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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Bei Zhang1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Laboratory of Neurodegenerative Diseases, The Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Ying Wang1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Hui Li1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Ran Xiong1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Zongbo Zhao1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Xingkun Chu2 Laboratory of Neurodegenerative Diseases, The Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Qiongqiong Li1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
,
Suya Sun1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Shengdi Chen1 Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;2 Laboratory of Neurodegenerative Diseases, The Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 1335-1343 | Published online: 06 Apr 2016

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Huiying Yan, Lina Feng & Mingquan Li. (2023) The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease. Drug Design, Development and Therapy 17, pages 3295-3323.
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Mengdi Wu, Ying Li, Yaodong Miao, Huanhuan Qiao & Yiwen Wang. (2023) Exploring the efficient natural products for Alzheimer’s disease therapy via Drosophila melanogaster (fruit fly) models. Journal of Drug Targeting 31:8, pages 817-831.
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Delong Pei, Shengri Tian, Yanqiu Bao, Jun Zhang, Dongyuan Xu & Minhu Piao. (2022) Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway. Pharmaceutical Biology 60:1, pages 1732-1738.
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Yongyan Xie, Bo Yan, Min Hou, Maofu Zhou, Chao Liu, Mengsheng Sun, Kun He, Cong Fang, Yaohui Chen & Liping Huang. (2021) Erzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and Aβ1–40 injection in ovariectomized Alzheimer’s disease model rats. Pharmaceutical Biology 59:1, pages 1400-1412.
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Zhifeng Zhong, Jing Han, Jizhou Zhang, Qing Xiao, Juan Hu & Lidian Chen. (2018) Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system. Drug Design, Development and Therapy 12, pages 1479-1489.
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Heba H. Awad, Mahmoud A. Desouky, Alaa Zidan, Mariam Bassem, Amaal Qasem, Mona Farouk, Haidy AlDeab, Miral Fouad, Cherry Hany, Nada Basem, Rita Nader, Ashrakat Alkalleny, Verina Reda & Mina Y. George. (2023) Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence. Inflammopharmacology 31:5, pages 2653-2673.
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天文 李. (2023) Research Progress of Rhodiola in Brain Diseases. Advances in Clinical Medicine 13:05, pages 8818-8823.
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Sixia Yang, Linshuang Wang, Zeping Xie, Yi Zeng, Qiaowu Xiong, Tingting Pei, Dongfeng Wei & Weidong Cheng. (2022) The Combination of Salidroside and Hedysari Radix Polysaccharide Inhibits Mitochondrial Damage and Apoptosis via the PKC/ERK Pathway. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Mayukha Bathini, Chandavalli Ramappa Raghushaker & Krishna Kishore Mahato. (2020) The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review. Cellular and Molecular Neurobiology 42:4, pages 955-971.
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Yingqing Chen, Minli Tang, Shuo Yuan, Shuang Fu, Yifei Li, You Li, Qi Wang, Yuying Cao, Liping Liu & Qinggao Zhang. (2022) Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
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Manish Kumar & Nitin Bansal. (2021) Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer’s Disease. Molecular Neurobiology 59:1, pages 354-385.
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Zhen Wang, Quanwei Zhang, Jhih-Rong Lin, M. Reza Jabalameli, Joydeep Mitra, Nha Nguyen & Zhengdong D. Zhang. (2021) Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer’s disease, providing new insights into its disease mechanisms. Scientific Reports 11:1.
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Giuseppe Uras, Alessia Manca, Pengfei Zhang, Zsuzsa Markus, Natalie Mack, Stephanie Allen, Marco Bo, Shengtao Xu, Jinyi Xu, Marios Georgiou & Zheying Zhu. (2021) In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease. Frontiers in Neuroscience 15.
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Yang Fan, Yajuan Bi & Haixia Chen. (2021) Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression. Frontiers in Pharmacology 12.
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Hui-Zhi Long, Yan Cheng, Zi-Wei Zhou, Hong-Yu Luo, Dan-Dan Wen & Li-Chen Gao. (2021) PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease. Frontiers in Pharmacology 12.
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Shu-Hsiang Huang, Sheng-Ting Fang & Yi-Cheng Chen. (2021) Molecular Mechanism of Vitamin K2 Protection against Amyloid-β-Induced Cytotoxicity. Biomolecules 11:3, pages 423.
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Hualong Wang, Qiongqiong Li, Suya Sun & Shengdi Chen. (2020) Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer’s Disease. Cellular and Molecular Neurobiology 40:7, pages 1133-1142.
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Ying Zhang, Nanqu Huang, Hao Lu, Juan Huang, Hai Jin, Jingshan Shi & Feng Jin. (2020) Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway. PeerJ 8, pages e8955.
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Nicholas G. Norwitz, Adrian Soto Mota, Sam G. Norwitz & Kieran Clarke. (2019) Multi-Loop Model of Alzheimer Disease: An Integrated Perspective on the Wnt/GSK3β, α-Synuclein, and Type 3 Diabetes Hypotheses. Frontiers in Aging Neuroscience 11.
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Wei Zhuang, Lifeng Yue, Xiaofang Dang, Fei Chen, Yuewen Gong, Xiaolan Lin & Yumin Luo. (2019) Rosenroot (Rhodiola): Potential Applications in Aging-related Diseases. Aging and disease 10:1, pages 134.
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Cristina Solana-Manrique, María Dolores Moltó, Pablo Calap-Quintana, Francisco José Sanz, José Vicente Llorens & Nuria Paricio. 2019. Insights into Human Neurodegeneration: Lessons Learnt from Drosophila. Insights into Human Neurodegeneration: Lessons Learnt from Drosophila 433 467 .
Michał Szulc, Piotr Mularczyk, Radosław Kujawski, Agnieszka Gryszczyńska, Ewa Kamińska, Bogna Geppert, Justyna Baraniak, Małgorzata Kania-Dobrowolska, Marcin Ożarowski, Anna Krajewska-Patan & Przemysław Ł. Mikołajczak. (2018) Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats . Herba Polonica 64:1, pages 22-35.
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Xia-Fang Wang, Xu Lin, Ding-You Li, Rou Zhou, Jonathan Greenbaum, Yuan-Cheng Chen, Chun-Ping Zeng, Lin-Ping Peng, Ke-Hao Wu, Zeng-Xin Ao, Jun-Min Lu, Yan-Fang Guo, Jie Shen & Hong-Wen Deng. (2017) Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach. Journal of the Neurological Sciences 380, pages 262-272.
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Hui Liu, Peizhen Lv, Yongjia Zhu, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng & Jinmin Zhao. (2017) Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo. Scientific Reports 7:1.
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Hui Liu, Peizhen Lv, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng & Jinmin Zhao. (2017) The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-10.
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Xiang Zhang, Jian-feng Zhao, Fan Zhao, Jun-feng Yan, Fan Yang, Xiao-jun Huang, Gang Chen, Hui-ying Fu & Bo-dong Lv. (2017) The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-11.
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