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Original Research

Tailored nanostructured platforms for boosting transcorneal permeation: Box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization

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Pages 7947-7962 | Published online: 30 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Sadek Ahmed, Maha M. Amin, Sarah Mohamed El-Korany & Sinar Sayed. (2022) Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management. Drug Delivery 29:1, pages 2945-2958.
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Rehab Abdelmonem, Inas Essam Ibrahim Al-Samadi, Rasha M. El Nashar, Bhaskara R. Jasti & Mohamed A. El-Nabarawi. (2022) Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation. Drug Delivery 29:1, pages 2868-2882.
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Eman Abdelhakeem, Mohamed El-nabarawi & Rehab Shamma. (2021) Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model. International Journal of Nanomedicine 16, pages 4985-5002.
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Rofida Albash, Menna M Abdellatif, Mariam Hassan & Noha M Badawi. (2021) Tailoring Terpesomes and Leciplex for the Effective Ocular Conveyance of Moxifloxacin Hydrochloride (Comparative Assessment): In-vitro, Ex-vivo, and In-vivo Evaluation. International Journal of Nanomedicine 16, pages 5247-5263.
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Sinar Sayed, Fatma M. Elsharkawy, Maha M. Amin, Hesham A. Shamsel-Din & Ahmed B. Ibrahim. (2021) Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m. Drug Delivery 28:1, pages 1524-1538.
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Sammar Fathy Elhabal, Shrouk A. Ghaffar, Raghda Hager, Nahla A. Elzohairy, Mohamed Mansour Khalifa, Passant M. Mohie, Rania A. Gad, Nasreen N. Omar, Mohammed H. Elkomy, Mohammad Ahmad Khasawneh & Nashwa Abdelaal. (2023) Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-vivo and in-vivo studies. International Journal of Pharmaceutics: X 5, pages 100174.
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Sadek Ahmed, Maha M. Amin & Sinar Sayed. (2023) Ocular Drug Delivery: a Comprehensive Review. AAPS PharmSciTech 24:2.
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Mariam Zewail, Passent M. E. Gaafar, Nancy Abdel Hamid Abou Youssef, Merhan E. Ali, Mai F. Ragab, Miranda F. Kamal, Mohamed H. Noureldin & Haidy Abbas. (2022) Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage. Pharmaceuticals 16:1, pages 36.
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Menna M. Abdellatif, Mina Josef, Mohamed A. El-Nabarawi & Mahmoud Teaima. (2022) Sertaconazole-Nitrate-Loaded Leciplex for Treating Keratomycosis: Optimization Using D-Optimal Design and In Vitro, Ex Vivo, and In Vivo Studies. Pharmaceutics 14:10, pages 2215.
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Ahmed Alaa Kassem, Abeer Salama & Amira Mohamed Mohsen. (2022) Formulation and optimization of cationic nanoemulsions for enhanced ocular delivery of dorzolamide hydrochloride using Box-Behnken design: In vitro and in vivo assessments. Journal of Drug Delivery Science and Technology 68, pages 103047.
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Marianne J. Naguib, Youssef R. Hassan & Wessam H. Abd-Elsalam. (2021) 3D printed ocusert laden with ultra-fluidic glycerosomes of ganciclovir for the management of ocular cytomegalovirus retinitis. International Journal of Pharmaceutics 607, pages 121010.
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Sadek Ahmed, Mohamed Aly Kassem & Sinar Sayed. (2021) Co-polymer mixed micelles enhanced transdermal transport of Lornoxicam: in vitro characterization, and in vivo assessment of anti-inflammatory effect and antinociceptive activity. Journal of Drug Delivery Science and Technology 62, pages 102365.
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Mayada Said, Ahmed A. Aboelwafa, Ahmed H. Elshafeey & Ibrahim Elsayed. (2021) Central composite optimization of ocular mucoadhesive cubosomes for enhanced bioavailability and controlled delivery of voriconazole. Journal of Drug Delivery Science and Technology 61, pages 102075.
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Sinar Sayed, Mostafa Abdelmoteleb, Maha M. Amin & Omnia M. Khowessah. (2020) Effect of Formulation Variables and Gamma Sterilization on Transcorneal Permeation and Stability of Proniosomal Gels as Ocular Platforms for Antiglaucomal Drug. AAPS PharmSciTech 21:3.
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Alaa Emad Eldeeb, Salwa Salah & Mahmoud Ghorab. (2019) Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in-vivo pharmacodynamic study. Journal of Drug Delivery Science and Technology 52, pages 236-247.
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Marwa Hasanein Asfour, Ahmed Alaa Kassem & Abeer Salama. (2019) Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences 134, pages 219-232.
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Nihal Farid Younes, Sally Adel Abdel-Halim & Abdelhalim I. Elassasy. (2018) Corneal targeted Sertaconazole nitrate loaded cubosomes: Preparation, statistical optimization, in vitro characterization, ex vivo permeation and in vivo studies. International Journal of Pharmaceutics 553:1-2, pages 386-397.
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Sinar Sayed, Ibrahim Elsayed & Maha M. Ismail. (2018) Optimization of β-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug. International Journal of Pharmaceutics 549:1-2, pages 249-260.
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