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Original Research

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

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Pages 2311-2321 | Published online: 18 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Xinghao Zhu, Shiqing Jiang, Zongyao Wu, Tonghua Liu, Wei Zhang, Lili Wu, Lijun Xu & Mingliang Shao. (2021) Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis. Bioengineered 12:1, pages 578-588.
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Li-rui Sun, Si-yu Li, Qiu-shi Guo, Wei Zhou & Hong-mei Zhang. (2020) SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?. Cancer Management and Research 12, pages 3561-3569.
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Articles from other publishers (37)

Yafeng Liu, Tao Han, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Zhi Xu, Yingru Xing, Ying Bai & Dong Hu. (2023) SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion. Journal of Translational Medicine 21:1.
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Jiaxuan Zhang, Xiaoqi Jiang, Yang Yang, Lei Yang, Bing Lu, Yannan Ji, Leijun Guo, Fan Zhang, Jianhua Xue & Xiaofei Zhi. (2023) Peptidome analysis reveals critical roles for peptides in a rat model of intestinal ischemia/reperfusion injury. Aging 15:22, pages 12852-12872.
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Zhentang Yu, Xijia Jiang, Jianjian Yin, Lei Han, Chengwei Xiong, Zhennan Huo, Jie Xu, Jingjing Shang, Kun Xi, Luming Nong, Yong Huang & Xindie Zhou. (2023) CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway. Aging 15:19, pages 10193-10212.
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Dahee Jeong, Seokbeom Ham, Minseong Lee, Hye Jeong Lee, Na Young Choi, Seung-Won Lee & Kinarm Ko. (2022) Multigenerational effect of maternal bisphenol A exposure on DNA methylation in F1 sperm. Molecular & Cellular Toxicology 19:4, pages 743-751.
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Tao ZhangLijian ChenXundi XuChao Shen. (2023) Knockdown of Long Noncoding RNA Urothelial Carcinoma-Associated 1 Represses Gallbladder Cancer Advancement by Regulating SPOCK1 Expression Through Sponging miR-613. Cancer Biotherapy and Radiopharmaceuticals 38:6, pages 354-363.
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Lin Xu, Daiting Liu & Xun Wang. (2023) LINC00562 drives gastric cancer development by regulating miR-4636–AP1S3 axis. The Korean Journal of Physiology & Pharmacology 27:3, pages 197-208.
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Lóránd Váncza, Anna Horváth, Lee Seungyeon, András Rókusz, Katalin Dezső, Andrea Reszegi, Gábor Petővári, Martin Götte, Ilona Kovalszky & Kornélia Baghy. (2023) SPOCK1 Overexpression Suggests Poor Prognosis of Ovarian Cancer. Cancers 15:7, pages 2037.
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Ying Liu, Linyuan Feng, Yang Yang, Zhenhua Lin & Wenquan Jiang. (2023) SPOCK1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Head and Neck Squamous Cell Carcinoma. Journal of Biomaterials and Tissue Engineering 13:2, pages 309-318.
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Yung-Wei Lin, Yu-Ching Wen, Chi-Hao Hsiao, Feng-Ru Lai, Shun-Fa Yang, Yi-Chieh Yang, Kuo-Hao Ho, Feng-Koo Hsieh, Michael Hsiao, Wei-Jiunn Lee & Ming-Hsien Chien. (2023) Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition. Cells 12:3, pages 352.
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Giovani Bravin Peres, Adriana Taveira da Cruz Peres, Najla dos Santos Pacheco de Campos & Eloah Rabello Suarez. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 56 .
Dechao Feng, Weizhen Zhu, Xu Shi, Wuran Wei, Ping Han, Qiang Wei & Lu Yang. (2022) Leucine zipper protein 2 serves as a prognostic biomarker for prostate cancer correlating with immune infiltration and epigenetic regulation. Heliyon 8:10, pages e10750.
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Gislene Pereira Gil, Galina Ananina, Mariana Maschietto, Sheila Coelho Soares Lima, Sueli Matilde da Silva Costa, Leticia de Carvalho Baptista, Mirta Tomie Ito, Fernando Ferreira Costa, Maria Laura Costa & Mônica Barbosa de Melo. (2022) Epigenetic analysis in placentas from sickle cell disease patients reveals a hypermethylation profile. PLOS ONE 17:9, pages e0274762.
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Lórand Váncza, Péter Tátrai, Andrea Reszegi, Kornélia Baghy & Ilona Kovalszky. (2022) SPOCK1 with unexpected function. The start of a new career. American Journal of Physiology-Cell Physiology 322:4, pages C688-C693.
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Yifei Liu, Xiaohui Zhu, Wenwen Zhang, Tingting Bian, Zheng Wu, Jianguo Zhang, Hongmei Qiu, Yingzi Hu, Jia Feng & Jiahai Shi. (2022) RASSF10 exhibits tumor‑suppressing potential involving tumor proliferation, metastasis and epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncology Reports 47:4.
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Lóránd Váncza, Katalin Karászi, Bálint Péterfia, Lilla Turiák, Katalin Dezső, Anna Sebestyén, Andrea Reszegi, Gábor Petővári, András Kiss, Zsuzsanna Schaff, Kornélia Baghy & Ilona Kovalszky. (2022) SPOCK1 Promotes the Development of Hepatocellular Carcinoma. Frontiers in Oncology 12.
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Xuelian Cui, Yixuan Wang, Weiqiang Lan, Shuhao Wang, Ying Cui, Xianglan Zhang, Zhenhua Lin & Junjie Piao. (2021) SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α. Cellular Oncology 45:1, pages 69-84.
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Dechao Feng, Xu Shi, Qiao Xiong, Facai Zhang, Dengxiong Li & Lu Yang. (2022) A Gene Prognostic Index Associated With Epithelial-Mesenchymal Transition Predicting Biochemical Recurrence and Tumor Chemoresistance for Prostate Cancer. Frontiers in Oncology 11.
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Hang Zheng, Heshu Liu, Huayu Li, Weidong Dou & Xin Wang. (2021) Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer. Frontiers in Molecular Biosciences 8.
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Żaneta Kałuzińska, Damian Kołat, Andrzej K. Bednarek & Elżbieta Płuciennik. (2021) PLEK2, RRM2, GCSH: A Novel WWOX-Dependent Biomarker Triad of Glioblastoma at the Crossroads of Cytoskeleton Reorganization and Metabolism Alterations. Cancers 13:12, pages 2955.
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Jie Han, Yihui Rong & Xudong Gao. (2021) Multiomic analysis of the function of SPOCK1 across cancers: an integrated bioinformatics approach . Journal of International Medical Research 49:6, pages 030006052096265.
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Sophie M Morgani, Jie Su, Jennifer Nichols, Joan Massagué & Anna-Katerina Hadjantonakis. (2021) The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. eLife 10.
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Zhonghua Xu, Jin He, Xindie Zhou, Yi Zhang, Yong Huang, Nanwei Xu & Haoyu Yang. (2020) Down-regulation of LECT2 promotes osteogenic differentiation of MSCs via activating Wnt/β-catenin pathway. Biomedicine & Pharmacotherapy 130, pages 110593.
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Ana Florencia Vega-Benedetti, Eleonora Loi, Loredana Moi, Sandra Orrù, Pina Ziranu, Andrea Pretta, Eleonora Lai, Marco Puzzoni, Letizia Ciccone, Andrea Casadei-Gardini, Francesco Cabras, Federica Fortunato, Angelo Restivo, Luigi Zorcolo, Mario Scartozzi & Patrizia Zavattari. (2020) Colorectal Cancer Early Detection in Stool Samples Tracing CpG Islands Methylation Alterations Affecting Gene Expression. International Journal of Molecular Sciences 21:12, pages 4494.
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Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Aiko Takano, Taiki Sanada, Misaki Iwashita, Takanori Shinjo, Takao Fukuda, Terukazu Sanui, Shosei Kishida & Fusanori Nishimura. (2020) SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth. Scientific Reports 10:1.
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Megan Crumbaker, Eva Chan, Tingting Gong, Niall Corcoran, Weerachai Jaratlerdsiri, Ruth Lyons, Anne-Maree Haynes, Anna Kulidjian, Anton Kalsbeek, Desiree Petersen, Phillip Stricker, Christina Jamieson, Peter Croucher, Christopher Hovens, Anthony Joshua & Vanessa Hayes. (2020) The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis. Cancers 12:5, pages 1178.
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Qing‐feng Ni, Yan Zhang, Jia‐wei Yu, Ru‐heng Hua, Qu‐hui Wang & Jian‐wei Zhu. (2019) miR‐92b promotes gastric cancer growth by activating the DAB2IP‐mediated PI3K/AKT signalling pathway. Cell Proliferation 53:1.
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Jia Li, Jing Ke, Jun Fang & Jin‐Peng Chen. (2019) A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells. Journal of Cellular Biochemistry 121:1, pages 743-754.
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Ming-Hsien Chien, Yung-Wei Lin, Yu-Ching Wen, Yi-Chieh Yang, Michael Hsiao, Junn-Liang Chang, Hsiang-Ching Huang & Wei-Jiunn Lee. (2019) Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis. Journal of Experimental & Clinical Cancer Research 38:1.
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Gang Liu, Fang Ren & Yongsheng Song. (2019) Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway. PeerJ 7, pages e7163.
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Mei-Ling Chen, Cheng-Ju Ho, Chung-Min Yeh, Sung-Lang Chen, Wen-Wei Sung, Shao-Chuan Wang & Chih-Jung Chen. (2019) High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer. Medicina 55:7, pages 343.
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Achilleas D. Theocharis & Nikos K. Karamanos. (2019) Proteoglycans remodeling in cancer: Underlying molecular mechanisms. Matrix Biology 75-76, pages 220-259.
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Dehu Chen, Haihua Zhou, Guiyuan Liu, Yinghai Zhao, Gan Cao & Qinghong Liu. (2017) SPOCK 1 promotes the invasion and metastasis of gastric cancer through Slug‐induced epithelial‐mesenchymal transition . Journal of Cellular and Molecular Medicine 22:2, pages 797-807.
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Vishalakshi Nanjappa, Remya Raja, Aneesha Radhakrishnan, Ankit P Jain, Keshava K Datta, Vinuth N Puttamallesh, Hitendra S Solanki, Sandip Chavan, Arun Patil, Santosh Renuse, Anu Jain, Don Mathew, Reetu Thakur, Rafael Guerrero-Preston, Bipin Nair, Samapika Routray, Neeta Mohanty, KB Linge Gowda, Ritesh Jadav, Sushmita Ghosal, Rekha V Kumar, Chaluvarayaswamy Ramesha, Vijay C Raghu, Premendu Prakash Mathur, TS Keshava Prasad, Joseph A Califano, David Sidransky, Arnab Pal, Mandakulutur S Ganesh, Jay Gopal Ray, Akhilesh Pandey, Harsha Gowda & Aditi Chatterjee. (2018) Testican 1 (SPOCK1) and protein tyrosine phosphatase, receptor type S (PTPRS) show significant increase in saliva of tobacco users with oral cancer. Translational Research in Oral Oncology 3, pages 2057178X1880053.
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Yusaku Osako, Naohiko Seki, Keiichi Koshizuka, Atsushi Okato, Tetsuya Idichi, Takayuki Arai, Itaru Omoto, Ken Sasaki, Yasuto Uchikado, Yoshiaki Kita, Hiroshi Kurahara, Kosei Maemura & Shoji Natsugoe. (2017) Regulation of SPOCK1 by dual strands of pre-miR-150 inhibit cancer cell migration and invasion in esophageal squamous cell carcinoma. Journal of Human Genetics 62:11, pages 935-944.
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Veronique L. Veenstra, Helene Damhofer, Cynthia Waasdorp, Anne Steins, Hemant M. Kocher, Jan P. Medema, Hanneke W. van Laarhoven & Maarten F Bijlsma. (2017) Stromal SPOCK 1 supports invasive pancreatic cancer growth . Molecular Oncology 11:8, pages 1050-1064.
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Atsushi Okato, Takayuki Arai, Satoko Kojima, Keiichi Koshizuka, Yusaku Osako, Tetsuya Idichi, Akira Kurozumi, Yusuke Goto, Mayuko Kato, Yukio Naya, Tomohiko Ichikawa & Naohiko Seki. (2017) Dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naïve and castration-resistant prostate cancer. International Journal of Oncology 51:1, pages 245-256.
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Jiaxuan Zhang, Xiaofei Zhi, Shiyu Shi, Ran Tao, Peisheng Chen, Shiyu Sun, Longjun Bian, Zhangyan Xu & Lilin Ma. (2017) SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer. Biochemical and Biophysical Research Communications 482:4, pages 870-876.
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