References
- ChuiCHLauFYTangJCActivities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell linesInt J Mol Med20051633734116012772
- RabeaEINasrHMBadawyMEToxic effect and biochemical study of chlorfluazuron, oxymatrine, and spinosad on honey bees (Apis mellifera)Arch Environ Contam Toxicol20105872273219812878
- WongSTsuiSKwanSAnalysis of proprietary Chinese medicines for the presence of toxic ingredients by LC/MS/MSJ Pharm Biomed Anal20023016117012151076
- HeXFangJHuangLSophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicineJ Ethnopharmacol2015172102926087234
- MaLWenSZhanYAnticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cellsPlanta Med20087424525118283616
- JiangHHouCZhangSMatrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cellsEur J Pharmacol20075599810817291488
- YamazakiMThe pharmacological studies on matrine and oxymatrineYakugaku Zasshi20001201025103311082713
- HongLSLeiLLeiSCardioprotective effects and underlying mechanisms of oxymatrine against Ischemic myocardial injuries of ratsPhytother Res20082298598918389484
- ZhangMWangXWangXOxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shockMol Med Rep201371293129923404057
- CaoYGJingSLiLAntiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescensPhytother Res2010241844184920564505
- HuSTTangYShenYFProtective effect of oxymatrine on chronic rat heart failureJ Physiol Sci20116136337221691940
- ChaiNLFuQShiHOxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cellsWorld J Gastroenterol2012184199420622919254
- RuntaoGGuoDJiangboYOxymatrine, the main alkaloid component of Sophora roots, protects heart against arrhythmias in ratsPlanta Med20117722623020717872
- UnahabhokhaTSucontphuntANimmannitUMolecular signalings in keloid disease and current therapeutic approaches from natural based compoundsPharm Biol20145345746325331681
- TangLDongLNPengXJPharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS methodJ Pharm Biomed Anal20138317918523747747
- WangSWangGLiXSimultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studiesJ Chromatogr B Analyt Technol Biomed Life Sci2005817319325
- FanRXLiuRMaRDetermination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometryFitoterapia20138927127723747322
- WanXYLuoMLiXDHepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrineChem Biol Interact2009181151919426721
- WangXYLiangLChangJLToxicity of matrine in Kunming miceNan fang yi ke da xue xue bao2010302154215520855277
- YuanFChenJWuWJEffects of matrine and oxymatrine on catalytic activity of cytochrome p450s in ratsBasic Clin Pharmacol Toxicol201010790691320524938
- BachmannKAGhoshRThe use of in vitro methods to predict in vivo pharmacokinetics and drug interactionsCurr Drug Metab2001229931411513332
- OmuraTForty years of cytochrome P450Biochem Biophys Res Commun199926669069810603307
- YeLTangLGongYCharacterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitineXenobiotica201141465821105783
- XieMZZhouWZZhangYOxymatrine metabolic fateChin Med J (Engl)1983961451506406172
- WangMLZhouQLWangBXStudies on metabolism of oxymatrine by human intestinal bacteriaZhongguo Zhong Yao Za Zhi20012627227412525054
- Al-LazikaniBBanerjiUWorkmanPCombinatorial drug therapy for cancer in the post-genomic eraNat Biotechnol20123067969222781697
- YeLWangTYangCMicrosomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum speciesToxicol Lett2011204819121550385
- EaglingVATjiaJFBackDJDifferential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomesBr J Clin Pharmacol1998451071149491822
- KobayashiKUrashimaKShimadaNSelectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the ratDrug Metab Dispos20033183383612814958
- AndoYFuseEFiggWDThalidomide metabolism by the CYP2C subfamilyClin Cancer Res200281964197312060642
- SchmiderJGreenblattDJFogelmanSMMetabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1Biopharm Drug Dispos1997182272409113345
- LiuXTamVHHuMDisposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNAMol Pharm2007487388217927138
- WangSWChenJJiaXDisposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic propertiesDrug Metab Dispos2006341837184816882763
- HoustonJBKenworthyKEIn vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten modelDrug Metab Dispos20002824625410681367
- HutzlerJMTracyTSAtypical kinetic profiles in drug metabolism reactionsDrug Metab Dispos20023035536211901086
- YamaokaKNakagawaTUnoTApplication of Akaike’s information criterion (AIC) in the evaluation of linear pharmacokinetic equationsJ Pharmacokinet Biopharm19786165175671222
- DaiDTangJRoseRIdentification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifosJ Pharmacol Exp Ther200129982583111714865
- LeeJYLeeSYOhSJAssessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 inhibitionChem Biol Interact2012198495622652334
- BaatiTHorcajadaPGrefRIn vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detectionJ Pharmacol Toxicol Methods2012661293422643301
- YaoNWangXIn vitro Immunomodulatory Activity of Oxymatrine on Toll-Like Receptor 9 Signal Pathway in Chronic Hepatitis BAm J Chin Med2014421399141025406654
- ZhangWZhangJKangYCardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in ratsEur J Pharmacol2014745293525310909
- MaoLHendersonGAntifeedant activity and acute and residual toxicity of alkaloids from Sophora flavescens (leguminosae) against formosan subterranean termites (Isoptera: Rhinotermitidae)J Econ Entomol200710086687017598549
- LiXLuanYLiXStudy on anti-inflammatory efficacy accompanied by side effects of different components of Sophorae Tonkinensis Radix et RhizomaZhongguo Zhong yao za zhi2012372232223723189725
- LuZGLiMHWangJSDevelopmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvaeReprod Toxicol201447334124911943
- GuengerichFPRole of cytochrome P450 enzymes in drug-drug interactionsAdv Pharmacol1997437359342171
- TopletzARDennisonJBBarbuchRJThe relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbineDrug Metab Dispos2013411651166123780963
- StresserDMKupferDProsubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoformsBiochem Pharmacol199855186118719714305
- LeeKSKimSKDirect and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactionsJ Appl Toxicol20133310010821915887
- ZhouZWZhouSFApplication of mechanism-based CYP inhibition for predicting drug-drug interactionsExpert Opin Drug Metab Toxicol2009557960519466877
- MarkowitzJSDonovanJLdeVaneCLEffect of St John’s Wort on drug metabolism by induction of cytochrome P450 3A4 enzymeJAMA20032901500150413129991
- ChowHHGarlandLLHsuCHResveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer studyCancer Prev Res2010311681175
- ChenXWSneedKBPanSYHerb-drug interactions and mechanistic and clinical considerationsCurr Drug Metab20121364065122292789
- BoinpallyRGadNGuptaSInfluence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjectsClin Ther2014361638164925236915
- ZhaoBRongDWangXRelationship of activity with electron structure for matrine and oxymatrineJ Mol Sci2000168893
- ZhangQLiRJinRStudy on the hepatotoxicity induced by matrine and oxymatrineChin Arch Tradit Chin Med20112912221225