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Review

Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

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Pages 211-223 | Published online: 23 Jun 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Mozafar Khazaei, Fatemeh Khazaei, Elham Niromand & Elham Ghanbari. (2023) Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes. Journal of Drug Targeting 31:1, pages 14-31.
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Ye-Jee Lee, Esder Lee, Young-Hye You, Yu-Bae Ahn, Ki-Ho Song, Ji-Won Kim & Seung-Hyun Ko. (2021) Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells. Journal of Drug Targeting 29:1, pages 88-98.
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Lukin Izeia, Tatiane Eufrasio-da-Silva, Alireza Dolatshahi-Pirouz, Serge Ostrovidov, Giovanna Paolone, Nicholas A. Peppas, Paul De Vos, Dwaine Emerich & Gorka Orive. (2020) Cell-laden alginate hydrogels for the treatment of diabetes. Expert Opinion on Drug Delivery 17:8, pages 1113-1118.
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Kuo-Cheng Lan, Ching-Chia Wang, Yuan-Peng Yen, Rong-Sen Yang, Shing-Hwa Liu & Ding-Cheng Chan. (2018) Islet-like clusters derived from skeletal muscle-derived stem/progenitor cells for autologous transplantation to control type 1 diabetes in mice. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 328-335.
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Hajime Imamura, Tomohiko Adachi, Tatsuya Kin, Shinichiro Ono, Yusuke Sakai, Toshiyuki Adachi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, A.M. James Shapiro & Susumu Eguchi. (2018) An engineered cell sheet composed of human islets and human fibroblast, bone marrow–derived mesenchymal stem cells, or adipose–derived mesenchymal stem cells: An in vitro comparison study . Islets 10:3.
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Eun-Mi Lee, Inwon Park, Ye-Jee Lee, Young-Hye You, Ji-Won Kim, Myung-Jun Kim, Yu-Bae Ahn, Pilhan Kim & Seung-Hyun Ko. (2018) Effect of resveratrol treatment on graft revascularization after islet transplantation in streptozotocin-induced diabetic mice. Islets 10:1, pages 25-39.
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Andrew R. Pepper, Antonio Bruni, Rena L. Pawlick, Boris Gala-Lopez, Yasmin Rafiei, John Wink, Tatsuya Kin & A. M. James Shapiro. (2016) Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site. Islets 8:6, pages 186-194.
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Kenjiro Kumano, Hitomi Nishinakamura, Toshiyuki Mera, Takeshi Itoh, Hiroyuki Takahashi, Toshiyoshi Fujiwara & Shohta Kodama. (2016) Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice. Islets 8:5, pages 145-155.
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Rena L. Pawlick, John Wink, Andrew R. Pepper, Antonio Bruni, Nasser Abualhassen, Yasmin Rafiei, Boris Gala-Lopez, Mariusz Bral & A.M. James Shapiro. (2016) Reparixin, a CXCR1/2 inhibitor in islet allotransplantation. Islets 8:5, pages 115-124.
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Antonio Bruni, Andrew R. Pepper, Boris Gala-Lopez, Rena Pawlick, Nasser Abualhassan, James D. Crapo, Jon D. Piganelli & A. M. James Shapiro. (2016) A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model. Islets 8:4.
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Jingping Liu, Shuyun Liu, Younan Chen, Xiaojun Zhao, Yanrong Lu & Jingqiu Cheng. (2015) Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway. International Journal of Nanomedicine 10, pages 3519-3531.
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Alice Anna Tomei, Chiara Villa & Camillo Ricordi. (2015) Development of an encapsulated stem cell-based therapy for diabetes. Expert Opinion on Biological Therapy 15:9, pages 1321-1336.
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Anessa Puskar, Bara Saadah, Asad Rauf, Szymon R. Kasperek & Muhammad Umair. (2023) A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant. Nano Select 4:3, pages 181-191.
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Kanchan Maji & Krishna Pramanik. 2023. Principles of Biomaterials Encapsulation : Volume Two. Principles of Biomaterials Encapsulation : Volume Two 749 772 .
Hiroyuki Kato, Tatsuaki Miwa, Janine Quijano, Leonard Medrano, Jose Ortiz, Akiko Desantis, Keiko Omori, Aya Wada, Kentaro Tatsukoshi, Fouad Kandeel, Yoko Mullen, Hsun Teresa Ku & Hirotake Komatsu. (2022) Microwell culture platform maintains viability and mass of human pancreatic islets. Frontiers in Endocrinology 13.
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Astgik Petrosyan, Filippo Montali, Andrea Peloso, Antonio Citro, Lori N. Byers, Catherine La Pointe, Mara Suleiman, Alice Marchetti, Eoin P. Mcneill, Allison L Speer, Wai Hoe Ng, Xi Ren, Benedetta Bussolati, Laura Perin, Paolo Di Nardo, Vincenzo Cardinale, Jerome Duisit, Alexandra Rose Monetti, John Richard Savino, Amish Asthana & Giuseppe Orlando. (2022) Regenerative medicine technologies applied to transplant medicine. An update. Frontiers in Bioengineering and Biotechnology 10.
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Quynh Dang Le, Watchareewan Rodprasert, Suryo Kuncorojakti, Prasit Pavasant, Thanaphum Osathanon & Chenphop Sawangmake. (2022) In vitro generation of transplantable insulin-producing cells from canine adipose-derived mesenchymal stem cells. Scientific Reports 12:1.
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In Kyong Shim, Seong Jin Lee, Yu Na Lee, Dohui Kim, Hanse Goh, Jaeseung Youn, Jinah Jang, Dong Sung Kim & Song Cheol Kim. (2022) Enhanced Differentiation Capacity and Transplantation Efficacy of Insulin-Producing Cell Clusters from Human iPSCs Using Permeable Nanofibrous Microwell-Arrayed Membrane for Diabetes Treatment. Pharmaceutics 14:2, pages 400.
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Ekaterina Shcheglova, Katarzyna Blaszczyk & Malgorzata Borowiak. (2022) Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation. Frontiers in Cell and Developmental Biology 9.
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Haotian Fu, Hongwei Sun, Hongru Kong, Bin Lou, Hao Chen, Yilin Zhou, Chaohao Huang, Lei Qin, Yunfeng Shan & Shengjie Dai. (2022) Discoveries in Pancreatic Physiology and Disease Biology Using Single-Cell RNA Sequencing. Frontiers in Cell and Developmental Biology 9.
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Pengxiu Dai, Jiakai Li, Yijing Chen, Luwen Zhang, Xinke Zhang, Jinglu Wang, Guixiang Qi & Yihua Zhang. (2021) Novel Functional Genes Involved in Transdifferentiation of Canine ADMSCs Into Insulin-Producing Cells, as Determined by Absolute Quantitative Transcriptome Sequencing Analysis. Frontiers in Cell and Developmental Biology 9.
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Ying Li, Anthony W. Frei, Irayme M. Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M. Samojlik, Chuqiao Sun, Steven Barash, Benjamin G. Keselowsky, Allison L. Bayer & Cherie L. Stabler. (2021) Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants. Frontiers in Immunology 12.
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Veronica Clavijo Jordan, Catherine D. G. Hines, Liza T. Gantert, Shubing Wang, Stacey Conarello, Christian Preihs, Sara Chirayil, Michael Klimas, Jeffrey L. Evelhoch & A. Dean Sherry. (2021) Imaging Beta-Cell Function in the Pancreas of Non-Human Primates Using a Zinc-Sensitive MRI Contrast Agent. Frontiers in Endocrinology 12.
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Kenjiro Kumano, Mazhar A. Kanak, Prathab Balaji Saravanan, J. P. Blanck, Yang Liu, Srividya Vasu, Michael Lawrence & Bashoo Naziruddin. (2021) Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival. Scientific Reports 11:1.
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Jinsha Liu, Joey Paolo Ting, Shams Al-Azzam, Yun Ding & Sepideh Afshar. (2021) Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases. International Journal of Molecular Sciences 22:6, pages 2805.
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Elisabeth Kemter, Alexander Kind, Bruno Reichart & Eckhard Wolf. 2020. Cell Engineering and Regeneration. Cell Engineering and Regeneration 367 412 .
Shuixan Hu & Paul de Vos. (2019) Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation. Frontiers in Bioengineering and Biotechnology 7.
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Junfeng Li, Jeffrey Rawson, Junie Chea, Wei Tang, Lynn Miao, Feng Sui, Lin Li, Erasmus Poku, John E. Shively & Fouad Kandeel. (2019) Evaluation of [68Ga]DO3A-VS-Cys40-Exendin-4 as a PET Probe for Imaging Human Transplanted Islets in the Liver. Scientific Reports 9:1.
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Shibu Marthandam Asokan, Ting Wang, Wei-Ting Su & Wan-Teng Lin. (2019) Antidiabetic Effects of a Short Peptide of Potato Protein Hydrolysate in STZ-Induced Diabetic Mice. Nutrients 11:4, pages 779.
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Alexandra M. Smink & Paul de Vos. (2018) Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation. Current Diabetes Reports 18:7.
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Litao Bai, Jialiang Gao, Fan Wei, Jing Zhao, Danwei Wang & Junping Wei. (2018) Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes. Frontiers in Pharmacology 9.
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Deanna R. FunkNormand G. BouléPeter A. SeniorJane E. Yardley. (2017) Does exercise pose a challenge to glucoregulation after clinical islet transplantation?. Applied Physiology, Nutrition, and Metabolism 42:1, pages 1-7.
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