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Review

Eltrombopag for the treatment of aplastic anemia: current perspectives

Su Han LumDepartment of Blood and Marrow Transplant, Royal Manchester Children’s Hospital, Manchester, UK

John D GraingerDepartment of Blood and Marrow Transplant, Royal Manchester Children’s Hospital, Manchester, UKCorrespondence[email protected]

Pages 2833-2843 | Published online: 13 Sep 2016

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P. David Josephy & Emma Allen-Vercoe. (2023) Reductive metabolism of azo dyes and drugs: Toxicological implications. Food and Chemical Toxicology 178, pages 113932.
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Rishab Bharadwaj, Jagadeesh Menon, Vimal Kumar, Naresh Shanmugam & Deenadayalan Munirathnam. (2023) Clinical Profile of Hepatitis Associated Aplastic Anemia (HAAA) in Six Children. Indian Pediatrics 60:5, pages 410-411.
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Akira Matsuda, Kazunori Imada, Naoshi Obara, Hiroatsu Iida, Hirohito Yamazaki, Yoshiaki Tomiyama, Koichi Miyamura, Osamu Sasaki, Tetsuo Maeda, Kensuke Ohta, Kensuke Usuki, Yukihiro Tokumine, Kenji Imajo, Yuji Okamoto, Mami Murakami & Shinji Nakao. (2022) Dysmegakaryopoiesis and Transient Mild Increase in Bone Marrow Blasts in Patients With Aplastic Anemia Treated With Eltrombopag May Be Signs of Hematologic Improvement and Not Portend Clonal Evolution. American Journal of Clinical Pathology 158:5, pages 604-615.
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Raheel Iftikhar, Parvez Ahmad, Regis de Latour, Carlo Dufour, Antonio Risitano, Naeem Chaudhri, Ali Bazarbachi, Josu De La Fuente, Britta Höchsmann, Syed Osman Ahmed, Usama Gergis, Alaa Elhaddad, Constantijn Halkes, Bassim Albeirouti, Sultan Alotaibi, Austin Kulasekararaj, Hazzaa Alzahrani, Tarek Ben Othman, Simone Cesaro, Ali Alahmari, Rawad Rihani, Salem Alshemmari, Amir Ali Hamidieh, Mohamed-Amine Bekadja, Jakob Passweg, Murtadha Al-Khabori, Walid Rasheed, Andrea Bacigalupo, Qamar-Un-Nisa Chaudhry, Per Ljungman, Judith Marsh, Riad El Fakih, Mahmoud Aljurf, Tarek Ben Othman & Regis de Latour. (2021) Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean blood and marrow transplantation (EMBMT) group and severe aplastic anemia working party of the European Society for blood and marrow transplantation (SAAWP of EBMT). Bone Marrow Transplantation 56:10, pages 2518-2532.
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Xiaoqing Liu, Lang Cheng, Yao He, Run Zhang, Ruinan Lu, Jianfu Zhang, Ming Hong, Guangsheng He & Jianyong Li. (2021) Eltrombopag restores erythropoiesis in refractory adult acquired pure red cell aplasia. International Journal of Hematology 114:1, pages 124-128.
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Yuan Yang, Jiang Ji, Zengwei Tang & Bing Han. (2021) Comparisons Between Frontline Therapy and a Combination of Eltrombopag Plus Immunosuppression Therapy and Human Leukocyte Antigen-Haploidentical Hematopoietic Stem Cell Transplantation in Patients With Severe Aplastic Anemia: A Systematic Review. Frontiers in Oncology 11.
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Jing Ruan, Wei Zuo, Miao Chen, Chen Yang & Bing Han. (2020) Eltrombopag is effective in patients with relapse/refractory aplastic anemia—report from a single center in China. Annals of Hematology 99:12, pages 2755-2761.
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Wei Zuo, Bo Zhang, Jing Ruan, Miao Chen & Bing Han. (2020) Correlation of the Plasma Concentration of Eltrombopag With Efficacy in the Treatment of Refractory Aplastic Anemia: A Single-Centre Study in China. Frontiers in Pharmacology 11.
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Luca Sala, Maddalena Mancin, Alessia Pastore, Davide Seminati, Diego Cortinovis, Paolo Bidoli & Andrea Alberti. (2020) Aplastic anemia in a patient with advanced lung adenocarcinoma during first line osimertinib: A case report and literature review. Lung Cancer 142, pages 120-122.
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Yuzhou Huang, Xianyong Jiang & Bing Han. (2020) Effective treatment of refractory acquired pure red blood cell aplasia with eltrombopag and sirolimus: a case report. Therapeutic Advances in Hematology 11, pages 204062072094014.
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Hirohito Yamazaki, Kensuke Ohta, Hiroatsu Iida, Kazunori Imada, Naoshi Obara, Yukihiro Tokumine, Yoshiaki Tomiyama, Kensuke Usuki, Kenji Imajo, Koichi Miyamura, Osamu Sasaki, Zhang Fanghong, Toshihiro Hattori, Takeshi Tajima, Akira Matsuda & Shinji Nakao. (2019) Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy. International Journal of Hematology 110:2, pages 187-196.
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Alba Rubio-San-Simón, Irene Lázaro Rodríguez, Felisa Vázquez Gómez, José Luis Vivanco Martínez & Vanesa Pérez Alonso. (2019) Eficacia y seguridad en el uso del eltrombopag en un caso de aplasia medular adquirida grave. Anales de Pediatría 90:4, pages 246-247.
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Alba Rubio-San-Simón, Irene Lázaro Rodríguez, Felisa Vázquez Gómez, José Luis Vivanco Martínez & Vanesa Pérez Alonso. (2019) Safety and efficacy of the use of eltrombopag in a case of severe acquired bone marrow aplasia. Anales de Pediatría (English Edition) 90:4, pages 246-247.
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Guang Yang, Lifen Zhao, Bing Liu, Yujia Shan, Yang Li, Huimin Zhou & Li Jia. (2018) Nutritional support contributes to recuperation in a rat model of aplastic anemia by enhancing mitochondrial function. Nutrition 46, pages 67-77.
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Eltrombopag for the treatment of aplastic anemia: current perspectives

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Eltrombopag for the treatment of aplastic anemia: current perspectives

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