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Diabetes, Metabolic Syndrome and Obesity Volume 12, 2019 - Issue
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Original Research

Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway

Tian-Kui Ma1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
,
Li Xu1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China;2 Department of Clinical Laboratories, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
,
Ling-Xu Lu1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China;3 The First Respiratory Department, General Hospital of Fushun Mining Bureau, Fushun, Liaoning, People’s Republic of ChinaView further author information
,
Xu Cao1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
,
Xin Li1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
,
Lu-Lu Li1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
,
Xu Wang4 Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaView further author information
&
Qiu-Ling Fan1 Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Pages 2597-2608 | Published online: 09 Dec 2019

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Zhaohui Jia, Wensheng Li, Pan Bian, Liuyang Yang, Hui Liu, Dong Pan & Zhongling Dou. (2021) Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation. Bioengineered 12:1, pages 5450-5461.
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Articles from other publishers (16)

I Made Wisnu Adhi Putra, Nanang Fakhrudin, Arief Nurrochmad & Subagus Wahyuono. (2023) A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models. Life 13:2, pages 560.
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Xin Li, Tian-Kui Ma, Min Wang, Xiao-Dan Zhang, Tian-Yan Liu, Yue Liu, Zhao-Hui Huang, Yong-Hong Zhu, Shuang Zhang, Li Yin, Yan-Yan Xu, Hong Ding, Cong Liu, Hang Shi & Qiu-Ling Fan. (2023) YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway. Frontiers in Pharmacology 14.
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Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Walaa A. Negm, Athanasios Alexiou & Gaber El-Saber Batiha. (2022) Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective. Inflammopharmacology 30:5, pages 1493-1501.
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Min Kyung Hyun, Dae Hyun Kim, Chan Hum Park, Sang Gyun Noh, Sihyun Choi, Jae Yong Lee, Ji Hye Choi, Duhyeon Park, Yeon Ja Choi & Hae Young Chung. (2022) Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation. Journal of Molecular Medicine 100:10, pages 1455-1464.
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Merve ARAS & Özlem YAYINTAŞ. (2022) Şeker hastalığı üzerinde quercetin, gallik asit, oleanolik asit ve ursolik asitin in siliko analizi. Troia Medical Journal.
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Kishor Mazumder, Biswajit Biswas, Abdullah Al Mamun, Hasan Billah, Ahsan Abid, Kishore Kumar Sarkar, Bisti Saha, Shorrowar Azom & Philip G. Kerr. (2022) Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications. Journal of Natural Medicines 76:2, pages 490-503.
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Tiankui Ma, Xin Li, Yonghong Zhu, Shufan Yu, Tianyan Liu, Xiaodan Zhang, Dong Chen, Shuyan Du, Tong Chen, Shuo Chen, Yanyan Xu & Qiuling Fan. (2022) Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis. Frontiers in Immunology 13.
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Hayder M. Al-kuraishy, Ali I. Al-Gareeb & Gaber El-Saber Batiha. (2022) The possible role of ursolic acid in Covid-19: A real game changer. Clinical Nutrition ESPEN 47, pages 414-417.
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Ancuta-Veronica Lupaescu, Monica Iavorschi & Mihai Covasa. (2022) The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease. Pharmaceutics 14:2, pages 235.
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Mohamed Mohany, Mohammed M. Ahmed & Salim S. Al-Rejaie. (2021) Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease. Antioxidants 11:1, pages 15.
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Huan Xu, Tianyi Wu & Leaf Huang. (2021) Therapeutic and delivery strategies of phytoconstituents for renal fibrosis. Advanced Drug Delivery Reviews 177, pages 113911.
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Juan Antonio Moreno, Eya Hamza, Melania Guerrero-Hue, Sandra Rayego-Mateos, Cristina García-Caballero, Mercedes Vallejo-Mudarra, Laurent Metzinger & Valérie Metzinger-Le Meuth. (2021) Non-Coding RNAs in Kidney Diseases: The Long and Short of Them. International Journal of Molecular Sciences 22:11, pages 6077.
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Xinmiao Wang, Haoyu Yang, Lili Zhang, Lin Han, Sha Di, Xiuxiu Wei, Haoran Wu, Haiyu Zhang, Linhua Zhao & Xiaolin Tong. (2021) Network Pharmacology-Based Prediction of Mechanism of Shenzhuo Formula for Application to DKD. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-13.
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Suchitra K. Panigrahy, Renu Bhatt & Awanish Kumar. (2020) Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics. Biologia 76:1, pages 241-254.
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Xianghua Xu, Chu Xia & Yi Huang. (2020) Different roles of intracellular and extracellular reactive oxygen species of neutrophils in type 2 diabetic mice with invasive aspergillosis. Immunobiology 225:5, pages 151996.
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Shan Huang, Meng Tan, Feng Guo, Linsha Dong, Zhiming Liu, Ruiying Yuan, Zhuoma Dongzhi, Dong-Sung Lee, Yuefei Wang & Bin Li. (2020) Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells. Journal of Ethnopharmacology 255, pages 112771.
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