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Drug Design, Development and Therapy Volume 9, 2015 - Issue
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Original Research

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Wenqin Liu1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China;2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Jian Shi1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China;2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Lijun Zhu2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Lingna Dong1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
,
Feifei Luo2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Min Zhao2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Ying Wang2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Ming Hu2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China;3 Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
,
Linlin Lu2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Zhongqiu Liu1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China;2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 5771-5783 | Published online: 30 Oct 2015

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Josiane V. Cruz, Silvana Giuliatti, Levy B. Alves, Raí C. Silva, Elenilze F. B. Ferreira, Njogu M. Kimani, Carlos H. T. P. Silva, João S. N. de Souza, José M. Espejo-Román & Cleydson B. R. Santos. (2022) Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches. Journal of Biomolecular Structure and Dynamics 40:12, pages 5386-5408.
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A. V. Rudik, A. V. Dmitriev, V. M. Bezhentsev, A. A. Lagunin, D. A. Filimonov & V. V. Poroikov. (2017) Prediction of metabolites of epoxidation reaction in MetaTox. SAR and QSAR in Environmental Research 28:10, pages 833-842.
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Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi & Jingqing Zhang. (2017) Metabolic pathways and pharmacokinetics of natural medicines with low permeability. Drug Metabolism Reviews 49:4, pages 464-476.
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Chuqi Hou, Wenqin Liu, Zhi Liang, Weichao Han, Jinqing Li, Ling Ye, Menghua Liu, Zheng Cai, Jie Zhao, Yi Chen, Shuwen Liu & Lan Tang. (2018) UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro. Journal of Pharmaceutical and Biomedical Analysis 154, pages 339-353.
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