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Review

Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

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Pages 9-20 | Published online: 22 Feb 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Yinghui Gao, Ruirui Zhu, Jianxia Dong & Zhiqin Li. (2023) Pathogenesis of NAFLD-Related Hepatocellular Carcinoma: An Up-to-Date Review. Journal of Hepatocellular Carcinoma 10, pages 347-356.
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Meichao Zhang, Furao Liu, Pingting Zhou, Qian Wang, Ci Xu, Yanyan Li, Lei Bian, Yuanhua Liu, Jiaxi Zhou, Fei Wang, Yuan Yao, Yong Fang & Dong Li. (2019) The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy. Autophagy 15:7, pages 1150-1162.
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Eunbyul Ji, Chongtae Kim, Hoin Kang, Sojin Ahn, Myeongwoo Jung, Youlim Hong, Hyosun Tak, Sukchan Lee, Wook Kim & Eun Kyung Lee. (2019) RNA Binding Protein HuR Promotes Autophagosome Formation by Regulating Expression of Autophagy-Related Proteins 5, 12, and 16 in Human Hepatocellular Carcinoma Cells. Molecular and Cellular Biology 39:6.
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Pei Hu, Bin Cheng, Yulin He, Zhiqiang Wei, Dongfang Wu & Zhongji Meng. (2018) Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling. OncoTargets and Therapy 11, pages 193-200.
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Articles from other publishers (26)

Farnaz Ahmadi‐Dehlaghi, Parisa Mohammadi, Elahe Valipour, Pouya Pournaghi, Sarah Kiani & Kamran Mansouri. (2023) Autophagy: A challengeable paradox in cancer treatment. Cancer Medicine 12:10, pages 11542-11569.
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Ding Wang, Jessica Lee, Jennifer S. Polson, David A. Liem & Peipei Ping. 2022. Biochemistry of Apoptosis and Autophagy. Biochemistry of Apoptosis and Autophagy 1 22 .
Ayman El Shayeb, Akram Deghedy, Essam Saeed Bedewy, Sahar Badawy & Nermeen Abdeen. (2021) Serum Beclin 1 and autophagy-related protein-5 and the risk of hepatocellular carcinoma among cirrhotic hepatitis C patients. Egyptian Liver Journal 11:1.
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Wenfang Xu, Wenke Guo, Ping Lu, Duan Ma, Lei Liu & Fudong Yu. (2021) Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma. Bioscience Reports 41:1.
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Y. S. Taskaeva, N. P. Bgatova, R. S. Dossymbekova, A. O. Solovieva, S. M. Miroshnichenko, K. O. Sharipov & Z. B. Tungushbaeva. (2020) In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells. Bulletin of Experimental Biology and Medicine 170:2, pages 246-250.
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Jianzhou Cui, Han-Ming Shen & Lina Hsiu Kim Lim. (2020) The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets. Pharmaceuticals 13:12, pages 432.
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Lokman Varisli, Osman Cen & Spiros Vlahopoulos. (2019) Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Immunology 159:3, pages 257-278.
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Lijie Ma, Yuehong Ma, Ziying Zhang, Qi Wang & Xudong Liu. (2019) The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesis. Anti-Cancer Drugs 30:10, pages 1031-1037.
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Asghar AbdoliMohsen NakhaieNeda FeiziAli Salimi JedaAmitis Ramezani. (2019) Harmonized Autophagy Versus Full-Fledged Hepatitis B Virus: Victorious or Defeated. Viral Immunology 32:8, pages 322-334.
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Iu. S. Taskaeva, N. P. Bgatova & A. O. Solovieva. (2019) Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. Cell and Tissue Biology 13:5, pages 353-359.
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Yu. S. Taskaeva & N. P. Bgatova. (2019) Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate. Bulletin of Experimental Biology and Medicine 167:1, pages 87-90.
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K Ashokachakkaravarthy & Biju Pottakkat. (2019) Sorafenib resistance and autophagy in hepatocellular carcinoma: A concealed threat. Journal of Cancer Research and Practice 6:3, pages 107.
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梦君 廖. (2019) Curcumin and Nonalcoholic Fatty Liver Disease. Traditional Chinese Medicine 08:01, pages 61-67.
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Keywan Mortezaee. (2018) Human hepatocellular carcinoma: Protection by melatonin. Journal of Cellular Physiology 233:10, pages 6486-6508.
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Younho Choi, James W. Bowman & Jae U. Jung. (2018) Autophagy during viral infection — a double-edged sword. Nature Reviews Microbiology 16:6, pages 341-354.
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Ana Santos-Llamas, Maria J. Monte, Jose J. G. Marin & Maria J. Perez. (2018) Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. Archives of Toxicology 92:6, pages 2109-2118.
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Youming Ding, Xiaoyan Chen, Bin Wang, Bin Yu & Jianhui Ge. (2018) Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells. European Journal of Pharmacology 825, pages 10-18.
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Mahmoud A Ali, Marwa Matboli, Nashwa El-Khazragy, Osama Saber, Sarah El-Nakeep, Hana M Abdelzaher, Ayman El-Sayed Shafei & Randa Mostafa. (2018) Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma . Biomarkers in Medicine 12:3, pages 245-256.
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Desirée Bartolini, Katiuscia Dallaglio, Pierangelo Torquato, Marta Piroddi & Francesco Galli. (2018) Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma. Translational Research 193, pages 54-71.
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Gizem Onal, Ozlem Kutlu, Devrim Gozuacik & Serap Dokmeci Emre. (2017) Lipid Droplets in Health and Disease. Lipids in Health and Disease 16:1.
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Katriina Nemes & Fredrik Åberg. (2017) Interpreting lipoproteins in nonalcoholic fatty liver disease. Current Opinion in Lipidology 28:4, pages 355-360.
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Nanis S. Holah, Rehab M. Samaka & Shereen F. El Goday. (2017) Does Beclin-1 have a role in hepatocellular carcinoma in Egyptian patients?. Egyptian Journal of Pathology 37:1, pages 120-127.
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Youming Ding, Bin Wang, Xiaoyan Chen, Yu Zhou & Jianhui Ge. (2017) Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway. Tumor Biology 39:3, pages 101042831769431.
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Rui Chen, Hao Wang, Beibei Liang, Guoke Liu, Min Tang, Rongjie Jia, Xiaoyu Fan, Wei Jing, Xuyu Zhou, Huajing Wang, Yang Yang, Huafeng Wei, Bohua Li & Jian Zhao. (2016) Downregulation of ASPP2 improves hepatocellular carcinoma cells survival via promoting BECN1-dependent autophagy initiation. Cell Death & Disease 7:12, pages e2512-e2512.
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Hong Li, Cong Liu, Yi-Ping Zeng, Yu-Hui Hao, Jia-Wei Huang, Zhang-You Yang & Rong Li. (2016) Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer. ACS Applied Materials & Interfaces 8:46, pages 31510-31523.
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Srikanta Dash, Srinivas Chava, Yucel Aydin, Partha Chandra, Pauline Ferraris, Weina Chen, Luis Balart, Tong Wu & Robert Garry. (2016) Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response. Viruses 8:5, pages 150.
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