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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Effects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats

Mahesh Kumar Seth1 Peptide Synthesis Laboratory, CSIR, Institute of Genomics and Integrative Biology, Delhi, India;2 Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India;3 Department of Physiology, Jamia Hamdard Deemed University, New Delhi, India
,
M Ejaz Hussain2 Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India
,
Santosh Pasha1 Peptide Synthesis Laboratory, CSIR, Institute of Genomics and Integrative Biology, Delhi, IndiaCorrespondence[email protected]
&
Mohammad Fahim3 Department of Physiology, Jamia Hamdard Deemed University, New Delhi, India
Pages 1533-1542 | Published online: 20 Apr 2016

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Esther Oluwasola Aluko, Victor Udo Nna & Adesoji Adedipe Fasanmade. (2022) Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats. Archives of Physiology and Biochemistry 128:6, pages 1524-1532.
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Ganiyu Oboh, Odunayo O. Oluokun, Sunday I. Oyeleye & Opeyemi B. Ogunsuyi. (2022) Moringa seed-supplemented diets modulate ACE activity but not its gene expression in L-NAME-induced hypertensive rats. Biomarkers 27:7, pages 684-693.
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Yan Wang, Fei Zhang, Yu Liu, Sha Yin, Xuefen Pang, Zhidong Li & Zehui Wei. (2017) Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats. Clinical and Experimental Hypertension 39:7, pages 628-639.
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Articles from other publishers (10)

Pattaneeya Prangthip, Watanalai Panbangred & Onrapak Reamtong. (2023) Potential antihypertensive activity of novel peptides from green basil leaves. BMC Complementary Medicine and Therapies 23:1.
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Gaurav Sharma & Abhishek Sharma. (2023) Recent Insights on Drug Delivery System in Hypertension: From Bench to Market. Current Hypertension Reviews 19:2, pages 93-105.
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Emuesiri Goodies Moke, Eric K.I. Omogbai, Sammy D.E. Osagie-Eweka, Adaeze P. Uchendu, Adrian I. Omogbiya, Benneth Ben-Azu, Anthony T. Eduviere, Kesiena E. Edje, Emuesiri K. Umukoro, Kenneth K. Anachuna, Jerome N. Asiwe, Ejiroghene Ahante & Ighohwo J. Oghoghovwe. (2023) Co-administration of metformin and/or glibenclamide with losartan reverse N-nitro-l-arginine-methyl ester-streptozotocin-induced hypertensive diabetes and haemodynamic sequelae in rats. Microvascular Research 147, pages 104497.
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Mirelly Cunha da Silva, Vanessa Maria dos Santos, Matheus Vinícius B. da Silva, Tereza Cristina M. M. Prazeres, Maria do Socorro S. Cartágenes, Natália Tabosa M. Calzerra & Thyago Moreira de Queiroz. (2022) Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension. Frontiers in Molecular Biosciences 9.
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Mahesh Kumar Seth, Rakesh Kumar Singh, M. Ejaz Hussain, Santosh Pasha & Mohammad Fahim. (2022) Toxicity Study of 3-Thienylalanine- Ornithine-Proline (TOP) Using as Novel ACE Inhibitor. International Journal of Peptide Research and Therapeutics 28:5.
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Mohamed A. Salem, Shahira M. Ezzat, Kawkab A. Ahmed, Saleh Alseekh, Alisdair R. Fernie & Reham M. Essam. (2022) A Comparative Study of the Antihypertensive and Cardioprotective Potentials of Hot and Cold Aqueous Extracts of Hibiscus sabdariffa L. in Relation to Their Metabolic Profiles. Frontiers in Pharmacology 13.
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Putcharawipa Maneesai, Metee Iampanichakul, Nisita Chaihongsa, Anuson Poasakate, Prapassorn Potue, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Petcharat Chiangsaen & Poungrat Pakdeechote. (2021) Butterfly Pea Flower (Clitoria ternatea Linn.) Extract Ameliorates Cardiovascular Dysfunction and Oxidative Stress in Nitric Oxide-Deficient Hypertensive Rats. Antioxidants 10:4, pages 523.
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Bo Li, Xinglishang He, Shan-Shan Lei, Fu-Chen Zhou, Ning-Yu Zhang, Ye-Hui Chen, Yu-Zhi Wang, Jie Su, Jing-Jing Yu, Lin-Zi Li, Xiang Zheng, Rong Luo, Dorota Kołodyńska, Shan Xiong, Gui-Yuan Lv & Su-Hong Chen. (2020) Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology. Frontiers in Pharmacology 10.
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Prapassorn Potue, Chutamas Wunpathe, Putcharawipa Maneesai, Upa Kukongviriyapan, Parichat Prachaney & Poungrat Pakdeechote. (2019) Nobiletin alleviates vascular alterations through modulation of Nrf-2/HO-1 and MMP pathways in l -NAME induced hypertensive rats . Food & Function 10:4, pages 1880-1892.
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Esther Oluwasola Aluko, Temidayo Olutayo Omobowale, Ademola Adetokunbo Oyagbemi, Olumuyiwa Abiola Adejumobi, Temitayo Olabisi Ajibade & Adesoji Adedipe Fasanmade. (2018) Reduction in nitric oxide bioavailability shifts serum lipid content towards atherogenic lipoprotein in rats. Biomedicine & Pharmacotherapy 101, pages 792-797.
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