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Review

Teneligliptin: a DPP-4 inhibitor for the treatment of type 2 diabetes

Pages 187-195 | Published online: 06 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Yao Chen, Xuejiao Qie, Wei Quan, Maomao Zeng, Fang Qin, Jie Chen, Benu Adhikari & Zhiyong He. (2023) Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?. Critical Reviews in Food Science and Nutrition 63:20, pages 4288-4324.
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Harmanjit Singh, Jasbir Singh, Ravneet Kaur Bhangu, Mandeep Singla, Jagjit Singh & Farideh Javid. (2023) Potential approaches using teneligliptin for the treatment of type 2 diabetes mellitus: current status and future prospects. Expert Review of Clinical Pharmacology 16:1, pages 49-59.
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Ashwani Sharma, Tarun Virmani, Anjali Sharma, Vaishnavi Chhabra, Girish Kumar, Kamla Pathak & Abdulsalam Alhalmi. (2022) Potential Effect of DPP-4 Inhibitors Towards Hepatic Diseases and Associated Glucose Intolerance. Diabetes, Metabolic Syndrome and Obesity 15, pages 1845-1864.
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Eugene Han, Minyoung Lee, Yong-ho Lee, Hye Soon Kim, Byung-wan Lee, Bong-Soo Cha & Eun Seok Kang. (2020) Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus. Diabetes, Metabolic Syndrome and Obesity 13, pages 4113-4121.
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Sohan S. Chitlange, Diptee G. Rawat & Sejal P. Gandhi. (2017) Estimation of Anti Diabetic Teneligliptin in Bulk and Formulation by Densitometric and Spectrophotometric Method. Analytical Chemistry Letters 7:4, pages 556-566.
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Yoshinori Okuda, Seitaro Omoto, Takehito Taniura, Akira Shouzu & Shosaku Nomura. (2016) Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis. International Journal of General Medicine 9, pages 65-71.
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Surendra Kumar Sharma, A Panneerselvam, KP Singh, Girish Parmar, Pradeep Gadge & Onkar C Swami. (2016) Teneligliptin in management of type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity 9, pages 251-260.
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Shuji Kinoshita & Kazuoki Kondo. (2015) Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers. Expert Opinion on Drug Metabolism & Toxicology 11:1, pages 7-14.
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Theodosios D Filippatos, Vasilios G Athyros & Moses S Elisaf. (2014) The pharmacokinetic considerations and adverse effects of DDP-4 inhibitors. Expert Opinion on Drug Metabolism & Toxicology 10:6, pages 787-812.
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Dilip C. Kanjariya, Hem N. Naik, Meet J. Sherashiya, Yogesh T. Naliapara, Iqrar Ahmad, Harun Patel, Dhanji Rajani & Smita Jauhari. α-Amylase and mycobacterium-TB H37Rv antagonistic efficacy of novel pyrazole-coumarin hybrids: an in vitro and in silico investigation. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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Katherine O. Kopp, Elliot J. Glotfelty, Yazhou Li & Nigel H. Greig. (2022) Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment. Pharmacological Research 186, pages 106550.
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Rajmohan Seetharaman, Sudhir Pawar & Manjari Advani. (2021) One hundred years since insulin discovery: An update on current and future perspectives for pharmacotherapy of diabetes mellitus. British Journal of Clinical Pharmacology 88:4, pages 1598-1612.
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Kumaravelrajan R, Thirumaran M, Sangavi T & Suba V. (2022) PREPARATION AND EVALUATION OF ACTIVE FILM COATING TABLET OF TENELIGLIPTIN HYDROBROMIDE HYDRATE WITH METFORMIN HYDROCHLORIDE FIXED DOSE COMBINATION. INDIAN DRUGS 58:12, pages 22-31.
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Banshi Saboo, Suhas Erande & A.G. Unnikrishnan. (2022) A prospective multicentre open label study to assess effect of Teneligliptin on glycemic control through parameters of time in range (TIR) Metric using continuous glucose monitoring (TOP-TIR study). Diabetes & Metabolic Syndrome: Clinical Research & Reviews 16:2, pages 102394.
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Takahiro Mori, Tomohisa Nagata, Masako Nagata, Kenji Fujimoto, Yoshihisa Fujino & Koji Mori. (2021) Diabetes severity measured by treatment control status and number of anti-diabetic drugs affects presenteeism among workers with type 2 diabetes. BMC Public Health 21:1.
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Hae Jin Kim, Young Sik Kim, Chang Beom Lee, Moon-Gi Choi, Hyuk-Jae Chang, Soo Kyoung Kim, Jae Myung Yu, Tae Ho Kim, Ji Hyun Lee, Kyu Jeung Ahn, Kyung Wan Min, Eun Jung Kyung, Yeo Kyeong Kim & Kwan Woo Lee. (2021) Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: 52-Week Results from a Prospective Observational Study. Diabetes Therapy 12:11, pages 2907-2920.
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Banshi Saboo, Sujoy Ghosh, Mangesh Tiwaskar & Rajeev Chawla. (2021) QTc prolongation Safety and Effectiveness of Teneligliptin in Indian patients with type 2 Diabetes Mellitus: A real world study (QSET 2). Diabetes & Metabolic Syndrome: Clinical Research & Reviews 15:5, pages 102264.
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Kalyani FarkadeMukund Tawar. (2021) Analytical Method Validation and Quantitative Analysis for Active Pharmaceutical Ingredient and Marketed Formulation of Teneligliptin Hydrobromide by UV Spectroscopy. Asian Journal of Pharmaceutical Analysis, pages 195-198.
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Linong Ji, Jianhua Ma, Weiping Lu, Jingdong Liu, Jiao’e Zeng, Jialin Yang, Wei Li, Xiuzhen Zhang, Xinhua Xiao, Gen Takayanagi & Yi Wang. (2020) Phase III, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of teneligliptin monotherapy in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise. Journal of Diabetes Investigation 12:4, pages 537-545.
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Ashit Syngle, Simran Chahal & Kanchan Vohra. (2020) Efficacy and tolerability of DPP4 inhibitor, teneligliptin, on autonomic and peripheral neuropathy in type 2 diabetes: an open label, pilot study. Neurological Sciences 42:4, pages 1429-1436.
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Linong Ji, Ling Li, Jianhua Ma, Xuefeng Li, Dongmei Li, Bangzhu Meng, Weiping Lu, Jiao Sun, Yanmei Liu, Gen Takayanagi & Yi Wang. (2021) Efficacy and safety of teneligliptin added to metformin in Chinese patients with type 2 diabetes mellitus inadequately controlled with metformin: A phase 3, randomized, double‐blind, placebo‐controlled study. Endocrinology, Diabetes & Metabolism 4:2.
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Sujoy Ghosh, Mangesh Tiwaskar, Rajiv Chawla, Shalini Jaggi, Arthur Asirvatham & Vijay Panikar. (2020) Teneligliptin Real-World Effectiveness Assessment in Patients with Type 2 Diabetes Mellitus in India: A Retrospective Analysis (TREAT-INDIA 2). Diabetes Therapy 11:10, pages 2257-2268.
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Amrish Chandra, Ramji Rathod, Faraat Ali, Anuj Prakash, Robin Kumar & Gyanendra Nath Singh. (2020) Development and Validation of a Rapid and Sensitive Method for the Simultaneous Estimation of Gemigliptin and Teneligliptin in Bulk and Dosage Forms by Using Liquid Chromatography-tandem Mass Spectrometry. Current Pharmaceutical Analysis 16:8, pages 1104-1111.
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Shrikrishna V. Acharya. (2020) Is Teneligliptin Safe in Patients with Diabetes Mellitus Mainly with Reference to QT Prolongation. Journal of Evolution of Medical and Dental Sciences 9:31, pages 2171-2175.
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Lei Zhang, Weiqiong Yuan, Xiangli Kong & Bei Zhang. (2020) Teneligliptin protects against ischemia/reperfusion-induced endothelial permeability in vivo and in vitro . RSC Advances 10:7, pages 3765-3774.
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Rajeev Chawla, SV Madhu, BM Makkar, Sujoy Ghosh, Banshi Saboo & Sanjay Kalra. (2020) RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020. Indian Journal of Endocrinology and Metabolism 24:1, pages 1.
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Shruti Surendran, Rekha Sapkal, David Paul & Satheeshkumar Nanjappan. (2020) Effect of resveratrol on dipeptidyl peptidase-4 inhibitors pharmacokinetics: An in vitro and in vivo approach. Chemico-Biological Interactions 315, pages 108909.
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Xiaoyan Deng, Na Wang, Liuwei Meng, Siru Zhou, Junli Huang, Junhao Xing, Linhong He, Weizhe Jiang & Qing Li. (2020) Optimization of the benzamide fragment targeting the S2′ site leads to potent dipeptidyl peptidase-IV inhibitors. Bioorganic Chemistry 94, pages 103366.
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Rajeev Chawla, S. V. Madhu, B. M. Makkar, Sujoy Ghosh, Banshi Saboo & Sanjay Kalra. (2020) RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020. International Journal of Diabetes in Developing Countries 40:S1, pages 1-122.
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Jin‐Woo Park, Kyoung‐Ah Kim, Yun Jung Choi, Soo Hyun Yoon & Ji‐Young Park. (2019) Effect of glimepiride on the pharmacokinetics of teneligliptin in healthy Korean subjects. Journal of Clinical Pharmacy and Therapeutics 44:5, pages 720-725.
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Krisyanti Budipramana, Junaidin Junaidin, Komar Ruslan Wirasutisna, Yanatra Budi Pramana & Sukrasno Sukrasno. (2019) An Integrated In Silico and In Vitro Assays of Dipeptidyl Peptidase-4 and α-Glucosidase Inhibition by Stellasterol from Ganoderma australe. Scientia Pharmaceutica 87:3, pages 21.
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Munehiro Kitada, Yoshio Ogura, Kyoko Nitta, Mizue Fujii, Keizo Kanasaki, Kazunori Konishi, Yasuo Iida, Atsushi Nakagawa & Daisuke Koya. (2018) Effect of switching to teneligliptin from other dipeptidyl peptidase‐4 inhibitors on glucose control and renoprotection in type 2 diabetes patients with diabetic kidney disease. Journal of Diabetes Investigation 10:3, pages 706-713.
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Naina Mohamed Pakkir Maideen. (2019) Drug interactions of dipeptidyl peptidase 4 inhibitors involving CYP enzymes and P-gp efflux pump. World Journal of Meta-Analysis 7:4, pages 156-161.
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Elliot J. Glotfelty, Thomas E. Delgado, Luis B. Tovar-y-Romo, Yu Luo, Barry J. Hoffer, Lars Olson, Tobias E. Karlsson, Mark P. Mattson, Brandon K. Harvey, David Tweedie, Yazhou Li & Nigel H. Greig. (2019) Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury. ACS Pharmacology & Translational Science 2:2, pages 66-91.
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Amankeldi A. Salybekov, Haruchika Masuda, Kozo Miyazaki, Yin Sheng, Atsuko Sato, Tomoko Shizuno, Yumi Iida, Yoshinori Okada & Takayuki Asahara. (2019) Dipeptidyl dipeptidase-4 inhibitor recovered ischemia through an increase in vasculogenic endothelial progenitor cells and regeneration-associated cells in diet-induced obese mice. PLOS ONE 14:3, pages e0205477.
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Yonghyun Kim, Eun Seok Kang, Hak Chul Jang, Dong Jun Kim, Taekeun Oh, Eun Sook Kim, Nan-Hee Kim, Kyung Mook Choi, Sung-Rae Kim, JiYoung You, Se-Jin Kim & Moon-Kyu Lee. (2019) Teneligliptin versus sitagliptin in Korean patients with type 2 diabetes inadequately controlled with metformin and glimepiride: A randomized, double-blind, non-inferiority trial. Diabetes, Obesity and Metabolism 21:3, pages 631-639.
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Takashi Kadowaki, Nobuaki Sarai, Takeshi Hirakawa, Kentaro Taki, Kosuke Iwasaki & Hisashi Urushihara. (2018) Persistence of oral antidiabetic treatment for type 2 diabetes characterized by drug class, patient characteristics and severity of renal impairment: A Japanese database analysis. Diabetes, Obesity and Metabolism 20:12, pages 2830-2839.
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Xiaoxuan Li, Xuefei Huang, Chongfei Bai, Dalian Qin, Shousong Cao, Qibing Mei, Yun Ye & Jianming Wu. (2018) Efficacy and Safety of Teneligliptin in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Pharmacology 9.
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Gulmira Turdu, Hongwei Gao, Yingying Jiang & Madina Kabas. (2018) Plant dipeptidyl peptidase-IV inhibitors as antidiabetic agents: a brief review. Future Medicinal Chemistry 10:10, pages 1229-1239.
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P Mandal, S Dan, B. Ghosh, S. Barma, R. Bose & T. K Pal. (2018) SIMULTANEOUS DETERMINATION AND QUANTITATION OF METFORMIN AND TENELIGLIPTIN IN HUMAN PLASMA BY LC-ESI-MS/MS WITH AN APPLICATION TO PHARMACOKINETIC STUDIES. INDIAN DRUGS 55:04, pages 28-38.
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Priyanka A Shah, Pranav S Shrivastav, Pravin G Vanol & Mallika Sanyal. (2018) Mechanistic study for the simultaneous determination of metformin and teneligliptin in human plasma using hydrophilic interaction liquid chromatography–MS/MS. Bioanalysis 10:7, pages 475-488.
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P. B. Deshpande & S. R. Butle. (2018) Determination of Dipeptidyl Peptidase-4 Inhibitors by Spectrophotometric and Chromatographic Methods. Journal of Analytical Chemistry 73:4, pages 303-316.
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Piyush Agarwal, Chhavi Jindal & Vinayak Sapakal. (2018) Efficacy and safety of teneligliptin in Indian patients with inadequately controlled Type 2 diabetes mellitus: A randomized, double-blind study. Indian Journal of Endocrinology and Metabolism 22:1, pages 41.
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Neeraj Kumar, Subba Rao Devineni, Kadirappa Aggile, Prasad Reddy Gajjala, Pramod Kumar & Shailendra Kumar Dubey. (2017) Facile new industrial process for synthesis of teneligliptin through new intermediates and its optimization with control of impurities. Research on Chemical Intermediates 44:1, pages 567-584.
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Chintan N. Koyani, Ewald Kolesnik, Gerald Wölkart, Niroj Shrestha, Susanne Scheruebel, Christopher Trummer, Klaus Zorn-Pauly, Astrid Hammer, Petra Lang, Helga Reicher, Heinrich Maechler, Klaus Groschner, Bernd Mayer, Peter P. Rainer, Harald Sourij, Wolfgang Sattler, Ernst Malle, Brigitte Pelzmann & Dirk von Lewinski. (2017) Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure. Biochemical Pharmacology 145, pages 64-80.
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T. N. V. Ganesh Kumar, S. Vidyadhara, Niteen Ashok Narkhede, Y. Sai Silpa & M. Rajya Lakshmi. (2016) RETRACTED ARTICLE: Method development, validation, and stability studies of teneligliptin by RP-HPLC and identification of degradation products by UPLC tandem mass spectroscopy. Journal of Analytical Science and Technology 7:1.
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Noritsugu Wada, Katsuhito Mori, Chie Nakagawa, Jun Sawa, Yasuro Kumeda, Tetsuo Shoji, Masanori Emoto & Masaaki Inaba. (2015) Improved glycemic control with teneligliptin in patients with type 2 diabetes mellitus on hemodialysis: Evaluation by continuous glucose monitoring. Journal of Diabetes and its Complications 29:8, pages 1310-1313.
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Yuji Kumagai, Tomoko Hasunuma, Soichi Sakai, Hidekazu Ochiai & Yoshishige Samukawa. (2015) Randomized, Controlled, Thorough QT/QTc Study Shows Absence of QT Prolongation with Luseogliflozin in Healthy Japanese Subjects. PLOS ONE 10:10, pages e0139873.
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Kazunari Kamiko, Kazutaka Aoki, Hiroshi Kamiyama, Masataka Taguri, Eriko Shibata, Yumiko Ashiya, Fuyuki Minagawa, Kazuaki Shinoda, Shigeru Nakajima & Yasuo Terauchi. (2015) Comparison of the administration of teneligliptin every day versus every other day in Japanese patients with type 2 diabetes: A randomized non-inferior test. The Journal of Clinical Pharmacology 55:2, pages 144-151.
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Atef Halabi, Haidar Maatouk, Karl Ernst Siegler, Nadja Faisst & Holger Hinrichsen. (2014) Pharmacokinetics and safety of teneligliptin in subjects with hepatic impairment. Clinical Pharmacology in Drug Development 3:4, pages 290-296.
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