applications 497 523 .
Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai & David Hui-Kang Ma. (2016) On the importance of Bloom number of gelatin to the development of biodegradable in situ gelling copolymers for intracameral drug delivery. International Journal of Pharmaceutics 511:1, pages 30-43.
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Shih-Feng Chou, Li-Jyuan Luo & Jui-Yang Lai. (2016) Gallic acid grafting effect on delivery performance and antiglaucoma efficacy of antioxidant-functionalized intracameral pilocarpine carriers. Acta Biomaterialia 38, pages 116-128.
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Nívia N. Marques, Bruna V. Lima, Valdelice R. Silveira, Bruna L. B. Lima, Ana M. S. Maia & Rosangela C. Balaban. (2016) PNIPAM-based graft copolymers prepared using potassium persulfate as free-radical initiator: synthesis reproducibility. Colloid and Polymer Science 294:6, pages 981-991.
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Jui-Yang Lai. (2016) Hyaluronic acid concentration-mediated changes in structure and function of porous carriers for corneal endothelial cell sheet delivery. Materials Science and Engineering: C 59, pages 411-419.
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Nathaniel J. Kim, Alon Harris, Alhasan Elghouche, Willy Gama & Brent Siesky. 2016. Nano-Biomaterials For Ophthalmic Drug Delivery. Nano-Biomaterials For Ophthalmic Drug Delivery 177 209 .
Jui-Yang Lai & Li-Jyuan Luo. (2015) Antioxidant Gallic Acid-Functionalized Biodegradable in Situ Gelling Copolymers for Cytoprotective Antiglaucoma Drug Delivery Systems. Biomacromolecules 16:9, pages 2950-2963.
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Jui-Yang Lai, Hsiao-Yun Cheng & David Hui-Kang Ma. (2015) Investigation of Overrun-Processed Porous Hyaluronic Acid Carriers in Corneal Endothelial Tissue Engineering. PLOS ONE 10:8, pages e0136067.
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Jui-Yang Lai. (2015) Carbodiimide cross-linking of amniotic membranes in the presence of amino acid bridges. Materials Science and Engineering: C 51, pages 28-36.
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Gabriella M. Fernandes-Cunha, Dayana Rubio Gouvea, Gustavo de Oliveira Fulgêncio, Cíntia M.F. Rezende, Gisele Rodrigues da Silva, Juliana M. Bretas, Sílvia Ligório Fialho, Norberto Peporine Lopes & Armando Silva-Cunha. (2015) Development of a method to quantify clindamycin in vitreous humor of rabbits’ eyes by UPLC–MS/MS: Application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation. Journal of Pharmaceutical and Biomedical Analysis 102, pages 346-352.
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Jui-Yang Lai. (2014) Photo-cross-linking of amniotic membranes for limbal epithelial cell cultivation. Materials Science and Engineering: C 45, pages 313-319.
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Jui-Yang Lai. (2014) Interrelationship between cross-linking structure, molecular stability, and cytocompatibility of amniotic membranes cross-linked with glutaraldehyde of varying concentrations. RSC Adv. 4:36, pages 18871-18880.
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