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Review

A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives

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Pages 3567-3602 | Published online: 10 Aug 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Haina Zhang, Lou Yu & Gai Yun. (2023) Reduced Serum Levels of Klotho are Associated with Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus. Diabetes, Metabolic Syndrome and Obesity 16, pages 129-137.
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Joris R. Delanghe, Evelyn Verlinde, Marijn M. Speeckaert & Thomas Maenhout. (2023) HOMA-IR and HOMA2-IR estimation based on glycated hemoglobin as an alternative for fasting glucose. Acta Clinica Belgica 78:4, pages 308-312.
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Nongzhang Xu, Jianwei Wan, Cuihong Wang, Jiatao Liu, Chenqai Qian & Hongyang Tan. (2022) Increased Serum Trimethylamine N-Oxide Level in Type 2 Diabetic Patients with Mild Cognitive Impairment. Diabetes, Metabolic Syndrome and Obesity 15, pages 2197-2205.
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Xin-Tian Cai, Qing Zhu, Sha-Sha Liu, Meng-Ru Wang, Ting Wu, Jing Hong, Jun-Li Hu & Nanfang Li. (2021) Associations Between the Metabolic Score for Insulin Resistance Index and the Risk of Type 2 Diabetes Mellitus Among Non-Obese Adults: Insights from a Population-Based Cohort Study. International Journal of General Medicine 14, pages 7729-7740.
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Crossref
Eva Tvrdá, Ján Kováč, Filip Benko, Michal Ďuračka, Anikó Varga, Oľga Uličná, Viera Almášiová, Marcela Capcarová & Mária Chomová. (2022) Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats. Open Life Sciences 17:1, pages 1383-1397.
Crossref
Tiago Bertola Lobato, Matheus Gennari-Felipe, Janaína Ribeiro Barbosa Pauferro, Ilana Souza Correa, Beatriz Ferreira Santos, Beatriz Belmiro Dias, João Carlos de Oliveira Borges, Camila Soares dos Santos, Elvirah Samantha de Sousa Santos, Maria Janaína Leite de Araújo, Liliane Araújo Ferreira, Sara Araujo Pereira, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Leandro Borges, Maria Fernanda Cury-Boaventura, Marco Aurélio Ramirez Vinolo, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Rui Curi, Sandro Massao Hirabara & Renata Gorjão. (2022) Leukocyte metabolism in obese type 2 diabetic individuals associated with COVID-19 severity. Frontiers in Microbiology 13.
Crossref
Dennis R.A. Mans. 2022. Basics of Hypoglycemia. Basics of Hypoglycemia.
Vivesh, Baljit Kaur, Sombir Jaglan, Sudesh Rani, Yatin Batra & Palwinder Singh. (2022) Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents. Bioorganic & Medicinal Chemistry Letters 76, pages 129018.
Crossref
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Crossref
Ina Ćorković, Dajana Gašo-Sokač, Anita Pichler, Josip Šimunović & Mirela Kopjar. (2022) Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase. Life 12:11, pages 1692.
Crossref
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Crossref
Aidan Joblin-Mills, Zhanxuan Wu, Karl Fraser, Beatrix Jones, Wilson Yip, Jia Jiet Lim, Louise Lu, Ivana Sequeira & Sally Poppitt. (2022) The impact of ethnicity and intra-pancreatic fat on the postprandial metabolome response to whey protein in overweight Asian Chinese and European Caucasian women with prediabetes. Frontiers in Clinical Diabetes and Healthcare 3.
Crossref
Matthew J. Varney, Wouter Steyaert, Paul J. Coucke, Joris R. Delanghe, David E. Uehling, Babu Joseph, Richard Marcellus, Rima Al-awar & Jeffrey L. Benovic. (2022) G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. Journal of Biological Chemistry 298:10, pages 102421.
Crossref
Sibhghatulla Shaikh, Shahid Ali, Jeong Ho Lim, Hee Jin Chun, Khurshid Ahmad, Syed Sayeed Ahmad, Ye Chan Hwang, Ki Soo Han, Na Ri Kim, Eun Ju Lee & Inho Choi. (2022) Dipeptidyl peptidase-4 inhibitory potentials of Glycyrrhiza uralensis and its bioactive compounds licochalcone A and licochalcone B: An in silico and in vitro study. Frontiers in Molecular Biosciences 9.
Crossref
Xuexue Zhang, Xujie Wang, Miaoran Wang, Biaoyan Hu, Wei Tang, Yufei Wu, Jiyu Gu, Tian Ni & Qiuyan Li. (2022) The global burden of type 2 diabetes attributable to high body mass index in 204 countries and territories, 1990–2019: An analysis of the Global Burden of Disease Study. Frontiers in Public Health 10.
Crossref
Kunwadee Noonong, Kanta Pranweerapaiboon, Kulathida Chaithirayanon, Kantamat Surayarn, Phicharinee Ditracha, Narin Changklungmoa, Pornanan Kueakhai, Poonsit Hiransai & Kingkan Bunluepuech. (2022) Antidiabetic potential of Lysiphyllum strychnifolium (Craib) A. Schmitz compounds in human intestinal epithelial Caco-2 cells and molecular docking-based approaches. BMC Complementary Medicine and Therapies 22:1.
Crossref
Phiwayinkosi V. Dludla, Bongani B. Nkambule, Ilenia Cirilli, Fabio Marcheggiani, Sihle E. Mabhida, Khanyisani Ziqubu, Yonela Ntamo, Babalwa Jack, Tawanda M. Nyambuya, Sidney Hanser & Sithandiwe E. Mazibuko-Mbeje. (2022) Capsaicin, its clinical significance in patients with painful diabetic neuropathy. Biomedicine & Pharmacotherapy 153, pages 113439.
Crossref
Juliet A. Prieto-Rodríguez, Kevin P. Lévuok-Mena, Juan C. Cardozo-Muñoz, Jorge E. Parra-Amin, Fabián Lopez-Vallejo, Luis E. Cuca-Suárez & Oscar J. Patiño-Ladino. (2022) In Vitro and In Silico Study of the α-Glucosidase and Lipase Inhibitory Activities of Chemical Constituents from Piper cumanense (Piperaceae) and Synthetic Analogs. Plants 11:17, pages 2188.
Crossref
Krisztina Kupai, Tamás Várkonyi, Szilvia Török, Viktória Gáti, Zsolt Czimmerer, László G. Puskás & Gábor J. Szebeni. (2022) Recent Progress in the Diagnosis and Management of Type 2 Diabetes Mellitus in the Era of COVID-19 and Single Cell Multi-Omics Technologies. Life 12:8, pages 1205.
Crossref
Zehua Zhang, Yulin Leng, Xiaoxu Fu, Chan Yang, Hongyan Xie, Haipo Yuan, Qingzhi Liang, Hong Gao & Chunguang Xie. (2022) The efficacy and safety of dachaihu decoction in the treatment of type 2 diabetes mellitus: A systematic review and meta-analysis. Frontiers in Pharmacology 13.
Crossref
Morteza Ashooriha, Reza Ahmadi, Hamideh Ahadi & Saeed Emami. (2022) Application of kojic acid scaffold in the design of non‐tyrosinase enzyme inhibitors. Chemical Biology & Drug Design 100:2, pages 290-303.
Crossref
Mina Salimi, Farzaneh Eskandari, Fateme Binayi, Afsaneh Eliassi, Hossein Ghanbarian, Mehdi Hedayati, Javad Fahanik-babaei, Mohamad Eftekhary, ‬Rana Keyhanmanesh & Homeira Zardooz. (2022) Maternal stress induced endoplasmic reticulum stress and impaired pancreatic islets’ insulin secretion via glucocorticoid receptor upregulation in adult male rat offspring. Scientific Reports 12:1.
Crossref
Iolanda Rosa, Marlene Lages, Carlos Grilo, Renata Barros & Maria P. Guarino. (2022) mHealth Applications to Monitor Lifestyle Behaviors and Circadian Rhythm in Clinical Settings: Current Perspective and Future Directions. Frontiers in Public Health 10.
Crossref
Giuseppina Piazzolla, Alfredo Vozza, Sara Volpe, Alessandro Bergamasco, Vincenzo Triggiani, Giuseppe Lisco, Michela Falconieri, Cosimo Tortorella, Vincenzo Solfrizzi & Carlo Sabbà. (2022) Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience. Open Medicine 17:1, pages 1203-1215.
Crossref
Gabriel Veniamin Cozma, Alexandru Apostu, Ioana Macasoi, Cristina Adriana Dehelean, Octavian Marius Cretu, Stefania Dinu, Dan Gaiță & Aniko Manea. (2022) In Vitro and In Ovo Evaluation of the Potential Hepatoprotective Effect of Metformin. Medicina 58:6, pages 705.
Crossref
Juan Cardozo-Muñoz, Luis E. Cuca-Suárez, Juliet A. Prieto-Rodríguez, Fabian Lopez-Vallejo & Oscar J. Patiño-Ladino. (2022) Multitarget Action of Xanthones from Garcinia mangostana against α-Amylase, α-Glucosidase and Pancreatic Lipase. Molecules 27:10, pages 3283.
Crossref
Zhaotong Cong, Qingtong Zhou, Yang Li, Li-Nan Chen, Zi-Chen Zhang, Anyi Liang, Qing Liu, Xiaoyan Wu, Antao Dai, Tian Xia, Wei Wu, Yan Zhang, Dehua Yang & Ming-Wei Wang. (2022) Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24. Proceedings of the National Academy of Sciences 119:20.
Crossref
Nguyen Ha Anh, Mai Quan Doan, Ngo Xuan Dinh, Tran Quang Huy, Doan Quang Tri, Le Thi Ngoc Loan, Bui Van Hao & Anh-Tuan Le. (2022) Gold nanoparticle-based optical nanosensors for food and health safety monitoring: recent advances and future perspectives. RSC Advances 12:18, pages 10950-10988.
Crossref
Abdullatif Azab. (2022) D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation. Nutrients 14:7, pages 1453.
Crossref
Mark A Jarosinski, Yen-Shan Chen, Nicolás Varas, Balamurugan Dhayalan, Deepak Chatterjee & Michael A Weiss. (2022) New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals. The Journal of Clinical Endocrinology & Metabolism 107:4, pages 909-928.
Crossref
Hesham El-Askary, Heba H. Salem & Amira Abdel Motaal. (2022) Potential Mechanisms Involved in the Protective Effect of Dicaffeoylquinic Acids from Artemisia annua L. Leaves against Diabetes and Its Complications. Molecules 27:3, pages 857.
Crossref
Yang Yang, Ying Luan, Qi Feng, Xing Chen, Bo Qin, Kai-Di Ren & Yi Luan. (2022) Epigenetics and Beyond: Targeting Histone Methylation to Treat Type 2 Diabetes Mellitus. Frontiers in Pharmacology 12.
Crossref
Stefanie Sperlich, Johannes Beller, Jelena Epping, Batoul Safieddine, Fabian Tetzlaff, Juliane Tetzlaff & Siegfried Geyer. 2022. Medizinische Soziologie in Deutschland. Medizinische Soziologie in Deutschland 179 203 .