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Original Research

Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study

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Pages 307-313 | Published online: 02 Aug 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Colin Tuft, Elie Matar, Zoe Menczel Schrire, Ronald R Grunstein, Brendon J Yee & Camilla M Hoyos. (2023) Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Clinical Interventions in Aging 18, pages 49-59.
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Hui Zhu, Zhi-jia Zhao, Hong-yi Liu, Jie Cai, Qin-kang Lu, Lin-dan Ji & Jin Xu. (2023) The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story. Annals of Medicine 55:1, pages 1262-1286.
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Chang Guo, Jianqiang He, Xia Deng, Dong Wang & Guoyue Yuan. (2023) Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress. Archives of Physiology and Biochemistry 129:6, pages 1250-1261.
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David J. Kennaway. (2022) What do we really know about the safety and efficacy of melatonin for sleep disorders?. Current Medical Research and Opinion 38:2, pages 211-227.
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Kazutaka Yoshida, Hideyuki Otaka, Hiroshi Murakami, Hirofumi Nakayama, Masaya Murabayashi, Satoru Mizushiri, Koki Matsumura, Jutaro Tanabe, Yuki Matsuhashi, Miyuki Yanagimachi, Norio Sugawara, Kazuhiko Nakamura, Makoto Daimon & Norio Yasui-Furukori. (2018) Association between insomnia and coping style in Japanese patients with type 2 diabetes mellitus. Neuropsychiatric Disease and Treatment 14, pages 1803-1809.
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Hajime Narisawa, Yoko Komada, Takashi Miwa, Junpei Shikuma, Mamoru Sakurai, Masato Odawara & Yuichi Inoue. (2017) Prevalence, symptomatic features, and factors associated with sleep disturbance/insomnia in Japanese patients with type-2 diabetes. Neuropsychiatric Disease and Treatment 13, pages 1873-1880.
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Sirimon Reutrakul, Nantaporn Siwasaranond, Hataikarn Nimitphong, Sunee Saetung, Naricha Chirakalwasan, La-or Chailurkit, Kriangsuk Srijaruskul, Boonsong Ongphiphadhanakul & Ammarin Thakkinstian. (2017) Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes. Chronobiology International 34:3, pages 382-392.
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Naser Farhadi, Abbas Doosti, Jamshid Mohammadi & Reza Mohammadi. (2015) Effects of orally-administered melatonin and long-term exposure to light and dark on serum indices and gene expression of insulin and glucagon in male Wistar rats. Biological Rhythm Research 46:3, pages 435-443.
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Konstantin V Danilenko & Yulia I Ragino. (2013) Melatonin and its use in atherosclerosis and dyslipidemia. ChronoPhysiology and Therapy 3, pages 15-22.
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Daniel P Cardinali, María F Vidal & Daniel E Vigo. (2012) New developments in the treatment of primary insomnia in elderly patients: focus on prolonged-release melatonin. ChronoPhysiology and Therapy 2, pages 67-79.
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Ludovit Paulis, Fedor Simko & Moshe Laudon. (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opinion on Investigational Drugs 21:11, pages 1661-1678.
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Nava Zisapel. (2012) Drugs for insomnia. Expert Opinion on Emerging Drugs 17:3, pages 299-317.
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Patrick Lemoine & Nava Zisapel. (2012) Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia. Expert Opinion on Pharmacotherapy 13:6, pages 895-905.
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Articles from other publishers (15)

Onur Ertik, Bertan Boran Bayrak, Goksel Sener & Refiye Yanardag. (2023) Melatonin improves liver and pancreatic tissue injuries in diabetic rats: role on antioxidant enzymes. Journal of Diabetes & Metabolic Disorders.
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Namkhang Polkern Woods, Juraporn Tangpukdee, Thiwawan Thepa & Nonglak Methakanchanasak. (2023) Consequences of Sleep Deprivation in Adult Diabetes Mellitus Type 2 Patients: An Integrative Review. Open Access Macedonian Journal of Medical Sciences 11:F, pages 1-10.
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S. V. Orlova, E. A. Nikitina, N. V. Balashova, Yu. A. Pigareva, E. V. Ankvab & T. I. Khadzhimuratova. (2022) The role of exogenous melatonin in the regulation of sleep. Medical alphabet:25, pages 26-33.
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Özgül Ocak, Fatma Silan & Erkan Melih ŞAHİN. (2022) Melatonin receptor gene polymorphisms as a risk factor in patients with diabetic peripheral neuropathy. Diabetes/Metabolism Research and Reviews 38:8.
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Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Fatma Abo Zakaib Ali, Malik A. Altayar, Mohammed M. Jalal, Rayan Salem M. Albalawi, Abdulwahab Ali Abuderman, Khalaf F. Alsharif, Waseem AlZamzami, Ashraf Albrakati & Ehab Kotb Elmahallawy. (2022) Melatonin ameliorates the adrenal and pancreatic alterations in streptozotocin-induced diabetic rats: Clinical, biochemical, and descriptive histopathological studies. Frontiers in Veterinary Science 9.
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Xueran Huang, Yang Qiu, Yongfen Gao, Rong Zhou, Qiantu Hu, Zouyan He, Yingnan Lv, Xi Wang, Wanrong Chen, Yuqing Deng, Zhuangzhuang An, Haiying Zhang, Zengnan Mo & Rui Lin. (2022) Gut microbiota mediate melatonin signalling in association with type 2 diabetes. Diabetologia 65:10, pages 1627-1641.
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Chin-Sung Kuo, Chi-Yu Chen, Hsin-Lei Huang, Hsiao-Ya Tsai, Ruey-Hsing Chou, Jih-Hua Wei, Po-Hsun Huang & Shing-Jong Lin. (2022) Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. International Journal of Molecular Sciences 23:17, pages 9839.
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Alyaa Farid, Passant Moussa, Manar Youssef, Merna Haytham, Ali Shamy & Gehan Safwat. (2022) Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats. Saudi Journal of Biological Sciences 29:7, pages 103313.
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Xuemin Peng, Rongping Fan, Lei Xie, Xiaoli Shi, Kun Dong, Shujun Zhang, Jing Tao, Weijie Xu, Delin Ma, Juan Chen & Yan Yang. (2022) A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease. International Journal of Molecular Sciences 23:1, pages 504.
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Samantha B. J. Schipper, Maaike M. Van Veen, Petra J. M. Elders, Annemieke van Straten, Ysbrand D. Van Der Werf, Kristen L. Knutson & Femke Rutters. (2021) Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature. Diabetologia 64:11, pages 2367-2377.
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Fareha Wajid, Raju Poolacherla, Fatiha Kabir Mim, Amna Bangash & Ian H. Rutkofsky. (2020) Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus. Journal of Diabetes & Metabolic Disorders 19:2, pages 1797-1825.
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Sirimon Reutrakul, Stephanie J. Crowley, Jason C. Park, Felix Y. Chau, Medha Priyadarshini, Erin C. Hanlon, Kirstie K. Danielson, Ben S. Gerber, Tracy Baynard, Jade J. Yeh & J. Jason McAnany. (2020) Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy. Scientific Reports 10:1.
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Tal Shomrat & Nir Nesher. (2019) Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders. Frontiers in Endocrinology 10.
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Adejoke Y Onaolapo & Olakunle J Onaolapo. (2018) Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin’s roles in prophylaxis and management. World Journal of Diabetes 9:7, pages 99-114.
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Vladimir Iosifovich Konenkov, Vadim Valerievich Klimontov, Svetlana Viktorovna Michurina, M A Prudnikova & I Ju Ishenko. (2013) Melatonin and diabetes: from pathophysiology to the treatment perspectives. Diabetes mellitus 16:2, pages 11-16.
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